Controle alternativo de Mycosphaerella fragariae na cultura de morango orgânico(Fragaria vesca).

A mancha das folhas ou micosferela causada pelo fungo Mycosphaerella fragariae é uma das mais severas e prejudiciais doenças na produção de morango. Este trabalho tem como objetivo a busca de alternativas viáveis e eficientes para o manejo ecológico da cultura de morango em pesquisa participativa desenvolvida no Sítio São José, , Botucatu - SP, Brasil. O desenho experimental foi de blocos ao acaso com cinco repetições. Os tratamentos foram 1) Água; 2) Preparado de Equisetum arvense; 3) Preparado de Equisetum hyemale; 4) Preparado de Equisetum giganteum; 5) Preparado homeopático de Equisetum hyemale, D28); 6) Preparado biodinâmico 501; 7) Calda bordalesa, a 1%. Todos os tratamentos foram eficazes no controle de micosferela, em relação a água, mostrando sua efetividade contra esta doença.Os tratamentos com preparados de E. hyemale e biodinâmico 501 apresentaram menor número de manchas nas folhas em todas as avaliações realizadas

Orthodontic and orthopaedic treatment for anterior open bite in children (Review)

Background: Anterior open bite occurs when there is a lack of vertical overlap of the upper and lower incisors. The aetiology is multifactorial including: oral habits, unfavourable growth patterns, enlarged lymphatic tissue with mouth breathing. Several treatments have been proposed to correct this malocclusion, but interventions are not supported by strong scientific evidence. Objectives: The aim of this systematic review was to evaluate orthodontic and orthopaedic treatments to correct anterior open bite in children. Search methods: The following databases were searched: the Cochrane Oral Health Group's Trials Register (to 14 February 2014); the Cochrane Central Register of Controlled Trials (CENTRAL)(The Cochrane Library 2014, Issue 1); MEDLINE via OVID (1946 to 14 February 2014); EMBASE via OVID (1980 to 14 February 2014); LILACS via BIREME Virtual Health Library (1982 to 14 February 2014); BBO via BIREME Virtual Health Library (1980 to 14 February 2014); and SciELO (1997 to 14 February 2014). We searched for ongoing trials via ClinicalTrials.gov (to 14 February 2014). Chinese journals were handsearched and the bibliographies of papers were retrieved. Selection criteria: All randomised or quasi-randomised controlled trials of orthodontic or orthopaedic treatments or both to correct anterior open bite in children. Data collection and analysis: Two review authors independently assessed the eligibility of all reports identified. Risk ratios (RRs) and corresponding 95% confidence intervals (CIs) were calculated for dichotomous data. The continuous data were expressed as described by the author. Main results: Three randomised controlled trials were included comparing: effects of Frankel's function regulator-4 (FR-4) with lip-seal training versus no treatment; repelling-magnet splints versus bite-blocks; and palatal crib associated with high-pull chincup versus no treatment.The study comparing repelling-magnet splints versus bite-blocks could not be analysed because the authors interrupted the treatment earlier than planned due to side effects in four of ten patients.FR-4 associated with lip-seal training (RR = 0.02 (95% CI 0.00 to 0.38)) and removable palatal crib associated with high-pull chincup (RR = 0.23 (95% CI 0.11 to 0.48)) were able to correct anterior open bite.No study described: randomisation process, sample size calculation, there was not blinding in the cephalometric analysis and the two studies evaluated two interventions at the same time. These results should be therefore viewed with caution. Authors' conclusions: There is weak evidence that the interventions FR-4 with lip-seal training and palatal crib associated with high-pull chincup are able to correct anterior open bite. Given that the trials included have potential bias, these results must be viewed with caution. Recommendations for clinical practice cannot be made based only on the results of these trials. More randomised controlled trials are needed to elucidate the interventions for treating anterior open bite

Association between Prenatal Care and Gestational Weight Gain: Cross-Sectional Study in a Low-Income Area of Rio de Janeiro

Objetivo: Verificar a associação entre a adequação da assistência pré-natal e o ganho de peso gestacional (GPG) em puérperas brasileiras de baixa renda. Métodos: Estudo transversal no município de Mesquita-RJ, incluindo 281 mulheres no pós-parto imediato. O GPG foi classificado como adequado, insuficiente e excessivo de acordo com as recomendações do Institute of Medicine (IOM). O número de consultas do pré-natal foi categorizado (1: nenhuma consulta; 2: 1-3 consultas; 3: 4-6 consultas; 4: 7 ou mais consultas) e o início do pré-natal, segundo as semanas gestacionais (SG), foi utilizado como variável contínua. A assistência pré-natal (AP) avaliou as duas dimensões agrupadas do Índice de Kotelchuck: adequado (adequado + mais adequado) ou inadequado (intermediário e inadequado). Modelos de regressão logística multinomial foram utilizados para estimar as associações entre assistência pré-natal inadequada e GPG. Resultados: AP foi iniciada em média com 12,6 (± 6,9) SG; 8,2% das mulheres (n = 23) fizeram ≤ 4 consultas de pré-natal e 38,4% (n = 108) foram classificadas com AP inadequada. Em média, o GPG foi de 12,9 kg (± 6,2) e 36,5%, 31,0% e 32,5% das mulheres apresentaram GPG adequado, insuficiente e excessivo, respectivamente. Após o ajuste, a inadequação da AP (OR = 2,01; IC 95% = 1,03-3,90) foi associada a uma maior probabilidade de GPG abaixo das recomendações do IOM. Conclusão: Observou-se uma associação significativa entre a inadequação da assistência pré-natal e o GPG insuficiente, o que reforça a relevância da adequada AP para monitorar o adequado GPG e intervir precocemente na gestação

Antiproliferative activity of synthetic fatty acid amides from renewable resources

AbstractIn the work, the in vitro antiproliferative activity of a series of synthetic fatty acid amides were investigated in seven cancer cell lines. The study revealed that most of the compounds showed antiproliferative activity against tested tumor cell lines, mainly on human glioma cells (U251) and human ovarian cancer cells with a multiple drug-resistant phenotype (NCI-ADR/RES). In addition, the fatty methyl benzylamide derived from ricinoleic acid (with the fatty acid obtained from castor oil, a renewable resource) showed a high selectivity with potent growth inhibition and cell death for the glioma cell line—the most aggressive CNS cancer

Efeitos da nutrição parenteral total associada à infecção bacteriana na função hepatobiliar de ratos da cepa Wistar

OBJECTIVE: To evaluate the hepatic alterations associated to parenteral nutrition inrats.MATERIAL AND METHODS: Four groups with 10 rats each: Group I (control group) -rats were orally fed with a regular diet; Group II - rats received a regular diet, and wereinfected with Escherichia coli through intraperitoneal inoculation; Group III - rats receivedparenteral nutrition; and group IV, rats received parenteral nutrition, and were infectedwith Escherichia coli. Serum concentrations of AST, ALT, GGT, and 5’ N were measuredon the first day of the experiment, and on the eighth day of parenteral nutrition (the dayanimals were sacrificed). Histological study of the liver of the rats included: evaluationof hydropic degeneration, dilation of the central lobular vein, cholestasis, sinusoidaldilation, proliferation of Kupffer cells, cellular necrosis, and steatosis. All alterationswere graded from 0 to 4+.RESULTS: The lab exams did not present consistent alterations at the end of theexperiment. Group IV presented a reduction in GGT concentration; in addition, thisgroup presented the largest variations in AST and ALT concentration, possibly as aresult of being submitted to more intense aggression to the hepatic parenchyma. Froma histological point-of-view, all animals (with the exception of one) presented dilation ofthe central lobular vein and of the sinusoids. Such findings were more frequent amonginfected animals. The animals did not present steatosis or cholestasis.CONCLUSIONS: 1) The proposed model of intraperitoneal inoculation of Escherichiacoli was appropriate for the study of bacterial infection in young rats of the Wistarstrain; 2) our results indicate that the association of parenteral nutrition and infectiondetermined histologic alterations which were unspecific, but more intense than thealterations determined by each of these situations in isolation.OBJETIVO: Avaliar as alterações hepáticas associadas à nutrição parenteral em ratos.MATERIAIS E MÉTODOS: Foram avaliados quatro grupos com 10 ratos cada: grupoI - controles alimentados, via oral, com dieta habitual; grupo II - em dieta habitual einfectados com Escherichia Coli inoculada por via intra peritoneal; grupo III - emnutrição parenteral; e grupo IV - em nutrição parenteral e infectados. Foram analisadasas concentrações séricas de AST, ALT, GGT e 5’N no primeiro dia do experimento eno oitavo dia da nutrição parenteral, por ocasião do sacrifício dos animais. O estudohistológico do fígado dos 40 ratos consistiu na avaliação de degeneração hidrópica,dilatação da veia centro-lobular, colestase, dilatação sinusoidal, proliferação de célulasde Kupffer, necrose celular e esteatose. As alterações foram graduadas de 0 a 4+.RESULTADOS: Os exames laboratoriais não foram consistentemente alterados aofinal do experimento. No grupo IV houve redução na concentração de GGT; alémdisso, este foi o grupo que apresentou as maiores variações de AST e ALT,possivelmente devido à maior agressão do parênquima hepático. Do ponto de vistahistológico, todos os animais submetidos à nutrição parenteral (com apenas umaexceção) apresentaram dilatação da veia centro-lobular e dos sinusóides. Estesachados foram mais comuns nos animais infectados. Não foram observadas esteatosee/ou colestase.CONCLUSÕES: 1) O modelo proposto de inoculação intra-peritoneal com EscherichiaColi foi adequado para estudar infecção em ratos jovens da cepa Wistar; 2) osresultados obtidos indicaram que a associação entre nutrição parenteral e infecçãodeterminou alterações histológicas inespecíficas, porém mais intensas do que asalterações determinadas em cada uma dessas situações isoladamente

Brazilian Morus nigra

Morus nigra has been used popularly for several proposes, including diabetic. In an attempt to support medicinal value, the acute hypoglycemic, hypolipidemic, and antioxidant effects of the ethanolic extract of Morus nigra (EEMn 200 or 400 mg/kg b.w.) were evaluated in normal and alloxan-induced diabetic treated for 14 days. Serum biochemical and antioxidant analysis were performed at the end of experiment. Oral glucose tolerance test was performed at 10th and 15th days. Chromatographic analysis by HPLC-DAD of EEMn was performed. Insulin was used as positive control to glycemic metabolism as well as fenofibrate to lipid metabolism. EEMn (400 mg/kg/day) reduced fasting and postprandial glycaemia, improved oral glucose tolerance, and reduced lipolysis and proteolysis in diabetic rats. EEMn decreased the blood levels of total cholesterol and increased HDL level when compared to the diabetic control rats. At higher levels, EEMn reduced triglycerides and VLDL levels in diabetic rats. Also, EEMn reduced malondialdehyde and increased the reduced glutathione levels in liver of diabetic rats. Chromatographic analysis identified the presence of the flavonoids rutin, isoquercetin, and kaempferitrin. Acute EEMn treatment reduced hyperglycemia, improved oral glucose tolerance, and minimized dyslipidemia and oxidative stress leading to a reduction in atherogenic index in alloxan-induced diabetic rats