ESTABLISHING EMPIRICAL RELATION TO PREDICT TEMPERATURE DIFFERENCE OF VORTEX TUBE USING RESPONSE SURFACE METHODOLOGY

Vortex tube is a device that produces cold and hot air simultaneously from the source of compressed air. In this work an attempt has been made to investigate the effect of three controllable input variables namely diameter of the orifices, diameter of the nozzles and inlet pressure over the temperature difference in the cold side as output using Response Surface Methodology (RSM). Experiments are conducted using central composite design with three factors at three levels. The influence of vital parameters and interaction among these are investigated using analysis of variance (ANOVA). The proposed mathematical model in this study has proven to fit and in line with experimental values with a 95% confidence interval. It is found that the inlet pressure and diameter of nozzle are significant factors that affect the performance of vortex tube

Relationship between qualitative physics and fuzzy logic in natural subsystems

The purpose of this research is to present a comparison between the two ad hoc appearance and control techniques of conceptual systems. In that respect, it is a description of the interconnected notion between the principle of qualitative physics and of ambiguous quality. On that basis the first point is to determine the key feature of each approach is significant. In the early stages of the product development and forecasting process, a large number of input energies were used for its creation. However, they are still being used in nature, though not subjectively impure. Therefore, this research presents the concept of the relationship between qualitative physics and fuzzy logic in terms of developing predictive outputs and using logical resources. Finally, the relationship between qualitative physics and fuzzy logic processes has been proven with the support of the selected natural subsystem

Relationship between qualitative physics and fuzzy logic in natural subsystems

44-49The purpose of this research is to present a comparison between the two ad hoc appearance and control techniques of conceptual systems. In that respect, it is a description of the interconnected notion between the principle of qualitative physics and of ambiguous quality. On that basis the first point is to determine the key feature of each approach is significant. In the early stages of the product development and forecasting process, a large number of input energies were used for its creation. However, they are still being used in nature, though not subjectively impure. Therefore, this research presents the concept of the relationship between qualitative physics and fuzzy logic in terms of developing predictive outputs and using logical resources. Finally, the relationship between qualitative physics and fuzzy logic processes has been proven with the support of the selected natural subsystem

Biopharmaceutical Classification System in Invitro/ In-vivo Correlation: Concept and Development Strategies in Drug Delivery

Drug development is a very laborious and expensive process. One of the major reasons for failure during the clinical phases of drug development is inadequate pharmacokinetic data on the drug candidate. Therefore, it would be advantageous if the pharmacokinetic properties of drug candidates be predicted beforehand. One major obstacle in making such  predictions is the inability to appropriately scale the in-vitro data to the in-vivo situation. Results from in-vitro in-vivo correlation (IVIVC) studies have been used to select the appropriate excipients and optimize the manufacturing processes for quality control purposes, and for characterizing the release patterns of newly formulated immediate release, and modified-release products relative to the references. In recent years, the concept and application of the IVIVC for pharmaceutical dosage forms have been a major focus of attention in the pharmaceutical industry, academia and regulatory agencies. Hence, this article highlights the importance of appropriate selection of IVIVC level with respect to the Biopharmaceutical Classification System (BCS) and also covers examples of BCS-based IVIVCs of drugs/products with different types of release profiles.Keywords: In vitro/In vivo correlation, Biopharmaceutical Classification System, Drug Delivery

Biopharmaceutical classification system In invitro/ In-vivo correlation: Concept and development strategies in drug delivery

Drug development is a very laborious and expensive process. One of the major reasons for failure during the clinical phases of drug development is inadequate pharmacokinetic data on the drug candidate. Therefore, it would be advantageous if the pharmacokinetic properties of drug candidates be predicted beforehand. One major obstacle in making such predictions is the inability to appropriately scale the in-vitro data to the in-vivo situation. Results from in-vitro in-vivo correlation (IVIVC) studies have been used to select the appropriate excipients and optimize the manufacturing processes for quality control purposes, and for characterizing the release patterns of newly formulated immediate release, and modified-release products relative to the references. In recent years, the concept and application of the IVIVC for pharmaceutical dosage forms have been a major focus of attention in the pharmaceutical industry, academia and regulatory agencies. Hence, this article highlights the importance of appropriate selection of IVIVC level with respect to the Biopharmaceutical Classification System (BCS) and also covers examples of BCS-based IVIVCs of drugs/products with different types of release profiles

Design and fabrication of angular post JIG

An objective of the mass production is to increase the productivity and the accuracy. This is done by reducing the set up cost and manual burnouts. Thus mass production can be acquired by the use of jigs.  For large scale production of unlike materials a lot of time is wasted in start of the device and clamping the device. An experimental approach method is regularly practiced until the axis of the hole is properly line up with the axis of the drill. In such a situation a division of time is being wasted to maintain the accuracy. This paper is mainly composed of design and fabrication of the Angular postjig which cover the absolute design to the described dimensions of the work piece and would make the production process easier

ETHNOBOTANICAL SURVEY OF CHITTERI HILLS OF EASTERN GHATS IN DHARMAPURI DISTRICT-TAMILNADU

Flora and fauna diversities are two facts components of biodiversity which covers the variety and variability of species. A survey was conducted to study the rare plants of chitteri hills, Tamil Nadu, India. 96 Plants Belonging to 48 Family, 90 Genus and 96 species were Documented Plants totally were under thorough investigation. Of these monocots are represented by 7 species belonging to 7 genera and 4 families, while dicot contributed by 87 species belonging to 82 genera and 39 families, Ferns 2 families and 2 genera, Fungi 1 family and 1 Genera. Plant species were recorded and identified during the survey. The results show that the habitat of plants belongs to herbs, shrubs and tree species. But, we have observed only minimum tree species. Of these monocots are represented by 7 species belonging to 7 genera and 4 families, while dicots contributed by 87 species belonging to 82 genera and 39 families, Ferns 2 families and 2 genera, Fungi 1 family and 1 Genera. The study decipts that Chitteri Hills have different variety of plants distributed all over the mountain

WS22D nanosheets in 3D nanoflowers

In this work it has been established that 3D nanoflowers of WS2 synthesized by chemical vapour deposition are composed of few layer WS2 along the edges of the petals. An experimental study to understand the evolution of these nanostructures shows the nucleation and growth along with the compositional changes they undergo

The Macronuclear Genome of \u3cem\u3eStentor coeruleus\u3c/em\u3e Reveals Tiny Introns in a Giant Cell

The giant, single-celled organism Stentor coeruleus has a long history as a model system for studying pattern formation and regeneration in single cells. Stentor [1, 2] is a heterotrichous ciliate distantly related to familiar ciliate models, such as Tetrahymena or Paramecium. The primary distinguishing feature of Stentor is its incredible size: a single cell is 1 mm long. Early developmental biologists, including T.H. Morgan [3], were attracted to the system because of its regenerative abilities—if large portions of a cell are surgically removed, the remnant reorganizes into a normal-looking but smaller cell with correct proportionality [2, 3]. These biologists were also drawn to Stentor because it exhibits a rich repertoire of behaviors, including light avoidance, mechanosensitive contraction, food selection, and even the ability to habituate to touch, a simple form of learning usually seen in higher organisms [4]. While early microsurgical approaches demonstrated a startling array of regenerative and morphogenetic processes in this single-celled organism, Stentor was never developed as a molecular model system. We report the sequencing of the Stentor coeruleus macronuclear genome and reveal key features of the genome. First, we find that Stentor uses the standard genetic code, suggesting that ciliate-specific genetic codes arose after Stentor branched from other ciliates. We also discover that ploidy correlates with Stentor’s cell size. Finally, in the Stentor genome, we discover the smallest spliceosomal introns reported for any species. The sequenced genome opens the door to molecular analysis of single-cell regeneration in Stentor