868 research outputs found
GLP-1 et détection cérébrale du glucose, un relais de régulation de l’homéostasie glucidique
Widespread Treponema pallidum Infection in Nonhuman Primates, Tanzania
We investigated Treponema pallidum infection in 8 nonhuman primate species (289 animals) in Tanzania during 2015–2017. We used a serologic treponemal test to detect antibodies against the bacterium. Infection was further confirmed from tissue samples of skin-ulcerated animals by 3 independent PCRs (polA, tp47, and TP_0619). Our findings indicate that T. pallidum infection is geographically widespread in Tanzania and occurs in several species (olive baboons, yellow baboons, vervet monkeys, and blue monkeys). We found the bacterium at 11 of 14 investigated geographic locations. Anogenital ulceration was the most common clinical manifestation; orofacial lesions also were observed. Molecular data show that nonhuman primates in Tanzania are most likely infected with T. pallidum subsp. pertenue–like strains, which could have implications for human yaws eradication
Entropy Distance: New Quantum Phenomena
We study a curve of Gibbsian families of complex 3x3-matrices and point out
new features, absent in commutative finite-dimensional algebras: a
discontinuous maximum-entropy inference, a discontinuous entropy distance and
non-exposed faces of the mean value set. We analyze these problems from various
aspects including convex geometry, topology and information geometry. This
research is motivated by a theory of info-max principles, where we contribute
by computing first order optimality conditions of the entropy distance.Comment: 34 pages, 5 figure
Impact of Intestinal Peptides on the Enteric Nervous System: Novel Approaches to Control Glucose Metabolism and Food Intake
The gut is one of the most important sources of bioactive peptides in the body. In addition to their direct actions in the brain and/or peripheral tissues, the intestinal peptides can also have an impact on enteric nervous neurons. By modifying the endogenousproduction of these peptides, one may expect modify the “local” physiology such as glucose absorption, but also could have a “global” action via the gut–brain axis. Due to the various origins of gut peptides (i.e., nutrients, intestinal wall, gut microbiota) and the heterogeneity of enteric neurons population, the potential physiological parameters control by the interaction between the two partners are multiple. In this review, we will exclusively focus on the role of enteric nervous system as a potential target of gut peptides to control glucose metabolism and food intake. Potential therapeutic strategies based on per os administration of gut peptides to treat type 2 diabetes will be described
Symbolic dynamics for the -centre problem at negative energies
We consider the planar -centre problem, with homogeneous potentials of
degree -\a<0, \a \in [1,2). We prove the existence of infinitely many
collisions-free periodic solutions with negative and small energy, for any
distribution of the centres inside a compact set. The proof is based upon
topological, variational and geometric arguments. The existence result allows
to characterize the associated dynamical system with a symbolic dynamics, where
the symbols are the partitions of the centres in two non-empty sets
On the Form Factor for the Unitary Group
We study the combinatorics of the contributions to the form factor of the
group U(N) in the large limit. This relates to questions about
semiclassical contributions to the form factor of quantum systems described by
the unitary ensemble.Comment: 35 page
The Non-Trapping Degree of Scattering
We consider classical potential scattering. If no orbit is trapped at energy
E, the Hamiltonian dynamics defines an integer-valued topological degree. This
can be calculated explicitly and be used for symbolic dynamics of
multi-obstacle scattering.
If the potential is bounded, then in the non-trapping case the boundary of
Hill's Region is empty or homeomorphic to a sphere.
We consider classical potential scattering. If at energy E no orbit is
trapped, the Hamiltonian dynamics defines an integer-valued topological degree
deg(E) < 2. This is calculated explicitly for all potentials, and exactly the
integers < 2 are shown to occur for suitable potentials.
The non-trapping condition is restrictive in the sense that for a bounded
potential it is shown to imply that the boundary of Hill's Region in
configuration space is either empty or homeomorphic to a sphere.
However, in many situations one can decompose a potential into a sum of
non-trapping potentials with non-trivial degree and embed symbolic dynamics of
multi-obstacle scattering. This comprises a large number of earlier results,
obtained by different authors on multi-obstacle scattering.Comment: 25 pages, 1 figure Revised and enlarged version, containing more
detailed proofs and remark
Double exponential stability of quasi-periodic motion in Hamiltonian systems
We prove that generically, both in a topological and measure-theoretical
sense, an invariant Lagrangian Diophantine torus of a Hamiltonian system is
doubly exponentially stable in the sense that nearby solutions remain close to
the torus for an interval of time which is doubly exponentially large with
respect to the inverse of the distance to the torus. We also prove that for an
arbitrary small perturbation of a generic integrable Hamiltonian system, there
is a set of almost full positive Lebesgue measure of KAM tori which are doubly
exponentially stable. Our results hold true for real-analytic but more
generally for Gevrey smooth systems
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