Cavernous sinus metastasis from oropharyngeal squamous cell carcinoma

Metastasis to the cavernous sinus from head and neck cancer is uncommon and has been previously reported by a few authors. It is usually a late manifestation of the primary tumor and may be the first evidence of a widespread dissemination of the disease. Main clinical findings are those related with involvement of cranial nerves III to VI as they pass through the cavernous sinus. Although diagnosis may be difficult, the appearance of clinical and radiological findings of cavernous sinus involvement in a context of head and neck cancer must alert us about an intracranial metastatic infiltration. In most cases treatment is palliative with radiotherapy and/or chemotherapy. The prognosis of this entity is poor, with survival of a few months. We present the case of cavernous sinus metastasis from oropharyngeal squamous cell carcinoma and review the literature about the clinical presentation and management of this rare entity

Análisis de la solución sólida aragonito-estroncianita mediante espectroscopia vibracional (Infrarrojo y FT-Raman)

Depto. de Mineralogía y PetrologíaFac. de Ciencias GeológicasTRUEpu

An analysis of existing production frameworks for statistical and geographic information: Synergies, gaps and integration

The production of official statistical and geospatial data is often in the hands of highly specialized public agencies that have traditionally followed their own paths and established their own production frameworks. In this article, we present the main frameworks of these two areas and focus on the possibility and need to achieve a better integration between them through the interoperability of systems, processes, and data. The statistical area is well led and has well-defined frameworks. The geospatial area does not have clear leadership and the large number of standards establish a framework that is not always obvious. On the other hand, the lack of a general and common legal framework is also highlighted. Additionally, three examples are offered: the first is the application of the spatial data quality model to the case of statistical data, the second of the application of the statistical process model to the geospatial case, and the third is the use of linked geospatial and statistical data. These examples demonstrate the possibility of transferring experiences/advances from one area to another. In this way, we emphasize the conceptual proximity of these two areas, highlighting synergies, gaps, and potential integration. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

Mandibular odontogenic myxoma : reconstructive considerations by means of the vascularized fibular free flap

The odontogenic myxoma is a rare entity located in mandible and upper maxilla. Due to its local aggressiveness, wide surgical excision is mandatory. Several surgical techniques have been described for the reconstruction of segmental mandibular defects. In comparison with other free flaps, the vascularized free fibular flap (VFFF) supports the longest amount of bone and, due to the nature of the vascular supply a complete freedom in location of the osteotomy is present. A precise mandibular arc can be performed following bone resection. We suggest the performance of the ?in situ? VFFF technique in order to recreate mandibular contour by means of several osteotomies, while the pedicle is still attached to the leg. Substantial decrease in surgical time is obtained. With the ?double-barrel? technique and subsequent osseointegrated implants, good results are obtained in the reconstruction of dentate patients without maxillary atrophy. We present two new cases of large odontogenic mandibular myxoma. Wide surgical excision by means of hemimandibulectomies and subsequent reconstruction with VFFF were performed

Aportación al conocimiento del género Cheilanthes en la Península Ibérica

Cheilanthes pulchella and Cheilanthes x insularis are mentionedas new from the Iberian Peninsula and distribution of Cheilanthes guanchica and Cheilanthes x iberica is amplied. The Cheilanthes taxa from the Iberian Peninsuli are listed. Key of determination is proposed.En esta nota se citan por primera vez en la Península Ibérica Cheilanthes pulcheIla y Cheilanthes x insularis y se amplia la distribución de Cheilanthes guanchica y Cheilanthes x iberica. Se completa el catálogo de los táxones de este género en la Península Ibérica, añadiéndose una clave de determinación para los mismos

Expansion of different subpopulations of CD26 −/low T cells in allergic and non-allergic asthmatics

CD26 displays variable levels between effector (TH ≫ TH > TH > Treg) and naïve/memory (memory > naïve) CD4 T lymphocytes. Besides, IL-6/IL 6R is associated with TH -differentiation and asthma severity. Allergic/atopic asthma (AA) is dominated by TH responses, while TH immunity might either modulate the TH -dependent inflammation in AA or be an important mechanism boosting non-allergic asthma (NAA). Therefore, in this work we have compared the expression of CD26 and CD126 (IL-6Rα) in lymphocytes from different groups of donors: allergic (AA) and non-allergic (NAA) asthma, rhinitis, and healthy subjects. For this purpose, flow cytometry, haematological/biochemical, and in vitro proliferation assays were performed. Our results show a strong CD26-CD126 correlation and an over-representation of CD26 subsets with a highly-differentiated effector phenotype in AA (CD4 CD26 T cells) and NAA (CD4 CD26 γδ-T cells). In addition, we found that circulating levels of CD26 (sCD26) were reduced in both AA and NAA, while loss of CD126 expression on different leukocytes correlated with higher disease severity. Finally, selective inhibition of CD26-mRNA translation led to enhanced T cell proliferation in vitro. These findings support that CD26 down-modulation could play a role in facilitating the expansion of highly-differentiated effector T cell subsets in asthma

Geological engineering problems associated with tunnel construction in karst rockmasses: The case of Gavarres tunnel (Spain)

A representative example of the problems associatedwith the excavation and support of tunnels in karst ground is presented. It is a peculiar case in terms of heterogeneity and spatial distribution of zones of poor geotechnical quality, requiring the need to define, preferably in the study phases, adequate site investigation, suitable design procedures, efficient construction techniques and appropriate ground treatment. The difficulties associatedwith the instability of the karstified ground, and the presence of cavities, wholly or partially filled with soils of low cohesion, are discussed via retrospective analysis. The solutions adopted to solve the problems encountered during the tunnel construction enabled a systematic approach, useful for newconstruction projects in limestone terrains of medium to high karstification.Alija, S.; Torrijo Echarri, FJ.; Quinta Ferreira, M. (2013). Geological engineering problems associated with tunnel construction in karst rockmasses: The case of Gavarres tunnel (Spain). Engineering Geology. 157:103-111. doi:10.1016/j.enggeo.2013.02.010S10311115

Submarine deltaic geometries linked to steep, mountainous drainage basins in the northern shelf of the Alboran Sea: Filling the gaps in the spectrum of deltaic deposition

A comprehensive analysis of small deltaic environments linked to short, mountainous, and seasonal fluvial systems in the northern shelf of the Alboran Sea was undertaken in order to define the controlling parameters of the geomorphological variability. The database includes multibeam and backscatter imagery, surficial sediment samples, and high-resolution seismic profiles. Additionally, geomorphological and hydrodynamic modeling and statistical analysis (principal component and cluster analysis) of hydrological and physiographic variables were performed.Most of the studied deltaic systems have high-gradient, coarse-grained deposits with preferential development of the submarine portions to the detriment of the deltaic plains. The geomorphological analysis identified three basic types of plan-viewdistributions according to the length-to-width ratios: elongate, linguoid and lobate. Cross-slope profiles evidence dominant concave-upward geometries, fewer occurrences of planar geometries, and no sigmoid profiles. Sediment depocenters are extremely thick in proximal locations, but thin out rapidly seawards. The geometric distribution patterns of the deltaic systems are characterized by a predictable pattern in plan-view according to the type of fluvial system, ranging from a relatively large river to ephemeral creeks. Prevailing concave and secondary planar profiles support strong sediment progradation in the submarine realmand lowsediment retention in the emerged deltaic environment. Two different types of systems are distinguished: (1) larger rivers,where deltaic deposition is largely controlled by basin dimensions, ultimately dictating themagnitude of water and sediment discharges; and (2) smaller rivers and creeks,where deltaic geometries are related to the basin slopes. The influence of hydrodynamic variables on defining the submarine deltaic geometry has been observed in the case of concave-upward geometries, where geomorphological boundaries are defined by medium- and high-energy wave conditions.Versión del editor2,520