Grain silo location-allocation problem with dwell time for optimization of food grain supply chain network

In the last few decades, production and procurement of food grain in India have steadily increased, however, storage capacity has not increased proportionally. The government of India (GOI) is establishing the various capacitated silos across the country to bridge this storage capacity gap. This paper presents a novel integrated multi-objective, multi-modal and multiperiod mathematical model for grain silo location-allocation problem with Dwell time to support the decision-making process of GOI. Two conflicting objectives- minimization of total supply chain network cost and total lead time (transit and dwell time) are simultaneously optimized using two Pareto based multi-objective algorithms with calibrated parameters

Knowledge of UK Dental Undergraduates and Dentists in Treating Dentine Hypersensitivity

Aim: The purpose of the present questionnaire-based study was to evaluate the knowledge and understanding of UK based dental undergraduates and qualified dentists in treating Dentine Hypersensitivity (DH). Methods: 120 questionnaires were handed out to 4th and 5th year dental students and Staff at the Dental Hospital in London UK as part of a collaborative study with the Faculdade de Odontologia de Bauru, University of Sao Paulo, Brazil. The questionnaire consisted of 22 questions, which included both open and closed questions. Results: 91 questionnaires (75.8% response rate) were returned; of the 91 respondents (38M; 52F, 1 missing value) 53 were dentists (61%) and 34 were dental students (39%) (4 missing values). 37.5% of students indicated that 10% of patients suffered from DH whereas 18.9% of dentists indicated that 25% of patients suffered from DH. Both dentists (22.6%) and 27.5% of students indicated that DH lasted >12 weeks. 18.9% of dentists considered that DH was a serious problem for patients although 32.5% of students were not sure. Dentists (66%) and students (62.5%) indicated that DH had a major impact on the quality of life (QOL) with 51.1% (dentists) and 56.3% (students) indicating that it was moderate in nature. Conclusion: The results of the present pilot study would suggest that in terms of knowledge and understanding of DH (e.g., hydrodynamic theory) both dentists (90.5%) and students (76.9%) were comparable although in the assessment and subsequent management of DH the results indicated that dentists were more confident than the student

Pharmaceutical fortification of Rasoushadhies for their better clinical utility

Ayurveda is known to be the oldest system of medicine whose virtue of holistic approach towards life attracts the attention of people worldwide. Ayurvedic formulations are conjuncture of herbal, mineral/metal and animal origin drugs. To effectuate therapeutic properties in these raw drugs, they are subjected to different pharmaceutical procedures (Samskaras). The fate of the drugs is predominantly decided by these procedures only. In the case of medical emergencies as well as in the management of critical diseases drug which brings about hastened relief in subordinate dose and dosage is endorsed. In Rasashastra, metals and minerals are subjected to different Samskara like Shodhana etc. to beget the properties like ‘Alpa Matra Upyogitvad’ and ‘Kshipram Aarogyam Daayitvad’ in them. The concept of incineration or Marana is the process which brings the particle size into nanometre range which makes the metal into absorbable and assimilable form. The present paper deals with the different pharmaceutical procedures which impregnate these properties in the rasa dravyas and make them suitable for use in various clinical manifestations

Functional characterisation of the methionine sulfoxide reductase repertoire in Trypanosoma brucei

We thank Guy Hanke (QMUL) for their critical review of this manuscript. We acknowledge the members of the T. brucei genome (http://tritrypdb.org/tritrypdb/) and TrypTag (http://tryptag.org) projects for sequence and localisation data, respectively. A component of this work was supported by grants from ANPCyT (PICT-2015-1149; PICT-2014-2103). SAG, and DGA are investigator career members from CONICET. AK was a recipient of a Queen Mary University of London PhD studentshi

A STUDY TO ASSESS KNOWLEDGE, ATTITUDE AND PRACTICE ON BREAST CANCER AMONG WOMEN IN GOVERNMENT GENERAL HOSPITAL

Objectives: Breast cancer is the most frequent cancer in women worldwide and it accounts for 27% of all cancer cases among women in India. This study aims to assess the awareness of the patients regarding the breast cancer and also to check their knowledge toward the symptoms of breast cancer as well as the breast self-examination process. This study also determines the attitude of patients regarding the breast cancer and breast self-examination. Methods: A prospective educational study was done using a pre-designed questionnaire on 523 patients in a tertiary care teaching hospital for a period of 6 months. All women greater than 20 years admitted in the Department of General Medicine and General Surgery in-patient female ward of SVRRGGH were included in the study. Results: Out of 523 women, a greater proportion respondents 515 (98%) had poor knowledge of breast cancer. Two hundred and eighty-one (53%) show positive attitude while 225 (43%) show neutral attitude and 17 (4%) show negative attitude toward breast cancer. Only 18 (0.3%) know how to perform breast self-examination while the remaining patients have never performed the breast self-examination. Two hundred and one (38%) have agreed to consult a doctor if they found any lumps in the breast whereas the remaining did not respond. After the counseling session with patients, their knowledge regarding the above problems related to breast cancer has significantly increased. Conclusion: Majority of the participants had poor knowledge of breast cancer as well as low level of practice of breast cancer screening procedures. However, patients do have a positive attitude toward the breast cancer which can help to detect the cancer in early stages. Hence, a greater focus on providing breast cancer education programs can create awareness among women in respect to screening programs which, in turn, can decrease the risk of death due to its late discovery

The role of union leader-member relationship capital within trade union for mental health

Objective – There are three main objectives of this study. First, this study is to examine the influence of union effectiveness and perceived union support on union relationship capital to achieve positive mental health in the workplace. Next, this study is to investigate the interdependency of the dimensions of union relationship capital: communication, trust and commitment between the union leader and union members in improving and strengthening the relationship within the union. Lastly, this study is to investigate the role of relationship capital as the mediator between union effectiveness, perceived union support and mental health. Methodology/Technique – A total of 600 questionnaires completed by trade union leaders and members in manufacturing sector based in Peninsular Malaysia were analysed using SEM (AMOS) and SPSS. The relationship between union effectiveness, perceived union support, union relationship capital and mental health were analysed using SEM. But the interaction between communication, trust and commitment were analysed using SPSS. Findings – The results demonstrated that union effectiveness and perceived union support are determinants for union relationship capital. The finding showed that communication, trust and commitment are interdependent. Furthermore, the finding also shows a significant relationship between union relationship capital and mental health. Novelty – It is said that good communication, trust and commitment within the trade union can increase cohesiveness and strengthen the trade union. A strong union can lead to positive mental health in the workplace. Type of Paper: Empirical

Levonorgestrel-releasing intrauterine system vs. usual medical treatment for menorrhagia: An economic evaluation alongside a randomised controlled trial

Objective: To undertake an economic evaluation alongside the largest randomised controlled trial comparing Levonorgestrel-releasing intrauterine device ('LNG-IUS') and usual medical treatment for women with menorrhagia in primary care; and compare the cost-effectiveness findings using two alternative measures of quality of life. Methods: 571 women with menorrhagia from 63 UK centres were randomised between February 2005 and July 2009. Women were randomised to having a LNG-IUS fitted, or usual medical treatment, after discussing with their general practitioner their contraceptive needs or desire to avoid hormonal treatment. The treatment was specified prior to randomisation. For the economic evaluation we developed a state transition (Markov) model with a 24 month follow-up. The model structure was informed by the trial women's pathway and clinical experts. The economic evaluation adopted a UK National Health Service perspective and was based on an outcome of incremental cost per Quality Adjusted Life Year (QALY) estimated using both EQ-5D and SF-6D. Results: Using EQ-5D, LNG-IUS was the most cost-effective treatment for menorrhagia. LNG-IUS costs £100 more than usual medical treatment but generated 0.07 more QALYs. The incremental cost-effectiveness ratio for LNG-IUS compared to usual medical treatment was £1600 per additional QALY. Using SF-6D, usual medical treatment was the most cost-effective treatment. Usual medical treatment was both less costly (£100) and generated 0.002 more QALYs. Conclusion: Impact on quality of life is the primary indicator of treatment success in menorrhagia. However, the most costeffective treatment differs depending on the quality of life measure used to estimate the QALY. Under UK guidelines LNG-IUS would be the recommended treatment for menorrhagia. This study demonstrates that the appropriate valuation of outcomes in menorrhagia is crucial. Copyright: © 2014 Sanghera et al

Palpitations following regular ibuprofen dosing in a 13-year-old girl: a case report

Abstract Introduction The sensation of palpitations may either be the initial or the only symptom of cardiac arrhythmia. We describe a case of an apparent clear temporal relationship between standard ibuprofen dosing and palpitations. A review of the medical literature revealed this to be, to the best of our knowledge, the first reported case of this type. Case presentation A 13-year-old Caucasian girl initially presented to our clinic with hamstring tendinitis. She was commenced on a medication regimen of paracetamol and ibuprofen. After the third ibuprofen dose, she experienced palpitations. These were associated with lower chest and/or upper abdominal discomfort, and a feeling of being hot and sweaty. Her symptoms ceased upon the cessation of ibuprofen therapy. Conclusion Cardiac arrhythmia is a potentially fatal disorder that may exhibit heart palpitations as its initial (or only) symptom. The prompt recognition of the cause of the symptom can reduce mortality and morbidity associated with any underlying pathological processes. There is a need to investigate cases of recurrent palpitations so as to exclude underlying structural cardiac pathology and/or abnormal cardiac rhythm.</p

Mycobacterium tuberculosis Responds to Chloride and pH as Synergistic Cues to the Immune Status of its Host Cell

PubMed ID: 23592993This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited