Evidence for entanglement at high temperatures in an engineered molecular magnet

The molecular compound [Fe$_{2}$($\mu_{2}$-oxo)(C$_{3}$H$_{4}$N$_{2}$)$_{6}$(C$_{2}$O$_{4}$)$_{2}$] was designed and synthesized for the first time and its structure was determined using single-crystal X-ray diffraction. The magnetic susceptibility of this compound was measured from 2 to 300 K. The analysis of the susceptibility data using protocols developed for other spin singlet ground-state systems indicates that the quantum entanglement would remain at temperatures up to 732 K, significantly above the highest entanglement temperature reported to date. The large gap between the ground state and the first-excited state (282 K) suggests that the spin system may be somewhat immune to decohering mechanisms. Our measurements strongly suggest that molecular magnets are promising candidate platforms for quantum information processing

RF cavity design for a low cost 1 MeV proton source

In this paper we present the design for a low-cost RF cavity capable of accelerating protons from 100 keV to 1 MeV. The system is designed to meet the specifications from the proposed Alceli LTD medical proton therapy linac, to deliver a 1 nA proton beam current with a 1 kHz repetition rate. We present a design of an RF normal conducting (NC) re-entrant Cu cavity operating at 40MHz consisting of a coupled two cavity system, both driven by a single Marx generator. The choice of such a low operating frequency for the cavity system enables us to use a relatively low-cost cost Marx Generator as the RF source. Marx generators work in a similar fashion to a Cockcroft-Walton accelerator (without the expensive components), creating a high-voltage pulse by charging a number of capacitors relatively slowly in parallel, then rapidly discharging in series, via spark gaps. Marx generators can deliver 2.5GW, 1 ns pulses, with rise times of 200 ps, and (relatively) low jitter

Coupling of Josephson flux-flow oscillators to an external RC load

We investigate by numerical simulations the behavior of the power dissipated in a resistive load capacitively coupled to a Josephson flux flow oscillator and compare the results to those obtained for a d.c. coupled purely resistive load. Assuming realistic values for the parameters R and C, both in the high- and in the low-Tc case the power is large enough to allow the operation of such a device in applications.Comment: uuencoded, gzipped tar archive containing 11 pages of REVTeX text + 4 PostScript figures. To appear in Supercond. Sci. Techno

Is Big Data for everyone? The challenges of Big Data adoption in SMEs

The aim of this paper is to present an investigative study on the concept of Big Data and its challenges towards implementation in manufacturing SMEs. Big Data aims to facilitate the collaborative approach in SMEs through the creation of real time data visualization to address key challenges to many of the market variations for every sector SMEs. Although, earlier research studies have highlighted the importance of Big Data from technological perspectives, this study focuses towards SMEs due to its feasibility and flexibility within the market space. This research aims to investigate the use of case study approach for the re-use, adoption and understanding of strategic future direction from the findings. The findings and early analysis from this paper could be referred by researchers when addressing the use of big data analytics within manufacturing SMEs. Finally, the paper provides a key strategic point towards the exploration of Big Data within SMEs

Markovian approach to tackle the interaction of simultaneous diseases

The simultaneous emergence of several abrupt disease outbreaks or the extinction of some serotypes of multistrain diseases are fingerprints of the interaction between pathogens spreading within the same population. Here, we propose a general and versatile benchmark to address the unfolding of both cooperative and competitive interacting diseases. We characterize the explosive transitions between the disease-free and the epidemic regimes arising from the cooperation between pathogens and show the critical degree of cooperation needed for the onset of such abrupt transitions. For the competing diseases, we characterize the mutually exclusive case and derive analytically the transition point between the full-dominance phase, in which only one pathogen propagates, and the coexistence regime. Finally, we use this framework to analyze the behavior of the former transition point as the competition between pathogens is relaxed

N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.PostprintPostprintPeer reviewe

Efeito da cheia fluvial na dinâmica das pastagens, Pantanal da Nhecolândia, MS.

bitstream/CPAP/56591/1/CT68.pdfFormato eletronico

Immune cells and oxidative stress in the endotoxin tolerance mouse model

Sepsis is a systemic inflammatory response that can lead to tissue damage and death. In order to increase our understanding of sepsis, experimental models are needed that produce relevant immune and inflammatory responses during a septic event. We describe a lipopolysaccharide tolerance mouse model to characterize the cellular and molecular alterations of immune cells during sepsis. The model presents a typical lipopolysaccharide tolerance pattern in which tolerance is related to decreased production and secretion of cytokines after a subsequent exposure to a lethal dose of lipopolysaccharide. The initial lipopolysaccharide exposure also altered the expression patterns of cytokines and was followed by an 8- and a 1.5-fold increase in the T helper 1 and 2 cell subpopulations. Behavioral data indicate a decrease in spontaneous activity and an increase in body temperature following exposure to lipopolysaccharide. In contrast, tolerant animals maintained production of reactive oxygen species and nitric oxide when terminally challenged by cecal ligation and puncture (CLP). Survival study after CLP showed protection in tolerant compared to naive animals. Spleen mass increased in tolerant animals followed by increases of B lymphocytes and subpopulation Th1 cells. An increase in the number of stem cells was found in spleen and bone marrow. We also showed that administration of spleen or bone marrow cells from tolerant to naive animals transfers the acquired resistance status. In conclusion, lipopolysaccharide tolerance is a natural reprogramming of the immune system that increases the number of immune cells, particularly T helper 1 cells, and does not reduce oxidative stress.FAPESPCNP