575 research outputs found
Chemical characterization and economic evaluation of the coal fly ash pre-washing and carbonation process
In the present laboratory-scale study, the combination of washing and carbonation processes was examined to evaluate the feasibility to reduce the environmental impact of coal power plants. Three different washing solutions (tap, distilled and sea water) were used to pre-treat coal fly ash and the corresponding effect on direct gas-solid carbonation and final metal leaching was evaluated. Finally, a preliminary economic evaluation of the process was performed. In terms of captured CO2, the results have shown that significant amounts can be captured, although, as expected, the leaching of soluble salts in water such as Ca and Mg reduce the CO2 uptake. In terms of heavy metal's leaching, the application of pre-washing and carbonation treatment significantly affected the metal immobilization on the final residue. The pre-washing with sea water allowed to reach a sensible improvement since only selenium, chlorides and sulphates resulted outside the range for disposing of the carbonated residue in landfill for non-hazardous waste
Morfologia e morfometria del settore ionico del Golfo di Taranto.
Il versante Ionico del Golfo di Taranto \ue8 caratterizzato dalla presenza di alti strutturali e bacini che
rappresentano l\u2019espressione morfologica di sistemi di faglie pleistoceniche transpressive. La dorsale di
Amendolara si estende per 45 Km in direzione N130\ub0E, ed \ue8 caratterizzato dalla presenza di tre alti
batimetrici minori (denominati Amendolara, Rossano e Cariati). Verso NE, la dorsale di Capo Spulico si
estende per 40 Km in direzione !N115\ub0E.
Durante la Campagna Oceanografica \u201cTeatioca\u201d sono stati acquisiti 1100Km2 di dati batimetrici
multibeam e profili sismici monocanale ad alta (Sparker) ed altissima risoluzione (Subbottom Chirp).
L\u2019analisi integrata dei nuovi dati ha consentito di ottenere una sintesi morfostrutturale preliminare dell\u2019area
sud-orientale del Golfo di Taranto [Santoro et al., 2012].
L\u2019insieme dei dati morfometrici evidenzia un ruolo chiave nell\u2019attivit\ue0 traspressiva della faglia che borda
a SW la dorsale di Amendolara, in quanto la regolarit\ue0 dei pendii rivolti a S \ue8 legata alla deformazione e
sollevamento dei versanti, che tende a superare l\u2019effetto dei processi erosivi (versanti a controllo morfostrutturale).
Il processo di basculamento guidato dall\u2019azione della faglia sembra essere all\u2019originedei processi
responsabili dell\u2019erosione gravitazionale canalizzata sui pendii esposti a nord (versanti a controllo morfosedimentario).
Sette ordini di terrazzi sono stati riconosciuti sul top del Banco di Amendolara, attraverso tecniche di
analisi dei picchi nel diagramma di distribuzione delle quote [Passaro et al., 2011]. Tale dato e le statistiche
sui profili estratti dal DTM testimoniano la presenza di tassi differenziali di sollevamento ed un complessivo
tilt (verso E) del settore frontale ionico dell\u2019Appennino Meridionale, in accordo con quanto suggerito in
letteratura [Ferranti et al., 2009].
Bibliografia
Ferranti, L., Santoro, E., Mazzella, M.E., Monaco, C., Morelli, D., (2009). Active transpression in the
northern Calabria Apennines, southern Italy. Tectonophysics, 476 (1-2), 226-251.
Passaro, S., Ferranti, L., de Alteriis, G., (2011). The use of high resolution elevation histograms for mapping
submerged terraces: a test from the Eastern Tyrrhenian Sea and the Eastern Atlantic Ocean. Quat. Int.,
232, 1-2, 238-249.
Santoro, E., Ferranti, L., Passaro, S., Burrato, P., Morelli, D., (2012). Morphometric analysis in the offshore
of the southern Taranto Gulf: unveiling the structures controlling the Late Pleistocene-Holocene
bathymetric evolution. Rend. On. Soc. Geol. It., 21 (2), 1132-1135
An active oblique-contractional belt at the transition between the Southern Apennines and Calabrian Arc: The Amendolara Ridge, Ionian Sea, Italy
High-resolution, single-channel seismic and multibeam bathymetry data collected at the
Amendolara Ridge, a key submarine area marking the junction between the Apennine collision belt and
the Calabrian subduction forearc, reveal active deformation in a supposedly stable crustal sector. New data,
integrated with existing multichannel seismic profiles calibrated with oil-exploratory wells, show that middle
to late Pleistocene sediments are deformed in growth folds above blind oblique-reverse faults that bound a
regional pop-up. Data analysis indicates that ~10 to 20 km long banks that top the ~80 km long, NW-SE
trending ridge are structural culminations above en echelon fault segments. Numeric modeling of bathymetry
and stratigraphic markers suggests that three 45\ub0 dipping upper crustal (2\u201310km) fault segments underlie the
ridge, with slip rates up to ~0.5mm/yr. Segments may be capable with M~ 6.1\u20136.3 earthquakes, although an
unknown fraction of aseismic slip undoubtedly contributes to deformation. The fault array that bounds the
southern flank of the ridge (Amendolara Fault System) parallels a belt of Mw<4.7 strike-slip and thrust
earthquakes, which suggest current left-oblique reverse motion on the array. The eastern segment of the array
shows apparent morphologic evidence of deformation and might be responsible for Mw 64 5.2 historic events.
Late Pliocene-Quaternary growth of the oblique contractional belt is related to the combined effects of stalling
of Adriatic slab retreat underneath the Apennines and subduction retreat of the Ionian slab underneath
Calabria. Deformation localization was controlled by an inherited mechanical interface between the thick
Apulian (Adriatic) platform crust and the attenuated Ionian Basin crust
Geometria e modellazione di un sistema di retro-scorrimenti attivosulla base di dati di geofisica marina ad alta risoluzione:la Dorsale di Amendolara (Golfo di Taranto).
Nuovi dati sismici ad alta (Sparker) ed altissima (Subbottm Chirp) risoluzione, acquisiti durante la
Campagna Oceanografica “Teatioca_2010”, integrati da dati sismici multicanale ad alta penetrazione,
pubblici disponibili sul sito www.videpi.com, calibrati con pozzi profondi, batimetrici multifascio e
carotaggi, rivelano che la dorsale di Amendolara, estensione sottomarina della zona frontale del sistema a
thrust dell’Appennino meridionale, è stata controllata nel Quaternario da un sistema di retro-scorrimenti e
faglie transpressive (ATFS) che dislocano verso SW la catena mio-pliocenica NE-vergente.
Il pacco di sequenze deposizionali attribuito, sulla base della facies sismica e della presenza di
discordanze controllate dalle oscillazioni glacio-eustatiche, al Pleistocene medio-superiore risulta piegato in
maniera consistente con le strutture desumibili dai profili multicanale. I dati morfometrici e sismici
documentano che la dorsale, orientata NW-SE, è formata da 3 banchi lunghi ~10-20 km, cresciuti sopra
rampe di sovrascorrimenti ciechi (~2 km) disposti en-echelon a formare un sistema segmentato. Sono stati
individuati e modellati i segmenti di Amendolara a NW e Cariati a SE, collegati da una più piccola rampa
laterale (segmento di Rossano). La modellazione numerica calibrata sui dati batimetrici e sismici indica che
le rampe hanno inclinazione di ~45° e sono radicate a ~10 km di profondità a possibili scollamenti o strutture
maggiori. I tassi di scorrimento negli ultimi 4-500 ka, calcolati per i segmenti sulla base degli strati di
crescita nei bacini sin tettonici variano da 0.5-0-9 mm/a per il segmento di Amendolara a 0.35-0.5 mm/a per
quello di Cariati.
L’ATFS coincide con una fascia di moderata sismicità (Mw<4.7) con meccanismi focali inversi o
transpressivi. L’orientazione degli assi di strain incrementale (sismico) e finito (geologico, come
documentano i dati a terra) suggerisce per i segmenti dell’ATFS un movimento da inverso a obliquo sinistro.
In base alla dimensione dei segmenti di faglia, nell’ipotesi di deformazione puramente elastica, si stima una
magnitudo potenziale massima per l’ATFS di M~6.1-6.4, ma è verosimile che buona parte della
deformazione sia asismica o microsismica. L’epicentro macrosismico del terremoto del 1988 (Mw=4.9)
ricade su un tratto del segmento di Cariati che mostra rotture a fondo mare e possibile risalita di fluidi
localizzata lungo strutture attive. La crescita dell’ATFS è stata verosimilmente controllata da un interfaccia
meccanica tra la spessa crosta apula e la crosta ionica assottigliata o in parte oceanica, quando in tempi
recenti la convergenza Adria-Europa ha prevalso sull’arretramento della cerniera della subduzione ionica
An active oblique-contractional belt at the transition between the Southern Apennines and Calabrian Arc: The Amendolara Ridge, Ionian Sea, Italy
High-resolution, single-channel seismic and multibeam bathymetry data collected at the Amendolara Ridge, a key submarine area marking the junction between the Apennine collision belt and the Calabrian subduction forearc, reveal active deformation in a supposedly stable crustal sector. New data, integrated with existing multichannel seismic profiles calibrated with oil-exploratory wells, show that middle to late Pleistocene sediments are deformed in growth folds above blind oblique-reverse faults that bound a regional pop-up. Data analysis indicates that ~10 to 20 km long banks that top the ~80 km long, NW-SE trending ridge are structural culminations above en echelon fault segments. Numeric modeling of bathymetry and stratigraphic markers suggests that three 45° dipping upper crustal (2–10 km) fault segments underlie the ridge, with slip rates up to ~0.5 mm/yr. Segments may be capable with M ~ 6.1–6.3 earthquakes, although an unknown fraction of aseismic slip undoubtedly contributes to deformation. The fault array that bounds the southern flank of the ridge (Amendolara Fault System) parallels a belt of Mw < 4.7 strike-slip and thrust earthquakes, which suggest current left-oblique reverse motion on the array. The eastern segment of the array shows apparent morphologic evidence of deformation and might be responsible for Mw ≤ 5.2 historic events. Late Pliocene-Quaternary growth of the oblique contractional belt is related to the combined effects of stalling of Adriatic slab retreat underneath the Apennines and subduction retreat of the Ionian slab underneath Calabria. Deformation localization was controlled by an inherited mechanical interface between the thick Apulian (Adriatic) platform crust and the attenuated Ionian Basin crust
Interleukin 28 polymorphisms and hepatocellular carcinoma development after direct acting antiviral therapy for chronihepatitis c
Background & Aims: Cirrhotic patients with hepatitis C virus (HCV) infection remain at risk of developing hepatocellular carcinoma (HCC) even after the sustained virologic response (SVR). We aimed to evaluate whether the IL28 (rs12979860) single nucleotide polymorphism (SNP) may constitute a predisposing genetic factor and to identify the SVR patients at risk of HCC. Methods: Two hundred patients undergoing DAAs treatment for chronic hepatitis C with advanced fibrosis (F3-F4) were consecutively enrolled. Besides normal routine laboratory testing for HCV, patients’ sera were evaluated also for retinol, retinol-binding protein 4 and the following SNPs: PNPLA3 (rs738409), TM6SF2 (rs58542926), MBOAT7 (rs641738), IL28B (rs12979860), TIMP-1 (rs4898), TIMP-2 (rs8179090), NF-kB promoter (rs28362491). Statistical analyses were conducted using Stata/SE 14.2 statistical software (Stata Corp, College Station, TX). Results: Almost all patients (197/200) obtained SVR24. Seventeen patients had a previous history of treated HCC before DAAs. Six patients developed HCC recurrence and five patients developed de novo HCC after a mean period of 18 months since EOT. All these patients had SVR. A significant association between IL28B – TT genotype and HCC development after DAAs therapy was observed (OR 4.728, CI 95% 1.222 – 18.297, p=0.024). Conclusion: IL28B rs12979860 polymorphism was significantly associated with HCC development after DAAs. Assessment of this SNP may better identify patients at risk of developing HCC after treatment. Further prospective studies are required to confirm these hypotheses
Phytochrome control of plant growth and metabolism in Arabidopsis thaliana
Plants rely on light to supply photosynthetic energy and to provide information of the
surrounding environment. Phytochromes are photoreceptors that sense external light
quality and quantity, which in turn guide the strategy of plant growth. A large body
of research has focused on Arabidopsis thaliana seedlings, where phytochrome
control of responses such as hypocotyl elongation, hook opening and cotyledon
greening, has been intensively explored. Mathematical models have also helped
elucidate the molecular mechanism of phytochrome signalling. A smaller proportion
of studies have investigated the role of phytochrome in controlling plant plasticity in
adult plants. This work has shown that phytochrome depletion enhances leaf petiole
elongation and slows growth, but there is a lack of information on how these marked
changes alter metabolism.
In this thesis, I use phytochrome multiple mutants of to explore how phytochromes
interact with metabolism to affect plant growth. My analysis revealed that
phytochrome loss results in dramatically reduced biomass production, especially in
high order phyABDE mutant that lacks four out of five phytochromes. This is caused,
at least partly, by impaired photosynthesis in phytochrome mutants, including
reduced chlorophyll level and less CO2 uptake. Furthermore, cell wall synthesis and
protein levels, major dry biomass constituents, are also repressed in phytochrome-depleted
plants. Interestingly, these mutants accumulate more daytime sucrose and
starch than wild type does, possibly due to their retarded growth in light. Further
metabolic profiling reveals that these phytochrome mutants over-accumulate sugars,
organic acids and amino acids. The sizable increase in raffinose and proline suggests
a possible link to stress tolerance. Indeed, ABA and salt responses are significantly
reduced in phytochrome mutants at both seedling and adult stages. These mutants are
also more resistant to prolonged darkness, with less chlorophyll degradation in dark
and higher survival rates.
Collectively, this thesis shows that phytochromes have a novel role in plant resource
management, controlling the allocation of resources for growth, switching the
metabolism between growth and stress-coping states based on the availability of light
from the environment. It brings new interest into phytochrome research in
Arabidopsis, suggesting possible application of such knowledge to crop studies in the
future
In Vivo Turnover of Tau and APP Metabolites in the Brains of Wild-Type and Tg2576 Mice: Greater Stability of sAPP in the β-Amyloid Depositing Mice
The metabolism of the amyloid precursor protein (APP) and tau are central to the pathobiology of Alzheimer's disease (AD). We have examined the in vivo turnover of APP, secreted APP (sAPP), Aβ and tau in the wild-type and Tg2576 mouse brain using cycloheximide to block protein synthesis. In spite of overexpression of APP in the Tg2576 mouse, APP is rapidly degraded, similar to the rapid turnover of the endogenous protein in the wild-type mouse. sAPP is cleared from the brain more slowly, particularly in the Tg2576 model where the half-life of both the endogenous murine and transgene-derived human sAPP is nearly doubled compared to wild-type mice. The important Aβ degrading enzymes neprilysin and IDE were found to be highly stable in the brain, and soluble Aβ40 and Aβ42 levels in both wild-type and Tg2576 mice rapidly declined following the depletion of APP. The cytoskeletal-associated protein tau was found to be highly stable in both wild-type and Tg2576 mice. Our findings unexpectedly show that of these various AD-relevant protein metabolites, sAPP turnover in the brain is the most different when comparing a wild-type mouse and a β-amyloid depositing, APP overexpressing transgenic model. Given the neurotrophic roles attributed to sAPP, the enhanced stability of sAPP in the β-amyloid depositing Tg2576 mice may represent a neuroprotective response
An in situ intercomparison exercise on passive samplers for the monitoring of metals, polycyclic aromatic hydrocarbons and pesticides in surface water
An intercomparison exercise on passive samplers (PSs) was organized in summer 2010 for the measurement of selected metals, polycyclic aromatic hydrocarbons (PAHs) and pesticides in surface waters. Various PSs were used and compared at 2 rivers sites and one marine lagoon. A total of 24 laboratories participated. We present selected significant outputs from this exercise, including discussion on quality assurance and quality control for PSs, the interlaboratory variability of field blanks, time weighted average water concentrations and its uncertainties, the representativity of DGT samples, the ability of PSs to lower limits of detection, PAH fingerprints in various PSs compared with spot samples, and the relevance of the permeability reference compounds (PRC) approach for POCIS with pesticides. These in situ intercomparison exercises should enable to progress on the harmonization of practices for the use of passive sampling, especially for priority chemical monitoring and regulatory programs in compliance with the Water Framework Directive (WFD) and Marine Strategy Framework Directive (MSFD)
Curcuma longa Extract Exerts a Myorelaxant Effect on the Ileum and Colon in a Mouse Experimental Colitis Model, Independent of the Anti-Inflammatory Effect
Background: Curcuma has long been used as an anti-inflammatory agent in inflammatory bowel disease. Since gastrointestinal motility is impaired in inflammatory states, the aim of this work was to evaluate if Curcuma Longa had any Methods: The biological activity of Curcuma extract was evaluated against Carbachol induced contraction in isolated mice intestine. Acute and chronic colitis were induced in Balb/c mice by Dextran Sulphate Sodium administration (5% and 2.5% respectively) and either Curcuma extract (200 mg/kg/day) or placebo was thereafter administered for 7 and 21 days respectively. Spontaneous contractions and the response to Carbachol and Atropine of ileum and colon were studied after
colitis induction and Curcuma administration. Results: Curcuma extract reduced the spontaneous contractions in the ileum and colon; the maximal response to Carbachol was inhibited in a non-competitive and reversible manner. Similar results were obtained in ileum and colon from Curcuma fed mice. DSS administration decreased the motility, mainly in the colon and Curcuma almost restored both the spontaneous contractions and the response to Carbachol after 14 days assumption, compared to standard diet, but a prolonged assumption of Curcuma decreased the spontaneous and Carbachol-induced contractions.
Conclusions: Curcuma extract has a direct and indirect myorelaxant effect on mouse ileum and colon, independent of the
anti-inflammatory effect. The indirect effect is reversible and non-competitive with the cholinergic agent. These results
suggest the use of curcuma extract as a spasmolytic agent
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