Classification of web services using data mining algorithms and improved learning model

As per the global digital report, 52.9% of the world population is using the internet, and 42% of the world population is actively using e-commerce, banking, and other online applications. Web servicesare software components accessed using networked communications and provide services to end users. Software developers provide a high quality of web service. To meet the demands of user requirements, it is necessary for a developer to ensure quality architecture and quality of services. To meet the demands of user measure service quality by the ranking of web services, in this paper, we analyzed QWS datasetand found important parameters are best practices, successability, availability, response time, reliability and throughput, and compliance. We have used various data mining techniques and conductedexperiments to classify QWS data set into four categorical values as class1, 2, 3, and 4. The results are compared with various techniques random forest, artificial neural network, J48 decision tree, extremegradient boosting, K-nearest neighbor, and support vector machine. Multiple classifiers analyzed, and it was observed that the classifier technique eXtreme gradient boosting got the maximum accuracy of98.44%, and random forest got the accuracy of 98.13%. In future, we can extend the quality of web service for mixed attributes

Role of Serum creatinine in forecasting the outcome after cardiac surgery beyond acute kidney injury-A Cross sectional Study

Objectives: Acute kidney damage (Acute kidney injury [AKI]) is defined by elevations in serum creatinine levels that occur after surgery. In cardiac surgery, creatinine is a critical determinant. This study highlights the detection of serum creatinine as an early diagnostic and predictive marker of AKI following coronary artery bypass grafting (CABG) and to estimate the serum creatinine concentrations before and at 24 and 48 h after CABG. Methods: It is a single center, Cross-sectional study. Patients from Cardiothoracic and Vascular surgery undergoing CABG in Sri Ramachandra Medical College and Research Institute were included in the study. A total of 80 cases were included in the study. The method used for measurement of serum creatinine is by modification of kinetic Jaffe reaction. Data were analyzed using Stata/SE version 16.0 and represented in terms of means, standard deviation at 95% confidence level and t’ test was performed as statistical analysis and p<0.05 indicates significance. Sigma plot software version 10.0 was used to draw the standard error mean graphs. Results: The serum creatinine values at 24 h after the surgery was statistically higher than the preoperative values at 5% significance level (p=0.04). The serum creatinine values 48 h after the surgery was also statistically higher than the preoperative values at 1% significance level (p=0.001). The serum creatinine values 48 h after surgery are highly significant (p=0.001) when compared to the serum creatinine values 24 h after surgery. Conclusion: Before an increase in serum creatinine level is detected, over 50% of renal function must be lost. It was concluded that serum creatinine is an inadequate and delayed marker of AKI

ROLE OF CLINICAL PHARMACIST IN ASSESSMENT OF DRUG RELATED PROBLEMS OF CARDIOVASCULAR AGENTS IN DEPARTMENT OF CARDIOLOGY IN A TERTIARY CARE HOSPITAL – A PROSPECTIVE OBSERVATIONAL STUDY

In total of 173 prescriptions of the patient, the total number of 329 drug interactions (DIs) was found, in which the 240 interactions were found in male and 89 in the female bearing 72.90% and 27.10%, respectively. Patient was of various age groups, in which the maximum frequency was seen in the age group of 61–70 years having 105 interactions bearing the percentage of 31.9%. According to the participation of different age group of the male and female with their corresponding age. The participation of male is high having frequency of 240 (72.9%) than female participation of frequency 89 (27.1%). The participation of male in the age group of 61–70 years is 83 and the female is 40 in the age group of 51–60 years. Potential DIs (PDIs) were categorized based on the gender. In that compared to 13 (40.6) females, males 19 (59.4%) were found to have more PDIs. Our study is more PDIs in adult patients. Because in adults lacking of nutrition’s and in elderly patients multiple prescribers, multiple drugs and multiple diseases. The number of potential drug-DI (PDDI) increased with an increase in the number of drugs prescribed. The numbers of drug prescribed increase with age. This DI has a potential to increase or decrease the therapeutic effect or to increase the risk of adverse drug reaction. An increased awareness of PDDIs, rational coprescription of drugs, and a close monitoring of patients in whom these drugs are prescribed are recommended. The recommendation is based on the special monitoring and the perspiration of the clinical pharmacist. The DI observed in the geriatric patient is more severe and common in compared to the other groups of study. The geriatric patient is physiological disability in correspond with the first-pass metabolism and the presence of the other diseases which also enables the multiple prescriptions causing polypharmacy. The gender specification also the cause of the interaction, the female is more prone to the DI due to the hormonal distribution in the body and inability of the physiological function to absorb and the distribution. The special training should be provided to the pharmacist for looking forward of the geriatric patient and female patient. The training regarding the prescription their adherence, use, toxicity, and dosage regimen is being properly enabled in the training for the practical application. This study helps to know the different interaction related to the cardiovascular agent with own class of the drug and the other class of drugs used therapeutically to care the disease

Carbamazepine Induced Drug Rash with Eosinophilia and Systemic Symptoms

Stabilizes inactivated state of sodium channels, thereby making neurons less excitable may reduce activity of nucleus ventralis of the thalamus or decrease synaptic transmission or summation of temporal stimulation leading to neuronal discharge.A adult of 68 years old patient came to dermatology department with chief complaints of neuralgia over scalp to relieve the symptoms physician prescribed carbamazepine 200mg Po OD. During his 2ndweek of treatment patient developed pain,fever,sore throat followed by skin rash.Better vigilance is necessary for implementation of safe and effective treatment for each individual patient.in order to  prevent serious adverse drug reactions of this drug,close monitoring drug treatment course, creating awareness, recognition of the problem and careful management of all the patients who receive medication are essential,because use of carbamazepine causes thrombocytopenia, leukopenia, leukocytosis, eosinophilia, anemia, pruritic and erythematous rashes, urticaria, photosensitivity reactions, alterations in skin pigmentation, exfoliative dermatitis, erythema multiforme and nodosum, purpura, aggravation of disseminated lupus erythematosus,Abnormalities in liver function tests, cholestatic and hepatocellular jaundice, hepatitis; very rare cases of hepatic failure, Pancreatitis ,Pulmonary hypersensitivity characterized by fever, dyspnea, pneumonitis, or pneumonia Keywords: Carbamazepine, Induced Drug Rash with Eosinophilia and Systemic Symptoms, adverse drug reaction

Circle grid fractal plate as a turbulent generator for premixed flame: an overview

This review paper focuses to ascertain a new approach in turbulence generation on the structure of premixed flames and external combustion using a fractal grid pattern. This review paper discusses the relationship between fractal pattern and turbulence flow. Many researchers have explored the fractal pattern as a new concept of turbulence generators, but researchers rarely study fractal turbulence generators on the structure premixed flame. The turbulent flow field characteristics have been studied tand investigated in a premixed combustion application. In terms of turbulence intensity, most researchers used fractal grid that can be tailored so that they can design the characteristic needed in premixed flame. This approach makes it extremely difficult to determine the exact turbulent burning velocity on the velocity fluctuation of the flow. The decision to carry out additional research on the effect circle grid fractal plate as a turbulent generator for premixed flame should depends on the blockage ratio and fractal pattern of the grid. 1

Subsurface signatures and timing of extreme wave events along the Southeast Indian coast

Written history's limitation becomes apparent when attempting to document the predecessors of extreme coastal events in the Indian Ocean, from 550-700 years in Thailand and 1000 years in Indonesia. Detailed ground-penetrating radar (GPR) surveys in Mahabalipuram, southeast India, complemented with sedimentological analyses, magnetic susceptibility measurements, and optical dating provide strong evidence of extreme wave events during the past 3700 years. The diagnostic event signatures include the extent and elevation of the deposits, as well as morphologic similarity of buried erosional scarps to those reported in northern Sumatra region. Optical ages immediately overlying the imaged discontinuities that coincides with high concentration of heavy minerals date the erosional events to 340 ± 35, 350 ± 20, 490 ± 30, 880 ± 40, 1080 ± 60, 1175 ± 188, 2193 ± 266, 2235 ± 881, 2489 ± 293, 2450 ± 130, 2585 ± 609, 3710 ± 200 years ago. These evidences are crucial in reconstructing paleo extreme wave events and will pave the way for regional correlation of erosional horizons along the northern margin of Indian Ocean

Circular Economy Pathways for Municipal Wastewater Management in India: A Practitioner’s Guide

The 2030 Water Resources Group is a unique publicprivate- civil society partnership that helps governments to accelerate reforms that will ensure sustainable water resource management for the long term development and economic growth of their country. It does so by helping to change the “political economy” for water reform in the country through convening a wide range of actors and providing water resource analysis in ways that are digestible for politicians and business leaders. The 2030 WRG was launched in 2008 at the World Economic Forum and has been hosted by the International Finance Corporation (IFC) since 2012

Evidence-based national vaccine policy

India has over a century old tradition of development and production of vaccines. The Government rightly adopted self-sufficiency in vaccine production and self-reliance in vaccine technology as its policy objectives in 1986. However, in the absence of a full-fledged vaccine policy, there have been concerns related to demand and supply, manufacture vs. import, role of public and private sectors, choice of vaccines, new and combination vaccines, universal vs. selective vaccination, routine immunization vs. special drives, cost-benefit aspects, regulatory issues, logistics etc. The need for a comprehensive and evidence based vaccine policy that enables informed decisions on all these aspects from the public health point of view brought together doctors, scientists, policy analysts, lawyers and civil society representatives to formulate this policy paper for the consideration of the Government. This paper evolved out of the first ever ICMR-NISTADS national brainstorming workshop on vaccine policy held during 4-5 June, 2009 in New Delhi, and subsequent discussions over email for several weeks, before being adopted unanimously in the present form

NK-CD11c+ Cell Crosstalk in Diabetes Enhances IL-6-Mediated Inflammation during Mycobacterium tuberculosis Infection

In this study, we developed a mouse model of type 2 diabetes mellitus (T2DM) using streptozotocin and nicotinamide and identified factors that increase susceptibility of T2DM mice to infection by Mycobacterium tuberculosis (Mtb). All Mtb-infected T2DM mice and 40% of uninfected T2DM mice died within 10 months, whereas all control mice survived. In Mtb-infected mice, T2DM increased the bacterial burden and pro- and anti-inflammatory cytokine and chemokine production in the lungs relative to those in uninfected T2DM mice and infected control mice. Levels of IL-6 also increased. Anti-IL-6 monoclonal antibody treatment of Mtb-infected acute- and chronic-T2DM mice increased survival (to 100%) and reduced pro- and anti-inflammatory cytokine expression. CD11c+ cells were the major source of IL-6 in Mtb-infected T2DM mice. Pulmonary natural killer (NK) cells in Mtb-infected T2DM mice further increased IL-6 production by autologous CD11c+ cells through their activating receptors. Anti-NK1.1 antibody treatment of Mtb-infected acute-T2DM mice increased survival and reduced pro- and anti-inflammatory cytokine expression. Furthermore, IL-6 increased inflammatory cytokine production by T lymphocytes in pulmonary tuberculosis patients with T2DM. Overall, the results suggest that NK-CD11c+ cell interactions increase IL-6 production, which in turn drives the pathological immune response and mortality associated with Mtb infection in diabetic mice