5,461 research outputs found
On Nichols algebras over PGL(2,q) and PSL(2,q)
We compute necessary conditions on Yetter-Drinfeld modules over the groups
\mathbf{PGL}(2,q)=\mathbf{PGL}(2,\FF_q) and
\mathbf{PSL}(2,q)=\mathbf{PSL}(2,\FF_q) to generate finite dimensional
Nichols algebras. This is a first step towards a classification of pointed Hopf
algebras with group of group-likes isomorphic to one of these groups.
As a by-product of the techniques developed in this work, we prove that there
is no non-trivial finite-dimensional pointed Hopf algebra over the Mathieu
groups and .Comment: Minor change
The effect of flight line spacing on radioactivity inventory and spatial feature characteristics of airborne gamma-ray spectrometry data
Airborne Gamma Spectrometry (AGS) is well suited to the mapping of radioactivity in the environment. Flight parameters (e.g. speed and line spacing) directly affect the rate of area coverage, cost, and data quality of any survey. The influences of line spacing have been investigated for data from interâtidal, coastal and upland environments with a range of <sup>137</sup>Cs activity concentrations and depositional histories. Estimates of the integrated <sup>137</sup>Cs activity (âinventoryâ) within specified areas and the shapes of depositional features were calculated for subsets of the data at different line spacings. Features with dimensions greater than the line spacing show variations in inventory and area of less than 3%, and features with dimensions less than the line spacing show larger variations and a decreased probability of detection. The choice of line spacing for a task is dependent on the dimensions of the features of interest and required edge definition. Options for line spacing for different tasks are suggested. It is noted that for regional mapping, even 5â10 km line spacing can produce useful data
Arterial pathology in canine mucopolysaccharidosis-I and response to therapy.
Mucopolysaccharidosis-I (MPS-I) is an inherited deficiency of α-L-iduronidase (IdU) that causes lysosomal accumulation of glycosaminoglycans (GAG) in a variety of parenchymal cell types and connective tissues. The fundamental link between genetic mutation and tissue GAG accumulation is clear, but relatively little attention has been given to the morphology or pathogenesis of associated lesions, particularly those affecting the vascular system. The terminal parietal branches of the abdominal aorta were examined from a colony of dogs homozygous (MPS-I affected) or heterozygous (unaffected carrier) for an IdU mutation that eliminated all enzyme activity, and in affected animals treated with human recombinant IdU. High-resolution computed tomography showed that vascular wall thickenings occurred in affected animals near branch points, and associated with low endothelial shear stress. Histologically these asymmetric 'plaques' entailed extensive intimal thickening with disruption of the internal elastic lamina, occluding more than 50% of the vascular lumen in some cases. Immunohistochemistry was used to show that areas of sclerosis contained foamy (GAG laden) macrophages, fibroblasts and smooth muscle cells, with loss of overlying endothelial basement membrane and claudin-5 expression. Lesions contained scattered cells expressing nuclear factor-ÎșÎČ (p65), increased fibronectin and transforming growth factor ÎČ-1 signaling (with nuclear Smad3 accumulation) in comparison to unaffected vessels. Intimal lesion development and morphology was improved by intravenous recombinant enzyme treatment, particularly with immune tolerance to this exogenous protein. The progressive sclerotic vasculopathy of MPS-I shares some morphological and molecular similarities to atherosclerosis, including formation in areas of low shear stress near branch points, and can be reduced or inhibited by intravenous administration of recombinant IdU
Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I.
BackgroundCardiovascular disease, a progressive manifestation of α-L-iduronidase deficiency or mucopolysaccharidosis type I, continues in patients both untreated and treated with hematopoietic stem cell transplantation or intravenous enzyme replacement. Few studies have examined the effects of α-L-iduronidase deficiency and subsequent glycosaminoglycan storage upon arterial gene expression to understand the pathogenesis of cardiovascular disease.MethodsGene expression in carotid artery, ascending, and descending aortas from four non-tolerized, non-enzyme treated 19 month-old mucopolysaccharidosis type I dogs was compared with expression in corresponding vascular segments from three normal, age-matched dogs. Data were analyzed using R and whole genome network correlation analysis, a bias-free method of categorizing expression level and significance into discrete modules. Genes were further categorized based on module-trait relationships. Expression of clusterin, a protein implicated in other etiologies of cardiovascular disease, was assessed in canine and murine mucopolysaccharidosis type I aortas via Western blot and in situ immunohistochemistry.ResultsGene families with more than two-fold, significant increased expression involved lysosomal function, proteasome function, and immune regulation. Significantly downregulated genes were related to cellular adhesion, cytoskeletal elements, and calcium regulation. Clusterin gene overexpression (9-fold) and protein overexpression (1.3 to 1.62-fold) was confirmed and located specifically in arterial plaques of mucopolysaccharidosis-affected dogs and mice.ConclusionsOverexpression of lysosomal and proteasomal-related genes are expected responses to cellular stress induced by lysosomal storage in mucopolysaccharidosis type I. Upregulation of immunity-related genes implicates the potential involvement of glycosaminoglycan-induced inflammation in the pathogenesis of mucopolysaccharidosis-related arterial disease, for which clusterin represents a potential biomarker
Open fissures along faults: Variscan examples from Gower, South Wales
The extent to which persistent, rather than transient, fissures (wide planar voids) can exist along upper crustal faults is important in assessing fault permeability to mineral and hydrocarbon-bearing fluids. Variscan (late Carboniferous) faults cutting Dinantian (Lower Carboniferous) limestones on the Gower peninsula, South Wales, host clear evidence for fissures up to several metres wide. Evidence includes dendritic hematite growth and elongate calcite growth into open voids, spar ball and cockade breccia formation, laminated sediment infill and void-collapse breccias. Detailed mapping reveals cross-cutting geometries and brecciation of earlier fissure fills, showing that fissures were formed during, rather than after, active faulting. Fissures therefore probably formed by geometric mismatch between displaced fault walls, rather than by solution widening along inactive faults
Complementarity and Scientific Rationality
Bohr's interpretation of quantum mechanics has been criticized as incoherent
and opportunistic, and based on doubtful philosophical premises. If so Bohr's
influence, in the pre-war period of 1927-1939, is the harder to explain, and
the acceptance of his approach to quantum mechanics over de Broglie's had no
reasonable foundation. But Bohr's interpretation changed little from the time
of its first appearance, and stood independent of any philosophical
presuppositions. The principle of complementarity is itself best read as a
conjecture of unusually wide scope, on the nature and future course of
explanations in the sciences (and not only the physical sciences). If it must
be judged a failure today, it is not because of any internal inconsistency.Comment: 29 page
Functional rescue of dystrophin deficiency in mice caused by frameshift mutations using Campylobacter jejuni Cas9
Duchenne muscular dystrophy (DMD) is a fatal, X-linked muscle wasting disease caused by mutations in the DMD gene. In 51% of DMD cases, a reading frame is disrupted because of deletion of several exons. Here, we show that CjCas9 derived from Campylobacter jejuni can be
used as a gene editing tool to correct an out-of-frame Dmd exon in Dmd knockout mice. Herein, we used Cas9 derived from S. pyogenes to generate Dmd knockout (KO) mice with a frameshift mutation in Dmd gene. Then, we expressed CjCas9, its single-guide RNA, and the eGFP gene
in the tibialis anterior muscle of the Dmd KO mice using an all-in-one adeno-associated virus (AAV) vector. CjCas9 cleaved the target site in the Dmd gene efficiently in vivo and induced small insertions or deletions at the target site. This treatment resulted in conversion of the
disrupted Dmd reading frame from out-of-frame to in-frame, leading to the expression of dystrophin in the sarcolemma. Importantly, muscle strength was enhanced in the CjCas9-treated muscles, without off-target mutations, indicating high efficiency and specificity of CjCas9. This work suggests that in vivo DMD frame correction, mediated by CjCas9 has great potential for the treatment of DMD and other neuromuscular diseases
PKS2250-41: a case study for triggering
We present the results of a multiwavelength study of the z = 0.31 radio
source PKS2250-41. Integral field unit and long-slit spectroscopy obtained
using VIMOS and FORS1 on the VLT, and archival HST optical imaging observations
are used to study the morphology, kinematics and ionisation state of the
extended emission line region (EELR) surrounding this source, and also a
companion galaxy at a similar redshift. Near-infrared imaging observations
obtained using the NTT are used to analyse the underlying galaxy morphologies.
The EELR displays a complex variety of different gas kinematics and ionization
states, consistent with a mixture of radio source shocks and AGN
photoionization. The radio galaxy is likely to lie within a group environment,
and is plausibly undergoing interactions with one or more other objects. The
disk-like galaxy to the northeast of the radio source lies at a similar
redshift to the radio galaxy itself, and has its major axis position angle
aligned with the filamentary continuum and line emission extending outwards
from the radio galaxy. This filamentary structure is most plausibly interpreted
as a tidal structure associated with an interaction involving the radio source
host galaxy and the aligned companion galaxy to the north-east; this encounter
may have potentially triggered the current epoch of radio source activity.
Overall, PKS2250-41 displays some of the best evidence that radio source
activity can be triggered in this manner. [abridged]Comment: 16 pages, 13 figures (some colour). Accepted for publication in
MNRAS. Abstract abridge
Rethinking place and the social work office in the delivery of children's social work services
Limited attention has been given to the concept of place in social work research and practice. This paper draws on the national evaluation of social work practices (SWPs) in England undertaken between 2009 and 2012. SWPs were pilot organisations providing independent social work services for children in out-of-home care in five sites. One factor distinguishing some of these pilots was their attention to place. The evaluation employed a mixed methods approach and we use data from interviews with 121 children and young people in out-of-home care, 19 birth parents and 31 interviews with SWP staff which explored their views and experiences of the SWP offices. Children and young people
were alert to the stigma which could attach to social work premises and appreciated offices which were planned and furnished to appear less institutional and more ânormalâ. Daily interactions with staff which conveyed a sense of recognition and value to service users also contributed to a view of some SWP offices as accessible and welcoming places. Both children and parents appreciated offices that provided fun activities that positioned them as active rather than passive. Staff valued opportunities for influencing planning decisions about offices and place
was seen to confer a value on them as well as on service users. However, not all the SWPs were able to achieve these aspects of place, and engaging children and families in place was less likely when the service user population was widely dispersed. Recognising the importance of place and how place is constructed through relationships between people as well as through the physical environment appeared to be key to creating offices that combated the stigma attached to out-of-home care.
Those leading and managing childrenâs services should explore ways of involving local communities in planning social work offices and turn attention to making these offices accessible, welcoming, places
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