Avenida Almirante Reis: um dispositivo da cidade de Lisboa

O propósito desta dissertação é refletir sobre a cidade de Lisboa, mais concretamente sobre a Avenida Almirante Reis. A abordagem ao projeto, é feita a partir da construção e da reapropriação do espaço público sobre uma área desqualificada e desadequada à vida quotidiana, a Rua das Barracas. O exercício proposto pretende reabilitar uma área da cidade que está em constante degradação e abandono, conta com uma memória e ideologia de lugar como já fomos habituados na cidade de Lisboa. Assim sendo, a principal preocupação é dar uma nova vida a este lugar, permitindo um novo olhar para a Avenida Almirante Reis e, por acréscimo, para a cidade. Pretende-se transformar este lugar através da demolição de espaços abandonados e esquecidos ao longo do tempo, aproveitando o seu potencial para a regeneração de um espaço que se quer coletivo, criando-se assim uma nova dinâmica de ocupação do espaço público e devolvendo um passado adormecido ao bairro e à cidade. O programa surge com a criação de um novo edifício para receber o Arquivo Fotográfico, que comunica a outro que me proponho reabilitar, com o objetivo de oferecer à população não só uma nova perspetiva do passado, do presente, mas acima de tudo, uma nova interação com o futuro, restabelecendo a ligação entre a Avenida Almirante Reis e o Campo Santana

A culture of conservation: How an ancient forest plantation turned into an old-growth forest reserve – The story of the Wamulin forest

The global expansion of forest plantations at the expense of natural forests, especially old-growth forests, raises concerns about habitat loss and a decline in ecosystem services. Natural regeneration of second-growth forests with minimal human assistance has been suggested as a cost-effective way to restore forests and increase forest ecosystem service potential. However, it is unclear whether natural regeneration will lead to the development of second-growth forests similar to natural forests because most naturally regenerated second-growth forests are still young. We present a case study of a very old second-growth forest in southeastern China in which a forest plantation established approximately six centuries ago has now developed into an old forest with extraordinary high biodiversity levels, an immense carbon pool, and a rich culture. The forest was established in the 14th century because of a charitable contribution, became protected under the Chinese cultural norm of ‘unity between humans and the nature’, and was conserved because of the belief that the prosperity of people is closely linked to the prosperity of trees. The recent designation of the forest as a nature reserve further protects it from development despite competing land-use demands related to recent economic growth. This case illustrates that, although human activity is the main cause for the disappearance and degradation of many forests, when human interests and cultural values align second-growth restoration and subsequent forest conservation can lead to the successional development of old-growth forests. Because this development takes multiple centuries, the protection of current second-growth forests within conservation easements (e.g. nature reserves) and the reformation of culture values for the linkage of forests to human well-being are key aspects of the continued conservation-aided succession of second-growth forests. A free Plain Language Summary can be found within the Supporting Information of this article

Fungal Adenylyl Cyclase Acts As a Signal Sensor and Integrator and Plays a Central Role in Interaction with Bacteria

10.1371/journal.ppat.1003612PLoS Pathogens910

Cross section of the pp→K+Σ+npp\to K^+\Sigma^+n reaction close to threshold

We have measured inclusive data on $K^+$-meson production in $pp$ collisions at COSY J\"ulich close to the hyperon production threshold and determined the hyperon-nucleon invariant mass spectra. The spectra were decomposed into three parts: $\Lambda p$, $\Sigma^0p$ and $\Sigma^+n$. The cross section for the $\Sigma^+n$ channel was found to be much smaller than a previous measurement in that excess energy region. The data together with previous results at higher energies are compatible with a phase space dependence.Comment: accepted by Phys. lett. B some typos correcte

Is early center-based child care associated with tantrums and unmanageable behavior over time up to school entry?

Background. Existing research suggests that there is a relationship between greater exposure to center-based child care and child behavioral problems though the mechanism for the impact is unclear. However the measure used to document child care has usually been average hours, which may be particularly unreliable in the early months when fewer children are in center care. In addition individual trajectories for behavior difficulties have not been studied. Objective. The purpose of the current study was to examine whether the extent of exposure to center-based child care before two years predicted the trajectory of children’s difficult behavior (i.e., tantrums and unmanageable behavior) from 30 to 51 months controlling for child and maternal characteristics. Method. Data were drawn from UK-based Families, Children and Child Care (FCCC) study (n=1201). Individual growth models were fitted to test the relation between early center-based child care experiences and subsequent difficult behavior. Results. Children with more exposure to center-based care before two had less difficult behavior at 30 months, but more increase over time. Initial levels were predicted by higher difficult temperament and lower verbal ability. Higher difficult temperament and lower family socio-economic status predicted its change over time. Conclusion. Findings suggest that early exposure to center-based care before two years old is a risk factor for subsequent behavior problems especially when children have a longer period of exposure. A possible explanatory process is that child coping strategies to manage frustration are less well developed in a group context, especially when they lag behind in expressive language

High resolution study of the Lambda p final state interaction in the reaction p + p -> K+ + (Lambda p)

The reaction pp -> K+ + (Lambda p) was measured at Tp=1.953 GeV and Theta = 0 deg with a high missing mass resolution in order to study the Lambda p final state interaction. The large final state enhancement near the Lambda p threshold can be described using the standard Jost-function approach. The singlet and triplet scattering lengths and effective ranges are deduced by fitting simultaneously the Lambda p invariant mass spectrum and the total cross section data of the free Lambda p scattering.Comment: submitted to Physics Letters B, 10 pages, 3 figure

COVID-19 restrictions increased perceptions of social isolation for older people discharged home after rehabilitation: A mixed-methods study

ObjectiveTo explore older persons perceptions of the impact of COVID-19 restrictions on participating in community activities after discharge from inpatient rehabilitation. MethodsMixed-methods study design. Participants were older adults who were discharged home following inpatient rehabilitation. Interviews were conducted with 70 participants, with a variety of diagnoses, 8 weeks after discharge from inpatient rehabilitation. Frequency of participation in domestic, leisure/work and outdoor activities was measured using the Frenchay Activities Index (FAI). Qualitative analysis was completed using qualitative content analysis and triangulated with FAI scores. ResultsIn all, 70 older adults (mean age: 73.0 years, SD: 9.9; 59% female) participated in the study. The overarching theme was that participants felt socially isolated following discharge from rehabilitation, with COVID-19 restrictions increasing perceptions of social isolation and complicating their return to participating in community activities. The four categories informing the overarching theme were as follows: physical health was the primary limitation to participation in community activities; COVID-19 restrictions limited participation in social activities and centre-based physical rehabilitation; low uptake of videoconferencing to facilitate socialisation and rehabilitation; and reduced incidental physical activity. Mean FAI score was 21.2 (SD 7.8), indicating that participants were moderately active. Participants most commonly performed domestic activities (mean: 10.0, SD: 4.1), followed by outdoor activities (mean: 6.6, SD: 3.5) and leisure/work activities (mean: 4.5, SD: 2.5). ConclusionsCOVID-19 restrictions exacerbated perceptions of social isolation and the limitations already imposed by poor physical health after discharge from rehabilitation. The findings highlight the need for rehabilitation that addresses the psychological and social dimensions of community reintegration

Molecular crowding defines a common origin for the Warburg effect in proliferating cells and the lactate threshold in muscle physiology

Aerobic glycolysis is a seemingly wasteful mode of ATP production that is seen both in rapidly proliferating mammalian cells and highly active contracting muscles, but whether there is a common origin for its presence in these widely different systems is unknown. To study this issue, here we develop a model of human central metabolism that incorporates a solvent capacity constraint of metabolic enzymes and mitochondria, accounting for their occupied volume densities, while assuming glucose and/or fatty acid utilization. The model demonstrates that activation of aerobic glycolysis is favored above a threshold metabolic rate in both rapidly proliferating cells and heavily contracting muscles, because it provides higher ATP yield per volume density than mitochondrial oxidative phosphorylation. In the case of muscle physiology, the model also predicts that before the lactate switch, fatty acid oxidation increases, reaches a maximum, and then decreases to zero with concomitant increase in glucose utilization, in agreement with the empirical evidence. These results are further corroborated by a larger scale model, including biosynthesis of major cell biomass components. The larger scale model also predicts that in proliferating cells the lactate switch is accompanied by activation of glutaminolysis, another distinctive feature of the Warburg effect. In conclusion, intracellular molecular crowding is a fundamental constraint for cell metabolism in both rapidly proliferating- and non-proliferating cells with high metabolic demand. Addition of this constraint to metabolic flux balance models can explain several observations of mammalian cell metabolism under steady state conditions