Evaluating LANDSAT wildland classification accuracies

Procedures to evaluate the accuracy of LANDSAT derived wildland cover classifications are described. The evaluation procedures include: (1) implementing a stratified random sample for obtaining unbiased verification data; (2) performing area by area comparisons between verification and LANDSAT data for both heterogeneous and homogeneous fields; (3) providing overall and individual classification accuracies with confidence limits; (4) displaying results within contingency tables for analysis of confusion between classes; and (5) quantifying the amount of information (bits/square kilometer) conveyed in the LANDSAT classification

The Added Value of Molecular Testing in Small Pancreatic Cysts

Background: Cystic lesions of the pancreas (CLP) represent a relatively common pathologic entity affecting at least 1% of medical patients and represent a spectrum of lesions from inflammatory pseudocyststo malignant neoplasms. A significant percentage of these cysts are found incidentally during imaging work-up for unrelated conditions and require appropriate diagnostic testing to characterize the nature of the CLP. A multi-disciplinary approach to characterize CLP is currently used involving cytology, imaging, and cyst fluid analysis. The most recent international guidelines recommend resection of pancreatic mucinouscysts \u3e3 cm, or smaller cysts with positive cytology, mural nodules, or symptoms. Recent work utilized DNA analysis to characterize CLP as either mucinousor serous, and assess malignant potential. Focusing on k-rasgene point mutation, this group was able to detect mucinousdifferentiation (specificity 96%). Further, high amplitude k-rasmutations combined with allelic loss were 96% specific for malignancy. Correlation of k-rasmutation / allelic imbalances with CEA, however, showed poor agreement in the diagnosis of mucinousCLP. Our aim is to determine the added benefit of molecular testing in diagnosing small (≤3 cm) pancreatic cysts

Preliminary evidence for the influence of physiography and scale upon the autocorrelation function of remotely sensed data

Previously established results demonstrate that LANDSAT data are autocorrelated and can be described by a univariate linear stochastic process known as auto-regressive-integrated-moving-average model of degree 1, 0, 1 or ARIMA (1, 0, 1). This model has two coefficients of interest for interpretation phi(1) and theta(1). In a comparison of LANDSAT thematic mapper simulator (TMS) data and LANDSAT MSS data several results were established: (1) The form of the relatedness as described by this model is not dependent upon system look angle or pixel size. (2) The phi(1) coefficient increases with decreasing pixel size and increasing topographic complexity. (3) Changes in topography have a greater influence upon phi(1) than changes in land cover class. (4) The theta(1) seems to vary with the amount of atmospheric haze. These patterns of variation in phi(1) and theta(1) are potentially exploitable by the remote sensing community to yield stochastically independent sets of observations, characterize topography, and reduce the number of bytes needed to store remotely sensed data

BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates

© 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.Background: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have agonist action at both mu opioid peptide (MOP) and nociceptin/orphanin FQ peptide (NOP) receptors. BU10038 is a recently identified bifunctional MOP/NOP partial agonist. The aim of this study was to determine the functional profile of systemic or spinal delivery of BU10038 in primates after acute and chronic administration. Methods: A series of behavioural and physiological assays have been established specifically to reflect the therapeutic (analgesia) and side-effects (abuse potential, respiratory depression, itch, physical dependence, and tolerance) of opioid analgesics in rhesus monkeys. Results: After systemic administration, BU10038 (0.001–0.01 mg kg −1 ) dose-dependently produced long-lasting antinociceptive and antihypersensitive effects. Unlike the MOP agonist oxycodone, BU10038 lacked reinforcing effects (i.e. little or no abuse liability), and BU10038 did not compromise the physiological functions of primates including respiration, cardiovascular activities, and body temperature at antinociceptive doses and a 10–30-fold higher dose (0.01–0.1 mg kg −1 ). After intrathecal administration, BU10038 (3 μg) exerted morphine-comparable antinociception and antihypersensitivity without itch scratching responses. Unlike morphine, BU10038 did not cause the development of physical dependence and tolerance after repeated and chronic administration. Conclusions: These in vivo findings demonstrate the translational potential of bifunctional MOP/NOP receptor agonists such as BU10038 as a safe, non-addictive analgesic with fewer side-effects in primates. This study strongly supports that bifunctional MOP/NOP agonists may provide improved analgesics and an alternative solution for the ongoing prescription opioid crisis.Peer reviewedFinal Published versio

The Refractive Index of Silicon at Gamma Ray Energies

The index of refraction n(E_{\gamma})=1+\delta(E_{\gamma})+i\beta(E_{\gamma}) is split into a real part \delta and an absorptive part \beta. The absorptive part has the three well-known contributions to the cross section \sigma_{abs}: the photo effect, the Compton effect and the pair creation, but there is also the inelastic Delbr\"uck scattering. Second-order elastic scattering cross sections \sigma_{sca} with Rayleigh scattering (virtual photo effect), virtual Compton effect and Delbr\"uck scattering (virtual pair creation) can be calculated by integrals of the Kramers-Kronig dispersion relations from the cross section \sigma_{abs}. The real elastic scattering amplitudes are proportional to the refractive indices \delta_{photo}, \delta_{Compton} and \delta_{pair}. While for X-rays the negative \delta_{photo} dominates, we show for the first time experimentally and theoretically that the positive \delta_{pair} dominates for \gamma rays, opening a new era of \gamma optics applications, i.e. of nuclear photonics.Comment: 4 pages, 3 figure

Advances in tensiometer-based suction control systems.

Cunningham (2000) and Jotisankasa (2005) pioneered the development of tensiometer-based suction control systems. In these systems, wetting and drying of the soil are achieved by water injection and circulation of air in contact with the specimen while suction is monitored by sample-mounted high suction tensiometers. Unlike the axis translation technique, these systems avoid using elevated air pressures and better reproduce the drying and wetting conditions occurring in the field. Building upon these earlier works, this pa-per describes an automated tensiometer-based suction control system that enables direct measurement of water content changes inside the sample. A diaphragm pump forces air to flow inside a closed loop that runs across the sample while a moisture trap ensures that the relative humidity of the circulating air is kept low. As the circulating air dries the soil, the amount of abstracted water is measured by continuous weighing of the desiccant inside the moisture trap. Wetting of the sample is instead achieved by controlled injection of water through a solenoid valve connected to a pressurized volume gauge. The changes of soil water content are given by the difference between the amounts of water injected by the volume gauge and that retained by the desiccant. The system is used to impose cycles of drying and wetting on compacted clayey specimens and results from preliminary tests are presented

Assessment of NASA's Physiographic and Meteorological Datasets as Input to HSPF and SWAT Hydrological Models

This paper documents the use of simulated Moderate Resolution Imaging Spectroradiometer land use/land cover (MODIS-LULC), NASA-LIS generated precipitation and evapo-transpiration (ET), and Shuttle Radar Topography Mission (SRTM) datasets (in conjunction with standard land use, topographical and meteorological datasets) as input to hydrological models routinely used by the watershed hydrology modeling community. The study is focused in coastal watersheds in the Mississippi Gulf Coast although one of the test cases focuses in an inland watershed located in northeastern State of Mississippi, USA. The decision support tools (DSTs) into which the NASA datasets were assimilated were the Soil Water & Assessment Tool (SWAT) and the Hydrological Simulation Program FORTRAN (HSPF). These DSTs are endorsed by several US government agencies (EPA, FEMA, USGS) for water resources management strategies. These models use physiographic and meteorological data extensively. Precipitation gages and USGS gage stations in the region were used to calibrate several HSPF and SWAT model applications. Land use and topographical datasets were swapped to assess model output sensitivities. NASA-LIS meteorological data were introduced in the calibrated model applications for simulation of watershed hydrology for a time period in which no weather data were available (1997-2006). The performance of the NASA datasets in the context of hydrological modeling was assessed through comparison of measured and model-simulated hydrographs. Overall, NASA datasets were as useful as standard land use, topographical , and meteorological datasets. Moreover, NASA datasets were used for performing analyses that the standard datasets could not made possible, e.g., introduction of land use dynamics into hydrological simulation

Prognostic significance of high-grade dysplasia in colorectal adenomas.

Aim  Colonoscopy to detect and remove polyps has contributed to a reduction in colorectal carcinoma. Three-year follow up is recommended for patients considered to be at high risk (at least three adenomas, adenoma ≥ 1 cm, villous or high-grade features). Our study focused on patients diagnosed with high-grade dysplasia with regard to initial management and follow up. Method  A search of patients who had had endoscopic removal of a high-grade adenoma was carried out. Patients with the following were excluded: follow up of \u3c 1 year, polyposis syndromes, prior colon cancer and a diagnosis of adenocarcinoma within 6 months following initial diagnosis. Results  Eighty-three patients treated between 1999 and 2007 for high-grade dysplasia (HGD) in a colorectal adenoma were identified. Over a median follow-up period of 4 years, 53 (64%) developed further adenomatous polyps. Among these, 7% had an adenoma with HGD or an adenocarcinoma. In all these patients, the initial high-grade adenoma was \u3e 1 cm in diameter. Initial follow-up colonoscopy was performed on average 7 months following the initial diagnosis. Ten per cent of patients underwent prophylactic segmental resection, and 6% received argon laser therapy. Conclusion  The study demonstrates that patients who have a colorectal adenoma \u3e 1 cm with HGD may be at high risk of developing further adenomas with HGD or carcinoma. Close follow up is warranted

Optimal Economic Growth under Stochastic Environmental Impact: Sensitivity Analysis

In this work we present an approach toward the sensitivity analysis of optimal economic growth to a negative environmental impact driven by random natural hazards that damage the production output . We use a simplified model of the GDP whose growth leads to the increase of GHG in the atmosphere provided investment in cleaning is insufficient. The hypothesis of the Poisson probability distribution of the natural hazards is used at the first stage of the research. We apply the standard utility function - the discounted integral consumption and construct an optimal investment policy in production and cleaning together with optimal GDP trajectories. We calibrate the model in the global scale and analyze the sensitivity of obtained optimal growth scenarios with respect to uncertain parameters of the Poisson distribution

Options and strategies for the conservation of farm animal genetic resources. Report of an International Workshop. Agropolis, Montpellier, France, 7-10 November 2005

Sixty-three experts from 28 countries and eight international organizations met for four days in Montpellier, France, in November 2005 to review the options and strategies for the conservation of farm animal genetic resources (FAnGR) and to identify priorities for action. The workshop focused primarily on the technical needs and opportunities and placed less emphasis on policy and institutional issues, although findings on such issues did arise naturally from many of the conclusions drawn. The workshop resulted in 11 major findings and 13 priorities for action. The workshop also identified four broad areas where information and knowledge were lacking. The findings and priorities for action are listed here in the executive summary and each is explained in more detail in the body of this report. They are presented in the order developed by the workshop. Participants did not attempt to rank the findings and actions. (Résumé d'auteur