Inelastic Proton Scattering to Unnatural Parity States in Even Mass Nuclei

This work was supported by National Science Foundation Grant PHY 76-84033 and Indiana Universit

Studies of Knock-Out Reactions

This work was supported by National Science Foundation Grant PHY 75-00289 and Indiana Universit

Phase 2 randomized placebo controlled double blind study to assess the efficacy and safety of tecfidera in patients with amyotrophic lateral sclerosis (TEALS Study)

Background: Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disorder of the human motor system. Neuroinflammation appears to be an important modulator of disease progression in ALS. Specifically, reduction of regulatory T cell (Treg) levels, along with an increase in pro-inflammatory effector T cells, macrophage activation and upregulation of co-stimulatory pathways have all been associated with a rapid disease course in ALS. Autologous infusion of expanded Tregs into sporadic ALS patients, resulted in greater suppressive function, slowing of disease progression and stabilization of respiratory function. Tecfidera (dimethyl fumarate) increases the ratio of anti-inflammatory (Treg) to proinflammatory T-cells in patients with relapsing remitting multiple sclerosis and rebalances the regulatory: inflammatory axis towards a neuroprotective phenotype. Consequently, the aim of this study was to assess the efficacy, safety, and tolerability of Tecfidera in sporadic ALS. Methods: The study is an investigator led Phase 2 multi-center, randomized, placebo controlled, double blind clinical trial assessing the efficacy and safety of Tecfidera in patients with sporadic ALS. The study duration is 40 weeks, with a 36-week study period and end of study visit occurring at 40 weeks or at early termination/withdrawal from study. The TEALS study has been registered with the Australian and New Zealand Clinical Trials registry (ANZCTR) under the trials registration number ACTRN12618000534280 and has been approved by the Human Research Ethics Committee and Research Governance Office at the lead site (Westmead Hospital) with the ethics number HREC/17/WMEAD/353. The participating sites have obtained site specific ethics and governance approvals from the local institution. Results: The primary endpoint is slowing of disease progression as reflected by the differences in the ALS Functional Rating Score-Revised (ALSFRS-R) score at Week 36. The secondary endpoints will include effects in survival, lower motor neuron function, respiratory function, quality of life and safety. Conclusion: This Phase 2 multi-center, randomized, placebo controlled, double blind clinical trial will provide evidence of efficacy and safety of Tecfidera in sporadic ALS

Inelastic Proton Scattering from 12-C, 16-O, 6-Li

This work was supported by National Science Foundation Grants PHY 76-84033A01, PHY 78-22774, and Indiana Universit

Studies of Knock-Out Reactions

This work was supported by National Science Foundation Grants PHY 76-84033A01, PHY 78-22774, and Indiana Universit

Studies of Knock-Out Reactions

This work was supported by National Science Foundation Grant PHY 76-84033 and Indiana Universit

Hard-Sphere Fluids in Contact with Curved Substrates

The properties of a hard-sphere fluid in contact with hard spherical and cylindrical walls are studied. Rosenfeld's density functional theory (DFT) is applied to determine the density profile and surface tension $\gamma$ for wide ranges of radii of the curved walls and densities of the hard-sphere fluid. Particular attention is paid to investigate the curvature dependence and the possible existence of a contribution to $\gamma$ that is proportional to the logarithm of the radius of curvature. Moreover, by treating the curved wall as a second component at infinite dilution we provide an analytical expression for the surface tension of a hard-sphere fluid close to arbitrary hard convex walls. The agreement between the analytical expression and DFT is good. Our results show no signs for the existence of a logarithmic term in the curvature dependence of $\gamma$.Comment: 15 pages, 6 figure

Glass Transition of Hard Sphere Systems: Molecular Dynamics and Density Functional Theory

The glass transition of a hard sphere system is investigated within the framework of the density functional theory (DFT). Molecular dynamics (MD) simulations are performed to study dynamical behavior of the system on the one hand and to provide the data to produce the density field for the DFT on the other hand. Energy landscape analysis based on the DFT shows that there appears a metastable (local) free energy minimum representing an amorphous state as the density is increased. This state turns out to become stable, compared with the uniform liquid, at some density, around which we also observe sharp slowing down of the $alpha$ relaxation in MD simulations.Comment: 5 pages, 5 figure

Active Amplification of the Terrestrial Albedo to Mitigate Climate Change: An Exploratory Study

This study explores the potential to enhance the reflectance of solar insolation by the human settlement and grassland components of the Earth's terrestrial surface as a climate change mitigation measure. Preliminary estimates derived using a static radiative transfer model indicate that such efforts could amplify the planetary albedo enough to offset the current global annual average level of radiative forcing caused by anthropogenic greenhouse gases by as much as 30 percent or 0.76 W/m2. Terrestrial albedo amplification may thus extend, by about 25 years, the time available to advance the development and use of low-emission energy conversion technologies which ultimately remain essential to mitigate long-term climate change. However, additional study is needed to confirm the estimates reported here and to assess the economic and environmental impacts of active land-surface albedo amplification as a climate change mitigation measure.Comment: 21 pages, 3 figures. In press with Mitigation and Adaptation Strategies for Global Change, Springer, N

Assessing the mechanisms of common Pb incorporation into titanite

Common Pb, the portion of non-radiogenic Pb within a U bearing mineral, needs to be accurately accounted for in order to subtract its effect on U-Pb isotopic ratios so that meaningful ages can be calculated. The propensity to accommodate common Pb during crystallization, or later, is different across the range of U bearing minerals used for geochronology. Titanite frequently accommodates significant amounts of common Pb. However, the most appropriate method to correct for this requires knowledge on the mechanism and timing of common Pb incorporation; information that is commonly difficult to extract. In this study, the spatial and compositional distribution of trace elements (including Pb) in metamorphic titanites from a Greenland amphibolite is investigated on the grain- to nano-scale. Titanites have an isotopically similar signature for both common and radiogenic-Pb in all grains but significantly different quantities of the non-radiogenic component. Microstructural and compositional examination of these grains reveals undeformed, but high common Pb (F207%) titanites have homogeneous element distributions on the atomic scale suggesting common Pb is incorporated into titanite during its growth and not during later processes. In contrast, deformed titanite comprising low-angle boundaries, formed by subgrain rotation recrystallization, comprise networks of dislocations that are enriched in Mg, Al, K and Fe. Smaller cations may migrate due to elastic strain in the vicinity of the dislocation network, yet the larger K cations more likely reflect the mobility of externally-derived K along the orien tation interface. The absence of Pb enrichment along the boundary indicates that either Pb was too large to fit into migrating lattice dislocations or static low-angle boundaries and/or that there was no external Pb available to diffuse along the grain boundary. As the common Pb composition is distinctly different to regional Pb models, the metamorphic titanite grew in a homogeneous Pb reservoir dominated by the break-down of precursor U-bearing phases. The different quantity of common Pb in the titanite grains indicates a mineral-driven element partitioning in an isotopically homogeneous metamorphic reservoir, consistent with low U, low total REE and flat LREE signatures in high F207% analyses. These results have implications for the selection of appropriate common Pb corrections in titanite and other accessory phases