Accumulation of aggregated alpha-synuclein in neural tissue structures in neurodegenerative diseases

A critical analysis of the literature on the structure and properties of alpha-synuclein under physiological and pathological conditions is presented, when the conformation of this protein changes, which contributes to its aggregation and changes in localization features in brain structures in such neurodegenerative diseases as Parkinson’s disease, dementia with Lewy bodies, multiple systemic atrophy and Alzheimer’s disease. It has been shown that the toxic effect of conformationally altered alpha-synuclein can indirectly affect the functions of neurons due to its interaction with neuroglial cells, primarily microglia and astrocytes, and can also modulate the aggregation and expression of other proteins that are functionally important for the development of neurodegeneration. Further study of the mechanisms of interaction of conformationally altered alphasynuclein with other proteins and clarification of the relationship between its accumulation in brain structures and neuronal dysfunction remains relevant for modern neurology. Literature search was carried out in the “PubMed” and “eLIBRARY” databases

How do methanol masers manage to appear in the youngest star vicinities and isolated molecular clumps?

General characteristics of methanol (CH3OH) maser emission are summarized. It is shown that methanol maser sources are concentrated in the spiral arms. Most of the methanol maser sources from the Perseus arm are associated with embedded stellar clusters and a considerable portion is situated close to compact HII regions. Almost 1/3 of the Perseus Arm sources lie at the edges of optically identified HII regions which means that massive star formation in the Perseus Arm is to a great extent triggered by local phenomena. A multiline analysis of the methanol masers allows us to determine the physical parameters in the regions of maser formation. Maser modelling shows that class II methanol masers can be pumped by the radiation of the warm dust as well as by free-free emission of a hypercompact region hcHII with a turnover frequency exceeding 100 GHz. Methanol masers of both classes can reside in the vicinity of hcHIIs. Modelling shows that periodic changes of maser fluxes can be reproduced by variations of the dust temperature by a few percent which may be caused by variations in the brightness of the central young stellar object reflecting the character of the accretion process. Sensitive observations have shown that the masers with low flux densities can still have considerable amplification factors. The analysis of class I maser surveys allows us to identify four distinct regimes that differ by the series of their brightest lines.Comment: 8 pages, 4 figures, invited presentation at IAU242 "Astrophysical Masers and their environments

Second-layer nucleation in coherent Stranski-Krastanov growth of quantum dots

We have studied the monolayer-bilayer transformation in the case of the coherent Stranski-Krastanov growth. We have found that the energy of formation of a second layer nucleus is largest at the center of the first-layer island and smallest on its corners. Thus nucleation is expected to take place at the corners (or the edges) rather than at the center of the islands as in the case of homoepitaxy. The critical nuclei have one atom in addition to a compact shape, which is either a square of i*i or a rectangle of i*(i-1) atoms, with i>1 an integer. When the edge of the initial monolayer island is much larger than the critical nucleus size, the latter is always a rectangle plus an additional atom, adsorbed at the longer edge, which gives rise to a new atomic row in order to transform the rectangle into the equilibrium square shape.Comment: 6 pages, 4 figures. Accepted version, minor change

A Multi-Wavelength High Resolution Study of the S255 Star Forming Region. General structure and kinematics

We present observational data for two main components (S255IR and S255N) of the S255 high mass star forming region in continuum and molecular lines obtained at 1.3 mm and 1.1 mm with the SMA, at 1.3 cm with the VLA and at 23 and 50 cm with the GMRT. The angular resolution was from ~ 2" to ~ 5" for all instruments. With the SMA we detected a total of about 50 spectral lines of 20 different molecules (including isotopologues). About half of the lines and half of the species (in particular N2H+, SiO, C34S, DCN, DNC, DCO+, HC3N, H2CO, H2CS, SO2) have not been previously reported in S255IR and partly in S255N at high angular resolution. Our data reveal several new clumps in the S255IR and S255N areas by their millimeter wave continuum emission. Masses of these clumps are estimated at a few solar masses. The line widths greatly exceed expected thermal widths. These clumps have practically no association with NIR or radio continuum sources, implying a very early stage of evolution. At the same time, our SiO data indicate the presence of high-velocity outflows related to some of these clumps. In some cases, strong molecular emission at velocities of the quiescent gas has no detectable counterpart in the continuum. We discuss the main features of the distribution of NH3, N2H+, and deuterated molecules. We estimate properties of decimeter wave radio continuum sources and their relationship with the molecular material.Comment: 21 pages, 26 figures, accepted for publication in Astrophysical Journa

Cold gas outflows from the Small Magellanic Cloud traced with ASKAP

Feedback from massive stars plays a critical role in the evolution of the Universe by driving powerful outflows from galaxies that enrich the intergalactic medium and regulate star formation. An important source of outflows may be the most numerous galaxies in the Universe: dwarf galaxies. With small gravitational potential wells, these galaxies easily lose their star-forming material in the presence of intense stellar feedback. Here, we show that the nearby dwarf galaxy, the Small Magellanic Cloud (SMC), has atomic hydrogen outflows extending at least 2 kiloparsecs (kpc) from the star-forming bar of the galaxy. The outflows are cold, $T<400~{\rm K}$, and may have formed during a period of active star formation $25 - 60$ million years (Myr) ago. The total mass of atomic gas in the outflow is $\sim 10^7$ solar masses, ${\rm M_{\odot}}$, or $\sim 3$% of the total atomic gas of the galaxy. The inferred mass flux in atomic gas alone, $\dot{M}_{HI}\sim 0.2 - 1.0~{\rm M_{\odot}~yr^{-1}}$, is up to an order of magnitude greater than the star formation rate. We suggest that most of the observed outflow will be stripped from the SMC through its interaction with its companion, the Large Magellanic Cloud (LMC), and the Milky Way, feeding the Magellanic Stream of hydrogen encircling the Milky Way.Comment: Published in Nature Astronomy, 29 October 2018, http://dx.doi.org/10.1038/s41550-018-0608-

Multibeam Maser Survey of methanol and excited OH in the Magellanic clouds: new detections and maser abundance estimates

‘The definitive version is available at www.blackwell-synergy.com.’ Copyright Blackwell Publishing DOI: 10.1111/j.1365-2966.2008.12888.xPeer reviewe

The politics of in/visibility: carving out queer space in Ul'yanovsk

&lt;p&gt;In spite of a growing interest within sexualities studies in the concept of queer space (Oswin 2008), existing literature focuses almost exclusively on its most visible and territorialised forms, such as the gay scene, thus privileging Western metropolitan areas as hubs of queer consumer culture (Binnie 2004). While the literature has emphasised the political significance of queer space as a site of resistance to hegemonic gender and sexual norms, it has again predominantly focused on overt claims to public space embodied in Pride events, neglecting other less open forms of resistance.&lt;/p&gt;&lt;p&gt; This article contributes new insights to current debates about the construction and meaning of queer space by considering how city space is appropriated by an informal queer network in Ul’ianovsk. The group routinely occupied very public locations meeting and socialising on the street or in mainstream cafés in central Ul’ianovsk, although claims to these spaces as queer were mostly contingent, precarious or invisible to outsiders. The article considers how provincial location affects tactics used to carve out communal space, foregrounding the importance of local context and collective agency in shaping specific forms of resistance, and questioning ethnocentric assumptions about the empowering potential of visibility.&lt;/p&gt

Electric field of a pointlike charge in a strong magnetic field and ground state of a hydrogenlike atom

In an external constant magnetic field, so strong that the electron Larmour length is much shorter than its Compton length, we consider the modification of the Coulomb potential of a point charge owing to the vacuum polarization. We establish a short-range component of the static interaction in the Larmour scale, expressed as a Yukawa-like law, and reveal the corresponding "photon mass" parameter. The electrostatic force regains its long-range character in the Compton scale: the tail of the potential follows an anisotropic Coulomb law, decreasing away from the charge slower along the magnetic field and faster across. In the infinite-magnetic-field limit the potential is confined to an infinitely thin string passing though the charge parallel to the external field. This is the first evidence for dimensional reduction in the photon sector of quantum electrodynamics. The one-dimensional form of the potential on the string is derived that includes a delta-function centered in the charge. The nonrelativistic ground-state energy of a hydrogenlike atom is found with its use and shown not to be infinite in the infinite-field limit, contrary to what was commonly accepted before, when the vacuum polarization had been ignored. These results may be useful for studying properties of matter at the surface of extremely magnetized neutron stars.Comment: 45 pages, 6 figures, accepted to Phys. Rev.

WALLABY Early Science - I. The NGC 7162 Galaxy Group

We present Widefield ASKAP L-band Legacy All-sky Blind Survey (WALLABY) early science results from the Australian Square Kilometre Array Pathfinder (ASKAP) observations of the NGC 7162 galaxy group. We use archival HIPASS and Australia Telescope Compact Array (ATCA) observations of this group to validate the new ASKAP data and the data reduction pipeline ASKAPsoft. We detect six galaxies in the neutral hydrogen (HI) 21-cm line, expanding the NGC 7162 group membership from four to seven galaxies. Two of the new detections are also the first HI detections of the dwarf galaxies, AM 2159-434 and GALEXASC J220338.65-431128.7, for which we have measured velocities of $cz=2558$ and $cz=2727$ km s$^{-1}$, respectively. We confirm that there is extended HI emission around NGC 7162 possibly due to past interactions in the group as indicated by the $40^{\circ}$ offset between the kinematic and morphological major axes for NGC 7162A, and its HI richness. Taking advantage of the increased resolution (factor of $\sim1.5$) of the ASKAP data over archival ATCA observations, we fit a tilted ring model and use envelope tracing to determine the galaxies' rotation curves. Using these we estimate the dynamical masses and find, as expected, high dark matter fractions of $f_{\mathrm{DM}}\sim0.81-0.95$ for all group members. The ASKAP data are publicly available.Comment: 20 pages, 11 figures, accepted for publication in MNRA