Description of In116, the first blaCTX-M-2-containing complex class 1 integron found in Morganella morganii isolates from Buenos Aires, Argentina

peer reviewe

Molecular characterization of InJR06, a class 1 integron located in a conjugative plasmid of Salmonella enterica ser. Typhimurium

The presence of class 1, 2, and 3 integrons was investigated in four pediatric isolates of Salmonella enterica ser. Typhimurium (S. Typhimurium). A class 1 integron was detected in one S. Typhimurium strain, the only one that also showed resistance to various aminoglycoside antibiotics. This integron, called InJR06, and the aminoglycoside resistance determinants were located in pS06, a large (≥55 kb) conjugative plasmid. Asingle mobile cassette (encoding the aminoglycoside adenylyltransferase ANT(3´´)-Ia) was detected in the variable region of InJR06, while the architecture of the attI1 and attC sites was conserved. [Int Microbiol 2005; 8(4):287-290

Psoriatic Disease and Tuberculosis Nowadays

Psoriasis is a chronic, relapsing and remitting inflammatory skin and joint disease that has a prevalence of 2-3% in the world's population, whereas of 1–2% in Europe. The traditional concept of psoriasis as the “healthy people's” disease has been recently revised because of ever-increasing reports of associations with various pathological conditions (hypertension, Crohn's disease, type II diabetes mellitus, obesity, dyslipidemia, metabolic syndrome, infectious conditions). Particularly, advances in psoriasis therapies have introduced biologic agents. All the tumor necrosis factor-alpha inhibitors are associated with an increased risk of developing active disease in patients with latent tuberculosis infection, because of TNF-α key role against Mycobacterium tuberculosis. For this reason, exclusion of active tuberculosis and treatment of latent tuberculosis infection are clinical imperatives prior to starting this therapy. Moreover active surveillance for a history of untreated or partially treated tuberculosis or latent form has already been shown to be effective in reducing the number of incident tuberculosis cases

ß-lactamasas producidas por enterobacterias resistentes a amoxicilina-ácido clavulánico aisladas en Buenos Aires, Argentina: un nuevo gen blaTEM

Resistance to β-lactam/β-lactamase inhibitors in enterobacteria is a growing problem that has not been intensively studied in Argentina. In the present work, 54/843 enterobacteria collected in a teaching hospital of Buenos Aires city were ampicillin-sulbactam-resistant isolates remaining susceptible to second- and third-generation cephalosporins. The enzymatic mechanisms present in the isolates, which were also amoxicillin-clavulanic acid (AMC)-resistant (18/54) were herein analyzed. Sequencing revealed two different variants of blaTEM-1, being blaTEM-1b the most frequently detected allelle (10 Escherichia coli, 3 Klebsiella pneumoniae, 2 Proteus mirabilis and 1 Raoultella terrigena) followed by blaTEM-1a (1 K. pneumoniae). Amoxicillin-clavulanate resistance seems to be mainly associated with TEM-1 overproduction (mostly in E. coli) or co-expressed with OXA-2-like and/or SHV β-lactamases (K. pneumoniae and P. mirabilis). A new blaTEM variant (TEM-163) was described in an E. coli strain having an AMC MIC value of 16/8 μg/ml. TEM-163 contains Arg275Gln and His289Leu amino acid substitutions. On the basis of the high specific activity and low IC50 for clavulanic acid observed, the resistance pattern seems to be due to overproduction of the new variant of broad spectrum β-lactamase rather than to an inhibitor-resistant TEM (IRT)-like behavior.Fil: Di Conza, José Alejandro. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Badaracco, Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ayala, Juan. Centro de Biología Molecular "Severo Ochoa"; EspañaFil: Rodriguez, Cynthia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Famiglietti, Angela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Leitura, poder e fake news: como enfrentar a (des)informação na era da (pós)verdade?

Este trabalho objetiva refletir sobre as estratégias de exercício do poder por meio da propagação de fake news na rede mundial de computadores, tomando por base a concepção de que a constituição de sujeito se dá pelas práticas discursivas, e de que maneira esse problema poderia ser solucionado ou amenizado. Essas leituras acabam por constituir modos de subjetivação a partir das condições de possibilidade da mídia digital. Essa empreitada será propiciada à luz das considerações de Foucault (1997; 2006; 2008; 2016) sobre poder, verdade e subjetividade, com o auxílio de Possenti (1999; 2001) sobre sujeito e leitura, além das considerações de Curcino (2012; 2014) que aborda a leitura na mídia supracitada. A formação do leitor crítico seria o caminho para o enfrentamento das fake news na contemporaneidade, pautada por uma formação em leitura digital sólida, de modo a conscientizar esse sujeito, levando-o à resistência em relação às vontades de verdade impostas

ENTRE A LIBERDADE E O CONTROLE DO SUJEITO: EMPRESARIAMENTO E BIOPODER DA VIDA ÍNTIMA NA CONTEMPORANEIDADE

A presente investigação objetiva problematizar/refletir em que medida nossos desejos de prazer são capturados e objetivados, reduzindo, a partir dessas estratégias de empresariamento, nossa possibilidade de resistência e de exercício de uma subjetividade singular. O corpus consiste em propagandas de produtos sexuais e de reportagens sobre as determinações governamentais em relação a essas práticas, no sentido de coibi-las. Para tanto, tomaremos como suporte teórico-metodológico algumas formulações de Michel Foucault (1984; 1985; 1988; 2008a; 2008b; 2010; 2016; 2018), pelas explanações de sexualidade, verdade, subjetividade e biopolítica/biopoder, com o auxílio dos teóricos Pierre Dardot e Christian Laval (2016) no que concerne à cultura de empresa e a nova subjetividade. As análises apontam para uma contradição que pode dividir o sujeito em relação à sua posição frente aos incentivos da mídia e às interferências proibitivas do governo, suscitando comportamentos de resistência e de práticas de liberdade nesses jogos de verdade sobre o exercício da sexualidade

Deep Inelastic Scattering Data and the Problem of Saturation in Small-x Physics

We investigate the role of unitarization effects in virtual photon-proton (\gamma^*p) interactions at small x. The q\bar{q}-fluctuation of the initial photon is separated into a small distance and a large distance component and a model for the unitarization of each component is proposed. The Born approximation for the small size component is calculated using QCD perturbation theory. Reggeon diagram technique is used in order to obtain a self-consistent scheme for both total \gamma^*p cross section and diffractive production. The model gives a good description of HERA data in the small-x region, with a single Pomeron of intercept 1.2.Comment: 27 pages, 8 postscript figure

Agronomic, physiological and quality response of romaine and red oak-leaf lettuce to nitrogen input

Protecting the environment by improving the crop-system nitrogen (N) use efficiency (NUE) while maximising yield and quality is a primary challenge for modern agriculture, and understanding the processes that govern N fluxes in the plant-soil system is essential to improve NUE. An on-farm study was conducted over two fall-winter seasons to evaluate the NUE, agronomical and physiological response of romaine (var. longifolia, cv Manavert) and red oak-leaf (var. crispa, cv Aruba) lettuce (Lactuca sativa L.) to different N-rates (0, 60, 120, 180 kg ha–1 of N). Nitrogen rate influenced all tested parameters, including plant fresh and dry weight, N accumulation, leaf NO3– and dry matter content, NUE indices, N nutrition index (NNI), soil residual N and the estimated N losses at the end of the crop season. Fresh yield, dry weight and N-accumulation response to N rate were influenced by lettuce genotype. Manavert had higher N recovery, NUE, and lower leaf NO3– concentration than Aruba. Analysing the NNI overtime, 120 kg ha–1 of N assured an optimal N status in both Manavert and Aruba, while N deficiency and excess were observed at lower and higher N-rates, respectively. An empirical relationship was observed between NNI and leaf NO3– concentration, suggesting that leaf NO3– concentration may be used to predict NNI and thus the crop N status. The relationship between NNI and leaf NO3– concentration may be used to define optimal leaf NO3– concentration ranges for the rapid and site-specific assessment of the crop N status, and the dynamic adjustment of N-fertilisation, contributing to improve crop NUE, minimise N-losses, and optimise yield and quality of lettuce crops