1,547 research outputs found

    The adaptive nature of the bone-periodontal ligament-cementum complex in a ligature-induced periodontitis rat model.

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    The novel aspect of this study involves illustrating significant adaptation of a functionally loaded bone-PDL-cementum complex in a ligature-induced periodontitis rat model. Following 4, 8, and 15 days of ligation, proinflammatory cytokines (TNF- α and RANKL), a mineral resorption indicator (TRAP), and a cell migration and adhesion molecule for tissue regeneration (fibronectin) within the complex were localized and correlated with changes in PDL-space (functional space). At 4 days of ligation, the functional space of the distal complex was widened compared to controls and was positively correlated with an increased expression of TNF- α. At 8 and 15 days, the number of RANKL(+) cells decreased near the mesial alveolar bone crest (ABC) but increased at the distal ABC. TRAP(+) cells on both sides of the complex significantly increased at 8 days. A gradual change in fibronectin expression from the distal PDL-secondary cementum interfaces through precementum layers was observed when compared to increased and abrupt changes at the mesial PDL-cementum and PDL-bone interfaces in ligated and control groups. Based on our results, we hypothesize that compromised strain fields can be created in a diseased periodontium, which in response to prolonged function can significantly alter the original bone and apical cementum formations

    Effect of different modes of pollination on yield parameters of summer squash (Cucurbita pepo L.) in India

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    Effect of different modes of pollination, viz., without insect pollination, hand-pollination, open-pollination and open-pollination + hand-pollination on yield parameters of 4 summer squash (Cucurbita pepo L.) hybrids viz., Parikrama, Chandra, Chamatkar and Gold Queen was studied at Research Farm of the Department of Entomology, CCS Haryana Agricultural University, Hisar during 2014. Irrespective of different hybrids, the treatment openpollination + hand-pollination and open-pollination produced the maximum number of fruits per plant (73.50 and 71.25%, respectively) followed by hand-pollination (59.08%) and no fruits were observed (0% fruit set) under without insect pollination treatment. Average fruit weight, fruit polar diameter and equatorial diameter were maximum (135.30 g, 3.74 cm and 3.47 cm, respectively) under open-pollination + hand-pollination, while these were minimum (94.81 cm, 2.14cm and 2.48 cm, respectively) under hand-pollination treatment. These results indicate that honey bees as well as wild pollinators are utmost essential for pollination of summer squash flowers and thus increasing fruit size and yield. Therefore pollinators conservation practices should be followed in summer squash growing areas for getting higher yield and returns

    Incidental finding of lymphoma after septoplasty.

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    IntroductionSeptoplasty, or surgical correction of the deviated septum, is an elective, routinely performed rhinologic procedure to address nasal airway obstruction. In many cases, resected septal cartilage and bone fragments are sent for pathologic review, although there is no consensus on this practice. We reported two cases of incidentally diagnosed lymphoma after elective septoplasty and discussed clinical presentation, diagnosis, and management.MethodsRetrospective chart review of two patients who underwent septoplasty at a tertiary academic medical center and found to have incidental lymphoma based on histopathology.ResultsTwo patients who underwent septoplasty had an incidental diagnosis of lymphoma on pathologic analysis. One patient was noted to have an S-shaped septal deviation that produced bilateral nasal obstruction. She underwent a difficult septoplasty, in which the mucoperichondrial flap was firmly adherent to the underlying septum and bone. Final pathology demonstrated diffuse large B-cell lymphoma. She was treated with chemoradiation and remained free of disease at 59 months. The other patient had a history of nasal trauma, which produced left septal deviation. He underwent an uncomplicated septoplasty, with pathology that demonstrated low-grade B-cell lymphoma. Because there was no evidence of active disease, the decision was made to not treat and to observe the patient clinically.ConclusionsThis is the first reported series of septal lymphoma incidentally diagnosed on routine septoplasty. Although histopathologic review of specimens from routine nasal and sinus surgery is not routinely performed, this report highlighted the importance of this process, on a case-by-case basis, in detecting unexpected malignancies that otherwise were clinically silent

    The role of metacognitive self-reflectivity in emotional awareness and subjective indices of recovery in schizophrenia

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    Emotional awareness deficits in people with schizophrenia have been linked to poorer objective outcomes, but, no work has investigated the relationship between emotional awareness and subjective recovery indices or metacognitive self-reflectivity. We hypothesized that increased emotional awareness would be associated with greater self-esteem, hope, and self-reflectivity and that self-reflectivity would moderate links between emotional awareness and self-esteem and hope -- such that significant relationships would only be observed at lower levels of self-reflectivity. Participants were 56 people with schizophrenia-spectrum disorders. Correlations revealed that better emotional awareness was significantly associated with increased self-esteem and hope but not self-reflectivity. Self-reflectivity moderated the relationship between emotional awareness and self-esteem but not hope. Overall, findings suggest that emotional awareness may affect self-esteem for those low in self-reflectivity, but other factors may be important for those with greater self-reflectivity. Results emphasize the importance of interventions tailored to enhance self-reflective capacity in clients with schizophrenia

    Rapid extraction of dissolved inorganic carbon from seawater and groundwater samples for radiocarbon dating

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    © The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Limnology and Oceanography: Methods 14 (2016): 24-30, doi:10.1002/lom3.10066.We designed and developed a system to efficiently extract dissolved inorganic carbon (DIC) from seawater and groundwater samples for radiocarbon dating. The Rapid Extraction of Dissolved Inorganic Carbon System (REDICS) utilizes a gas-permeable polymer membrane contactor to extract the DIC from an acidified water sample in the form of carbon dioxide (CO2), introduce it to a helium gas stream, cryogenically isolate it, and store it for stable and radiocarbon isotope analysis. The REDICS system offers multiple advantages to the DIC extraction method which has been used for the last several decades at the National Ocean Sciences Accelerator Mass Spectrometry Facility (NOSAMS) at the Woods Hole Oceanographic Institution, including faster DIC extraction, streamlined analysis, and minimized set-up and prep time. The system was tested using sodium carbonate and seawater standards, duplicates of which were also processed on the water stripping line (WSL) at NOSAMS. The results demonstrate that the system successfully extracts, quantifies, and stores more than 99% of the DIC in less than 20 min. Stable and radiocarbon isotope analysis demonstrated system precision of 0.04‰ and 7.8‰, respectively. A Sargasso Sea depth profile was used to further validate the system. The results show high precision for both stable and radiocarbon analysis with pooled standard deviations of 0.02‰ and 5.6‰, respectively. A comparison between the REDICS and WSL analyses indicates a good accuracy for both stable and radio-isotope analysis.NSF Cooperative Agreements for the Operation of a National Ocean Sciences Accelerator Mass Spectrometry Facility (OCE-0753487 and OCE-123966) supported this research

    Variable X-ray Absorption toward Gravitationally-Lensed Blazar PKS1830-211

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    We present X-ray spectral analysis of five Chandra and XMM-Newton observations of the gravitationally-lensed blazar PKS1830-211 from 2000 to 2004. We show that the X-ray absorption toward PKS1830-211 is variable, and the variable absorption is most likely to be intrinsic with amplitudes of about 2-30e22 cm^-2 depending on whether or not the absorber is partially covering the X-ray source. Our results confirm the variable absorption observed previously, although interpreted differently, in a sequence of ASCA observations. This large variation in the absorption column density can be interpreted as outflows from the central engine in the polar direction, consistent with recent numerical models of inflow/outflows in AGNs. In addition, it could possibly be caused by the interaction between the blazar jet and its environment, or the variation from the geometric configuration of the jet. While the spectra can also be fitted with a variable absorption at the lens redshift, we show that this model is unlikely. We also rule out the simple microlensing interpretation of variability which was previously suggested.Comment: 15 pages, 4 figures, Accepted to A

    Effect of different modes of pollination on quantitative and qualitative parameters of Egyptian Clover, Trifolium alexandrinum L.

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    The effect of different modes of pollination on quantitative and qualitative parameters of Egyptian clover, Trifolium alexandrinum L. was studied at Forage Section, Department of Genetics and Plant Breeding, CCS, Haryana Agricultural University, Hisar during 2012 and 2013. Maximum seed setting (81.5%) was recorded in A. mellifera pollination with an 8 frame colony (BP-8F) followed by 4 frame colony (BP-4F) (75.1%), open pollination (OP) (73.8%) and 2 frame colony (BP-2F) (71.5%). Maximum seed yield (2662.3 seeds) was observed in treatment BP-8F followed by BP-4F (2373.8), OP (2316.3) and BP-2F (2235.5). Still lower yield of 2103.0 seeds was found in hand pollination (HP) treatment that was significantly higher than the without insect pollination (WIP) treatment (1114.2). Minimum 1000-seed weight was observed in WIP (2.64 g). The seed weight of BP-4F (3.30), HP (3.20), BP-2F (3.17) and OP (3.03), the heaviest seeds were recorded in BP-8F (3.62 g/1000 grains) and it was at par with the treatment BP-4F (3.30 g). Highest seed germination per cent was recorded in BP-8F (94.7) followed by OP (90.7%). Lowest germination was found in WIP (84.7%). Though some work has been done on this aspect in India but comprehensive pollination studies has not been worked out

    Holographic spectrum splitter for ultra-high efficiency photovoltaics

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    To move beyond the efficiency limits of single-junction solar cells, junctions of different bandgaps must be used to avoid losses from lack of absorption of low energy photons and energy lost as excited carriers thermalize to the semiconductor band edge. Traditional tandem multijunction solar cells are limited, however, by lattice-matching and current-matching constraints. As an alternative we propose a lateral multijunction design in which a compound holographic optic splits the solar spectrum into four frequency bands each incident on a dual-junction, III-V tandem cell with bandgaps matched to the spectral band. The compound splitting element is composed of four stacks of three volume phase holographic diffraction gratings. Each stack of three diffracts three bands and allows a fourth to pass straight through to a cell placed beneath the stack, with each of the three gratings in the stack responsible for diffracting one frequency band. Generalized coupled wave analysis is used to model the holographic splitting. Concentration is achieved using compound parabolic trough concentrators. An iterative design process includes updating the ideal bandgaps of the four dual-junction cells to account for photon misallocation after design of the optic. Simulation predicts a two-terminal efficiency of 36.14% with 380x concentration including realistic losses

    Phenotype-genotype correlations for clinical variants caused by CYLD mutations

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    Background Studies evaluating acceptability of simplified follow-up after medical abortion have focused on high-resource or urban settings where telephones, road connections, and modes of transport are available and where women have formal education. Objective To investigate women’s acceptability of home-assessment of abortion and whether acceptability of medical abortion differs by in-clinic or home-assessment of abortion outcome in a low-resource setting in India. Design Secondary outcome of a randomised, controlled, non-inferiority trial. Setting Outpatient primary health care clinics in rural and urban Rajasthan, India. Population Women were eligible if they sought abortion with a gestation up to 9 weeks, lived within defined study area and agreed to follow-up. Women were ineligible if they had known contraindications to medical abortion, haemoglobin < 85mg/l and were below 18 years. Methods Abortion outcome assessment through routine clinic follow-up by a doctor was compared with home-assessment using a low-sensitivity pregnancy test and a pictorial instruction sheet. A computerized random number generator generated the randomisation sequence (1:1) in blocks of six. Research assistants randomly allocated eligible women who opted for medical abortion (mifepristone and misoprostol), using opaque sealed envelopes. Blinding during outcome assessment was not possible. Main Outcome Measures Women’s acceptability of home-assessment was measured as future preference of follow-up. Overall satisfaction, expectations, and comparison with previous abortion experiences were compared between study groups. Results 731 women were randomized to the clinic follow-up group (n = 353) or home-assessment group (n = 378). 623 (85%) women were successfully followed up, of those 597 (96%) were satisfied and 592 (95%) found the abortion better or as expected, with no difference between study groups. The majority, 355 (57%) women, preferred home-assessment in the event of a future abortion. Significantly more women, 284 (82%), in the home-assessment group preferred home-assessment in the future, as compared with 188 (70%) of women in the clinic follow-up group, who preferred clinic follow-up in the future (p < 0.001). Conclusion Home-assessment is highly acceptable among women in low-resource, and rural, settings. The choice to follow-up an early medical abortion according to women’s preference should be offered to foster women’s reproductive autonomy
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