Accurate and Efficient Design of Double Post Substrate Integrated Waveguide Filters Using Simulators Based on Open Space Modal Expansions

© 2012 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.An Agressive Space Mapping (ASM) strategy for efficiently and accurately designing passive filters in substrate integrated waveguide (SIW) technology is presented and successfully validated for the double post topology. Full-wave simulators based on open space modal expansions are used in both the coarse and fine models of this strategy.Díaz Caballero, E.; Morro, JV.; Esteban González, H.; Boria Esbert, VE.; Belenguer Martínez, Á. (2012). Accurate and Efficient Design of Double Post Substrate Integrated Waveguide Filters Using Simulators Based on Open Space Modal Expansions. IEEE. doi:10.1109/APS.2012.6348982

Health literacy of patients on oral anticoagulation treatment- individual and social determinants and effect on health and treatment outcomes

Background Assessment health literacy in people with cardiovascular health problems would facilitate the development of appropriate health strategies for the care and reduction of complications associated with oral anticoagulation therapy. Aim: To evaluate the relationship between health literacy and health and treatment outcomes (concordance with oral anticoagulants, Normalized Ratio control and occurrence of complications) in patients with cardiovascular pathology. Methods Observational, analytic and cross-sectional study carried out on 252 patients with cardiovascular pathology (atrial fibrillation, flutter or valve prosthesis), aged 50-85 years, accessing primary care services in Valencia (Spain) in 2018-2019. Variables referring to anticoagulant treatment with vitamin K antagonists (years of treatment, adequate control, polypharmacy and occurrence of complications, among others) and health literacy (Health Literacy Questionnaire) were analysed. Results All dimensions of health literacy were significantly related to the level of education (p < 0.02), social class (p < 0.02), an adequate control of acenocoumarol (p < 0.001), frequentation of health services (p < 0.001), information by patients to health professionals about anticoagulant treatment (p < 0.03), emergency care visits (p < 0.001) and unscheduled hospital admissions (p < 0.001). Conclusion Health literacy has a relevant influence on the adequate self-management of anticoagulation treatment and the frequency of complications. The different dimensions that comprise health literacy play an important role, but the 'social health support' dimension seems to be essential for such optimal self-management. Trial registration ACC-ACE-2016-01. Registration date: December 2015

El uso de monteas en los talleres catedralicios: el caso murciano

Es bien conocido el empleo de trazados a tamaño natural, denominados monteas, como paso previo a la ejecución de construcciones pétreas. Los autores argumentan que estas monteas aportan datos acerca de las técnicas de cantería que no facilitan ni las propias piezas, ni los tratados y manuscritos, incluso los más cercanos a la práctica constructiva. En concreto, examinan dos monteas renacentistas en la catedral de Murcia: una de ellas hallada en 1999 bajo el altar de la recapilla de Junterón y otra recientemente aparecida en los muros de la sacristía catedralicia al desmontar la cajonería quinientista. Tras comparar ambas monteas con las piezas de cantería correspondientes, los autores analizan en qué medida ambas monteas se separan de los métodos estereotómicos propuestos por la literatura hispánica de la cantería.The use of full-scale tracings as a preliminary step in stone construction is well known. The authors assert that those tracings furnish a number of valuable data about stonecutting techniques that cannot be obtained from actual members, treatises or manuscripts, even those closest to building practice. In particular, the article deals with two tracings in Murcia cathedral: the first one was found in 1999 under the altar of the inner chamber or recapilla of the funerary chapel of Gil Rodríguez de Junterón, while the second one has appeared recently behind the vestry drawers. The authors compare both tracings with the members built using them, explaining how the tracings depart from standard construction methods, in particular those described in Spanish stereotomic literature

Uso de FAO-56 y cintilómetro para estimar la evapotranspiración de sorgo (Sorghum bicolor L.) y sus componentes: evaporación del suelo y transpiración de la planta

Estimar la evapotranspiración de los cultivos (ETc) es esencial para la planificación y manejo del agua en una zona agrícola, particularmente en las regiones áridas y semiáridas; la separación de ETc en la evaporación del suelo (E) y la transpiración de la planta (T) permitiría el uso de estrategias más eficientes de gestión del agua. Los objetivos del presente estudio fueron estimar la evapotranspiración diaria de sorgo (Sorghum bicolor L.) y sus componentes, utilizando los métodos FAO-56 con la aproximación del coeficiente dual de cultivo (Kc dual) y cintilómetro, así como, determinar los coeficientes de cultivo únicos (Kc) y basales (Kcb) para las diferentes etapas de desarrollo de sorgo. Los resultados demostraron que usar la aproximación del Kc dual permite una estimación razonable de ETc en comparación con los valores estimados utilizando el método del cintilómetro. La ETc estimada con ambos métodos fue 413.8 y 406.3 mm, respectivamente, lo que arrojó una sobreestimación del 1.8% para FAO-56. El error cuadrático medio (RMSE) entre ETc estimada fue 0.584 mm d-1 y el coeficiente de concordancia de Willmott (d) fue 0.91. La evaporación representa el 17.1% de ETc estimada con FAO-56 y el 21.6% con el método del cintilómetro; el RMSE entre los valores de E estimados con ambos métodos fue 0.397 mm d-1 y d = 0.94, mientras que, cuando se comparó T, el RMSE calculado fue 0.371 mm d-1 y d = 0.98. Los valores de Kc estimados con el método FAO-56 fueron 0.68, 1.06 y 0.4 para las etapas inicial, media y f inal del cultivo, mientras que con el cintilómetro los valores fueron 0.75, 0.94 y 0.41, respectivamente

Marco legislativo y bases metodológicas para la elaboración del Catálogo de Elementos Geológicos y Geomorfológicos de Interés Especial de Castilla-La Mancha

La Comunidad Autónoma de Castilla-La Mancha ha llevado a cabo a lo largo de las dos últimas décadas importantes iniciativas de geoconservación amparadas en la Ley 9/1999 de Conservación de la Naturaleza de Castilla-La Mancha. Entre los diferentes mecanismos que establece dicha Ley, el Catálogo de Elementos Geológicos y Geomorfológicos de Interés Especial constituyó un novedoso enfoque en materia de conservación del patrimonio geológico. El objetivo final de dicho Catálogo es constituir una herramienta que permita gestionar con eficacia el patrimonio geológico en los procesos de planificación territorial. Esta comunicación pretende dar a conocer la metodología utilizada para el desarrollo de dicho Catálogo y analizar el enfoque empleado en el diseño de la base de datos geográfica tanto en relación con su marco legislativo y teórico como en sus aspectos más técnicos de identificación y valoración de los elementos.Instituto Geológico y Minero de España, Españ

Efficient and Accurate Design of Passive Devices in Substrate Integrated Waveguide Technology and their Tapered Transitions from Microstrip Lines

[EN] In this paper, a strategy for the efficient design of passive devices in substrate integrated waveguide (SIW) technology is presented and validated with the analysis of several devices and the real design of filters in different topologies. In addition, a procedure for accurately designing tapered microstrip-to-substrate integrated waveguide transitions is described.Díaz Caballero, E.; Miralles, E.; Esteban González, H.; Belenguer Martínez, Á.; Boria Esbert, VE.; Bachiller Martin, MC.; Morro Ros, JV.... (2011). Efficient and Accurate Design of Passive Devices in Substrate Integrated Waveguide Technology and their Tapered Transitions from Microstrip Lines. Waves. 3:76-85. http://hdl.handle.net/10251/55349S7685

Identification of factors associated with diagnostic error in primary care

Background Missed, delayed or incorrect diagnoses are considered to be diagnostic errors. The aim of this paper is to describe the methodology of a study to analyse cognitive aspects of the process by which primary care (PC) physicians diagnose dyspnoea. It examines the possible links between the use of heuristics, suboptimal cognitive acts and diagnostic errors, using Reason’s taxonomy of human error (slips, lapses, mistakes and violations). The influence of situational factors (professional experience, perceived overwork and fatigue) is also analysed.Methods Cohort study of new episodes of dyspnoea in patients receiving care from family physicians and residents at PC centres in Granada (Spain). With an initial expected diagnostic error rate of 20%, and a sampling error of 3%, 384 episodes of dyspnoea are calculated to be required. In addition to filling out the electronic medical record of the patients attended, each physician fills out 2 specially designed questionnaires about the diagnostic process performed in each case of dyspnoea. The first questionnaire includes questions on the physician’s initial diagnostic impression, the 3 most likely diagnoses (in order of likelihood), and the diagnosis reached after the initial medical history and physical examination. It also includes items on the physicians’ perceived overwork and fatigue during patient care. The second questionnaire records the confirmed diagnosis once it is reached. The complete diagnostic process is peer-reviewed to identify and classify the diagnostic errors. The possible use of heuristics of representativeness, availability, and anchoring and adjustment in each diagnostic process is also analysed. Each audit is reviewed with the physician responsible for the diagnostic process. Finally, logistic regression models are used to determine if there are differences in the diagnostic error variables based on the heuristics identified.Discussion This work sets out a new approach to studying the diagnostic decision-making process in PC, taking advantage of new technologies which allow immediate recording of the decision-making process.The authors gratefully acknowledge funding of this research from the Spanish Research Agency. Ministry of Health (Fondo de Investigaciones Sanitarias) FIS PI10/01468 and the European Regional Development Fund (ERDF)

VE-Cadherin modulates ß-catenin/TCF-4 to enhance Vasculogenic Mimicry

Vasculogenic Mimicry (VM) refers to the capacity to form a blood network from aggressive cancer cells in an independent way of endothelial cells, to provide nutrients and oxygen leading to enhanced microenvironment complexity and treatment failure. In a previous study, we demonstrated that VE-Cadherin and its phosphorylation at Y658 modulated kaiso-dependent gene expression (CCND1 and Wnt 11) through a pathway involving Focal Adhesion kinase (FAK). In the present research, using a proteomic approach, we have found that ß-catenin/TCF-4 is associated with nuclear VE-cadherin and enhances the capacity of malignant melanoma cells to undergo VM in cooperation with VE-Cadherin; in addition, preventing the phosphorylation of Y658 of VEcadherin upon FAK disabling resulted in VE-Cadherin/ß-catenin complex dissociation, increased ß-catenin degradation while reducing TCF-4-dependent genes transcription (C-Myc and Twist-1). Uveal melanoma cells knockout for VE-Cadherin loses ß-catenin expression while the rescue of VE-Cadherin (but not of the phosphorylation defective VE-Cadherin Y658F mutant) permits stabilization of ß-catenin and tumor growth reduction in vivo experiments. In vivo, the concomitant treatment with the FAK inhibitor PF-271 and the anti-angiogenic agent bevacizumab leads to a strong reduction in tumor growth concerning the single treatment. In conclusion, the anomalous expression of VE-Cadherin in metastatic melanoma cells (from both uveal and cutaneous origins), together with its permanent phosphorylation at Y658, favors the induction of the aggressive VM phenotype through the cooperation of ß-catenin with VE-Cadherin and by enhancing TCF-4 genes-dependent transcription.This work was supported by grants from the Spanish Ministry of Economy and Competitiveness SAF2015-70520-R, the Spanish Ministry of Science and Technology RTI2018-098968-B-I00, CIBERONC ISCIII CB16/12/00421 and Junta de Andalucía, a project of Excellence from Junta de Andalucía P10-CTS-0662, P12-CTS-383 to FJO. Fundación Domingo Martínez to FJO. Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía (PAIDI 2020, POSTDOC_21_00865) to DD-B. Fundación Getthi ONC18PE01/2022 to DAE, AT