Cosmological solutions in F(R) Horava-Lifshitz gravity

At the present work, it is studied the extension of F (R) gravities to the new recently proposed theory of gravity, the so-called Horava-Lifshitz gravity, which provides a way to make the theory power counting renormalizable by breaking Lorentz invariance. It is showed that dark energy can be well explained in the frame of this extension, just in terms of gravity. It is also explored the possibility to unify inflation and late-time acceleration under the same mechanism, providing a natural explanation the accelerated expansion.Comment: 4 pages. Contribution to the Proceedings of the Spanish Relativity Meeting (ERE) 2010, Granada, Spai

Testing the equation of state for viscous dark energy

Some cosmological scenarios with bulk viscosity for the dark energy fluid are considered. Based on some considerations related to hydrodynamics, two different equations of state for dark energy are assumed, leading to power-law and logarithmic effective corrections to the pressure. The models are tested with the latest astronomical data from type Ia supernovae (Pantheon sample), measurements of the Hubble parameter HðzÞ, baryon acoustic oscillations and cosmic microwave background radiation. In comparison with the ΛCDM model, some different results are obtained and their viability is discussed. The power-law model shows some modest results, achieved under negative values of bulk viscosity, while the logarithmic scenario provide good fits in comparison to the ΛCDM model.Ministerio de Economía, Industria y Competitividad (project FIS2016-76363-P)Agencia de Gestión de Ayudas Universitarias y de Investigación (project 2017 SGR 247)CANTATA COST action (grant CA15117

Cardy-Verlinde formula in FRW Universe with inhomogeneous generalized fluid and dynamical entropy bounds near the future singularity

We derive a Cardy-Verlinde-like formula which relates the entropy of the closed FRW universe to its energy, and Casimir energy, for a multicomponent coupled fluid. The generalized fluid obeys an inhomogeneous equation of state. A viscous dark fluid is included, and we include also modified gravity using its fluid representation. It is demonstrated how such an expression reduces to the standard Cardy-Verlinde formula corresponding to the 2d CFT entropy only in some special cases. The dynamical entropy bound for a closed FRW universe with dark components is obtained. The universality of the dynamical entropy bound near a future singularity (of all four types), as well as near the Big Bang singularity, is investigated. It is demonstrated that except from some special cases of Type II and Type IV singularities the dynamical entropy bound is violated near the singularity even if quantum effects are taken into account. The dynamical entropy bound seems to be universal for the case of a regular universe, including the asymptotic de Sitter one.Comment: 14 pages. Published versio

Exponential F(R) gravity with axion dark matter

The cosmological evolution within the framework of exponential $F(R)$ gravity is analysed by assuming two forms for dark matter: (a) a standard dust-like fluid and (b) an axion scalar field. As shown in previous literature, an axion-like field oscillates during the cosmological evolution but can play the role of dark matter when approaching the minimum of its potential. Both scenarios are confronted with recent observational data including the Pantheon Type Ia supernovae, Hubble parameter estimations (Cosmic Chronometers), Baryon Acoustic Oscillations and Cosmic Microwave Background distances. The models show great possibilities in describing these observations when compared with the $\Lambda$CDM model, supporting the viability of exponential $F(R)$ gravity. The differences between both descriptions of dark matter is analysed.Comment: 13 pages, 3 figures. To be published in Phys. Dark Univers

Inflationary universe from perfect fluid and F (R) gravity and its comparison with observational data

© 2014 American Physical Society. We investigate the descriptions for the observables of inflationary models, in particular, the spectral index of curvature perturbations, the tensor-to-scalar ratio, and the running of the spectral index, in the framework of perfect fluid models and F(R) gravity theories through the reconstruction methods. Furthermore, the perfect fluid and F(R) gravity descriptions of inflation are compared with the recent cosmological observations such as the Planck satellite and BICEP2 experiment. It is demonstrated with explicit examples that perfect fluid may lead to the inflationary universe consistent with the Planck data. It is also shown that several F(R) gravity models, especially, a power-law model gives the best fit values compatible with the spectral index and tensor-to-scalar ratio within the allowed ranges suggested by the Planck and BICEP2 results

Proper cytoskeleton α‐tubulin distribution is concomitant to tyrosine phosphorylation during in vitro capacitation and acrosomal reaction in human spermatozoa

Spermatozoa motility is a key parameter during the fertilization process. In this context, spermatozoa tyrosine protein phosphorylation and an appropriate cytoskeleton α‐tubulin distribution are some of the most important physiological events involved in motility. However, the relationship between these two biomarkers remains poorly defined. Here, we characterized simultaneously by immunocytochemistry the α‐tubulin (TUBA4A) distribution and the tyrosine phosphorylation at flagellum before capacitation, during different capacitation times (1 and 4 hr), and after acrosome reaction induction in human spermatozoa. We found that the absence of spermatozoa phosphorylation in tyrosine residues positively and significantly correlated (p < 0.05) with the terminal piece α‐tubulin flagellar distribution in all physiological conditions. Conversely, we observed a positive significant correlation (p < 0.01) between phosphorylated spermatozoa and continuous α‐tubulin distribution in spermatozoa flagellum, independently of the physiological condition. Similarly, the subpopulation of spermatozoa with tyrosine phosphorylated and continuous α‐tubulin increases with longer capacitation times and after the acrosome reaction induction. Overall, these findings provide novel insights into the post‐transcriptional physiological events associated to α‐tubulin and the tyrosine phosphorylation during fertilization, which present potential implications for the improvement of spermatozoa selection methods.This research was supported by Human Fertility Cathedra of the University of Alicante, VIOGROB-186, and the project of the Ministry of Economy and Competitiveness AGL2015-70159-P

Comparative Cytotoxic Activity of Hydroxytyrosol and Its Semisynthetic Lipophilic Derivatives in Prostate Cancer Cells

A high adherence to a Mediterranean diet has been related to numerous beneficial effects in human health, including a lower incidence and mortality of prostate cancer (PCa). Olive oil is an important source of phenolic bioactive compounds, mainly hydroxytyrosol (HT), of this diet. Because of the growing interest of this compound and its derivatives as a cancer chemopreventive agent, we aimed to compare the in vitro effect of HT isolated from olive mill wastewaters and five semisynthetic alkyl ether, ester, and nitro-derivatives against prostate cancer (PCa) cell lines. The effect in cell proliferation was determined in RWPE-1, LNCaP, 22Rv1, and PC-3 cells by resazurin assay, the effect in cell migration by wound healing assay, and tumorsphere and colony formation were evaluated. The changes in key signaling pathways involved in carcinogenesis were assessed by using a phosphorylation pathway profiling array and by Western blotting. Antiproliferative effects of HT and two lipophilic derivatives [hydroxytyrosyl acetate (HT-Ac)/ethyl hydroxytyrosyl ether (HT-Et)] were significantly higher in cancerous PC-3 and 22Rv1 cells than in non-malignant RWPE-1 cells. HT/HT-Ac/HT-Et significantly reduced migration capacity in RWPE-1 and PC-3 and prostatosphere size and colony formation in 22Rv1, whereas only HT-Ac and HT-Et reduced these functional parameters in PC-3. The cytotoxic effect in 22Rv1 cells was correlated with modifications in the phosphorylation pattern of key proteins, including ERK1/2 and AKT. Consistently, HT-Ac and HT-Et decreased p-AKT levels in PC-3. In sum, our results suggest that HT and its lipophilic derivatives could be considered as potential therapeutic tools in PCa