1,888 research outputs found
Thymic Function After Allogeneic Stem Cell Transplantation Is Dependent on Graft Source and Predictive of Long Term Survival
Probing the interiors of the ice giants: Shock compression of water to 700 GPa and 3.8 g/ccm
Recently there has been tremendous increase in the number of identified
extra-solar planetary systems. Our understanding of their formation is tied to
exoplanet internal structure models, which rely upon equations of state of
light elements and compounds like water. Here we present shock compression data
for water with unprecedented accuracy that shows water equations of state
commonly used in planetary modeling significantly overestimate the
compressibility at conditions relevant to planetary interiors. Furthermore, we
show its behavior at these conditions, including reflectivity and isentropic
response, is well described by a recent first-principles based equation of
state. These findings advocate this water model be used as the standard for
modeling Neptune, Uranus, and "hot Neptune" exoplanets, and should improve our
understanding of these types of planets.Comment: Accepted to Phys. Rev. Lett.; supplementary material attached
including 2 figures and 2 tables; to view attachments, please download and
extract the gzipped tar source file listed under "Other formats
CSF protein biomarkers predicting longitudinal reduction of CSF β-amyloid42 in cognitively healthy elders.
β-amyloid (Aβ) plaque accumulation is a hallmark of Alzheimer's disease (AD). It is believed to start many years prior to symptoms and is reflected by reduced cerebrospinal fluid (CSF) levels of the peptide Aβ1-42 (Aβ42). Here we tested the hypothesis that baseline levels of CSF proteins involved in microglia activity, synaptic function and Aβ metabolism predict the development of Aβ plaques, assessed by longitudinal CSF Aβ42 decrease in cognitively healthy people. Forty-six healthy people with three to four serial CSF samples were included (mean follow-up 3 years, range 2-4 years). There was an overall reduction in Aβ42 from a mean concentration of 211-195 pg ml(-1) after 4 years. Linear mixed-effects models using longitudinal Aβ42 as the response variable, and baseline proteins as explanatory variables (n=69 proteins potentially relevant for Aβ metabolism, microglia or synaptic/neuronal function), identified 10 proteins with significant effects on longitudinal Aβ42. The most significant proteins were angiotensin-converting enzyme (ACE, P=0.009), Chromogranin A (CgA, P=0.009) and Axl receptor tyrosine kinase (AXL, P=0.009). Receiver-operating characteristic analysis identified 11 proteins with significant effects on longitudinal Aβ42 (largely overlapping with the proteins identified by linear mixed-effects models). Several proteins (including ACE, CgA and AXL) were associated with Aβ42 reduction only in subjects with normal baseline Aβ42, and not in subjects with reduced baseline Aβ42. We conclude that baseline CSF proteins related to Aβ metabolism, microglia activity or synapses predict longitudinal Aβ42 reduction in cognitively healthy elders. The finding that some proteins only predict Aβ42 reduction in subjects with normal baseline Aβ42 suggest that they predict future development of the brain Aβ pathology at the earliest stages of AD, prior to widespread development of Aβ plaques
Supernovae data and perturbative deviation from homogeneity
We show that a spherically symmetric perturbation of a dust dominated
FRW universe in the Newtonian gauge can lead to an apparent
acceleration of standard candles and provide a fit to the magnitude-redshift
relation inferred from the supernovae data, while the perturbation in the
gravitational potential remains small at all scales. We also demonstrate that
the supernovae data does not necessarily imply the presence of some additional
non-perturbative contribution by showing that any Lemaitre-Tolman-Bondi model
fitting the supernovae data (with appropriate initial conditions) will be
equivalent to a perturbed FRW spacetime along the past light cone.Comment: 8 pages, 3 figures; v2: 1 figure added, references added/updated,
minor modifications and clarifications, matches published versio
Back-reaction and effective acceleration in generic LTB dust models
We provide a thorough examination of the conditions for the existence of
back-reaction and an "effective" acceleration (in the context of Buchert's
averaging formalism) in regular generic spherically symmetric
Lemaitre-Tolman-Bondi (LTB) dust models. By considering arbitrary spherical
comoving domains, we verify rigorously the fulfillment of these conditions
expressed in terms of suitable scalar variables that are evaluated at the
boundary of every domain. Effective deceleration necessarily occurs in all
domains in: (a) the asymptotic radial range of models converging to a FLRW
background, (b) the asymptotic time range of non-vacuum hyperbolic models, (c)
LTB self-similar solutions and (d) near a simultaneous big bang. Accelerating
domains are proven to exist in the following scenarios: (i) central vacuum
regions, (ii) central (non-vacuum) density voids, (iii) the intermediate radial
range of models converging to a FLRW background, (iv) the asymptotic radial
range of models converging to a Minkowski vacuum and (v) domains near and/or
intersecting a non-simultaneous big bang. All these scenarios occur in
hyperbolic models with negative averaged and local spatial curvature, though
scenarios (iv) and (v) are also possible in low density regions of a class of
elliptic models in which local spatial curvature is negative but its average is
positive. Rough numerical estimates between -0.003 and -0.5 were found for the
effective deceleration parameter. While the existence of accelerating domains
cannot be ruled out in models converging to an Einstein de Sitter background
and in domains undergoing gravitational collapse, the conditions for this are
very restrictive. The results obtained may provide important theoretical clues
on the effects of back-reaction and averaging in more general non-spherical
models.Comment: Final version accepted for publication in Classical and Quantum
Gravity. 47 pages in IOP LaTeX macros, 12 pdf figure
Would You Choose to be Happy? Tradeoffs Between Happiness and the Other Dimensions of Life in a Large Population Survey
A large literature documents the correlates and causes of subjective well-being, or happiness. But few studies have investigated whether people choose happiness. Is happiness all that people want from life, or are they willing to sacrifice it for other attributes, such as income and health? Tackling this question has largely been the preserve of philosophers. In this article, we find out just how much happiness matters to ordinary citizens. Our sample consists of nearly 13,000 members of the UK and US general populations. We ask them to choose between, and make judgments over, lives that are high (or low) in different types of happiness and low (or high) in income, physical health, family, career success, or education. We find that people by and large choose the life that is highest in happiness but health is by far the most important other concern, with considerable numbers of people choosing to be healthy rather than happy. We discuss some possible reasons for this preference
Radio and IR interferometry of SiO maser stars
Radio and infrared interferometry of SiO maser stars provide complementary
information on the atmosphere and circumstellar environment at comparable
spatial resolution. Here, we present the latest results on the atmospheric
structure and the dust condensation region of AGB stars based on our recent
infrared spectro-interferometric observations, which represent the environment
of SiO masers. We discuss, as an example, new results from simultaneous VLTI
and VLBA observations of the Mira variable AGB star R Cnc, including VLTI near-
and mid-infrared interferometry, as well as VLBA observations of the SiO maser
emission toward this source. We present preliminary results from a monitoring
campaign of high-frequency SiO maser emission toward evolved stars obtained
with the APEX telescope, which also serves as a precursor of ALMA images of the
SiO emitting region. We speculate that large-scale long-period chaotic motion
in the extended molecular atmosphere may be the physical reason for observed
deviations from point symmetry of atmospheric molecular layers, and for the
observed erratic variability of high-frequency SiO maser emissionComment: 8 pages, 4 figures, submitted to Proc. IAU Symp. 287 "Cosmic masers -
from OH to H_0", R.S. Booth, E.M.L. Humphreys, W.H.T. Vlemmings (eds.),
invited pape
Boundary Effects on Spectral Properties of Interacting Electrons in One Dimension
The single electron Green's function of the one-dimensional
Tomonaga-Luttinger model in the presence of open boundaries is calculated with
bosonization methods. We show that the critical exponents of the local spectral
density and of the momentum distribution change in the presence of a boundary.
The well understood universal bulk behavior always crosses over to a boundary
dominated regime for small energies or small momenta. We show this crossover
explicitly for the large-U Hubbard model in the low-temperature limit.
Consequences for photoemission experiments are discussed.Comment: revised and reformatted paper to appear in Phys. Rev. Lett. (Feb.
1996). 5 pages (revtex) and 3 embedded figures (macro included). A complete
postscript file is available from http://FY.CHALMERS.SE/~eggert/luttinger.ps
or by request from [email protected]
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