Modelo de calidad para la evaluación de herramientas case. Adaptado al estándar internacional ISO/IEC 14102. Caso de estudio

A main objective of software engineering is to produce high quality software, in this report we applied a quality model that is one of the most delicate fields in systems development such as CASE tools, as we know CASE tools are a software product used to support almost all a activities involved in the analysis, design and software construction. A description of quality model allows the evaluation and selection of CASE tools; this model used as main resources Rojas and Pérez Technological Indicators and ISO/IEC 14102 standars, in addition we detailed results of the application to a studied case.Uno de los principales objetivos de la Ingeniería del Software es producir software de calidad, en este trabajo se aplica un Modelo de Calidad en uno de los campos más delicados para el desarrollo de Sistemas como lo son las herramientas CASE, partiendo del hecho de que las herramientas CASE son un producto de software utilizado para soportar todas o casi todas las actividades involucradas en el análisis, diseño y construcción de software. Aquí se describe la concepción del Modelo de Calidad que permite evaluar y seleccionar las herramientas CASE; este modelo utilizó como recursos principales los Indicadores Tecnológicos propuestos por Rojas y Pérez y el Estándar ISO/IEC 14102. Además se detallan los resultados que arrojó la aplicación del mismo a un caso de estudio

Senescence-associated proteolysis induced by abiotic and biotic stresses in barley leaves

Leaf senescence is a recycling process characterized by a massive degradation of macromolecules to relocalize nutrients from leaves to growing or storage tissues. Our aim is to identify and analyze the C1A Cysteine ‐Protease (CysProt) family members from barley (35 cathepsin L‐,3B‐,1Hand3F‐like) involved in leaf senescence, to study their modulation by their specific inhibitors (cystatins) and to determine their roles mediated by abiotic (darkness and N starvation) and biotic (pathogens and pest) stresses

Educación y pensamiento contemporáneo: práctica, experiencia y educación.

El libro emplea las nociones de experiencia y práctica como instrumentos filosóficos para la investigación en educación y pedagogía. Aunque se trata de conceptos que han sido retomados y elaborados desde los trabajos de Foucault, el trabajo conjunto adelantado al interior de la Red Riepco ha permitido continuar con la exploración de la potencia metodológica de los conceptos mediante el diálogo con otras perspectivas, autores e investigaciones. De este modo, se proponen lecturas cruzadas y diálogos con planteamientos como los de Gilles Deleuze, Judith Butler, Peter Sloterdijk, Giorgio Agamben, Jorge Larrosa, Boaventura de Sousa Santos, Roland Barthes, Michel de Certeau y el mismo Emil Cioran. Todo ello bajo la comprensión que investigar, pensar y hacer filosofía, se configuran como ejercicios para modelar y crear problemas, interrogantes y, por tanto, formas de mirar.The book uses notions of experience and practice as philosophical tools for researching in education and pedagogy. Although these concepts have been taken up and elaborated from Foucault’s work, the joint work carried out with RIEPCO has allowed the exploration of the methodological power of these concepts in order to dialogue with other perspectives, authors and research. In this way, cross readings and dialogues with approaches such as those of Gilles Deleuze, Judith Butler, Peter Sloterdijk, Giorgio Agamben, Jorge Larrosa, Boaventura de Sousa Santos, Roland Barthes, Michel de Certeau and Emil Cioran himself are proposed. All this under the understanding that researching, thinking and doing philosophy are configured as exercises to model and create problems and, therefore, ways of looking

Educación y pensamiento contemporáneo: práctica, experiencia y educación.

El libro emplea las nociones de experiencia y práctica como instrumentos filosóficos para la investigación en educación y pedagogía. Aunque se trata de conceptos que han sido retomados y elaborados desde los trabajos de Foucault, el trabajo conjunto adelantado al interior de la Red Riepco ha permitido continuar con la exploración de la potencia metodológica de los conceptos mediante el diálogo con otras perspectivas, autores e investigaciones. De este modo, se proponen lecturas cruzadas y diálogos con planteamientos como los de Gilles Deleuze, Judith Butler, Peter Sloterdijk, Giorgio Agamben, Jorge Larrosa, Boaventura de Sousa Santos, Roland Barthes, Michel de Certeau y el mismo Emil Cioran. Todo ello bajo la comprensión que investigar, pensar y hacer filosofía, se configuran como ejercicios para modelar y crear problemas, interrogantes y, por tanto, formas de mirar.The book uses notions of experience and practice as philosophical tools for researching in education and pedagogy. Although these concepts have been taken up and elaborated from Foucault’s work, the joint work carried out with RIEPCO has allowed the exploration of the methodological power of these concepts in order to dialogue with other perspectives, authors and research. In this way, cross readings and dialogues with approaches such as those of Gilles Deleuze, Judith Butler, Peter Sloterdijk, Giorgio Agamben, Jorge Larrosa, Boaventura de Sousa Santos, Roland Barthes, Michel de Certeau and Emil Cioran himself are proposed. All this under the understanding that researching, thinking and doing philosophy are configured as exercises to model and create problems and, therefore, ways of looking

Distinct epidemiology and resistance mechanisms affecting ceftolozane/tazobactam in Pseudomonas aeruginosa isolates recovered from ICU patients in Spain and Portugal depicted by WGS

STEP and SUPERIOR study groups.[Objectives] To analyse the epidemiology, the resistome and the virulome of ceftolozane/tazobactam-susceptible or -resistant Pseudomonas aeruginosa clinical isolates recovered from surveillance studies in Portugal (STEP, 2017–18) and Spain (SUPERIOR, 2016–17).[Methods] P. aeruginosa isolates were recovered from intra-abdominal, urinary tract and lower respiratory tract infections in ICU patients admitted to 11 Portuguese and 8 Spanish hospitals. MICs were determined (ISO-standard broth microdilution, EUCAST 2020 breakpoints). A subset of 28 ceftolozane/tazobactam-resistant P. aeruginosa isolates were analysed and compared with 28 ceftolozane/tazobactam-susceptible P. aeruginosa strains by WGS.[Results] Clonal complex (CC) 235 (27%) and CC175 (18%) were the most frequent, followed by CC244 (13%), CC348 (9%), CC253 (5%) and CC309 (5%). Inter-hospital clonal dissemination was observed, limited to a geographical region (CC235, CC244, CC348 and CC253 in Portugal and CC175 and CC309 in Spain). Carbapenemases were detected in 25 isolates (45%): GES-13 (13/25); VIM type (10/25) [VIM-2 (4/10), VIM-20 (3/10), VIM-1 (2/10) and VIM-36 (1/10)]; and KPC-3 (2/25). GES-13-CC235 (13/15) and VIM type-CC175 (5/10) associations were observed. Interestingly, KPC-3 and VIM-36 producers showed ceftolozane/tazobactam-susceptible phenotypes. However, ceftolozane/tazobactam resistance was significantly associated with GES-13 and VIM-type carbapenemase production. Six non-carbapenemase producers also displayed ceftolozane/tazobactam resistance, three of them showing known ceftolozane/tazobactam resistance-associated mutations in the PBP3 gene, ftsI (R504C and F533L). Overall, an extensive virulome was identified in all P. aeruginosa isolates, particularly in carbapenemase-producing strains.[Conclusions] GES-13-CC235 and VIM type-CC175 were the most frequent MDR/XDR P. aeruginosa clones causing infections in Portuguese and Spanish ICU patients, respectively. Ceftolozane/tazobactam resistance was mainly due to carbapenemase production, although mutations in PBP-encoding genes may additionally be involved.The study was funded by MSD Portugal (protocol VP6918) and MSD Spain (protocol MSD-CEF-2016-01). This study was also supported by Plan Nacional de I + D + i 2013–16 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economía, Industria y Competitividad, Spanish Network for Research in Infectious Diseases [RD16/0016/0001, RD16/0016/0004, RD16/0016/0006, RD16/0016/0007, RD16/0016/0010 and REIPI RD16/0016/0011], co-financed by the European Development Regional Fund ‘A way to achieve Europe’ (EDRF), Operative Program Intelligent Growth 2014–20. M.H.-G. is supported by a research contract from a European Project [IMI-JU-9–2013, Ref. iABC - 115721–2].Peer reviewe

UNIMINUTO: Cinco Años Cambiando Vidas en el Sur del país.

UNIMINUTO: Cinco años cambiando vidas en el sur del país, es construido de manera colectiva por la Corporación Universitaria Minuto de Dios a través del Centro Regional Neiva, sistematiza retos, limitaciones, fortalezas y la prospectiva de la Universidad en el siglo XXI desde los ejes de la docencia, la investigación y la proyección social. El texto contiene cuatro apartados y trece capítulos que dan cuenta de los procesos investigativos adelantados en el Centro Regional, aporta reflexiones en temas educativos, sociales, políticos, económicos y psicológicos . Este libro ofrece al lector la posibilidad de pensar los retos que presenta la Universidad en la formación de ciudadanos y ciudadanas acordes a las realidades contemporáneas, logrando un despliegue significativo de metodologías novedosas y pertinentes para el país y la región Surcolombiana

UNIMINUTO: Cinco Años Cambiando Vidas en el Sur del país.

UNIMINUTO: Cinco años cambiando vidas en el sur del país, es construido de manera colectiva por la Corporación Universitaria Minuto de Dios a través del Centro Regional Neiva, sistematiza retos, limitaciones, fortalezas y la prospectiva de la Universidad en el siglo XXI desde los ejes de la docencia, la investigación y la proyección social. El texto contiene cuatro apartados y trece capítulos que dan cuenta de los procesos investigativos adelantados en el Centro Regional, aporta reflexiones en temas educativos, sociales, políticos, económicos y psicológicos . Este libro ofrece al lector la posibilidad de pensar los retos que presenta la Universidad en la formación de ciudadanos y ciudadanas acordes a las realidades contemporáneas, logrando un despliegue significativo de metodologías novedosas y pertinentes para el país y la región Surcolombiana

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Investigación joven con perspectiva de género II

Actas del II Congreso de jóvenes investigadorxs con perspectiva de género (Getafe, 26 y 27 de junio de 2017) organizado por el Instituto Universitario de Estudios de Género de la Universidad Carlos III de Madrid

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio