441 research outputs found
The application of Skylab altimetry to marine geoid determination
The author had identified the following significant results. The major results can be divided broadly into two groups. One group is concerned with the effects of errors inherent in the various input data, such as the orbit emphemeris, a priori geoid etc. The other consists of the results of the actual analysis of the data from the Skylab EREP passes 4, 6, 7, and 9. Results from the first group were obtained from the analysis of some preliminary data from EREP pass 9 mode 5. The second group of results consists of a set of recovered bias terms for each of the submodes of observations and a set of nine altimetry geoid profiles corresponding to the various passes and modes. Along with each of these profiles, the a priori geoid, gravity anomaly, and the bathymetric data profiles are also presented for easy comparison
Calibration and evaluation of Skylab altimetry for geodetic determination of the geoid
There are no author-identified significant results in this report
Effectiveness evaluation of STOL transport operations (phase 2)
A computer simulation program which models a commercial short-haul aircraft operating in the civil air system was developed. The purpose of the program is to evaluate the effect of a given aircraft avionics capability on the ability of the aircraft to perform on-time carrier operations. The program outputs consist primarily of those quantities which can be used to determine direct operating costs. These include: (1) schedule reliability or delays, (2) repairs/replacements, (3) fuel consumption, and (4) cancellations. More comprehensive models of the terminal area environment were added and a simulation of an existing airline operation was conducted to obtain a form of model verification. The capability of the program to provide comparative results (sensitivity analysis) was then demonstrated by modifying the aircraft avionics capability for additional computer simulations
Improved ground truth geoid for the GEOS-3 calibration area
The purpose of this investigation is to develop methods and procedures are reported for computing a detailed geoid to be used as geodetic ground truth for the calibration and verification of GEOS-3 altimeter data. The technique developed is based on rectifying the best available detailed geoid so that the rectified geoid will have correct scale, orientation, shape and position with respect to the geocenter. The approach involved the development of a mathematical model based on a second degree polynomial, in rectangular Cartesian coordinates, describing the geoid undulations at the control stations. A generalized least squares solution was obtained for the polynomial which describes the variation of the undulation differences between the control stations geoid and the gravimetric geoid. Three rectified geoid were determined. These geoids correspond to three sets of tracking station data: (1) WFC/C-band data; (2) GSFC/C-band data; and (3) OSU-275 data. The absolute accuracy of these rectified geoids is linearly correlated with the uncertainties of the tracking station coordinates and, to a certain extent, with those of the detailed geoid being rectified
Calibration and evaluation of Skylab altimetry for geodetic determination of the geoid
The author has identified the following significant results. The Skylab altimeter experiment has proven the capability of the altimeter for measurement of sea surface topography. The geometric determination of the geoid/mean sea level from satellite altimetry is a new approach having significant applications in many disciplines including geodesy and oceanography. A generalized least squares collocation technique was developed for determination of the geoid from altimetry data. The technique solves for the altimetry geoid and determines one bias term for the combined effect of sea state, orbit, tides, geoid, and instrument error using sparse ground truth data. The influence of errors in orbit and a priori geoid values are discussed. Although the Skylab altimeter instrument accuracy is about plus or minus 1m, significant results were obtained in identification of large geoidal features such as over the Puerto Rico trench. Comparison of the results of several passes shows that good agreement exists between the general slopes of the altimeter geoid and the ground truth, and that the altimeter appears to be capable of providing more details than are now available with best known geoids
The Time Machine: A Simulation Approach for Stochastic Trees
In the following paper we consider a simulation technique for stochastic
trees. One of the most important areas in computational genetics is the
calculation and subsequent maximization of the likelihood function associated
to such models. This typically consists of using importance sampling (IS) and
sequential Monte Carlo (SMC) techniques. The approach proceeds by simulating
the tree, backward in time from observed data, to a most recent common ancestor
(MRCA). However, in many cases, the computational time and variance of
estimators are often too high to make standard approaches useful. In this paper
we propose to stop the simulation, subsequently yielding biased estimates of
the likelihood surface. The bias is investigated from a theoretical point of
view. Results from simulation studies are also given to investigate the balance
between loss of accuracy, saving in computing time and variance reduction.Comment: 22 Pages, 5 Figure
Calibration and evaluation of Skylab altimetry for geodetic determination of the geoid
There are no author-identified significant results in this report
Calibration and evaluation of Skylab altimetry for geodetic determination of the geoid
There are no author-identified significant results in this report
Mott insulators in strong electric fields
Recent experiments on ultracold atomic gases in an optical lattice potential
have produced a Mott insulating state of Rb atoms. This state is stable to a
small applied potential gradient (an `electric' field), but a resonant response
was observed when the potential energy drop per lattice spacing (E), was close
to the repulsive interaction energy (U) between two atoms in the same lattice
potential well. We identify all states which are resonantly coupled to the Mott
insulator for E close to U via an infinitesimal tunneling amplitude between
neighboring potential wells. The strong correlation between these states is
described by an effective Hamiltonian for the resonant subspace. This
Hamiltonian exhibits quantum phase transitions associated with an Ising density
wave order, and with the appearance of superfluidity in the directions
transverse to the electric field. We suggest that the observed resonant
response is related to these transitions, and propose experiments to directly
detect the order parameters. The generalizations to electric fields applied in
different directions, and to a variety of lattices, should allow study of
numerous other correlated quantum phases.Comment: 17 pages, 14 figures; (v2) minor additions and new reference
A high throughput molecular force assay for protein-DNA interactions.
An accurate and genome-wide characterization of protein–DNA interactions such as transcription factor binding is of utmost importance for modern biology. Powerful screening methods emerged. But the vast majority of these techniques depend on special labels or markers against the ligand of interest and moreover most of them are not suitable for detecting low-affinity binders. In this article a molecular force assay is described based on measuring comparative unbinding forces of biomolecules for the detection of protein–DNA interactions. The measurement of binding or unbinding forces has several unique advantages in biological applications since the interaction between certain molecules and not the mere presence of one of them is detected. No label or marker against the protein is needed and only specifically bound ligands are detected. In addition the force-based assay permits the detection of ligands over a broad range of affinities in a crowded and opaque ambient environment. We demonstrate that the molecular force assay allows highly sensitive and fast detection of protein–DNA interactions. As a proof of principle, binding of the protein EcoRI to its DNA recognition sequence is measured and the corresponding dissociation constant in the sub-nanomolar range is determined. Furthermore, we introduce a new, simplified setup employing FRET pairs on the molecular level and standard epi-fluorescence for readout. Due to these advancements we can now demonstrate that a feature size of a few microns is sufficient for the measurement process. This will open a new paradigm in high-throughput screening with all the advantages of force-based ligand detection.
Graphical abstract: A high throughput molecular force assay for protein–DNA interaction
- …