1,972 research outputs found
Chemical potential oscillations from a single nodal pocket in the underdoped high-Tc superconductor YBa2Cu3O6+x
The mystery of the normal state in the underdoped cuprates has deepened with
the use of newer and complementary experimental probes. While photoemission
studies have revealed solely `Fermi arcs' centered on nodal points in the
Brillouin zone at which holes aggregate upon doping, more recent quantum
oscillation experiments have been interpreted in terms of an ambipolar Fermi
surface, that includes sections containing electron carriers located at the
antinodal region. To address the question of whether an ambipolar Fermi surface
truly exists, here we utilize measurements of the second harmonic quantum
oscillations, which reveal that the amplitude of these oscillations arises
mainly from oscillations in the chemical potential, providing crucial
information on the nature of the Fermi surface in underdoped YBa2Cu3O6+x. In
particular, the detailed relationship between the second harmonic amplitude and
the fundamental amplitude of the quantum oscillations leads us to the
conclusion that there exists only a single underlying quasi-two dimensional
Fermi surface pocket giving rise to the multiple frequency components observed
via the effects of warping, bilayer splitting and magnetic breakdown. A range
of studies suggest that the pocket is most likely associated with states near
the nodal region of the Brillouin zone of underdoped YBa2Cu3O6+x at high
magnetic fields.Comment: 7 pages, 4 figure
Semi-analytical approach to magnetized temperature autocorrelations
The cosmic microwave background (CMB) temperature autocorrelations, induced
by a magnetized adiabatic mode of curvature inhomogeneities, are computed with
semi-analytical methods. As suggested by the latest CMB data, a nearly
scale-invariant spectrum for the adiabatic mode is consistently assumed. In
this situation, the effects of a fully inhomogeneous magnetic field are
scrutinized and constrained with particular attention to harmonics which are
relevant for the region of Doppler oscillations. Depending on the parameters of
the stochastic magnetic field a hump may replace the second peak of the angular
power spectrum. Detectable effects on the Doppler region are then expected only
if the magnetic power spectra have quasi-flat slopes and typical amplitude
(smoothed over a comoving scale of Mpc size and redshifted to the epoch of
gravitational collapse of the protogalaxy) exceeding 0.1 nG. If the magnetic
energy spectra are bluer (i.e. steeper in frequency) the allowed value of the
smoothed amplitude becomes, comparatively, larger (in the range of 20 nG). The
implications of this investigation for the origin of large-scale magnetic
fields in the Universe are discussed. Connections with forthcoming experimental
observations of CMB temperature fluctuations are also suggested and partially
explored.Comment: 40 pages, 13 figure
Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human Natural Killer cells
It has been suggested that receptor-ligand complexes segregate or co-localise within immune synapses according to their size, and this is important for receptor signaling. Here, we set out to test the importance of receptor-ligand complex dimensions for immune surveillance of target cells by human Natural Killer (NK) cells. NK cell activation is regulated by integrating signals from activating receptors, such as NKG2D, and inhibitory receptors, such as KIR2DL1. Elongating the NKG2D ligand MICA reduced its ability to trigger NK cell activation. Conversely, elongation of KIR2DL1 ligand HLA-C reduced its ability to inhibit NK cells. Whereas normal-sized HLA-C was most effective at inhibiting activation by normal-length MICA, only elongated HLA-C could inhibit activation by elongated MICA. Moreover, HLA-C and MICA that were matched in size co-localised, whereas HLA-C and MICA that were different in size were segregated. These results demonstrate that receptor-ligand dimensions are important in NK cell recognition, and suggest that optimal integration of activating and inhibitory receptor signals requires the receptor-ligand complexes to have similar dimensions
Minimal Supersymmetric Inverse Seesaw: Neutrino masses, lepton flavour violation and LHC phenomenology
We study neutrino masses in the framework of the supersymmetric inverse
seesaw model. Different from the non-supersymmetric version a minimal
realization with just one pair of singlets is sufficient to explain all
neutrino data. We compute the neutrino mass matrix up to 1-loop order and show
how neutrino data can be described in terms of the model parameters. We then
calculate rates for lepton flavour violating (LFV) processes, such as , and chargino decays to singlet scalar neutrinos. The latter decays
are potentially observable at the LHC and show a characteristic decay pattern
dictated by the same parameters which generate the observed large neutrino
angles.Comment: 26 pages, 4 figures; added explanatory comments, final version for
publicatio
Iron, silicate, and light co-limitation of three Southern Ocean diatom species
The effect of combined iron, silicate, and light co-limitation was investigated in the three diatom species Actinocyclus sp. Ehrenberg, Chaetoceros dichaeta Ehrenberg, and Chaetoceros debilis Cleve, isolated from the Southern Ocean (SO). Growth of all species was co-limited by iron and silicate, reflected in a significant increase in the number of cell divisions compared to the control. Lowest relative Si uptake and drastic frustule malformation was found under iron and silicate co-limitation in C. dichaeta, while Si limitation in general caused cell elongation in both Chaetoceros species. Higher light intensities similar to SO surface conditions showed a negative impact on growth of C. dichaeta and Actinocyclus sp. and no effect on C. debilis. This is in contrast to the assumed light limitation of SO diatoms due to deep wind driven mixing. Our results suggest that growth and species composition of Southern Ocean diatoms is influenced by a sensitive interaction of the abiotic factors, iron, silicate, and light
Increased ventral striatal volume in college-aged binge drinkers
BACKGROUND
Binge drinking is a serious public health issue associated with cognitive, physiological, and anatomical differences from healthy individuals. No studies, however, have reported subcortical grey matter differences in this population. To address this, we compared the grey matter volumes of college-age binge drinkers and healthy controls, focusing on the ventral striatum, hippocampus and amygdala.
METHOD
T1-weighted images of 19 binge drinkers and 19 healthy volunteers were analyzed using voxel-based morphometry. Structural data were also covaried with Alcohol Use Disorders Identification Test (AUDIT) scores. Cluster-extent threshold and small volume corrections were both used to analyze imaging data.
RESULTS
Binge drinkers had significantly larger ventral striatal grey matter volumes compared to controls. There were no between group differences in hippocampal or amygdalar volume. Ventral striatal, amygdalar, and hippocampal volumes were also negatively related to AUDIT scores across groups.
CONCLUSIONS
Our findings stand in contrast to the lower ventral striatal volume previously observed in more severe forms of alcohol use disorders, suggesting that college-age binge drinkers may represent a distinct population from those groups. These findings may instead represent early sequelae, compensatory effects of repeated binge and withdrawal, or an endophenotypic risk factor
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Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros
This study describes the discovery and characterisation of a novel aminopeptidase A from the venom of B. g. rhinoceros and highlights its potential biological importance. Similar to mammalian aminopeptidases, rhiminopeptidase A might be capable of playing roles in altering the blood pressure and brain function of victims. Furthermore, it could have additional effects on the biological functions of other host proteins by cleaving their N-terminal amino acids. This study points towards the importance of complete analysis of individual components of snake venom in order to develop effective therapies for snake bites
Network model of immune responses reveals key effectors to single and co-infection dynamics by a respiratory bacterium and a gastrointestinal helminth
Co-infections alter the host immune response but how the systemic and local processes at the site of infection interact is still unclear. The majority of studies on co-infections concentrate on one of the infecting species, an immune function or group of cells and often focus on the initial phase of the infection. Here, we used a combination of experiments and mathematical modelling to investigate the network of immune responses against single and co-infections with the respiratory bacterium Bordetella bronchiseptica and the gastrointestinal helminth Trichostrongylus retortaeformis. Our goal was to identify representative mediators and functions that could capture the essence of the host immune response as a whole, and to assess how their relative contribution dynamically changed over time and between single and co-infected individuals. Network-based discrete dynamic models of single infections were built using current knowledge of bacterial and helminth immunology; the two single infection models were combined into a co-infection model that was then verified by our empirical findings. Simulations showed that a T helper cell mediated antibody and neutrophil response led to phagocytosis and clearance of B. bronchiseptica from the lungs. This was consistent in single and co-infection with no significant delay induced by the helminth. In contrast, T. retortaeformis intensity decreased faster when co-infected with the bacterium. Simulations suggested that the robust recruitment of neutrophils in the co-infection, added to the activation of IgG and eosinophil driven reduction of larvae, which also played an important role in single infection, contributed to this fast clearance. Perturbation analysis of the models, through the knockout of individual nodes (immune cells), identified the cells critical to parasite persistence and clearance both in single and co-infections. Our integrated approach captured the within-host immuno-dynamics of bacteria-helminth infection and identified key components that can be crucial for explaining individual variability between single and co-infections in natural populations
Adaptive remodeling of the bacterial proteome by specific ribosomal modification regulates Pseudomonas infection and niche colonisation
Post-transcriptional control of protein abundance is a highly important, underexplored regulatory process by which organisms respond to their environments. Here we describe an important and previously unidentified regulatory pathway involving the ribosomal modification protein RimK, its regulator proteins RimA and RimB, and the widespread bacterial second messenger cyclic-di-GMP (cdG). Disruption of rimK affects motility and surface attachment in pathogenic and commensal Pseudomonas species, with rimK deletion significantly compromising rhizosphere colonisation by the commensal soil bacterium P. fluorescens, and plant infection by the pathogens P. syringae and P. aeruginosa. RimK functions as an ATP-dependent glutamyl ligase, adding glutamate residues to the C-terminus of ribosomal protein RpsF and inducing specific effects on both ribosome protein complement and function. Deletion of rimK in P. fluorescens leads to markedly reduced levels of multiple ribosomal proteins, and also of the key translational regulator Hfq. In turn, reduced Hfq levels induce specific downstream proteomic changes, with significant increases in multiple ABC transporters, stress response proteins and non-ribosomal peptide synthetases seen for both ΔrimK and Δhfq mutants. The activity of RimK is itself controlled by interactions with RimA, RimB and cdG. We propose that control of RimK activity represents a novel regulatory mechanism that dynamically influences interactions between bacteria and their hosts; translating environmental pressures into dynamic ribosomal changes, and consequently to an adaptive remodeling of the bacterial proteome
North-South technology transfer in unionised multinationals
We study how incentives for North-South technology transfers in multinational enterprises
are affected by labour market institutions. If workers are collectively organised, incentives
for technology transfers are partly governed by .rms. desire to curb trade union power.
This will affect not only the extent but also the type of technology transfer. While skill
upgrading of southern workers benefits these workers at the expense of northern worker
welfare, quality upgrading of products produced in the South may harm not only northern
but also southern workers. A minimum wage policy to raise the wage levels of southern
workers may spur technology transfer, possibly to the extent that the utility of northern
workers decline. These conclusions are reached in a setting where a unionised multinational
multiproduct firm produces two vertically differentiated products in northern and southern
subsidiaries, respectively.FEDERQRENCOMPETEFundação para a Ciência e a Tecnologia (FCT
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