DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown

Damage-associated molecular patterns (DAMPs) or cell death associated molecular patterns (CDAMPs) are a subset of endogenous intracellular molecules that are normally hidden within living cells but become either passively released by primary and secondary necrotic cells or actively exposed and secreted by the dying cells. Once released, DAMPs are sensed by the innate immune system and act as activators of antigen-presenting cells (APCs) to stimulate innate and adaptive immunity. Cancer cells dying in response to a subset of conventional anticancer modalities exhibit a particular composition of DAMPs at their cell surface, which has been recently shown to be vital for the stimulation of the host immune system and the control of residual disease. Photodynamic therapy (PDT) for cancer has long been shown to be capable of killing malignant cells and concomitantly stimulate the host immune system, properties that are likely linked to its ability of inducing exposure/release of certain DAMPs. PDT, by evoking oxidative stress at specific subcellular sites through the light activation of organelle-associated photosensitizers, may be unique in incorporating tumour cells destruction and antitumor immune response in one therapeutic paradigm. Here we review the current knowledge about mechanisms and signalling cascades leading to the exposure of DAMPs at the cell surface or promoting their release, the cell death mechanism associated to these processes and its immunological consequences. We also discuss how certain PDT paradigms may yield therapies that optimally stimulate the immune system and lead to the discovery of new DAMPs

Imagina que eres... Indagación sobre el uso de la lengua común en contexto matemático en la escuela media

Este artículo presenta los resultados de una investigación, realizada en la escuela media, sobre el uso de la lengua natural en contexto matemático, y sobre la producción de modelos externos en torno a las concepciones profundas de algunos conceptos elementales que poseen los alumnos. Con una técnica que invita a los alumnos a asumir un papel diferente del que usualmente juegan en la clase de matemáticas, se intentaba empujarlos a escribir acerca de asuntos matemáticos elementales en un lenguaje coloquial, sin los aparatos formales que con frecuencia exhiben. No obstante haber acogido bien el juego del cambio de papel que les propusimos y haber respondido a las situaciones problemáticas usando lengua natural, la mayoría de los alumnos presentó la tendencia a completar su respuesta inicial con una respuesta formal, a menudo vacía, que tenía poco que ver con la tarea. En casos en que los alumnos no usaron aparatos formales para responder se identificaron modelos que resultan interesantes en el plano de verificación de los aprendizajes

Fast optimal transition between two equilibrium states

We demonstrate a technique based on invariants of motion for a time-dependent Hamiltonian, allowing a fast transition to a final state identical in theory to that obtained through a perfectly adiabatic transformation. This method is experimentally applied to the fast decompression of an ultracold cloud of Rubidium 87 atoms held in a harmonic magnetic trap, in the presence of gravity. We are able to decompress the trap by a factor of 15 within 35 ms with a strong suppression of the sloshing and breathing modes induced by the large vertical displacement and curvature reduction of the trap. When compared to a standard linear decompression, we achieve a gain of a factor of 37 on the transition time.Comment: 5 pages, 4 figures, an error in Eq. (2) has been correcte

Bone-immune cell crosstalk: Bone diseases

Bone diseases are associated with great morbidity; thus, the understanding of the mechanisms leading to their development represents a great challenge to improve bone health. Recent reports suggest that a large number of molecules produced by immune cells affect bone cell activity. However, the mechanisms are incompletely understood. This review aims to shed new lights into the mechanisms of bone diseases involving immune cells. In particular, we focused our attention on the major pathogenic mechanism underlying periodontal disease, psoriatic arthritis, postmenopausal osteoporosis, glucocorticoid-induced osteoporosis, metastatic solid tumors, and multiple myeloma

One-dimensional non-interacting fermions in harmonic confinement: equilibrium and dynamical properties

We consider a system of one-dimensional non-interacting fermions in external harmonic confinement. Using an efficient Green's function method we evaluate the exact profiles and the pair correlation function, showing a direct signature of the Fermi statistics and of the single quantum-level occupancy. We also study the dynamical properties of the gas, obtaining the spectrum both in the collisionless and in the collisional regime. Our results apply as well to describe a one-dimensional Bose gas with point-like hard-core interactions.Comment: 11 pages, 5 figure

Translation Invariance, Commutation Relations and Ultraviolet/Infrared Mixing

We show that the Ultraviolet/Infrared mixing of noncommutative field theories with the Gronewold-Moyal product, whereby some (but not all) ultraviolet divergences become infrared, is a generic feature of translationally invariant associative products. We find, with an explicit calculation that the phase appearing in the nonplanar diagrams is the one given by the commutator of the coordinates, the semiclassical Poisson structure of the non commutative spacetime. We do this with an explicit calculation for represented generic products.Comment: 24 pages, 1 figur

On the SO(2,1) symmetry in General Relativity

The role of the SO(2,1) symmetry in General Relativity is analyzed. Cosmological solutions of Einstein field equations invariant with respect to a space-like Lie algebra G_r, with r between 3 and 6 and containing so(2,1) as a subalgebra, are also classified.Comment: 10 pages, latex, no figure

Dbl oncogene expression in MCF-10 A epithelial cells disrupts mammary acinar architecture, induces EMT and angiogenic factor secretion.

The proteins of the Dbl family are guanine nucleotide exchange factors (GEFs) of Rho GTPases and are known to be involved in cell growth regulation. Alterations of the normal function of these proteins lead to pathological processes such as developmental disorders, neoplastic transformation, and tumor metastasis. We have previously demonstrated that expression of Dbl oncogene in lens epithelial cells modulates genes encoding proteins involved in epithelial-mesenchymal-transition (EMT) and induces angiogenesis in the lens. Our present study was undertaken to investigate the role of Dbl oncogene in epithelial cells transformation, providing new insights into carcinoma progression. To assess how Dbl oncogene can modulate EMT, cell migration, morphogenesis, and expression of pro-apoptotic and angiogenic factors we utilized bi- and three-dimensional cultures of MCF-10░A cells. We show that upon Dbl expression MCF-10░A cells undergo EMT. In addition, we found that Dbl overexpression sustain