Signal Detection in Older Individuals with Neurocognitive Disorder

Past research has been inconclusive when assessing older individuals and their responding on stimulus equivalence tasks. Therefore, the purpose of this study was to assess the ability of individuals with neurocognitive disorder (NCD) to detect the presence of a stimulus when presented along with varying amounts of distracter stimuli or “noise”. In this study, two older female participants, ages 71 and 84, with NCD, were asked to participate in a computer based task designed using a visual signal detection procedure. This procedure consisted of three parts, each presented elctronically using a computer and designed to assess their ability to percieve the presense or lack of a visual stimulus, a red circle, when also presented with several distractor stimuli. It was hypothesized that the performance of older individuals would decline when presented with increased “noise” levels

Prolonged survival of patients receiving trastuzumab beyond disease progression for HER2 overexpressing metastatic breast cancer (MBC)

Background: The aim of this retrospective analysis was to evaluate the impact of trastuzumab-based regimens on the survival of patients with HER2-overexpressing metastatic breast cancer (MBC). The study specifically focussed on the influence of the continuation of trastuzumab-based treatment despite tumor progression on survival. Patients and Methods: Patients with HER2 overexpressing MBC were included in this retrospective analysis. HER2 overexpression was determined by the immunohistochemical staining score (DAKO Hercep Test (TM)). Trastuzumab was applied at a loading dose of 4 mg/kg and a maintenance dose of 2 mg/kg. Results: Among 136 HER2 overexpressing patients (DAKO score 3+), 66 patients received first-line trastuzumab, 47 patients received trastuzumab as second-line therapy and 23 patients received trastuzumab beyond disease progression. There was no significant difference regarding the duration of trastuzumab-based treatment (first-line: 29.5 weeks vs. second-line: 25 weeks). Moreover, there was no difference in the response rate (first-line: 37.9% vs. second-line: 35.7%) or the median survival (p = 0.47 log rank). Patients who received >= 2 trastuzumab-based regimens for MBC survived significantly longer compared to those who had received only 1 regimen (>= 2 regimens: 62.4 months vs. 1 regimen: 38.5 months; p = 0.01 log rank). Conclusions: Trastuzumab is highly effective in the treatment of HER2 overexpressing MBC. Compared to historical controls, overall survival appears to be markedly prolonged, particularly in patients who received sequential trastuzumab-based treatment beyond disease progression

The cooperative forest management program : suggestions for improvement

Cover title."April 1988.""Issued in furtherance of Cooperative Extension Work Acts of May 8 and June 30, 1914 in cooperation with the United States Department of Agriculture ... Cooperative Extension Service, University of Missouri and Lincoln University, Columbia, Missouri.""Funding provided by Missouri Department of Conservation, Division of Forestry and University of Missouri-Columbia.

The VST telescope control software in the ESO VLT environment

The VST (VLT Survey Telescope) is a 2.6 m Alt-Az telescope to be installed at Mount Paranal in Chile, in the European Southern Observatory (ESO) site. The VST is a wide-field imaging facility planned to supply databases for the ESO Very Large Telescope (VLT) science and carry out stand-alone observations in the UV to I spectral range. This paper will focus mainly on control software aspects, describing the VST software architecture in the context of the whole ESO VLT control concept. The general architecture and the main components of the control software will be described.Comment: 3 pages, 2 figures, ICALEPCS 2001 Conference, PSN#THAP05

Subdiffusion and cage effect in a sheared granular material

We investigate experimentally the diffusion properties of a bidimensional bidisperse dry granular material under quasistatic cyclic shear.The comparison of these properties with results obtained both in computer simulations of hard spheres systems and Lenard-Jones liquids and experiments on colloidal systems near the glass transition demonstrates a strong analogy between the behaviour of granular matter and these systems. More specifically, we study in detail the cage dynamics responsible for the subdiffusion in the slow relaxation regime, and obtain the values of relevant time and length scales.Comment: 4 pages, 6 figures, submitted to PR

Dimensionality cross-over in magnetism: from domain walls (2D) to vortices (1D)

Dimensionality cross-over is a classical topic in physics. Surprisingly it has not been searched in micromagnetism, which deals with objects such as domain walls (2D) and vortices (1D). We predict by simulation a second-order transition between these two objects, with the wall length as the Landau parameter. This was conrmed experimentally based on micron-sized ux-closure dots

Using the International Monitoring System infrasound network to study gravity waves

International audienceThe infrasound network of the International Monitoring System (IMS) has been designed for the detection of atmospheric pressure fluctuations produced in the [0.02 Hz-4 Hz] frequency range. However, the majority of the measuring chains used in this network also record pressure fluctuations at lower frequencies. The objective of this paper is to demonstrate the accuracy of IMS pressure measurements in the gravity wave band, whose period usually ranges from a few minutes to 24 hours. Application examples such as the monitoring of worldwide gravity wave time-spectra and the characterization of surface pressure fluctuations produced by atmospheric tides are presented. This study opens the way to the analysis of gravity waves using IMS data, which constitute a unique and accurate set of pressure measurements

Temperature dependence of the resonance and low energy spin excitations in superconducting FeTe0.6_{0.6}Se0.4_{0.4}

We use inelastic neutron scattering to study the temperature dependence of the low-energy spin excitations in single crystals of superconducting FeTe$_{0.6}$Se$_{0.4}$ ($T_c=14$ K). In the low-temperature superconducting state, the imaginary part of the dynamic susceptibility at the electron and hole Fermi surfaces nesting wave vector $Q=(0.5,0.5)$, $\chi^{\prime\prime}(Q,\omega)$, has a small spin gap, a two-dimensional neutron spin resonance above the spin gap, and increases linearly with increasing $\hbar\omega$ for energies above the resonance. While the intensity of the resonance decreases like an order parameter with increasing temperature and disappears at temperature slightly above $T_c$, the energy of the mode is weakly temperature dependent and vanishes concurrently above $T_c$. This suggests that in spite of its similarities with the resonance in electron-doped superconducting BaFe$_{2-x}$(Co,Ni)$_x$As$_2$, the mode in FeTe$_{0.6}$Se$_{0.4}$ is not directly associated with the superconducting electronic gap.Comment: 7 pages, 6 figure