Finite Group Modular Data

In a remarkable variety of contexts appears the modular data associated to finite groups. And yet, compared to the well-understood affine algebra modular data, the general properties of this finite group modular data has been poorly explored. In this paper we undergo such a study. We identify some senses in which the finite group data is similar to, and different from, the affine data. We also consider the data arising from a cohomological twist, and write down, explicitly in terms of quantities associated directly with the finite group, the modular S and T matrices for a general twist, for what appears to be the first time in print.Comment: 38 pp, latex; 5 references added, "questions" section touched-u

Galois Modular Invariants of WZW Models

The set of modular invariants that can be obtained from Galois transformations is investigated systematically for WZW models. It is shown that a large subset of Galois modular invariants coincides with simple current invariants. For algebras of type B and D infinite series of previously unknown exceptional automorphism invariants are found.Comment: phyzzx macros, 38 pages. NIKHEF-H/94-3

Potent and highly selective inhibitors of the proteasome trypsin-like site by incorporation of basic side chain containing amino acid derived sulfonyl fluorides

A unique category of basic side chain containing amino acid derived sulfonyl fluorides (SFs) has been synthesized for incorporation into new proteasome inhibitors targeting the trypsin-like site of the 20S proteasome. Masking the former α-amino functionality of the amino acid starting derivatives as an azido functionality allowed an elegant conversion to the corresponding amino acid derived sulfonyl fluorides. The inclusion of different SFs at the P1 site of a proteasome inhibitor resulted in 14 different peptidosulfonyl fluorides (PSFs) having a high potency and an excellent selectivity for the proteolytic activity of the β2 subunit over that of the β5 subunit. The results of this study strongly indicate that a free N-terminus of PSFs inhibitors is crucial for high selectivity toward the trypsin-like site of the 20S proteasome. Nevertheless, all compounds are slightly more selective for inhibition of the constitutive over the immunoproteasome

Loop Operators and the Kondo Problem

We analyse the renormalisation group flow for D-branes in WZW models from the point of view of the boundary states. To this end we consider loop operators that perturb the boundary states away from their ultraviolet fixed points, and show how to regularise and renormalise them consistently with the global symmetries of the problem. We pay particular attention to the chiral operators that only depend on left-moving currents, and which are attractors of the renormalisation group flow. We check (to lowest non-trivial order in the coupling constant) that at their stable infrared fixed points these operators measure quantum monodromies, in agreement with previous semiclassical studies. Our results help clarify the general relationship between boundary transfer matrices and defect lines, which parallels the relation between (non-commutative) fields on (a stack of) D-branes and their push-forwards to the target-space bulk.Comment: 22 pages, 2 figure

Modular Invariants in the Fractional Quantum Hall Effect

We investigate the modular properties of the characters which appear in the partition functions of nonabelian fractional quantum Hall states. We first give the annulus partition function for nonabelian FQH states formed by spinon and holon (spinon-holon state). The degrees of freedom of spin are described by the affine SU(2) Kac-Moody algebra at level $k$. The partition function and the Hilbert space of the edge excitations decomposed differently according to whether $k$ is even or odd. We then investigate the full modular properties of the extended characters for nonabelian fractional quantum Hall states. We explicitly verify the modular invariance of the annulus grand partition functions for spinon-holon states, the Pfaffian state and the 331 states. This enables one to extend the relation between the modular behavior and the topological order to nonabelian cases. For the Haldane-Rezayi state, we find that the extended characters do not form a representation of the modular group, thus the modular invariance is broken.Comment: Latex,21 pages.version to appear in Nucl.Phys.

First Shiga Toxin-Producing Escherichia coli Isolate from a Patient with Hemolytic Uremic Syndrome, Brazil

Univ Fed Sao Paulo, Escola Paulista Med, Sao Paulo, BrazilHosp Sao Paulo, Sao Paulo, BrazilInst Adolfo Lutz Registro, Sao Paulo, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Sao Paulo, BrazilHosp Sao Paulo, Sao Paulo, BrazilWeb of Scienc

Engineering zonal cartilaginous tissue by modulating oxygen levels and mechanical cues through the depth of infrapatellar fat pad stem cell laden hydrogels.

Engineering tissues with a structure and spatial composition mimicking those of native articular cartilage (AC) remains a challenge. This study examined if infrapatellar fat pad-derived stem cells (FPSCs) can be used to engineer cartilage grafts with a bulk composition and a spatial distribution of matrix similar to the native tissue. In an attempt to mimic the oxygen gradients and mechanical environment within AC, FPSC-laden hydrogels (either 2 mm or 4 mm in height) were confined to half of their thickness and/or subjected to dynamic compression (DC). Confining FPSC-laden hydrogels was predicted to accentuate the gradient in oxygen tension through the depth of the constructs (higher in the top and lower in the bottom), leading to enhanced glycosaminoglycan (GAG) and collagen synthesis in 2 mm high tissues. When subjected to DC alone, both GAG and collagen accumulation increased within 2 mm high unconfined constructs. Furthermore, the dynamic modulus of constructs increased from 0.96 MPa to 1.45 MPa following the application of DC. There was no synergistic benefit of coupling confinement and DC on overall levels of matrix accumulation; however in all constructs, irrespective of their height, the combination of these boundary conditions led to the development of engineered tissues that spatially best resembled native AC. The superficial region of these constructs mimicked that of native tissue, staining weakly for GAG, strongly for type II collagen, and in 4 mm high tissues more intensely for proteoglycan 4 (lubricin). This study demonstrated that FPSCs respond to joint-like environmental conditions by producing cartilage tissues mimicking native AC. Copyright © 2016 John Wiley & Sons, Ltd.European Research Council Starter Grant. Grant Number: 25846

Pancreatic ductal deletion of Hnf1b disrupts exocrine homeostasis, leads to pancreatitis and facilitates tumorigenesis

BACKGROUND AND AIMS: The exocrine pancreas consists of acinar cells that produce digestive enzymes transported to the intestine through a branched ductal epithelium. Chronic pancreatitis is characterized by progressive inflammation, fibrosis and loss of acinar tissue. These changes of the exocrine tissue are risk factors for pancreatic cancer. The cause of chronic pancreatitis cannot be identified in one-quarter of patients. Here, we investigated how duct dysfunction could contribute to pancreatitis development. METHODS: The transcription factor Hnf1b, first expressed in pancreatic progenitors, is strictly restricted to ductal cells from late embryogenesis. We have previously shown that Hnf1b is crucial for pancreas morphogenesis but its postnatal role still remains unelucidated. To investigate the role of pancreatic ducts in exocrine homeostasis, we inactivated Hnf1b gene in vivo in mouse ductal cells. RESULTS: We uncovered that postnatal Hnf1b inactivation in pancreatic ducts leads to chronic pancreatitis in adults. Hnf1bΔduct mutants display dilatation of ducts, loss of acinar cells, acinar-to-ductal metaplasia (ADM) and lipomatosis. We deciphered the early events involved, with downregulation of cystic disease-associated genes, loss of primary cilia, upregulation of signaling pathways, especially Yap pathway involved in ADM. Remarkably, Hnf1bΔduct mutants developed pancreatic intraepithelial neoplasia and promote PanIN progression in concert with KRAS. We further showed that adult Hnf1b inactivation in pancreatic ducts is associated with impaired regeneration after injury, with persistent metaplasia and initiation of neoplasia. CONCLUSION: Loss of Hnf1b in ductal cells leads to chronic pancreatitis and neoplasia. This reveals that Hnf1b deficiency may contribute to diseases of the exocrine pancreas and could gain further insight into the etiology of pancreatitis and tumorigenesis.Support to CH was received from theCentre National de la Recherche Scientifique (CNRS), the Universite Pierre et Marie Curie (UPMC)- Sorbonne Université , the GEFLUC - Les entreprises contre le Cancer, the Societe Francophone du Diabete (SFD)-Ypsomed, the programme Emergence UPMC. EQ was supported by a PhD fellowship from the French Ministère de la Recherche et de la Technologie. MF is an assistant engineer of the CNRS. TD and AS were supported by Sorbonne Université. MDV was supported by a PhD student fellowship from the European Marie Curie Initial Training Network (ITN)-Biology of Liver and Pancreatic Development and Disease (BOLD). O. O. was supported by a Master1 fellowship. RCP was supported by a postdoctoral fellowship from the American Heart Association (14POST20380262). MG was supported by the National Institutes of Health (U01 DK089540) and the Juvenile Diabetes Research Foundation (1-2011-592). CH is a permanent senior researcher of the Institut National de la Sante et de la Recherche Medicale (INSERM).S

Lectures on conformal field theory and Kac-Moody algebras

This is an introduction to the basic ideas and to a few further selected topics in conformal quantum field theory and in the theory of Kac-Moody algebras.Comment: 59 pages, LaTeX2e, extended version of lectures given at the Graduate Course on Conformal Field Theory and Integrable Models (Budapest, August 1996), to appear in Springer Lecture Notes in Physic

Simple current symmetries in RCFT

The question ''Which abelian permutation groups arise as group of simple currents in Rational Conformal Field Theory?'' is investigated using the formalism of weighted permutation actions. After a review of the relevant properties of simple current symmetries, the general theory of WPA-s and admissibility conditions are described, and classification results are illustrated by a couple of examples.Comment: 12 pages, 1 reference adde