Fear memory uncovered: Prediction error as the key to memory plasticity

Anxiety disorders rank among the most prevalent and chronic forms of psychopathology. While commonly used therapeutic techniques such as exposure therapy are effective in reducing fear, many patients suffer from relapse of fear. This can be explained by the observation that during therapy a new memory is formed that transiently suppresses the original fear memory. According to the traditional view on memory, once an emotional memory has been stored in the brain through the process of consolidation, the memory remains as a permanent trace. Fear reduction was hence considered to be established only through inhibition - but not elimination - of the fear memory. However, exciting insights from neuroscience have shown that by reactivating a consolidated fear memory, it can return to a plastic state. From this plastic state the memory has to reconsolidate in order to endure. The finding that fear memory is more malleable than previously thought is very promising for clinical practice. Nevertheless, the conditions under which reconsolidation does and does not take place remain to be elucidated. In a series of human fear conditioning experiments we investigated the conditions under which a reactivated memory remains stable or is open to modification. With the demonstration that new learning is a prerequisite for reconsolidation, the current thesis shows that memory reconsolidation allows for memory updating. These findings are of relevance for the mechanisms underlying learning and memory by demonstrating the unique role reconsolidation holds in memory plasticity. Clinical practice will hopefully benefit from these insights in the development of new reconsolidation-based therapies for those who suffer from anxiety disorders and PTSD

New constraints on a triaxial model of the Galaxy

We determine the values of parameters of an N-body model for the Galaxy developed by Fux via comparison with an unbiased, homogeneous sample of OH/IR stars. Via Monte-Carlo simulation, we find the plausibilities of the best-fitting models, as well as their errors. The parameters that are constrained best by these projected data are the total mass of the model and the viewing angle of the central Bar, although the distribution of the latter has multiple maxima. The best model has a viewing angle of 44 degrees, semi-major axis of 2.5 kpc, a bar mass of 1.7E10 solar masses and a tangential velocity of the local standard of rest of 171 km/s . We argue that the lower values that are commonly found from stellar data for the viewing angle (around 25 degrees) arise when too few coordinates are available, when the longitude range is too narrow or when low latitudes are excluded from the fit. The new constraints on the viewing angle of the galactic Bar from stellar line-of-sight velocities decrease further the ability of the Bar's distribution to account for the observed micro-lensing optical depth toward Baade's window : our model reproduces only half the observed value. The signal of triaxiality diminishes quickly with increasing latitude, fading within approximately one scaleheight. This suggests that Baade's window is not a very appropriate region to sample Bar properties.Comment: 10 pages, 8 figures, TeX, accepted for publication in MNRA

Using Cepheids to determine the galactic abundance gradient II. Towards the galactic center

Based on spectra obtained at the Anglo-Australian Observatory, we present a discussion of the metallicity of the galactic disc derived using Cepheids at galactocentric distances 4-6 kpc. Our new results together with previous gradient determination (Paper I) show that the overall abundance distribution within the galactocentric distances 4-11 kpc cannot by represented by a single gradient value. The distribution is more likely bimodal: it is flatter in the solar neighbourhood with a small gradient, and steepens towards the galactic center. The steepening begins at a distance of about 6.6 kpc.Comment: 8 pages, 6 postscript figures, LaTeX, uses Astronomy and Astrophysics macro aa.cls, graphicx package, to be published in Astronomy and Astrophysics (2002) also available at http://www.iagusp.usp.br/~maciel/index.htm

Recent star formation in the inner Galactic Bulge seen by ISOGAL. I - Classification of bright mid-IR sources in a test field

Context: The stellar populations in the central region of the Galaxy are poorly known because of the high visual extinction and very great source density in this direction. Aims: To use recent infrared surveys for studying the dusty stellar objects in this region. Methods: We analyse the content of a 20x20 arcmin^2 field centred at (l,b)=(-0.27,-0.06) observed at 7 and 15 microns as part of the ISOGAL survey. These ISO observations are more than an order of magnitude better in sensitivity and spatial resolution than the IRAS observations. The sources are cross-associated with other catalogues to identify various types of objects. We then derive criteria to distinguish young objects from post-main sequence stars. Results: We find that a sample of about 50 young stellar objects and ultra-compact HII regions emerges, out of a population of evolved AGB stars. We demonstrate that the sources colours and spatial extents, as they appear in the ISOGAL catalogue, possibly complemented with MSX photometry at 21 microns, can be used to determine whether the ISOGAL sources brighter than 300 mJy at 15 microns (or [15] < 4.5 mag) are young objects or late-type evolved stars.Comment: 15 pages, 12 figures. Accepted for publication in Astronomy and Astrophysic

H2O Maser Observations of Candidate Post-AGB Stars and Discovery of Three High-velocity Water Sources

We present the results of 22 GHz H_2O maser observations of a sample of 85 post-Asymptotic Giant Branch (post-AGB) candidate stars, selected on the basis of their OH 1612 MHz maser and far-infrared properties. All sources were observed with the Tidbinbilla 70-m radio telescope and 21 detections were made. 86 GHz SiO Mopra observations of a subset of the sample are also presented. Of the 21 H_2O detections, 15 are from sources that are likely to be massive AGB stars and most of these show typical, regular H_2O maser profiles. In contrast, nearly all the detections of more evolved stars exhibited high-velocity H_2O maser emission. Of the five sources seen, v223 (W43A, IRAS 18450-0148) is a well known `water-fountain' source which belongs to a small group of post-AGB stars with highly collimated, high-velocity H_2O maser emission. A second source in our sample, v270 (IRAS 18596+0315), is also known to have high-velocity emission. We report the discovery of similar emission from a further three sources, d46 (IRAS 15445-5449), d62 (IRAS 15544-5332) and b292 (IRAS 18043-2116). The source d46 is an evolved post-AGB star with highly unusual maser properties. The H_2O maser emission from d62 is probably associated with a massive star. The source b292 is a young post-AGB star that is highly likely to be a water-fountain source, with masers detected over a velocity range of 210 km s^{-1}.Comment: 47 pages, 9 figures, 4 tables, accepted by Ap

ISOGAL Survey of Baade's Windows in the Mid-infrared

The ISOGAL mid-infrared survey of areas close to the Galactic Plane aims to determine their stellar content and its possible bearing on the history of the Galaxy. The NGC6522 and Sgr I Baade's Windows of low obscuration towards the inner parts of the Bulge represent ideal places in which to calibrate and understand the ISOGAL colour-magnitude diagrams. The survey observations were made with the ISOCAM instrument of the ISO satellite. The filter bands chosen were LW2(~7 microns) and LW3(~15 microns). The results presented here show that most of the detected objects are late M-type giants on the AGB, with a cut-off for those earlier than M3-M4. The most luminous members of these two Bulge fields at 7 microns are the Mira variables. However, it is evident that they represent the end of a sequence of increasing 15 micron dust emission which commences with M giants of earlier sub-type. In observations of late-type giants the ISOCAM 15 micron band is mainly sensitive to the cool silicate or aluminate dust shells which overwhelm the photospheric emission. However, in ordinary M-giant stars, the 7 micron band is not strongly affected by dust emission and may be influenced instead by absorption. The nu2 band of water at 6.25 microns and the SiO fundamental at 7.9 microns are likely contribitors to this effect. A group of late M stars has been found which vary little or not at all but have infrared colours typical of well-developed dust shells. Their luminosities are similar to those of 200-300 day Miras but they have slightly redder [7]-[15] colours which form an extension of the ordinary M giant sequence. The Mira dust shells show a mid-infrared [7]-[15] colour-period relation. ca 700 days.Comment: 13 pages 15 figure

Herschel/HIFI observations of O-rich AGB stars : molecular inventory

Spectra, taken with the heterodyne instrument, HIFI, aboard the Herschel Space Observatory, of O-rich asymptotic giant branch (AGB) stars which form part of the guaranteed time key program HIFISTARS are presented. The aim of this program is to study the dynamical structure, mass-loss driving mechanism, and chemistry of the outflows from AGB stars as a function of chemical composition and initial mass. We used the HIFI instrument to observe nine AGB stars, mainly in the H2O and high rotational CO lines We investigate the correlation between line luminosity, line ratio and mass-loss rate, line width and excitation energy. A total of nine different molecules, along with some of their isotopologues have been identified, covering a wide range of excitation temperature. Maser emission is detected in both the ortho- and para-H2O molecules. The line luminosities of ground state lines of ortho- and para-H2O, the high-J CO and NH3 lines show a clear correlation with mass-loss rate. The line ratios of H2O and NH3 relative to CO J=6-5 correlate with the mass-loss rate while ratios of higher CO lines to the 6-5 is independent of it. In most cases, the expansion velocity derived from the observed line width of highly excited transitions formed relatively close to the stellar photosphere is lower than that of lower excitation transitions, formed farther out, pointing to an accelerated outflow. In some objects, the vibrationally excited H2O and SiO which probe the acceleration zone suggests the wind reaches its terminal velocity already in the innermost part of the envelope, i.e., the acceleration is rapid. Interestingly, for R Dor we find indications of a deceleration of the outflow in the region where the material has already escaped from the star.Comment: 6 Figures in the main paper + 12 further figures in the appendix (to be printed in electronic form) Accepted for publication by A&

Automatic Assessment of Speech Capability Loss in Disordered Speech

International audienceIn this article, we report on the use of an automatic technique to assess pronunciation in the context of several types of speech disorders. Even if such tools already exist, they are more widely used in a different context, namely, Computer-Assisted Language Learning, in which the objective is to assess nonnative pronunciation by detecting learners' mispronunciations at segmental and/or suprasegmental levels. In our work, we sought to determine if the Goodness of Pronunciation (GOP) algorithm, which aims to detect phone-level mispronunciations by means of automatic speech recognition, could also detect segmental deviances in disordered speech. Our main experiment is an analysis of speech from people with unilateral facial palsy. This pathology may impact the realization of certain phonemes such as bilabial plosives and sibilants. Speech read by 32 speakers at four different clinical severity grades was automatically aligned and GOP scores were computed for each phone realization. The highest scores, which indicate large dissimilarities with standard phone realizations, were obtained for the most severely impaired speakers. The corresponding speech subset was manually transcribed at phone level; 8.3% of the phones differed from standard pronunciations extracted from our lexicon. The GOP technique allowed the detection of 70.2% of mispronunciations with an equal rate of about 30% of false rejections and false acceptances. Finally, to broaden the scope of the study, we explored the correlation between GOP values and speech comprehensibility scores on a second corpus, composed of sentences recorded by six people with speech impairments due to cancer surgery or neurological disorders. Strong correlations were achieved between GOP scores and subjective comprehensibility scores (about 0.7 absolute). Results from both experiments tend to validate the use of GOP to measure speech capability loss, a dimension that could be used as a complement to physiological measures in pathologies causing speech disorders