X-ray Lighthouses of the High-Redshift Universe. II. Further Snapshot Observations of the Most Luminous z>4 Quasars with Chandra

We report on Chandra observations of a sample of 11 optically luminous (Mb<-28.5) quasars at z=3.96-4.55 selected from the Palomar Digital Sky Survey and the Automatic Plate Measuring Facility Survey. These are among the most luminous z>4 quasars known and hence represent ideal witnesses of the end of the "dark age ''. Nine quasars are detected by Chandra, with ~2-57 counts in the observed 0.5-8 keV band. These detections increase the number of X-ray detected AGN at z>4 to ~90; overall, Chandra has detected ~85% of the high-redshift quasars observed with snapshot (few kilosecond) observations. PSS 1506+5220, one of the two X-ray undetected quasars, displays a number of notable features in its rest-frame ultraviolet spectrum, the most prominent being broad, deep SiIV and CIV absorption lines. The average optical-to-X-ray spectral index for the present sample (=-1.88+/-0.05) is steeper than that typically found for z>4 quasars but consistent with the expected value from the known dependence of this spectral index on quasar luminosity. We present joint X-ray spectral fitting for a sample of 48 radio-quiet quasars in the redshift range 3.99-6.28 for which Chandra observations are available. The X-ray spectrum (~870 counts) is well parameterized by a power law with Gamma=1.93+0.10/-0.09 in the rest-frame ~2-40 keV band, and a tight upper limit of N_H~5x10^21 cm^-2 is obtained on any average intrinsic X-ray absorption. There is no indication of any significant evolution in the X-ray properties of quasars between redshifts zero and six, suggesting that the physical processes of accretion onto massive black holes have not changed over the bulk of cosmic time.Comment: 15 pages, 7 figures, accepted for publication in A

Strain control of superlattice implies weak charge-lattice coupling in La0.5_{0.5}Ca0.5_{0.5}MnO3_3

We have recently argued that manganites do not possess stripes of charge order, implying that the electron-lattice coupling is weak [Phys Rev Lett \textbf{94} (2005) 097202]. Here we independently argue the same conclusion based on transmission electron microscopy measurements of a nanopatterned epitaxial film of La$_{0.5}$Ca$_{0.5}$MnO$_3$. In strain relaxed regions, the superlattice period is modified by 2-3% with respect to the parent lattice, suggesting that the two are not strongly tied.Comment: 4 pages, 4 figures It is now explained why the work provides evidence to support weak-coupling, and rule out charge orde

Accurate Liability Estimation Improves Power in Ascertained Case Control Studies

Linear mixed models (LMMs) have emerged as the method of choice for confounded genome-wide association studies. However, the performance of LMMs in non-randomly ascertained case-control studies deteriorates with increasing sample size. We propose a framework called LEAP (Liability Estimator As a Phenotype, https://github.com/omerwe/LEAP) that tests for association with estimated latent values corresponding to severity of phenotype, and demonstrate that this can lead to a substantial power increase

Dynamic Gaussian graphical models for modelling genomic networks

After sequencing the entire DNA for various organisms, the challenge has become understanding the functional interrelatedness of the genome. Only by understanding the pathways for various complex diseases can we begin to make sense of any type of treatment. Unfortu- nately, decyphering the genomic network structure is an enormous task. Even with a small number of genes the number of possible networks is very large. This problem becomes even more difficult, when we consider dynamical networks. We consider the problem of estimating a sparse dy- namic Gaussian graphical model with L1 penalized maximum likelihood of structured precision matrix. The structure can consist of specific time dynamics, known presence or absence of links in the graphical model or equality constraints on the parameters. The model is defined on the basis of partial correlations, which results in a specific class precision matrices. A priori L1 penalized maximum likelihood estimation in this class is extremely difficult, because of the above mentioned constraints, the computational complexity of the L1 constraint on the side of the usual positive-definite constraint. The implementation is non-trivial, but we show that the computation can be done effectively by taking advan- tage of an efficient maximum determinant algorithm developed in convex optimization

Self-calibrating Tomography for Angular Schmidt Modes in Spontaneous Parametric Down-Conversion

We report an experimental self-calibrating tomography scheme for entanglement characterization in high-dimensional quantum systems using Schmidt decomposition techniques. The self-tomography technique based on maximal likelihood estimation was developed for characterizing non-ideal measurements in Schmidt basis allowing us to infer both Schmidt eigenvalues and detecting efficiencies.Comment: 10 pages, 11 figure

Retinal blood vessels extraction using probabilistic modelling

© 2014 Kaba et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.This article has been made available through the Brunel Open Access Publishing Fund.The analysis of retinal blood vessels plays an important role in detecting and treating retinal diseases. In this review, we present an automated method to segment blood vessels of fundus retinal image. The proposed method could be used to support a non-intrusive diagnosis in modern ophthalmology for early detection of retinal diseases, treatment evaluation or clinical study. This study combines the bias correction and an adaptive histogram equalisation to enhance the appearance of the blood vessels. Then the blood vessels are extracted using probabilistic modelling that is optimised by the expectation maximisation algorithm. The method is evaluated on fundus retinal images of STARE and DRIVE datasets. The experimental results are compared with some recently published methods of retinal blood vessels segmentation. The experimental results show that our method achieved the best overall performance and it is comparable to the performance of human experts.The Department of Information Systems, Computing and Mathematics, Brunel University

Dynamic Monitoring and Control of Irreversible Chronic Diseases with Application to Glaucoma

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149269/1/poms12975_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149269/2/poms12975-sup-0001-Appendix.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149269/3/poms12975.pd

Host Galaxy Evolution in Radio-Loud AGN

We investigate the luminosity evolution of the host galaxies of radio-loud AGN through Hubble Space Telescope imaging of 72 BL Lac objects, including new STIS imaging of nine z > 0.6 BL Lacs. With their intrinsically low accretion rates and their strongly beamed jets, BL Lacs provide a unique opportunity to probe host galaxy evolution independent of the biases and ambiguities implicit in quasar studies. We find that the host galaxies of BL Lacs evolve strongly, consistent with passive evolution from a period of active star formation in the range 0.5 <~ z <~ 2.5, and inconsistent with either passive evolution from a high formation redshift or a non-evolving population. This evolution is broadly consistent with that observed in the hosts of other radio-loud AGN, and inconsistent with the flatter luminosity evolution of quiescent early types and radio-quiet hosts. This indicates that active star formation, and hence galaxy interactions, are associated with the formation for radio-loud AGN, and that these host galaxies preferentially accrete less material after their formation epoch than galaxies without powerful radio jets. We discuss possible explanations for the link between merger history and the incidence of a radio jet.Comment: 37 pages, 8 figures, accepted for publication in ApJ, for full PDF incl. figures see http://www.ph.unimelb.edu.au/~modowd/papers/odowdurry2005.pd

Deformation of the N=Z nucleus 76Sr using beta-decay studies

A novel method of deducing the deformation of the N=Z nucleus 76Sr is presented. It is based on the comparison of the experimental Gamow-Teller strength distribution B(GT) from its beta decay with the results of QRPA calculations. This method confirms previous indications of the strong prolate deformation of this nucleus in a totally independent way. The measurement has been carried out with a large Total Absorption gamma Spectrometer, "Lucrecia", newly installed at CERN-ISOLDE.Comment: Accepted in Phys. Rev. Letter

Maxwell-like Lagrangians for higher spins

We show how implementing invariance under divergence-free gauge transformations leads to a remarkably simple Lagrangian description of massless bosons of any spin. Our construction covers both flat and (A)dS backgrounds and extends to tensors of arbitrary mixed-symmetry type. Irreducible and traceless fields produce single-particle actions, while whenever trace constraints can be dispensed with the resulting Lagrangians display the same reducible, multi-particle spectra as those emerging from the tensionless limit of free open-string field theory. For all explored options the corresponding kinetic operators take essentially the same form as in the spin-one, Maxwell case.Comment: 77 pages, revised version. Erroneous interpretation and proof of the gauge-fixing procedure for mixed-symmetry fields corrected. As a consequence, the mixed-symmetry, one-particle Lagrangians are to be complemented with conditions on the divergences of the fields; all other conclusions unchanged. Additional minor changes including references added. To appear in JHE