Tidal instability in a rotating and differentially heated ellipsoidal shell

The stability of a rotating flow in a triaxial ellipsoidal shell with an imposed temperature difference between inner and outer boundaries is studied numerically. We demonstrate that (i) a stable temperature field encourages the tidal instability, (ii) the tidal instability can grow on a convective flow, which confirms its relevance to geo- and astrophysical contexts and (iii) its growth rate decreases when the intensity of convection increases. Simple scaling laws characterizing the evolution of the heat flux based on a competition between viscous and thermal boundary layers are derived analytically and verified numerically. Our results confirm that thermal and tidal effects have to be simultaneously taken into account when studying geophysical and astrophysical flows

Libration driven elliptical instability

The elliptical instability is a generic instability which takes place in any rotating flow whose streamlines are elliptically deformed. Up to now, it has been widely studied in the case of a constant, non-zero differential rotation between the fluid and the elliptical distortion with applications in turbulence, aeronautics, planetology and astrophysics. In this letter, we extend previous analytical studies and report the first numerical and experimental evidence that elliptical instability can also be driven by libration, i.e. periodic oscillations of the differential rotation between the fluid and the elliptical distortion, with a zero mean value. Our results suggest that intermittent, space-filling turbulence due to this instability can exist in the liquid cores and sub-surface oceans of so-called synchronized planets and moons

A systematic numerical study of the tidal instability in a rotating triaxial ellipsoid

The full non-linear evolution of the tidal instability is studied numerically in an ellipsoidal fluid domain relevant for planetary cores applications. Our numerical model, based on a finite element method, is first validated by reproducing some known analytical results. This model is then used to address open questions that were up to now inaccessible using theoretical and experimental approaches. Growth rates and mode selection of the instability are systematically studied as a function of the aspect ratio of the ellipsoid and as a function of the inclination of the rotation axis compared to the deformation plane. We also quantify the saturation amplitude of the flow driven by the instability and calculate the viscous dissipation that it causes. This tidal dissipation can be of major importance for some geophysical situations and we thus derive general scaling laws which are applied to typical planetary cores

Systematic review of the behavioural assessment of pain in cats

Objectives The objectives were to review systematically the range of assessment tools used in cats to detect the behavioural expression of pain and the evidence of their quality; and to examine behavioural metrics (considering both the sensory and affective domains) used to assess pain. Methods A search of PubMed and ScienceDirect, alongside articles known to the authors, from 2000 onwards, for papers in English was performed. This was followed by a manual search of the references within the primary data sources. Only peer-reviewed publications that provided information on the assessment tool used to evaluate the behavioural expression of pain in cats, in conscious animals (not anaesthetised cats), were included. Results No previous systematic reviews were identified. One hundred papers were included in the final assessment. Studies were primarily related to the assessment of pain in relation to surgical procedures, and no clear distinction was made concerning the onset of acute and chronic pain. Ten broad types of instrument to assess pain were identified, and generally the quality of evidence to support the use of the various instruments was poor. Only one specific instrument (UNESP-Botucatu scale) had published evidence of validity, reliability and sensitivity at the level of a randomised control trial, but with a positive rather than placebo control, and limited to its use in the ovariohysterectomy situation. The metrics used within the tools appeared to focus primarily on the sensory aspect of pain, with no study clearly discriminating between the sensory and affective components of pain. Conclusions and relevance Further studies are required to provide a higher quality of evidence for methods used to assess pain in cats. Furthermore, a consistent definition for acute and chronic pain is needed. Tools need to be validated that can detect pain in a range of conditions and by different evaluators (veterinary surgeons and owners), which consider both the sensory and emotional aspects of pain

An observed 20-year time series of Agulhas leakage

We provide a time series of Agulhas leakage anomalies over the last 20-years from satellite altimetry. Until now, measuring the interannual variability of Indo-Atlantic exchange has been the major barrier in the investigation of the dynamics and large scale impact of Agulhas leakage. We compute the difference of transport between the Agulhas Current and Agulhas Return Current, which allows us to deduce Agulhas leakage. The main difficulty is to separate the Agulhas Return Current from the southern limb of the subtropical "supergyre" south of Africa. For this purpose, an algorithm that uses absolute dynamic topography data is developed. The algorithm is applied to a state-of-the-art ocean model. The comparison with a Lagrangian method to measure the leakage allows us to validate the new method. An important result is that it is possible to measure Agulhas leakage in this model using the velocity field along a section that crosses both the Agulhas Current and the Agulhas Return Current. In the model a good correlation is found between measuring leakage using the full depth velocities and using only the surface geostrophic velocities. This allows us to extend the method to along-track absolute dynamic topography from satellites. It is shown that the accuracy of the mean dynamic topography does not allow us to determine the mean leakage but that leakage anomalies can be accurately computed

Étude de la motricité du rumen chez les petits ruminants VI. — Influence de l’ingestion d’urée

Annicolas D., Le Bars Henri, Nugues J., Simonnet Henri. Étude de la motricité du rumen chez les petits ruminants VI. — Influence de l’ingestion d’urée. In: Bulletin de l'Académie Vétérinaire de France tome 109 n°5, 1956. pp. 257-261

Toxicité de l’urée chez les petits ruminants

Annicolas D., Le Bars Henri, Nugues J., Simonnet Henri. Toxicité de l’urée chez les petits ruminants. In: Bulletin de l'Académie Vétérinaire de France tome 109 n°5, 1956. pp. 225-232

Body mass index and treatment response to subcutaneous abatacept in patients with psoriatic arthritis: a

Objective: This Methods: In ASTRAEA, patients with active PsA were randomised (1:1) to receive blinded weekly SC abatacept 125 mg or placebo for 24 weeks. Treatment response at week 24 was assessed by the proportions of patients achieving American College of Rheumatology 20% improvement response, Disease Activity Score in 28 joints (DAS28 (C reactive protein (CRP))) ≤3.6 and Results: Of 212/213 and 210/211 patients with baseline BMI data in the abatacept and placebo groups, respectively, 15% and 19% were underweight/normal, 36% and 27% were overweight, and 49% and 54% were obese. After adjusting for baseline characteristics, there were no significant differences for any outcome measure at week 24 with abatacept in the overweight or obese versus underweight/normal subgroup. In the placebo group, patients in the obese versus underweight/normal subgroup were significantly less likely to achieve DAS28 (CRP) Conclusion: BMI does not impact clinical or radiographic response to SC abatacept in patients with PsA. Trial registration number: NCT01860976

Tilt-over mode in a precessing triaxial ellipsoid

The tilt-over mode in a precessing triaxial ellipsoid is studied theoretically and numerically. Inviscid and viscous analytical models previously developed for the spheroidal geometry by Poincar\'e [Bull. Astr. 27, 321 (1910)] and Busse [J. Fluid Mech., 33, 739 (1968)] are extended to this more complex geometry, which corresponds to a tidally deformed spinning astrophysical body. As confirmed by three-dimensional numerical simulations, the proposed analytical model provides an accurate description of the stationary flow in an arbitrary triaxial ellipsoid, until the appearance at more vigorous forcing of time dependent flows driven by tidal and/or precessional instabilities.Comment: http://link.aip.org/link/doi/10.1063/1.350435

Freezing of Enkephalinergic Functions by Multiple Noxious Foci: A Source of Pain Sensitization?

BACKGROUND:The functional significance of proenkephalin systems in processing pain remains an open question and indeed is puzzling. For example, a noxious mechanical stimulus does not alter the release of Met-enkephalin-like material (MELM) from segments of the spinal cord related to the stimulated area of the body, but does increase its release from other segments. METHODOLOGY/PRINCIPAL FINDINGS:Here we show that, in the rat, a noxious mechanical stimulus applied to either the right or the left hind paw elicits a marked increase of MELM release during perifusion of either the whole spinal cord or the cervico-trigeminal area. However, these stimulatory effects were not additive and indeed, disappeared completely when the right and left paws were stimulated simultaneously. CONCLUSION/SIGNIFICANCE:We have concluded that in addition to the concept of a diffuse control of the transmission of nociceptive signals through the dorsal horn, there is a diffuse control of the modulation of this transmission. The "freezing" of Met-enkephalinergic functions represents a potential source of central sensitization in the spinal cord, notably in clinical situations involving multiple painful foci, e.g. cancer with metastases, poly-traumatism or rheumatoid arthritis