Validation of a Continuum-based Weak Zone Joint Model for Simulating Anisotropic Rock Mass Strength

Abstract In recent decades, the approach to estimating rock mass strength and its anisotropic behaviour more accurately has been a growing topic of interest in the rock mechanics community. To evaluate jointed rock mass behaviour more accurately, sophisticated modelling techniques such as Synthetic Rock Mass (SRM) models are becoming increasingly popular. Still, these methods are computationally intensive and require detailed site characterization data that are often unavailable during the initial stages of project development and are not always the most practical option. This study developed an alternative continuum-based SRM-like model where thin contiguous regions of weak continuum material with equivalent joint properties are in place of explicit interface joint elements. The finite-difference program FLAC used these weak zone joints (WZJ) to generate a jointed rock mass continuum model (JRCM). The JRCM concept was applied to systematic sets of persistent joints, a single non-persistent joint, and two intersecting joints to validate the practicality of using WZJ. Results found that the concept produced reasonable anisotropic rock mass strength estimates for most cases, with some limitations. The model captured the anisotropic behaviour while reducing time requirements to develop and recalibrate a conventional SRM. The JRCM concept demonstrates a practical alternative to estimating anisotropic rock mass strength for specific projects where the quantity or quality of data is limited. Furthermore, the reduced run times could allow multiple iterations to perform a probabilistic assessment of the rock mass strength.</jats:p

Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm

This study compares the relative effects of advancing male age on multiple genomic defects in human sperm [DNA fragmentation index (DFI), chromatin integrity, gene mutations, and numerical chromosomal abnormalities], characterizes the relationships among these defects and with semen quality, and estimates the incidence of susceptible individuals for a well characterized nonclinical nonsmoking group of 97 men (22–80 years). Adjusting for confounders, we found major associations between age and the frequencies of sperm with DFI and fibroblast growth factor receptor 3 gene (FGFR3) mutations associated with achondroplasia (P < 0.01) with no evidence for age thresholds. However, we found no associations between age and the frequencies of sperm with immature chromatin, aneuploidies/diploidies, FGFR2 mutations (Apert syndrome), or sex ratio in this cohort. There were also no consistent correlations among genomic and semen-quality endpoints, except between DFI and sperm motility (r = −0.65, P < 0.001). These findings suggest there are multiple spermatogenic targets for genomically defective sperm with substantially variable susceptibilities to age. Our findings predict that as healthy males age, they have decreased pregnancy success with trends beginning in their early reproductive years, increased risk for producing offspring with achondroplasia mutations, and risk of fathering offspring with Apert syndrome that may vary across cohorts, but with no increased risk for fathering aneuploid offspring (Down, Klinefelter, Turner, triple X, and XYY syndromes) or triploid embryos. Our findings also suggest that the burden of genomic damage in sperm cannot be inferred from semen quality, and that a small fraction of men are at increased risk for transmitting multiple genetic and chromosomal defects