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A foreign speech accent in a case of conversion disorder
Objective: The aim of this paper is to report the psychiatric, neuroradiological and linguistic characteristics in a native speaker of Dutch who developed speech symptoms which strongly resemble Foreign Accent Syndrome.
Background: Foreign Accent Syndrome is a rare speech production disorder in which the speech of a patient is perceived as foreign by speakers of the same speech community. This syndrome is generally related to focal brain damage. Only in few reported cases the Foreign Accent Syndrome is assumed to be of psychogenic and/or psychotic origin.
Method: In addition to clinical and neuroradiological examinations, an extensive test battery of standardized neuropsychological and neurolinguistic investigations was carried out. Two samples of the patient's spontaneous speech were analysed and compared to a 500,000-words reference corpus of 160 normal native speakers of Dutch.
Results: The patient had a prominent French accent in her pronunciation of Dutch. This accent had persisted over the past eight years and has become progressively stronger. The foreign qualities of her speech did not only relate to pronunciation, but also to the lexicon, syntax and pragmatics. Structural as well as functional neuroimaging did not reveal evidence that could account for the behavioural symptoms. By contrast psychological investigations indicated conversion disorder.
Conclusions: To the best of our knowledge this is the first reported case of a foreign accent like syndrome in conversion disorder
Clinical characteristics of depressive episodes in Bipolar I and Bipolar II disorders
peer reviewe
Effects of repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex on the attentional processing of emotional information in major depression: A pilot study
Dopamine D2/D3 receptor abnormalities after traumatic brain injury and their relationship to post-traumatic depression
Objective To investigate dopamine D2/D3 receptor availability following traumatic brain injury (TBI) and their relationship to the presence of DSM-IV Major Depressive Disorder (MDD) and patterns of axonal injury. Methods Twelve moderate-severe TBI patients and 26 controls were imaged using [11C]PHNO positron emission tomography (PET) and structural magnetic resonance imaging (MRI). TBI patients and a second group of 32 controls also underwent diffusion tensor imaging (DTI) and neuropsychological assessment. Patients included six with post-injury MDD (TBI-MDD) and six without (TBI-NON). Non-displaceable binding potential (BPND) [11C]PHNO values were used to index D2/D3 receptor availability, and were calculated using a reference region procedure. Differences in BPND were examined using voxelwise and region-of-interest analyses. White matter microstructure integrity, quantified by fractional anisotropy (FA), was assessed and correlated with BPND. Results Lower [11C]PHNO BPND was found in the caudate across all TBI patients when compared to controls. Lower [11C]PHNO BPND was observed in the caudate of TBI-MDD patients and increased [11C]PHNO BPND in the Amygdala of TBI-NON patients compared to controls. There were no significant differences in [11C]PHNO BPND between TBI-MDD and TBI-NON patients. Furthermore, DTI provided evidence of axonal injury following TBI. The uncinate fasciculus and cingulum had abnormally low FA, with the uncinate particularly affected in TBI-MDD patients. Caudate [11C]PHNO BPND correlated with FA within the nigro-caudate tract. Conclusions [11C]PHNO BPND is abnormal following TBI, which indicates post-traumatic changes in D2/D3 receptors. Patterns of [11C]PHNO BPND seen in patients with and without MDD suggest that further research would be beneficial to determine whether the use of dopaminergic treatment might be effective in the treatment of post-traumatic depression
Knowles (M. D.) et Obolensky (D.). Le Moyen Age
D'Haenen A. Knowles (M. D.) et Obolensky (D.). Le Moyen Age. In: Revue belge de philologie et d'histoire, tome 48, fasc. 1, 1970. Antiquité — Oudheid. pp. 94-97
Schmale (Franz- Josef). Studien zum Schisma des Jahres 1130
D'Haenen A. Schmale (Franz- Josef). Studien zum Schisma des Jahres 1130. In: Revue belge de philologie et d'histoire, tome 42, fasc. 1, 1964. Antiquité — Oudheid. pp. 167-170
Schmale (Franz- Josef). Studien zum Schisma des Jahres 1130
D'Haenen A. Schmale (Franz- Josef). Studien zum Schisma des Jahres 1130. In: Revue belge de philologie et d'histoire, tome 42, fasc. 1, 1964. Antiquité — Oudheid. pp. 167-170
Knowles (M. D.) et Obolensky (D.). Le Moyen Age
D'Haenen A. Knowles (M. D.) et Obolensky (D.). Le Moyen Age. In: Revue belge de philologie et d'histoire, tome 48, fasc. 1, 1970. Antiquité — Oudheid. pp. 94-97
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