More anxious than depressed: prevalence and correlates in a 15-nation study of anxiety disorders in people with type 2 diabetes mellitus

Background Anxiety disorder, one of the highly disabling, prevalent and common mental disorders, is known to be more prevalent in persons with type 2 diabetes mellitus (T2DM) than the general population, and the comorbid presence of anxiety disorders is known to have an impact on the diabetes outcome and the quality of life. However, the information on the type of anxiety disorder and its prevalence in persons with T2DM is limited. Aims To assess the prevalence and correlates of anxiety disorder in people with type 2 diabetes in different countries. Methods People aged 18–65 years with diabetes and treated in outpatient settings were recruited in 15 countries and underwent a psychiatric interview with the Mini-International Neuropsychiatric Interview. Demographic and medical record data were collected. Results A total of 3170 people with type 2 diabetes (56.2% women; with mean (SD) duration of diabetes 10.01 (7.0) years) participated. The overall prevalence of anxiety disorders in type 2 diabetic persons was 18%; however, 2.8% of the study population had more than one type of anxiety disorder. The most prevalent anxiety disorders were generalised anxiety disorder (8.1%) and panic disorder (5.1%). Female gender, presence of diabetic complications, longer duration of diabetes and poorer glycaemic control (HbA1c levels) were significantly associated with comorbid anxiety disorder. A higher prevalence of anxiety disorders was observed in Ukraine, Saudi Arabia and Argentina with a lower prevalence in Bangladesh and India. Conclusions Our international study shows that people with type 2 diabetes have a high prevalence of anxiety disorders, especially women, those with diabetic complications, those with a longer duration of diabetes and poorer glycaemic control. Early identification and appropriate timely care of psychiatric problems of people with type 2 diabetes is warranted

Observational constraints on spatial anisotropy of G from orbital motions

A phenomenological anisotropic variation \Delta G/G of the Newtonian gravitational coupling parameter G, if real, would affect the orbital dynamics of a two-body gravitationally bound system in a specific way. We analytically work out the long-term effects that such a putative modification of the usual Newtonian inverse-square law would induce on the trajectory of a test particle orbiting a central mass. Without making any a-priori simplifying assumptions concerning the orbital configuration of the test particle, it turns out that its osculating semi-major axis a, eccentricity e, pericenter \varpi and mean anomaly M undergo long-term temporal variations, while the inclination I and the node \Omega are left unaffected. Moreover, the radial and the transverse components of the position and the velocity vectors r and v of the test particle experience non-vanishing changes per orbit, contrary to the out-of-plane ones. Then, we compute our theoretical predictions for some of the major bodies of the solar system by orienting the gradient of G(r) towards the Galactic Center and keeping it fixed over the characteristic timescales involved. By comparing our calculation to the latest observational determinations for the same bodies, we infer \Delta G/G <= 10^-17 over about 1 au. Finally, we consider also the Supermassive Black Hole hosted by the Galactic Center in Sgr A^* and the main sequence star S2 orbiting it in about 16 yr, obtaining just \Delta G/G <= 10^-2 over 1 kau.Comment: LaTex2e, 18 pages, no figures, 4 tables. Accepted by Classical and Quantum Gravity (CQG). Typo fixed. Reference update

Sequence-non-specific effects of RNA interference triggers and microRNA regulators

RNA reagents of diverse lengths and structures, unmodified or containing various chemical modifications are powerful tools of RNA interference and microRNA technologies. These reagents which are either delivered to cells using appropriate carriers or are expressed in cells from suitable vectors often cause unintended sequence-non-specific immune responses besides triggering intended sequence-specific silencing effects. This article reviews the present state of knowledge regarding the cellular sensors of foreign RNA, the signaling pathways these sensors mobilize and shows which specific features of the RNA reagents set the responsive systems on alert. The representative examples of toxic effects caused in the investigated cell lines and tissues by the RNAs of specific types and structures are collected and may be instructive for further studies of sequence-non-specific responses to foreign RNA in human cells

La Baie de Seine

The waters of the River Seine are polluted by urban, industrial and agricultural effluents: overall the River's catchment area accounts for 20% of the cultivated areas, 30% of the population, and 40% of the economic activities of France. In addition direct industrial waste inputs are emptied into the estuary. Finally, various pollutants are introduced into the "Baie de Seine" by deposits from harbour dredging activities near the estuary. Together these various anthropogenic inputs emerge into a strongly tidal region. A multidisciplinary study of the estuary of the Seine and of the "Baie de Seine" has demonstrated the principal physical and sedimentological phenomena governed by this tidal regime and their consequences in terms of pollutant dynamics and on the benthic populations, directly subject to the estuary influences. The "Baie de Seine" is one of the most exploited regions in France, and consequently an area where there are sharp conflicts of interest between the needs of industrial development, town-planning, fisheries and tourism. The recent scientific study of the functioning of the estuary and the "Baie de Seine" provides a base line reference at the beginning of the 80's, permits a certain number of answers in terms of the importance relative to perturbations of anthropogenic origin, taking into account the peculiarities of the tidal regime.Les eaux de la Seine sont polluées par des effluents industriels, urbains et agricoles: son bassin fluvial supporte en effet 20Z des surfaces cultivées, 30% de la population et 40% des activités économiques de la France. Aux apports du fleuve s'ajoutent dans l'estuaire des rejets industriels directs. Enfin, divers polluants sont introduits en Baie de Seine par des dépôts de dragages portuaires, accumulés en mer à proximité de l'estuaire. L'ensemble de ces apports anthropiques aboutit dans une mer à fortes marées. Une étude pluridisciplinaire de l'estuaire de la Seine et de la Baie de Seine a permis de mettre en évidence les principaux phénomènes physiques et sédimentologiques gouvernés par ce régime de marée et leurs conséquences en matière de dynamique des polluants et de fonctionnement d’un témoin biologique: les peuplements benthiques soumis à l'influence immédiate de l'estuaire. La Baie de Seine est une des régions de France les plus aménagées et donc une des régions où les conflits sont les plus aigus entre les nécessités du développement industriel, de l'urbanisme, de la pêche et du tourisme. La connaissance scientifique du fonctionnement de l'estuaire et de la baie fournit un état de référence du site au début des années 1980 et apporte un certain nombre de réponses en matière d'importance relative des perturbations d'origine anthropique, compte tenu des particularités du régime de marée

Recouvrement de l'activite des cholinesterases cerebrales chez le Rat apres inhibition par des composes organophosphores : essai de correlation en histochimie, biochimie et electrophysiologie

CNRS T 57055 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEFRFranc

Functional results after surgical repair of quadriceps tendon rupture.

We present the long-term results of surgical repair of a traumatic rupture of the quadriceps tendon in a group of 24 patients with a mean age of 58 years. There were 21 male and 3 female patients. Fifteen patients were seen for clinical control after a mean follow-up of 75 months and they all presented with some quadriceps muscle atrophy. Twelve patients had normal knee mobility, three had a flexion deformity of 10 degrees and two had less than 120 degrees of knee flexion. Active knee extension was normal in all patients. Three patients experienced some decrease in stability of their knee joint. Subjectively all patients were satisfied with the result. Nine patients underwent a Cybex-test for evaluation of the isokinetic force of knee flexion and extension, with a comparison between the injured and the uninjured side. For concentric force there was a mean deficit at low speed of 36.1% for the quadriceps muscle; at high speed it was 28.2%. For the knee flexors, the deficits were 30.7% and 27.2% respectively. Regarding eccentric force, the mean deficit for knee extensors was 13.8% and 0.25% respectively and for knee flexors 6.5% and 5.5% respectively

Les Administrateurs de la commune de Gatteville à M. Cabart, médecin à St-Pierre-Église, en réponse à son mémoire sur les fièvres régnant en cette commune et autres communes voisines. [Signé : le maire, Le Fèvre.]

Appartient à l’ensemble documentaire : BNormand1Avec mode text

Notices, mémoires et documents publiés par la Société d'agriculture, d'archéologie et d'histoire naturelle du département de la Manche

19081908 (VOL26).Appartient à l’ensemble documentaire : BNormand

Notices, mémoires et documents publiés par la Société d'agriculture, d'archéologie et d'histoire naturelle du département de la Manche

18851885 (VOL6).Appartient à l’ensemble documentaire : BNormand