660 research outputs found
Development of a community of inquiry in online and blended learning contexts
AbstractThis paper discusses findings of a mixed method research project with the goal to study the development of a community of inquiry in online and blended learning environments. A graduate course delivered online and blended format was the focus of the study. Data was gathered from the Community of Inquiry Survey and transcript analysis of online discussions to explore the developmental differences on each presence (social, teaching and cognitive). The results showed: significant differences on social and cognitive presence between two course formats and higher perceptions of the presences in blended course
Social presence in the 21st Century: an adjustment to the Community of Inquiry framework
The Community of Inquiry framework, originally proposed by Garrison, Anderson and Archer (2000) identifies teaching, social and cognitive presences as central to a successful online educational experience. This article presents the findings of a study conducted in Uruguay between 2007 and 2010. The research aimed to establish the role of cognitive, social and teaching presences in the professional development of 40 English language teachers on Continuous Professional Development (CPD) programmes delivered in blended learning settings. The findings suggest that teaching presence and cognitive presence have themselves 'become social'. The research points to social presence as a major lever for engagement, sense-making and peer support. Based on the patterns identified in the study, this article puts forward an adjustment to the Community of Inquiry framework, which shows social presence as more prominent within the teaching and cognitive constructs than the original version of the framework suggests
M-Horizons
We solve the Killing spinor equations and determine the near horizon
geometries of M-theory that preserve at least one supersymmetry. The M-horizon
spatial sections are 9-dimensional manifolds with a Spin(7) structure
restricted by geometric constraints which we give explicitly. We also provide
an alternative characterization of the solutions of the Killing spinor
equation, utilizing the compactness of the horizon section and the field
equations, by proving a Lichnerowicz type of theorem which implies that the
zero modes of a Dirac operator coupled to 4-form fluxes are Killing spinors. We
use this, and the maximum principle, to solve the field equations of the theory
for some special cases and present some examples.Comment: 36 pages, latex. Reference added, minor typos correcte
ACOX2 deficiency: A disorder of bile acid synthesis with transaminase elevation, liver fibrosis, ataxia, and cognitive impairment
Acyl CoA Oxidase 2 (ACOX2) encodes branched-chain acyl-CoA oxidase, a peroxisomal enzyme believed to be involved in the metabolism of branched-chain fatty acids and bile acid intermediates. Deficiency of this enzyme has not been described previously. We report an 8-y-old male with intermittently elevated transaminase levels, liver fibrosis, mild ataxia, and cognitive impairment. Exome sequencing revealed a previously unidentified homozygous premature termination mutation (p.Y69*) in ACOX2 Immunohistochemistry confirmed the absence of ACOX2 expression in the patient's liver, and biochemical analysis showed marked elevation of intermediate bile acids upstream of ACOX2. These findings define a potentially treatable inborn error of bile acid biosynthesis caused by ACOX2 deficiency
Overcoming cross-cultural group work tensions: mixed student perspectives on the role of social relationships
As universities worldwide rapidly internationalise, higher education classrooms have become unique spaces for collaboration between students from different countries. One common way to encourage collaboration between diverse peers is through group work. However, previous research has highlighted that cross-cultural group work can be challenging and has hinted at potential social tensions. To understand this notion better, we have used robust quantitative tools in this study to select 20 participants from a larger classroom of 860 students to take part in an in-depth qualitative interview about cross-cultural group work experiences. Participant views on social tensions in cross-cultural group work were elicited using a unique mediating artefact method to encourage reflection and in-depth discussion. In our analysis of emergent interview themes, we compared student perspectives on the role of social relationships in group work by their academic performance level. Our findings indicated that all students interviewed desired the opportunity to form social relationships with their group work members, but their motivations for doing so varied widely by academic performance level
Four-dimensional hierarchical structure of love constructs in a cross-cultural perspective
This article reports new methodology for cross-cultural exploration of psychometric properties of a four-dimensional hierarchical love scale. We collected data from 2831 participants from nine regional locations from six countries and assessed their responses to the love scale as well as several other love feelings. We applied a new methodological approach using recently advanced statistical methods to the comparison of forty love attitudes underscoring four distinct latent attitudes associated with love to another person in romantic relationships across these samples. The results demonstrate the importance of measurement invariance tests for cross-cultural comparison of scores on love scales. To properly assess measurement invariance, we suggest five statistical procedures, which we investigated in this study: (1) making corrections for acquiescence and extreme response biases; (2) taking into consideration cultural uniqueness in how participants respond to the measures, which may contribute to poor model fit; (3) accounting for such cultural uniqueness to make cross-cultural comparisons more valid; (4) removing items, which substantially contribute to poor model fit; and (5) shortening the subscales when scoring and analyzing the data. The results of the studies propose two shortened versions (33 and 30 items) of the love scale as two cross-culturally valid and invariant alternatives to the original 40-item scale
Spinorial geometry and Killing spinor equations of 6-D supergravity
We solve the Killing spinor equations of 6-dimensional (1,0)-supergravity
coupled to any number of tensor, vector and scalar multiplets in all cases. The
isotropy groups of Killing spinors are Sp(1)\cdot Sp(1)\ltimes \bH (1),
U(1)\cdot Sp(1)\ltimes \bH (2), Sp(1)\ltimes \bH (3,4), , and , where in parenthesis is the number of supersymmetries
preserved in each case. If the isotropy group is non-compact, the spacetime
admits a parallel null 1-form with respect to a connection with torsion the
3-form field strength of the gravitational multiplet. The associated vector
field is Killing and the 3-form is determined in terms of the geometry of
spacetime. The Sp(1)\ltimes \bH case admits a descendant solution preserving
3 out of 4 supersymmetries due to the hyperini Killing spinor equation. If the
isotropy group is compact, the spacetime admits a natural frame constructed
from 1-form spinor bi-linears. In the and U(1) cases, the spacetime
admits 3 and 4 parallel 1-forms with respect to the connection with torsion,
respectively. The associated vector fields are Killing and under some
additional restrictions the spacetime is a principal bundle with fibre a
Lorentzian Lie group. The conditions imposed by the Killing spinor equations on
all other fields are also determined.Comment: 34 pages, Minor change
Polarity in GaN and ZnO: Theory, measurement, growth, and devices
This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Appl. Phys. Rev. 3, 041303 (2016) and may be found at https://doi.org/10.1063/1.4963919.The polar nature of the wurtzite crystalline structure of GaN and ZnO results in the existence of a spontaneous electric polarization within these materials and their associated alloys (Ga,Al,In)N and (Zn,Mg,Cd)O. The polarity has also important consequences on the stability of the different crystallographic surfaces, and this becomes especially important when considering epitaxial growth. Furthermore, the internal polarization fields may adversely affect the properties of optoelectronic devices but is also used as a potential advantage for advanced electronic devices. In this article, polarity-related issues in GaN and ZnO are reviewed, going from theoretical considerations to electronic and optoelectronic devices, through thin film, and nanostructure growth. The necessary theoretical background is first introduced and the stability of the cation and anion polarity surfaces is discussed. For assessing the polarity, one has to make use of specific characterization methods, which are described in detail. Subsequently, the nucleation and growth mechanisms of thin films and nanostructures, including nanowires, are presented, reviewing the specific growth conditions that allow controlling the polarity of such objects. Eventually, the demonstrated and/or expected effects of polarity on the properties and performances of optoelectronic and electronic devices are reported. The present review is intended to yield an in-depth view of some of the hot topics related to polarity in GaN and ZnO, a fast growing subject over the last decade
An improved constraint satisfaction adaptive neural network for job-shop scheduling
Copyright @ Springer Science + Business Media, LLC 2009This paper presents an improved constraint satisfaction adaptive neural network for job-shop scheduling problems. The neural network is constructed based on the constraint conditions of a job-shop scheduling problem. Its structure and neuron connections can change adaptively according to the real-time constraint satisfaction situations that arise during the solving process. Several heuristics are also integrated within the neural network to enhance its convergence, accelerate its convergence, and improve the quality of the solutions produced. An experimental study based on a set of benchmark job-shop scheduling problems shows that the improved constraint satisfaction adaptive neural network outperforms the original constraint satisfaction adaptive neural network in terms of computational time and the quality of schedules it produces. The neural network approach is also experimentally validated to outperform three classical heuristic algorithms that are widely used as the basis of many state-of-the-art scheduling systems. Hence, it may also be used to construct advanced job-shop scheduling systems.This work was supported in part by the Engineering and Physical Sciences Research Council (EPSRC) of UK under Grant EP/E060722/01 and in part by the National Nature Science Fundation of China under Grant 60821063 and National Basic Research Program of China under Grant 2009CB320601
Recommendations for the management of MPS IVA: systematic evidence- and consensus-based guidance.
IntroductionMucopolysaccharidosis (MPS) IVA or Morquio A syndrome is an autosomal recessive lysosomal storage disorder (LSD) caused by deficiency of the N-acetylgalactosamine-6-sulfatase (GALNS) enzyme, which impairs lysosomal degradation of keratan sulphate and chondroitin-6-sulphate. The multiple clinical manifestations of MPS IVA present numerous challenges for management and necessitate the need for individualised treatment. Although treatment guidelines are available, the methodology used to develop this guidance has come under increased scrutiny. This programme was conducted to provide evidence-based, expert-agreed recommendations to optimise management of MPS IVA.MethodsTwenty six international healthcare professionals across multiple disciplines, with expertise in managing MPS IVA, and three patient advocates formed the Steering Committee (SC) and contributed to the development of this guidance. Representatives from six Patient Advocacy Groups (PAGs) were interviewed to gain insights on patient perspectives. A modified-Delphi methodology was used to demonstrate consensus among a wider group of healthcare professionals with experience managing patients with MPS IVA and the manuscript was evaluated against the validated Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument by three independent reviewers.ResultsA total of 87 guidance statements were developed covering five domains: (1) general management principles; (2) recommended routine monitoring and assessments; (3) disease-modifying interventions (enzyme replacement therapy [ERT] and haematopoietic stem cell transplantation [HSCT]); (4) interventions to support respiratory and sleep disorders; (5) anaesthetics and surgical interventions (including spinal, limb, ophthalmic, cardio-thoracic and ear-nose-throat [ENT] surgeries). Consensus was reached on all statements after two rounds of voting. The overall guideline AGREE II assessment score obtained for the development of the guidance was 5.3/7 (where 1 represents the lowest quality and 7 represents the highest quality of guidance).ConclusionThis manuscript provides evidence- and consensus-based recommendations for the management of patients with MPS IVA and is for use by healthcare professionals that manage the holistic care of patients with the intention to improve clinical- and patient-reported outcomes and enhance patient quality of life. It is recognised that the guidance provided represents a point in time and further research is required to address current knowledge and evidence gaps
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