510 research outputs found
Generating Single Microwave Photons in a Circuit
Electromagnetic signals in circuits consist of discrete photons, though
conventional voltage sources can only generate classical fields with a coherent
superposition of many different photon numbers. While these classical signals
can control and measure bits in a quantum computer (qubits), single photons can
carry quantum information, enabling non-local quantum interactions, an
important resource for scalable quantum computing. Here, we demonstrate an
on-chip single photon source in a circuit quantum electrodynamics (QED)
architecture, with a microwave transmission line cavity that collects the
spontaneous emission of a single superconducting qubit with high efficiency.
The photon source is triggered by a qubit rotation, as a photon is generated
only when the qubit is excited. Tomography of both qubit and fluorescence
photon shows that arbitrary qubit states can be mapped onto the photon state,
demonstrating an ability to convert a stationary qubit into a flying qubit.
Both the average power and voltage of the photon source are characterized to
verify performance of the system. This single photon source is an important
addition to a rapidly growing toolbox for quantum optics on a chip.Comment: 6 pages, 5 figures, hires version at
http://www.eng.yale.edu/rslab/papers/single_photon_hires.pd
An Electron Fixed Target Experiment to Search for a New Vector Boson A' Decaying to e+e-
We describe an experiment to search for a new vector boson A' with weak
coupling alpha' > 6 x 10^{-8} alpha to electrons (alpha=e^2/4pi) in the mass
range 65 MeV < m_A' < 550 MeV. New vector bosons with such small couplings
arise naturally from a small kinetic mixing of the "dark photon" A' with the
photon -- one of the very few ways in which new forces can couple to the
Standard Model -- and have received considerable attention as an explanation of
various dark matter related anomalies. A' bosons are produced by radiation off
an electron beam, and could appear as narrow resonances with small production
cross-section in the trident e+e- spectrum. We summarize the experimental
approach described in a proposal submitted to Jefferson Laboratory's PAC35,
PR-10-009. This experiment, the A' Experiment (APEX), uses the electron beam of
the Continuous Electron Beam Accelerator Facility at Jefferson Laboratory
(CEBAF) at energies of ~1-4 GeV incident on 0.5-10% radiation length Tungsten
wire mesh targets, and measures the resulting e+e- pairs to search for the A'
using the High Resolution Spectrometer and the septum magnet in Hall A. With a
~1 month run, APEX will achieve very good sensitivity because the statistics of
e+e- pairs will be ~10,000 times larger in the explored mass range than any
previous search for the A' boson. These statistics and the excellent mass
resolution of the spectrometers allow sensitivity to alpha'/alpha one to three
orders of magnitude below current limits, in a region of parameter space of
great theoretical and phenomenological interest. Similar experiments could also
be performed at other facilities, such as the Mainz Microtron.Comment: 19 pages, 12 figures, 2 table
Instrument development, data collection, and characteristics of practices, staff, and measures in the Improving Quality of Care in Diabetes (iQuaD) Study
Peer reviewedPublisher PD
The Cosmology of Composite Inelastic Dark Matter
Composite dark matter is a natural setting for implementing inelastic dark
matter - the O(100 keV) mass splitting arises from spin-spin interactions of
constituent fermions. In models where the constituents are charged under an
axial U(1) gauge symmetry that also couples to the Standard Model quarks, dark
matter scatters inelastically off Standard Model nuclei and can explain the
DAMA/LIBRA annual modulation signal. This article describes the early Universe
cosmology of a minimal implementation of a composite inelastic dark matter
model where the dark matter is a meson composed of a light and a heavy quark.
The synthesis of the constituent quarks into dark mesons and baryons results in
several qualitatively different configurations of the resulting dark matter
hadrons depending on the relative mass scales in the system.Comment: 31 pages, 4 figures; references added, typos correcte
Secluded Dark Matter Coupled to a Hidden CFT
Models of secluded dark matter offer a variant on the standard WIMP picture
and can modify our expectations for hidden sector phenomenology and detection.
In this work we extend a minimal model of secluded dark matter, comprised of a
U(1)'-charged dark matter candidate, to include a confining hidden-sector CFT.
This provides a technically natural explanation for the hierarchically small
mediator-scale, with hidden-sector confinement generating m_{gamma'}>0.
Furthermore, the thermal history of the universe can differ markedly from the
WIMP picture due to (i) new annihilation channels, (ii) a (potentially) large
number of hidden-sector degrees of freedom, and (iii) a hidden-sector phase
transition at temperatures T << M_{dm} after freeze out. The mediator allows
both the dark matter and the Standard Model to communicate with the CFT, thus
modifying the low-energy phenomenology and cosmic-ray signals from the secluded
sector.Comment: ~50p, 8 figs; v2 JHEP versio
Breaking the Lightweight Secure PUF: Understanding the Relation of Input Transformations and Machine Learning Resistance
Physical Unclonable Functions (PUFs) and, in particular, XOR Arbiter PUFs have gained much research interest as an authentication mechanism for embedded systems.
One of the biggest problems of (strong) PUFs is their vulnerability to so called machine learning attacks.
In this paper we take a closer look at one aspect of machine learning attacks that has not yet gained the needed attention:
the generation of the sub-challenges in XOR Arbiter PUFs fed to the individual Arbiter PUFs.
Specifically, we look at one of the most popular ways to generate sub-challenges based on a combination of permutations and XORs as it has been described for the Lightweight Secure PUF .
Previous research suggested that using such a sub-challenge generation increases the machine learning resistance significantly.
Our contribution in the field of sub-challenge generation is three-fold: First, drastically improving attack results by Rührmair et al., we describe a novel attack that can break the Lightweight Secure PUF in time roughly equivalent to an XOR Arbiter PUF without transformation of the challenge input. Second, we give a mathematical model that gives insight into the weakness of the Lightweight Secure PUF and provides a way to study generation of sub-challenges in general. Third, we propose a new, efficient, and cost-effective way for sub-challenge generation that mitigates the attack strategy we used and outperforms the Lightweight Secure PUF in both machine learning resistance and resource overhead
Predicting ICU survival: A meta-level approach
<p>Abstract</p> <p>Background</p> <p>The performance of separate Intensive Care Unit (ICU) status scoring systems vis-à-vis prediction of outcome is not satisfactory. Computer-based predictive modeling techniques may yield good results but their performance has seldom been extensively compared to that of other mature or emerging predictive models. The objective of the present study was twofold: to propose a prototype meta-level predicting approach concerning Intensive Care Unit (ICU) survival and to evaluate the effectiveness of typical mining models in this context.</p> <p>Methods</p> <p>Data on 158 men and 46 women, were used retrospectively (75% of the patients survived). We used Glasgow Coma Scale (GCS), Acute Physiology And Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA) and Injury Severity Score (ISS) values to structure a decision tree (DTM), a neural network (NNM) and a logistic regression (LRM) model and we evaluated the assessment indicators implementing Receiver Operating Characteristics (ROC) plot analysis.</p> <p>Results</p> <p>Our findings indicate that regarding the assessment of indicators' capacity there are specific discrete limits that should be taken into account. The Az score ± SE was 0.8773± 0.0376 for the DTM, 0.8061± 0.0427 for the NNM and 0.8204± 0.0376 for the LRM, suggesting that the proposed DTM achieved a near optimal Az score.</p> <p>Conclusion</p> <p>The predicting processes of ICU survival may go "one step forward", by using classic composite assessment indicators as variables.</p
A comprehensive re-analysis of the Golden Spike data: Towards a benchmark for differential expression methods
<p>Abstract</p> <p>Background</p> <p>The Golden Spike data set has been used to validate a number of methods for summarizing Affymetrix data sets, sometimes with seemingly contradictory results. Much less use has been made of this data set to evaluate differential expression methods. It has been suggested that this data set should not be used for method comparison due to a number of inherent flaws.</p> <p>Results</p> <p>We have used this data set in a comparison of methods which is far more extensive than any previous study. We outline six stages in the analysis pipeline where decisions need to be made, and show how the results of these decisions can lead to the apparently contradictory results previously found. We also show that, while flawed, this data set is still a useful tool for method comparison, particularly for identifying combinations of summarization and differential expression methods that are unlikely to perform well on real data sets. We describe a new benchmark, AffyDEComp, that can be used for such a comparison.</p> <p>Conclusion</p> <p>We conclude with recommendations for preferred Affymetrix analysis tools, and for the development of future spike-in data sets.</p
Measuring inter-rater reliability for nominal data – which coefficients and confidence intervals are appropriate?
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