Influencia del sistema de evaluación continua en el rendimiento de los alumnos

Desde la implantación del Espacio Europeo de Educación Superior (EEES) en la Universidad española, los esfuerzos en cuanto al diseño e implantación de nuevas metodologías de enseñanza, aprendizaje, y evaluación han sido constantes. Uno de los pilares de este nuevo modelo es la evaluación continua del alumnado. Sin embargo, dada la actual coyuntura, los sistemas diseñados inicialmente han tenido que adaptarse a las condiciones del aula, manteniendo el espíritu inicial. El propósito principal de este trabajo es mostrar los resultados de la adaptación de la metodología docente y el sistema de evaluación, en el marco de una asignatura que requiere un elevado nivel de abstracción y que por lo general resulta, a priori, poco atractiva para el perfil del alumnado de titulaciones informáticas. Este estudio se ha realizado sobre la asignatura Computabilidad a lo largo de tres cursos académicos. Durante cada uno de ellos la metodología docente y el sistema de evaluación se han ido adaptando progresivamente a las necesidades y particularidades de la asignatura y del alumno, logrando mejorar los resultados e incrementar las tasas de Rendimiento, Éxito y Expectativa. También se han estudiado las posibles diferencias en cuanto a estas tasas del curso con docencia en español frente a su equivalente con docencia en inglés.SUMMARY -- During the last years Spanish higher education is involved in the European Higher Education Area (EHEA) which requires new teaching, learning and evaluation methods. One of the keypoint in this new context is the continuous assessment. However, systems designed in advance have been adapted to the current classroom conditions, trying to keep the original spirit. The goal of this paper is the adaptation of the teaching methodology and evaluation system in the context of a course that requires a high level of abstraction and that usually is, a priori, unattractive for the profile of students from computer grades. This study has been conducted on the course computability over three academic years. During each one, teaching methodology and evaluation system have gradually adapted to the needs and characteristics of the course and student, achieving better results and increasing rates of Output, Success and Expectation. In addition, we have also studied the possible differences in these rates with teaching the course in Spanish versus equivalent teaching in English

Influencia del sistema de evaluación continua en el rendimiento de los alumnos

Desde la implantación del Espacio Europeo de Educación Superior (EEES) en la Universidad española, los esfuerzos en cuanto al diseño e implantación de nuevas metodologías de enseñanza, aprendizaje, y evaluación han sido constantes. Uno de los pilares de este nuevo modelo es la evaluación continua del alumnado. Sin embargo, dada la actual coyuntura, los sistemas diseñados inicialmente han tenido que adaptarse a las condiciones del aula, manteniendo el espíritu inicial. El propósito principal de este trabajo es mostrar los resultados de la adaptación de la metodología docente y el sistema de evaluación, en el marco de una asignatura que requiere un elevado nivel de abstracción y que por lo general resulta, a priori, poco atractiva para el perfil del alumnado de titulaciones informáticas. Este estudio se ha realizado sobre la asignatura Computabilidad a lo largo de tres cursos académicos. Durante cada uno de ellos la metodología docente y el sistema de evaluación se han ido adaptando progresivamente a las necesidades y particularidades de la asignatura y del alumno, logrando mejorar los resultados e incrementar las tasas de Rendimiento, Éxito y Expectativa. También se han estudiado las posibles diferencias en cuanto a estas tasas del curso con docencia en español frente a su equivalente con docencia en inglés.During the last years Spanish higher education is involved in the European Higher Education Area (EHEA) which requires new teaching, learning and evaluation methods. One of the keypoint in this new context is the continuous assessment. However, systems designed in advance have been adapted to the current classroom conditions, trying to keep the original spirit. The goal of this paper is the adaptation of the teaching methodology and evaluation system in the context of a course that requires a high level of abstraction and that usually is, a priori, unattractive for the profile of students from computer grades. This study has been conducted on the course computability over three academic years. During each one, teaching methodology and evaluation system have gradually adapted to the needs and characteristics of the course and student, achieving better results and increasing rates of Output, Success and Expectation. In addition, we have also studied the possible differences in these rates with teaching the course in Spanish versus equivalent teaching in English

Intra-seasonal rainfall variability and herbivory affect the interaction outcome of two dryland plant species

Increases in drought frequency in combination with overgrazing may result in degradation of (semi-) arid ecosystems. Facilitative interactions between plants are a key mechanism in preventing degradation, but it is poorly understood how they respond to increased stress by combined drought and herbivory. In this study, we used an ecohydrological model, to simulate the plant growth of two plant species interacting with each other under different rainfall and herbivory pressure scenarios. The functional traits of the two modeled plants were based on a prior field experiment in southeastern Spain, in which an unpalatable “nurse” species protected a palatable protégé’ species from herbivory. Moreover, the nurse species was more drought-resistant; that is, it had a lower wilting point, whereas the protégé species had a higher optimal growth rate. Firstly, we investigated the coexistence of the two plant species growing under a single limiting resource, focusing on the effect of intra-seasonal rainfall variability. We found that longer periods without rainfall within the wet season resulted in stable coexistence, whereas nearly constant rainfall led to competitive exclusion of the protégé by the nurse species. Secondly, we investigated how plant interactions varied along our studied gradients. Using the neighbor effect intensity and importance indices, we found that competitive effects increased with more constant rainfall. Moreover, higher herbivory rates resulted in increased facilitative effects of the nurse on the protégé species, but facilitative effects could only prevail over competitive effects under currently observed or higher intra-seasonal rainfall variability. This study highlights the relevance of intra-seasonal rainfall variability in explaining coexistence of species in dryland ecosystems and shows that increasing intra-seasonal rainfall variability or herbivory pressure can result in more facilitative effects from a nurse species. This information is crucial to obtain a better insight into the long-term coexistence of species, and the resulting stability of dryland ecosystems in response to future climate change

Chronic lymphocytic leukemia patients with IGH translocations are characterized by a distinct genetic landscape with prognostic implications

Chromosome 14q32 rearrangements/translocations involving the immunoglobulin heavy chain (IGH) are rarely detected in chronic lymphocytic leukemia (CLL). The prognostic significance of the IGH translocation is controversial and its mutational profile remains unknown. Here, we present for the first time a comprehensive next-generation sequencing (NGS) analysis of 46 CLL patients with IGH rearrangement (IGHR-CLLs) and we demonstrate that IGHR-CLLs have a distinct mutational profile with recurrent mutations in NOTCH1, IGLL5, POT1, BCL2, FBXW7, ZMYM3, MGA, BRAF and HIST1H1E genes. Interestingly, BCL2 and FBXW7 mutations were significantly associated with this subgroup and almost half of BCL2, IGLL5 and HISTH1E mutations reported were previously identified in non-Hodgkin lymphomas. Notably, IGH/BCL2 rearrangements were associated with a lower mutation frequency and carried BCL2 and IGLL5 mutations, while the other IGHR-CLLs had mutations in genes related to poor prognosis (NOTCH1, SF3B1 and TP53) and shorter time to first treatment (TFT). Moreover, IGHR-CLLs patients showed a shorter TFT than CLL patients carrying 13q-, normal fluorescence in situ hybridization (FISH) and +12 CLL, being this prognosis particularly poor when NOTCH1, SF3B1, TP53, BIRC3 and BRAF were also mutated. The presence of these mutations not only was an independent risk factor within IGHR-CLLs, but also refined the prognosis of low-risk cytogenetic patients (13q-/normal FISH). Hence, our study demonstrates that IGHR-CLLs have a distinct mutational profile from the majority of CLLs and highlights the relevance of incorporating NGS and the status of IGH by FISH analysis to refine the risk-stratification CLL model

Reflexiones universitarias. San Pedro Valencia: renovación urbana, saneamiento ambiental y emprendimientos turísticos. Otoño 2015

Los trabajos que aquí se presentan se elaboraron por las y los estudiantes como parte de las actividades del Proyecto de Aplicación Profesional (PAP) “San Pedro Valencia: renovación urbana, saneamiento ambiental y emprendimientos turísticos”, durante el periodo de Otoño de 2015. A lo largo del periodo los autores compartieron sus reflexiones en torno a su percepción sobre el contexto en el que actúa el PAP; sobre las alternativas posibles a la problemática detectada y lo que significa pensar una alternativa; sobre los sujetos con los que se ha interactuado a lo largo de la experiencia de trabajo y sobre el papel del profesionista y del ciudadano en un mundo como el que nos tocó vivir. La obra está compuesta por reflexiones personales de las y los estudiantes que, explorando estas temáticas, comparten sus aprendizajes y observaciones de forma vívida.ITESO, A.C

The expression level of BAALC -associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia

Acute myeloid leukemia (AML) is a heterogeneous disease whose prognosis is mainly related to the biological risk conferred by cytogenetics and molecular profiling. In elderly patients (⩾60 years) with normal karyotype AML miR-3151 have been identified as a prognostic factor. However, miR-3151 prognostic value has not been examined in younger AML patients. In the present work, we have studied miR-3151 alone and in combination with BAALC, its host gene, in a cohort of 181 younger intermediate-risk AML (IR-AML) patients. Patients with higher expression of miR-3151 had shorter overall survival (P =0.0025), shorter leukemia-free survival (P =0.026) and higher cumulative incidence of relapse (P =0.082). Moreover, in the multivariate analysis miR-3151 emerged as independent prognostic marker in both the overall series and within the unfavorable molecular prognostic category. Interestingly, the combined determination of both miR-3151 and BAALC improved this prognostic stratification, with patients with low levels of both parameters showing a better outcome compared with those patients harboring increased levels of one or both markers (P =0.003). In addition, we studied the microRNA expression profile associated with miR-3151 identifying a six-microRNA signature. In conclusion, the analysis of miR-3151 and BAALC expression may well contribute to an improved prognostic stratification of younger patients with IR-AML

Efficacy of a strategy for implementing a guideline for the control of cardiovascular risk in a primary healthcare setting: the SIRVA2 study a controlled, blinded community intervention trial randomised by clusters

This work describes the methodology used to assess a strategy for implementing clinical practice guidelines (CPG) for cardiovascular risk control in a health area of Madrid

Ruxolitinib in refractory acute and chronic graft-versus-host disease : a multicenter survey study

Graft-versus-host disease is the main cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. First-line treatment is based on the use of high doses of corticosteroids. Unfortunately, second-line treatment for both acute and chronic graft-versus-host disease, remains a challenge. Ruxolitinib has been shown as an effective and safe treatment option for these patients. Seventy-nine patients received ruxolitinib and were evaluated in this retrospective and multicenter study. Twenty-three patients received ruxolitinib for refractory acute graft-versus-host disease after a median of 3 (range 1-5) previous lines of therapy. Overall response rate was 69.5% (16/23) which was obtained after a median of 2 weeks of treatment, and 21.7% (5/23) reached complete remission. Fifty-six patients were evaluated for refractory chronic graft-versus-host disease. The median number of previous lines of therapy was 3 (range 1-10). Overall response rate was 57.1% (32/56) with 3.5% (2/56) obtaining complete remission after a median of 4 weeks. Tapering of corticosteroids was possible in both acute (17/23, 73%) and chronic graft-versus-host disease (32/56, 57.1%) groups. Overall survival was 47% (CI: 23-67%) at 6 months for patients with aGVHD (62 vs 28% in responders vs non-responders) and 81% (CI: 63-89%) at 1 year for patients with cGVHD (83 vs 76% in responders vs non-responders). Ruxolitinib in the real life setting is an effective and safe treatment option for GVHD, with an ORR of 69.5% and 57.1% for refractory acute and chronic graft-versus-host disease, respectively, in heavily pretreated patients