Hydrology of debris-covered glaciers in High Mountain Asia

The hydrological characteristics of debris-covered glaciers are known to be fundamentally different from those of clean-ice glaciers, even within the same climatological, geological, and geomorphological setting. Understanding how these characteristics influence the timing and magnitude of meltwater discharge is particularly important for regions where downstream communities rely on this resource for sanitation, irrigation, and hydropower, such as High Mountain Asia. The hydrology of debris-covered glaciers is complex: rugged surface topographies typically route meltwater through compound supraglacial-englacial systems involving both channels and ponds, as well as pathways that remain unknown. Low-gradient tongues that extend several kilometres retard water conveyance and promote englacial storage. Englacial conduits are frequently abandoned and reactivated as water supply changes, new lines of permeability are exploited, and drainage is captured due to high rates of surface and subsurface change. Seasonal influences, such as the monsoon, are superimposed on these distinctive characteristics, reorganising surface and subsurface drainage rapidly from one season to the next. Recent advances in understanding have mostly come from studies aimed at quantifying and describing supraglacial processes; little is known about the subsurface hydrology, particularly the nature (or even existence) of subglacial drainage. In this review, we consider in turn the supraglacial, englacial, subglacial, and proglacial hydrological domains of debris-covered glaciers in High Mountain Asia. We summarise different lines of evidence to establish the current state of knowledge and, in doing so, identify major knowledge gaps. Finally, we use this information to suggest six themes for future hydrological research at High Mountain Asian debris-covered glaciers in order to make timely long-term predictions of changes in the water they supply

Provenance and transport of supraglacial debris revealed by variations in debris geochemistry on Khumbu Glacier, Nepal Himalaya

The origin of supraglacial debris covers is often conceptualised as the formation of a surface lag by melt-out of englacial debris from slow-moving ice, where complexity arises from feedback between debris thickness and sub-debris ice melt. Here, we examine the origin of a debris cover from the perspective of debris provenance and changing tributary supply in a high-elevation compound valley glacier. Geochemical analysis of 11 major elements in 21 debris samples from six tributaries of Khumbu Glacier (Nepal) shows unambiguous statistical differentiation of debris sources reflecting lithological differences between tributary catchments. Twenty-four samples from transects across the ablation area are partitioned according to their source areas using the FR2000 sediment unmixing model. We estimate the age of ice at each transect using a higher order ice flow model. The results show greater proportions of debris from lateral tributaries in downglacier locations that have experienced longer flowline histories. More recently, ice from the Main Himalayan Divide (Western Cwm) has become relatively more important. This suggests a change in the state of the lower glacier's structure depending on the relative ice discharges of lateral and divide sources. Ice flux from lower elevation tributaries was more important probably prior to a weakening of the Indian Summer Monsoon at around 1420 CE. The lower elevation tributaries lie within the range of late Holocene equilibrium line altitude variation and therefore respond most sensitively to climatic drivers of the glacier's flow structure. Negative glacier mass balance since around 1900 CE caused tributary glaciers to detach and high-elevation catchments to re-establish as the dominant ice source to Khumbu Glacier

1/3-Octave Analysis of Core/Combustor-Noise Measurements for the DGEN Aeropropulsion Research Turbofan with Application to Noise Prediction

This work continues the analysis of data obtained during a 2017 NASA DGEN Aeropropulsion Research Turbofan (DART) core/combustor-noise baseline test in the NASA GRC Aero-Acoustic Propulsion Laboratory (AAPL). The DART is a cost-efficient testbed for the study of core-noise physics and mitigation. Acoustic data were simultaneously acquired using the AAPL overhead microphone array in the engine aft-quadrant farfield, a single midfield microphone, and two infinite-tube-probe sensors for unsteady pressures at the core-nozzle exit. The data are here examined on an 1/3-octave basis as a first step in extending and improving core-noise prediction capability

Structure optimization effects on the electronic properties of Bi2_2Sr2_2CaCu2_2O8_8

We present detailed first-principles calculations for the normal state electronic properties of the high T$_C$ superconductor Bi$_2$Sr$_2$CaCu$_2$O$_8$, by means of the linearized augmented plane wave (LAPW) method within the framework of density functional theory (DFT). As a first step, the body centered tetragonal (BCT) cell has been adopted, and optimized regarding its volume, $c/a$ ratio and internal atomic positions by total energy and force minimizations. The full optimization of the BCT cell leads to small but visible changes in the topology of the Fermi surface, rounding the shape of CuO$_2$ barrels, and causing both the BiO bands, responsible for the pockets near the \textit{\=M} 2D symmetry point, to dip below the Fermi level. We have then studied the influence of the distortions in the BiO plane observed in nature by means of a $\sqrt{2}\times\sqrt{2}$ orthorhombic cell (AD-ORTH) with $Bbmb$ space group. Contrary to what has been observed for the Bi-2201 compound, we find that for Bi-2212 the distortion does not sensibly shift the BiO bands which retain their metallic character. As a severe test for the considered structures we present Raman-active phonon frequencies ($q = 0$) and eigenvectors calculated within the frozen-phonon approximation. Focussing on the totally symmetric A$_{g}$ modes, we observe that for a reliable attribution of the peaks observed in Raman experiments, both $c$- and a-axis vibrations must be taken into account, the latter being activated by the in-plane orthorhombic distortion.Comment: 22 pages, 4 figure

Anthropogenic Space Weather

Anthropogenic effects on the space environment started in the late 19th century and reached their peak in the 1960s when high-altitude nuclear explosions were carried out by the USA and the Soviet Union. These explosions created artificial radiation belts near Earth that resulted in major damages to several satellites. Another, unexpected impact of the high-altitude nuclear tests was the electromagnetic pulse (EMP) that can have devastating effects over a large geographic area (as large as the continental United States). Other anthropogenic impacts on the space environment include chemical release ex- periments, high-frequency wave heating of the ionosphere and the interaction of VLF waves with the radiation belts. This paper reviews the fundamental physical process behind these phenomena and discusses the observations of their impacts.Comment: 71 pages, 35 figure

The Structure of Interpretations in Family Therapy: A Video-Enhanced Exploration *

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73991/1/j.1545-5300.2000.39204.x.pd

Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2)

BACKGROUND: Worldwide data for cancer survival are scarce. We aimed to initiate worldwide surveillance of cancer survival by central analysis of population-based registry data, as a metric of the effectiveness of health systems, and to inform global policy on cancer control. METHODS: Individual tumour records were submitted by 279 population-based cancer registries in 67 countries for 25·7 million adults (age 15-99 years) and 75,000 children (age 0-14 years) diagnosed with cancer during 1995-2009 and followed up to Dec 31, 2009, or later. We looked at cancers of the stomach, colon, rectum, liver, lung, breast (women), cervix, ovary, and prostate in adults, and adult and childhood leukaemia. Standardised quality control procedures were applied; errors were corrected by the registry concerned. We estimated 5-year net survival, adjusted for background mortality in every country or region by age (single year), sex, and calendar year, and by race or ethnic origin in some countries. Estimates were age-standardised with the International Cancer Survival Standard weights. FINDINGS: 5-year survival from colon, rectal, and breast cancers has increased steadily in most developed countries. For patients diagnosed during 2005-09, survival for colon and rectal cancer reached 60% or more in 22 countries around the world; for breast cancer, 5-year survival rose to 85% or higher in 17 countries worldwide. Liver and lung cancer remain lethal in all nations: for both cancers, 5-year survival is below 20% everywhere in Europe, in the range 15-19% in North America, and as low as 7-9% in Mongolia and Thailand. Striking rises in 5-year survival from prostate cancer have occurred in many countries: survival rose by 10-20% between 1995-99 and 2005-09 in 22 countries in South America, Asia, and Europe, but survival still varies widely around the world, from less than 60% in Bulgaria and Thailand to 95% or more in Brazil, Puerto Rico, and the USA. For cervical cancer, national estimates of 5-year survival range from less than 50% to more than 70%; regional variations are much wider, and improvements between 1995-99 and 2005-09 have generally been slight. For women diagnosed with ovarian cancer in 2005-09, 5-year survival was 40% or higher only in Ecuador, the USA, and 17 countries in Asia and Europe. 5-year survival for stomach cancer in 2005-09 was high (54-58%) in Japan and South Korea, compared with less than 40% in other countries. By contrast, 5-year survival from adult leukaemia in Japan and South Korea (18-23%) is lower than in most other countries. 5-year survival from childhood acute lymphoblastic leukaemia is less than 60% in several countries, but as high as 90% in Canada and four European countries, which suggests major deficiencies in the management of a largely curable disease. INTERPRETATION: International comparison of survival trends reveals very wide differences that are likely to be attributable to differences in access to early diagnosis and optimum treatment. Continuous worldwide surveillance of cancer survival should become an indispensable source of information for cancer patients and researchers and a stimulus for politicians to improve health policy and health-care systems

Hyperglycaemic conditions perturb mouse oocyte in vitro developmental competence via beta-O-linked glycosylation of Heat shock protein 90

STUDY QUESTION What is the effect of beta-O-linked glycosylation (O-GlcNAcylation) on specific proteins in the cumulus-oocyte complex (COC) under hyperglycaemic conditions? SUMMARY ANSWER Heat shock protein 90 (HSP90) was identified and confirmed as being O-GlcNAcylated in mouse COCs under hyperglycaemic conditions (modelled using glucosamine), causing detrimental outcomes for embryo development. WHAT IS KNOWN ALREADY O-GlcNAcylation of proteins occurs as a result of increased activity of the hexosamine biosynthesis pathway, which provides substrates for cumulus matrix production during COC maturation, and also for O-GlcNAcylation. COCs matured under hyperglycaemic conditions have decreased developmental competence, mediated at least in part through the mechanism of increased O-GlcNAcylation. STUDY DESIGN, SIZE, DURATION This study was designed to examine the effect of hyperglycaemic conditions (using the hyperglycaemic mimetic, glucosamine) on O-GlcNAc levels in the mouse COC, and furthermore to identify potential candidate proteins which are targets of this modification, and their roles in oocyte maturation. PARTICIPANTS/MATERIALS, SETTING, METHODS COCs from 21-day-old superovulated CBA × C57BL6 F1 hybrid female mice were matured in vitro (IVM). Levels of O-GlcNAcylated proteins, HSP90 and O-GlcNAc transferase (OGT, the enzyme responsible for O-GlcNAcylation) in COCs were measured using western blot, and localization observed using immunocytochemistry. For glycosylated HSP90 levels, and to test OGT-HSP90 interaction, immunoprecipitation was performed prior to western blotting. Embryo development was assessed using in vitro fertilization and embryo culture post-maturation. MAIN RESULTS AND THE ROLE OF CHANCE Addition of the hyperglycaemic mimetic glucosamine to IVM medium for mouse COCs increased detectable O-GlcNAcylated protein levels (by western blot and immunocytochemistry), and this effect was reversed using an OGT inhibitor (P < 0.05). HSP90 was identified as a target of O-GlcNAcylation in the COC, and inhibition of HSP90 during IVM reversed glucosamine-induced decreases in oocyte developmental competence (P < 0.05). We also demonstrated the novel finding of an association between HSP90 and OGT in COCs, suggesting a possible client–chaperone relationship. LIMITATIONS, REASONS FOR CAUTION In vitro maturation of COCs was used so that treatment time could be limited to the 17 h of maturation prior to ovulation. Additionally, glucosamine, a hyperglycaemic mimetic, was used because it specifically activates the hexosamine pathway which provides the O-GlcNAc moieties. The results in this study should be confirmed using in vivo models of hyperglycaemia and different HSP90 inhibitors. WIDER IMPLICATIONS OF THE FINDINGS This study leads to a new understanding of how diabetes influences oocyte competence and provides insight into possible therapeutic interventions based on inhibiting HSP90 to improve oocyte quality.L.A. Frank, M.L. Sutton-McDowall, H.M. Brown, D.L. Russell, R.B. Gilchrist, and J.G. Thompso