Synthesis, Characterization and Anti-hyperglycemic Activity of some novel Formazans Derivatives

In the present investigation, a series of novel formazans 4[a – h]were synthesized by the condensation of Schiff bases2[a-c] and diazonium salt chloride of various substituted aromatic amines 3[a-c] . The intermediate Schiff bases (2a-2h) were itself synthesized by the condensation of different aromatic amines2( thiocarbohydrazide , nicotinic hydrazide , carbohydrazide) with various aromatic aldehydes1.The completion of reactions  was checked by TLC.The structures of the  formazan compoundswere identified by FT- IR ,1H-NMR , 13C- NMR and mass spectral studies. Newly synthesized compound was  screened for their anti- hyperglycemiaactivity. Keywords:: Formazans, Schiff bases Anti-hyperglycemi

Chirurgie hépatique mineure par laparoscopie en ambulatoire : étude rétrospective observationnelle

RésuméAu cours de la dernière décennie, la chirurgie hépatique laparoscopique (CHL) a connu un essor dans le monde entier. Parallèlement, la chirurgie ambulatoire a été développée afin d’améliorer le confort des patients et de réduire les dépenses de santé. L’objectif de cette étude est de rapporter notre expérience préliminaire de la CHL en ambulatoire. Entre 1999 et 2014, 172 patients ont été opérés dans notre institution d’une CHL, incluant 151 résections hépatiques et 21 fenestrations de kystes hépatiques. Tous les patients consécutifs, hautement sélectionnés, opérés d’une CHL en ambulatoire ont été inclus. Vingt patients ont été opérés d’une CHL en ambulatoire. Les indications étaient des kystes hépatiques dans 10 cas, un angiome hépatique dans 3 cas, une hyperplasie nodulaire focale dans 3 cas, et une métastase hépatique de cancer colorectal dans 4 cas. La durée opératoire médiane était de 92minutes (dispersion : 50–240minutes). La perte sanguine médiane était de 35mL (dispersion : 20–150mL). Il n’a pas été observé de complication ni de réhospitalisation. Tous les patients étaient hospitalisés en postopératoire dans notre unité de chirurgie ambulatoire, et ont pu quitter l’établissement 5 à 7heures après la fin de la chirurgie. Le score médian de douleur postopératoire à la sortie était de 3 (échelle visuelle analogique à 10 niveaux ; dispersion : 0–4). Le score médian de qualité de vie à la première consultation postopératoire était de 8 (dispersion : 6–10), et le score médian de satisfaction esthétique était de 8 (dispersion : 7–10). Cette série montre que la CHL ambulatoire est faisable et sûre et chez des patients sélectionnés pour des interventions mineures.SummaryOver the last decade, laparoscopic hepatic surgery (LHS) has been increasingly performed throughout the world. Meanwhile, ambulatory surgery has been developed and implemented with the aims of improving patient satisfaction and reducing health care costs. The objective of this study was to report our preliminary experience with ambulatory minimally-invasive LHS. Between 1999 and 2014, 172 patients underwent LHS at our institution, including 151 liver resections and 21 fenestrations of hepatic cysts. The consecutive series of highly selected patients who underwent ambulatory LHS were included in this study. Twenty patients underwent ambulatory LHS. The indications were liver cysts in 10 cases, liver angioma in 3 cases, focal nodular hyperplasia in 3 cases, and colorectal hepatic metastasis in 4 cases. The median operative time was 92minutes (range: 50–240minutes). The median blood loss was 35mL (range: 20–150mL). There were no postoperative complications or re-hospitalizations. All patients were hospitalized after surgery in our ambulatory surgery unit, and were discharged 5–7hours after surgery. The median postoperative pain score at the time of discharge was 3 (visual analogue scale 0–10; range: 0–4). The median quality-of-life score at the first postoperative visit was 8 (range: 6–10) and the median cosmetic satisfaction score was 8 (range: 7–10). This series shows that, in selected patients, ambulatory LHS is feasible and safe for minor hepatic procedures

Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney

Tamm-Horsfall protein (THP), also known as uromodulin, is a kidney-specific protein produced by cells of the thick ascending limb of the loop of Henle. Although predominantly secreted apically into the urine, where it becomes highly polymerized, THP is also released basolaterally, toward the interstitium and circulation, to inhibit tubular inflammatory signaling. Whether, through this latter route, THP can also regulate the function of renal interstitial mononuclear phagocytes (MPCs) remains unclear, however. Here, we show that THP is primarily in a monomeric form in human serum. Compared with wild-type mice, THP-/- mice had markedly fewer MPCs in the kidney. A nonpolymerizing, truncated form of THP stimulated the proliferation of human macrophage cells in culture and partially restored the number of kidney MPCs when administered to THP-/- mice. Furthermore, resident renal MPCs had impaired phagocytic activity in the absence of THP. After ischemia-reperfusion injury, THP-/- mice, compared with wild-type mice, exhibited aggravated injury and an impaired transition of renal macrophages toward an M2 healing phenotype. However, treatment of THP-/- mice with truncated THP after ischemia-reperfusion injury mitigated the worsening of AKI. Taken together, our data suggest that interstitial THP positively regulates mononuclear phagocyte number, plasticity, and phagocytic activity. In addition to the effect of THP on the epithelium and granulopoiesis, this new immunomodulatory role could explain the protection conferred by THP during AKI

Working sick and out of sorts: a cross-cultural approach on presenteeism climate, organizational justice and work–family conflict

A climate of presenteeism has important effects on employee well-being and the organization itself. Our study, based on surveys of health sector employees in six different countries (Brazil, Ecuador, Lebanon, Portugal, Russia and Spain) examines whether organizational justice plays a mediating role in the relationship between a presenteeism climate in the organization and work–family conflict (WFC). Our results indicate that the perception of organizational justice and the presenteeism climate do influence WFC. Moreover, higher levels of WFC were found in non-Latin countries. This study contributes to the work attendance and life balance field by providing cross-cultural empirical evidence corroborating the effect of justice and presenteeism climate on the WFC.info:eu-repo/semantics/acceptedVersio

Gain Characterization of Praseodymium Doped SingleMode Optical Fiber Amplifier

A theoretical study for three level laser systems, describes the interaction process between optical fields and optical fiber material of amplifier. This study gives a simple approach expression for gain coefficient which depends on some parameters such as input power pump rate, number of doped atoms per unit volume, fiber length and core radius. It has been found that In order to keep the fiber amplifiers doped with praseodymium as short as possible with good efficiency, it is best to increasing the doped concentration. For 3m length and doping concentration, the gain is 8dB, while for same length and pump power the gain is >10dB if doping concentration

Role of the Microbiome in Allergic Disease Development

PURPOSE OF REVIEW: Evidence suggests that the microbiome of the skin, gastrointestinal tract, and airway contribute to health and disease. As we learn more about the role that the microbiota plays in allergic disease development, we can develop therapeutics to alter this pathway. RECENT FINDINGS: Epidemiologic studies reveal that an association exists between environmental exposures, which alter the microbiota, and developing atopic dermatitis, food allergy, and/or asthma. In fact, samples from the skin, gastrointestinal tract, and respiratory tract reveal distinct microbiotas compared with healthy controls, with microbial changes (dysbiosis) often preceding the development of allergic disease. Mechanistic studies have confirmed that microbes can either promote skin, gut, and airway health by strengthening barrier integrity, or they can alter skin integrity and damage gut and airway epithelium. In this review, we will discuss recent studies that reveal the link between the microbiota and immune development, and we will discuss ways to influence these changes

Simulation Study of the Variations in Driving Pressure and Frequency on Microbubbles Contras Agents Behavior

The difference between the density of the gas core of microbubbles and the surrounding media causes the behavior of microbubbles contrast agents in an ultrasound field to be nonlinear and intricate. In addition, many factors affect the radial oscillations of these microbubbles. Some of these factors are related with the bubble structure and its shell material such as the initial radius of the bubble, shell thickness, viscosity of the shell material and its elasticity. Other factors are related with the incident acoustic wave such as the driving frequency and driving pressure amplitude. In this simulation study the effects of pressure and frequency as influential factors on the stability of the microbubble were studied in wide range (frequencies are extend from f<fr to f≈3 fr, pressure extends from 0.05 to 1.5 MPa.), and analyzed using the bifurcation theory to visualize and characterize the effect of these factors on the microbubbles behavior. The study expounded theoretically that the generation the higher order of subharmonic oscillations is possible to result at high driving frequencies with low and appropriate driving pressures

Enhancing reuse of data and biological material in medical research : from FAIR to FAIR-Health

The known challenge of underutilization of data and biological material from biorepositories as potential resources formedical research has been the focus of discussion for over a decade. Recently developed guidelines for improved data availability and reusability—entitled FAIR Principles (Findability, Accessibility, Interoperability, and Reusability)—are likely to address only parts of the problem. In this article,we argue that biologicalmaterial and data should be viewed as a unified resource. This approach would facilitate access to complete provenance information, which is a prerequisite for reproducibility and meaningful integration of the data. A unified view also allows for optimization of long-term storage strategies, as demonstrated in the case of biobanks.Wepropose an extension of the FAIR Principles to include the following additional components: (1) quality aspects related to research reproducibility and meaningful reuse of the data, (2) incentives to stimulate effective enrichment of data sets and biological material collections and its reuse on all levels, and (3) privacy-respecting approaches for working with the human material and data. These FAIR-Health principles should then be applied to both the biological material and data. We also propose the development of common guidelines for cloud architectures, due to the unprecedented growth of volume and breadth of medical data generation, as well as the associated need to process the data efficiently.peer-reviewe