32 research outputs found
First Observation of Coherent Production in Neutrino Nucleus Interactions with 2 GeV
The MiniBooNE experiment at Fermilab has amassed the largest sample to date
of s produced in neutral current (NC) neutrino-nucleus interactions at
low energy. This paper reports a measurement of the momentum distribution of
s produced in mineral oil (CH) and the first observation of coherent
production below 2 GeV. In the forward direction, the yield of events
observed above the expectation for resonant production is attributed primarily
to coherent production off carbon, but may also include a small contribution
from diffractive production on hydrogen. Integrated over the MiniBooNE neutrino
flux, the sum of the NC coherent and diffractive modes is found to be (19.5
1.1 (stat) 2.5 (sys))% of all exclusive NC production at
MiniBooNE. These measurements are of immediate utility because they quantify an
important background to MiniBooNE's search for
oscillations.Comment: Submitted to Phys. Lett.
A conditionally replicating adenovirus with strict selectivity in killing cells expressing epidermal growth factor receptor
AbstractVirotherapy of cancer using oncolytic adenoviruses has shown promise in both preclinical and clinical settings. One important challenge to reach the full therapeutic potential of oncolytic adenoviruses is accomplishing efficient infection of cancer cells and avoiding uptake by normal tissue through tropism modification. Towards this goal, we constructed and characterized an oncolytic adenovirus, carrying mutated capsid proteins to abolish the promiscuous adenovirus native tropism and encoding a bispecific adapter molecule to target the virus to the epidermal growth factor receptor (EGFR). The new virus displayed a highly selective targeting profile, with reduced infection of EGFR-negative cells and efficient killing of EGFR-positive cancer cells including primary EGFR-positive osteosarcoma cells that are refractory to infection by conventional adenoviruses. Our method to modify adenovirus tropism might thus be useful to design new oncolytic adenoviruses for more effective treatment of cancer
Variability in the nucleic acid binding site size and the amount of single-stranded DNA-binding protein in Escherichia coli
Feasibility and variability of six methods for the echocardiographic and Doppler determination of cardiac output.
Influence of humoral immunity on leukotriene B4 production by neutrophils in response to Trichomonas vaginalis stimulation
EVALUATION RESEARCH AND POLITICAL SCIENCE: AN ARGUMENT AGAINST THE DIVISION OF SCHOLARLY LABOR
Political science might have been the birthplace of evaluation research, but it has instead been unreceptive to it for a number of reasons. Hofferbert's suggestion that political scientists become involved by studying the impact of policy on democratic processes does not take into account the ferment that has been taking place in the field of evaluation. Political scientists should not conduct evaluation studies using the same methodology they normally use because these may not produce the kind of information needed for improving policies or programs. A disciplinary division of labor is impractical for a number of reasons. Instead, they should use a policy sciences framework, which contains normative elements and focuses on potentials for change, among other things. Copyright 1986 by The Policy Studies Organization.