Incretin-Based Therapies for the Treatment of Type 2 Diabetes: Evaluation of the Risks and Benefits

Limited evidence suggests that GLP-I may also preserve ventricular function and improve outcomes in human subjects with heart failure or myocardial infarction (11,12). [...] both exenatide and liraglutide reduce blood pressure, body weight, and plasma lipid profiles in subjects with type 2 diabetes (13), raising the hope that longterm treatment with these agents may reduce the incidence of cardiovascular events.\n However, two safety issues have been raised - pancreatitis and medullary carcinoma of the thyroid

A Full Characterization of Quantum Advice

We prove the following surprising result: given any quantum state rho on n qubits, there exists a local Hamiltonian H on poly(n) qubits (e.g., a sum of two-qubit interactions), such that any ground state of H can be used to simulate rho on all quantum circuits of fixed polynomial size. In terms of complexity classes, this implies that BQP/qpoly is contained in QMA/poly, which supersedes the previous result of Aaronson that BQP/qpoly is contained in PP/poly. Indeed, we can exactly characterize quantum advice, as equivalent in power to untrusted quantum advice combined with trusted classical advice. Proving our main result requires combining a large number of previous tools -- including a result of Alon et al. on learning of real-valued concept classes, a result of Aaronson on the learnability of quantum states, and a result of Aharonov and Regev on "QMA+ super-verifiers" -- and also creating some new ones. The main new tool is a so-called majority-certificates lemma, which is closely related to boosting in machine learning, and which seems likely to find independent applications. In its simplest version, this lemma says the following. Given any set S of Boolean functions on n variables, any function f in S can be expressed as the pointwise majority of m=O(n) functions f1,...,fm in S, such that each fi is the unique function in S compatible with O(log|S|) input/output constraints.Comment: We fixed two significant issues: 1. The definition of YQP machines needed to be changed to preserve our results. The revised definition is more natural and has the same intuitive interpretation. 2. We needed properties of Local Hamiltonian reductions going beyond those proved in previous works (whose results we'd misstated). We now prove the needed properties. See p. 6 for more on both point

The seasonality of tuberculosis, sunlight, vitamin D, and household crowding.

BACKGROUND: Unlike other respiratory infections, tuberculosis diagnoses increase in summer. We performed an ecological analysis of this paradoxical seasonality in a Peruvian shantytown over 4 years. METHODS: Tuberculosis symptom-onset and diagnosis dates were recorded for 852 patients. Their tuberculosis-exposed cohabitants were tested for tuberculosis infection with the tuberculin skin test (n = 1389) and QuantiFERON assay (n = 576) and vitamin D concentrations (n = 195) quantified from randomly selected cohabitants. Crowding was calculated for all tuberculosis-affected households and daily sunlight records obtained. RESULTS: Fifty-seven percent of vitamin D measurements revealed deficiency (<50 nmol/L). Risk of deficiency was increased 2.0-fold by female sex (P < .001) and 1.4-fold by winter (P < .05). During the weeks following peak crowding and trough sunlight, there was a midwinter peak in vitamin D deficiency (P < .02). Peak vitamin D deficiency was followed 6 weeks later by a late-winter peak in tuberculin skin test positivity and 12 weeks after that by an early-summer peak in QuantiFERON positivity (both P < .04). Twelve weeks after peak QuantiFERON positivity, there was a midsummer peak in tuberculosis symptom onset (P < .05) followed after 3 weeks by a late-summer peak in tuberculosis diagnoses (P < .001). CONCLUSIONS: The intervals from midwinter peak crowding and trough sunlight to sequential peaks in vitamin D deficiency, tuberculosis infection, symptom onset, and diagnosis may explain the enigmatic late-summer peak in tuberculosis

New Measurements of Nucleon Structure Functions from the CCFR/NuTeV Collaboration

We report on the extraction of the structure functions F_2 and Delta xF_3 = xF_3nu-xF_3nubar from CCFR neutrino-Fe and antineutrino-Fe differential cross sections. The extraction is performed in a physics model independent (PMI) way. This first measurement for Delta xF_3, which is useful in testing models of heavy charm production, is higher than current theoretical predictions. The F_2 (PMI) values measured in neutrino and muon scattering are in good agreement with the predictions of Next to Leading Order PDFs (using massive charm production schemes), thus resolving the long-standing discrepancy between the two sets of data.Comment: 5 pages. Presented by Arie Bodek at the CIPNAP2000 Conference, Quebec City, May 200

Teachers as leaders in a knowledge society: encouraging signs of a new professionalism

[Abstract]: Challenges confronting schools worldwide are greater than ever,and, likewise, many teachers possess capabilities, talents, and formal credentials more sophisticated than ever. However, the responsibility and authority accorded to teachers have not grown significantly, nor has the image of teaching as a profession advanced significantly. The question becomes, what are the implications for the image and status of the teaching profession as the concept of knowledge society takes a firm hold in the industrialized world? This article addresses the philosophical underpinnings of teacher leadership manifested in case studies where schools sought to achieve the generation of new knowledge as part of a process of whole-school revitalization. Specifically, this article reports on Australian research that has illuminated the work of teacher leaders engaged in the IDEAS project, a joint school revitalization initiative of the University of Southern Queensland and the Queensland Department of Education and the Arts