586 research outputs found
THE DEVELOPMENT OF THORACIC SURGERY1 1An address delivered at the Sixth Session of Congress of the Australian Physiotherapy Association at Adelaide on September 24, 1956
An English text-book of thoracic surgery published in 1933 does not mention the word physiotherapy, but Mr. D'Abreu's book the âPractice of Thoracic Surgeryâ, published in England in 1953, apart from frequent references in the text, contains a whole section on physiotherapy in relationship to thoracic diseases. So somewhere in this period of twenty years the advantages of physiotherapy became apparent to an enlightened somebody (almost certainly at the Brompton Hospital) and those of us who follow the British line of thought in the management of thoracic diseases would not be prepared to run a thoracic surgical unit without a trained chest physiotherapist as part of the team
Injection gate definition for improving the accuracy of liquid composite molding process simulation
The Viscous Nonlinear Dynamics of Twist and Writhe
Exploiting the "natural" frame of space curves, we formulate an intrinsic
dynamics of twisted elastic filaments in viscous fluids. A pair of coupled
nonlinear equations describing the temporal evolution of the filament's complex
curvature and twist density embodies the dynamic interplay of twist and writhe.
These are used to illustrate a novel nonlinear phenomenon: ``geometric
untwisting" of open filaments, whereby twisting strains relax through a
transient writhing instability without performing axial rotation. This may
explain certain experimentally observed motions of fibers of the bacterium B.
subtilis [N.H. Mendelson, et al., J. Bacteriol. 177, 7060 (1995)].Comment: 9 pages, 4 figure
Arnol'd Tongues and Quantum Accelerator Modes
The stable periodic orbits of an area-preserving map on the 2-torus, which is
formally a variant of the Standard Map, have been shown to explain the quantum
accelerator modes that were discovered in experiments with laser-cooled atoms.
We show that their parametric dependence exhibits Arnol'd-like tongues and
perform a perturbative analysis of such structures. We thus explain the
arithmetical organisation of the accelerator modes and discuss experimental
implications thereof.Comment: 20 pages, 6 encapsulated postscript figure
CNV Workshop: an integrated platform for high-throughput copy number variation discovery and clinical diagnostics
<p>Abstract</p> <p>Background</p> <p>Recent studies have shown that copy number variations (CNVs) are frequent in higher eukaryotes and associated with a substantial portion of inherited and acquired risk for various human diseases. The increasing availability of high-resolution genome surveillance platforms provides opportunity for rapidly assessing research and clinical samples for CNV content, as well as for determining the potential pathogenicity of identified variants. However, few informatics tools for accurate and efficient CNV detection and assessment currently exist.</p> <p>Results</p> <p>We developed a suite of software tools and resources (CNV Workshop) for automated, genome-wide CNV detection from a variety of SNP array platforms. CNV Workshop includes three major components: detection, annotation, and presentation of structural variants from genome array data. CNV detection utilizes a robust and genotype-specific extension of the Circular Binary Segmentation algorithm, and the use of additional detection algorithms is supported. Predicted CNVs are captured in a MySQL database that supports cohort-based projects and incorporates a secure user authentication layer and user/admin roles. To assist with determination of pathogenicity, detected CNVs are also annotated automatically for gene content, known disease loci, and gene-based literature references. Results are easily queried, sorted, filtered, and visualized via a web-based presentation layer that includes a GBrowse-based graphical representation of CNV content and relevant public data, integration with the UCSC Genome Browser, and tabular displays of genomic attributes for each CNV.</p> <p>Conclusions</p> <p>To our knowledge, CNV Workshop represents the first cohesive and convenient platform for detection, annotation, and assessment of the biological and clinical significance of structural variants. CNV Workshop has been successfully utilized for assessment of genomic variation in healthy individuals and disease cohorts and is an ideal platform for coordinating multiple associated projects.</p> <p>Availability and Implementation</p> <p>Available on the web at: <url>http://sourceforge.net/projects/cnv</url></p
Morphological Instabilities in a growing Yeast Colony: Experiment and Theory
We study the growth of colonies of the yeast Pichia membranaefaciens on
agarose film. The growth conditions are controlled in a setup where nutrients
are supplied through an agarose film suspended over a solution of nutrients. As
the thickness of the agarose film is varied, the morphology of the front of the
colony changes. The growth of the front is modeled by coupling it to a
diffusive field of inhibitory metabolites. Qualitative agreement with
experiments suggests that such a coupling is responsible for the observed
instability of the front.Comment: RevTex, 4 pages and 3 figure
Renin inhibition by substituted piperidines: A novel paradigm for the inhibition of monomeric aspartic proteinases?
BackgroundThe aspartic proteinase renin catalyses the first and rate-limiting step in the conversion of angiotensinogen to the hormone angiotensin II, and therefore plays an important physiological role in the regulation of blood pressure. Numerous potent peptidomimetic inhibitors of this important drug target have been developed, but none of these compounds have progressed past clinical phase II trials. Limited oral bioavailability or excessive production costs have prevented these inhibitors from becoming new antihypertensive drugs. We were interested in developing new nonpeptidomimetic renin inhibitors.ResultsHigh-throughput screening of the Roche compound library identified a simple 3,4-disubstituted piperidine lead compound. We determined the crystal structures of recombinant human renin complexed with two representatives of this new class. Binding of these substituted piperidine derivatives is accompanied by major induced-fit adaptations around the enzyme's active site.ConclusionsThe efficient optimisation of the piperidine inhibitors was facilitated by structural analysis of the renin active site in two renin-inhibitor complexes (some of the piperidine derivatives have picomolar affinities for renin). These structural changes provide the basis for a novel paradigm for inhibition of monomeric aspartic proteinases
The Cyprinodon variegatus genome reveals gene expression changes underlying differences in skull morphology among closely related species
Genes in durophage intersection set at 15 dpf. This is a comma separated table of the genes in the 15 dpf durophage intersection set. Given are edgeR results for each pairwise comparison. Columns indicating whether a gene is included in the intersection set at a threshold of 1.5 or 2 fold are provided. (CSV 13ĂÂ kb
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