678 research outputs found
Evans Syndrome Presented with Marginal Zone Lymphoma and Duodenal Neuroendocrine Tumor in an Elderly Woman
Summary Evans syndrome (ES) is an autoimmune disorder characterized by simultaneous or sequential development of autoimmune hemolytic anemia, immune thrombocytopenia, and/or neutropenia. ES can be classified as a primary (idiopathic) or secondary (associated with an underlying disease) syndrome. We report a case of ES in an elderly patient in the presence of multiple trigger factors such as recent influenza vaccine, marginal zone lymphoma, and neuroendocrine tumor G1. Whether this association is casual or causal remains a matter of speculation. It is however necessary to have a thorough work-up in a newly diagnosed ES and a more accurate search of miscellaneous factors especially in elderly patients
Role of permanent atrial fibrillation (AF) on long-term mortality in community-dwelling elderly people with and without chronic heart failure (CHF)
Permanent AF is characterized by an increased mortality in elderly subjects with CHF. Moreover, AF increased the risk of mortality also in elderly subjects without CHF. Thus, we examined long-term mortality in community-dwelling elderly people with and without CHF. A total of 1332 subjects aged 65 and older were selected from the electoral rolls of Campania, a region of southern Italy. The relationship between AF and mortality during a 12-year follow-up in 125 subjects with CHF and in 1.143 subjects without CHF were studied. Elderly subjects showed a higher mortality in those with respect to those without AF (72.1% vs. 51.8%; p < 0.01). Similarly, elderly subjects without CHF showed a higher mortality in those with respect to those without AF (61.8% vs. 49.8%; p < 0.05). In contrast, elderly subjects with CHF showed a similar mortality in those with respect to those without AF (74.7% vs. 82.4%; p = 0.234). Multivariate analysis shows that AF was predictive of mortality in all elderly subjects (Hazard Risk = HR = 1.39, 95% confidence interval (CI) = 1.25-2.82; p < 0.001). When the analysis was conducted considering the presence and the absence of CHF, AF was strongly predictive of mortality in elderly subjects without CHF (HR = 1.95, 95% CI = 1.25-4.51; p < 0.001) but not in those with CHF (HR = 1.12, 95% CI = 0.97-3.69; p = 0.321). We concluded that AF is able to predict long-term mortality in elderly subjects. Moreover, AF is strongly predictive of long-term mortality in the absence but not in the presence of CHF. (C) 2011 Elsevier Ireland Ltd. All rights reserved
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Mortality and heart rate in the elderly: role of cognitive impairment
Mortality related to heart rate ( HR) increase in the elderly has not yet been well established. To ascertain the relationships among cognitive impairment ( CI), mortality, and HR increase, the authors prospectively studied a random sample of elderly subjects stratified according to presence or absence of CI. Elderly subjects randomly selected in 1991 ( n = 1332) were followed up for 12 years. Mortality was established in 98.1% of the subjects. When HR was stratified in quartiles (< 69,70-75,76-80, and > 80 bpm), mortality was linearly associated with increased HR in all ( from 47.7 to 57.0; r(2) = .43, p = .019) and in subjects without ( from 41.7 to 51.1%; r(2) = .50, p = .043) but not in those with CI ( from 57.5 to 66.1; r(2) = .20, p = .363). Cox regression analysis, adjusted for several variables, shows that HR doesn't predict mortality in all subjects ( RR 0.69; 95% CI = 0.27-1.73) or in those with CI ( RR 0.91; 95% CI = 0.81-1.02). In contrast, HR predicts mortality in subjects without CI ( RR 1.10; 95% CI = 1.00-1.22). Hence, HR increase is a predictor of mortality in elderly subjects without CI. However, when considering all elderly subjects and those with CI, HR increase seems to have no effect on mortality. Thus, CI should be considered when focusing on HR increase as risk factor for mortality in the elderly
Main postharvest fungal diseases of pomegranate fruit in southern Italy
Pomegranate (Punica granatum L.) is an increasingly important crop in Apulia, where most of the Italian production occur. The main yield problem is related to postharvest losses caused by fungi. The present research was conducted using fruit of two cultivars (Mollar de Elche and Wonderful) with different characteristics, from local markets, orchards, and packinghouses in the province of Lecce (southern Italy). The main fungi observed on stored pomegranate fruit were Botrytis sp., Pilidiella granati, Alternaria spp., Penicillium spp. (s.l.), Colletotrichum acutatum, and Cytospora punicae. The early three pathogens infected fruit through the calyx area during blossom, and then spread to the entire pomegranate. Moreover, Botrytis sp. was responsible for harmful latent infections, especially during the cold storage, which was a critical stage even for C. acutatum. Two different species of Alternaria, causing âblack heartâ or âblack spotâ, were identified: A. alternata and A. arborescens. The main Penicillium spp. s.s. observed were P. glabrum, P. adametzioides, and P. brevicompactum. Few isolates of Talaromyces albobiverticillius were also present. These fungi, that share very similar macroscopic characteristics, were mainly present on decayed stamens and wounds. In the present study, P. granati and C. punicae, predominantly recorded as etiological agents of pomegranate trunk canker, were isolated from fruit
Short versus standard treatment with pegylated interferon alfa-2A plus ribavirin in patients with hepatitis C virus genotype 2 or 3: the cleo trial
<p>Abstract</p> <p>Background</p> <p>In patients with chronic hepatitis C virus (HCV) genotype 2 or 3, 24 weeks' treatment with pegylated interferon alfa (PEG-IFN-alpha) and ribavirin induces a sustained virological response (SVR) in almost 80% of cases. Evidence suggests that a similar response rate may be obtained with shorter treatment periods, especially in patients with a rapid virological response (RVR). The aim of this study was to compare the efficacy of 12 or 24 weeks of treatment in patients with chronic HCV genotype 2 or 3 and to identify patients suitable for 12 weeks treatment.</p> <p>Methods</p> <p>Two hundred and ten patients received PEG-IFN-alpha-2a (180 ug/week) and ribavirin (800-1200 mg/day) for 4 weeks. Patients with a RVR (HCV RNA not detectable) were randomized (1:1) to either 12 (group A1) or 24 (group A2) weeks of combination therapy. Patients without a RVR continued with 24-weeks' combination therapy (group B). HCV RNA was monitored at weeks 4, 8, 12, and 24, and at week 24 post-treatment.</p> <p>Results</p> <p>At study end, end of treatment response (ETR) was observed in 62 (86%) patients of group A1 and in 55 (77%) patients of group A2 (p < 0.05) Relapse rate was 3% each in groups A1 and A2, and 6% in group B. Among patients with a HCVRNA test 24 weeks after the end of treatment, SVR was observed in 60 (83%) of group A1 patients and in 53 (75%) of group A2 patients. Rapid virological response, low baseline HCV RNA levels, elevated alanine aminotransferase levels and low fibrosis score, were the strongest covariates associated with SVR, independent of HCV genotype. No baseline characteristic was associated with relapse.</p> <p>Conclusion</p> <p>In HCV patients with genotype 2 or 3, 12-week combination therapy is as efficacious as 24-week therapy and several independent covariates were predictive of SVR.</p> <p>Trial registration</p> <p>Trial number ISRCTN29259563</p
Multidifferential study of identified charged hadron distributions in -tagged jets in proton-proton collisions at 13 TeV
Jet fragmentation functions are measured for the first time in proton-proton
collisions for charged pions, kaons, and protons within jets recoiling against
a boson. The charged-hadron distributions are studied longitudinally and
transversely to the jet direction for jets with transverse momentum 20 GeV and in the pseudorapidity range . The
data sample was collected with the LHCb experiment at a center-of-mass energy
of 13 TeV, corresponding to an integrated luminosity of 1.64 fb. Triple
differential distributions as a function of the hadron longitudinal momentum
fraction, hadron transverse momentum, and jet transverse momentum are also
measured for the first time. This helps constrain transverse-momentum-dependent
fragmentation functions. Differences in the shapes and magnitudes of the
measured distributions for the different hadron species provide insights into
the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb
public pages
Study of the decay
The decay is studied
in proton-proton collisions at a center-of-mass energy of TeV
using data corresponding to an integrated luminosity of 5
collected by the LHCb experiment. In the system, the
state observed at the BaBar and Belle experiments is
resolved into two narrower states, and ,
whose masses and widths are measured to be where the first uncertainties are statistical and the second
systematic. The results are consistent with a previous LHCb measurement using a
prompt sample. Evidence of a new
state is found with a local significance of , whose mass and width
are measured to be and , respectively. In addition, evidence of a new decay mode
is found with a significance of
. The relative branching fraction of with respect to the
decay is measured to be , where the first
uncertainty is statistical, the second systematic and the third originates from
the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb
public pages
Measurement of the ratios of branching fractions and
The ratios of branching fractions
and are measured, assuming isospin symmetry, using a
sample of proton-proton collision data corresponding to 3.0 fb of
integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The
tau lepton is identified in the decay mode
. The measured values are
and
, where the first uncertainty is
statistical and the second is systematic. The correlation between these
measurements is . Results are consistent with the current average
of these quantities and are at a combined 1.9 standard deviations from the
predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb
public pages
pengaruh model pembelajaran inductive thinking - deductive thinking terhadap hasil belajar IPS ditinjau dari jenis kelamin siswa kelas VII SMP N 2 KARTASURA
ABSTRAK Ulfah Fajar Hayati (K5411064) PENGARUH MODEL PEMBELAJARAN DEDUCTIVE THINKINGâINDUCTIVE THINKING DITINJAU DARI JENIS KELAMIN TERHADAP HASIL BELAJAR SISWA KELAS VII SMP NEGERI 2 KARTASURA TAHUN AJARAN 2014/2015 (Materi Pembelajaran Kondisi Geografis dan Penduduk). Proposal Skripsi, Surakarta: Fakultas Keguruan dan Ilmu Pendidikan. Universitas Sebelas Maret. Februari 2015. Tujuan penelitian ini adalah 1) Untuk mengetahui perbedaan hasil belajar IPS materi pembelajaran kondisi geografis dan penduduk antara model pembelajaran deductive thinking dan model pembelajaran induktive thinking pada siswa kelas VII SMP Negeri 2 Kartasura tahun ajaran 2014/2015. 2) Untuk mengetahui perbedaan hasil belajar IPS materi pembelajaran kondisi geografis dan penduduk pada siswa laki-laki yang disampaikan dengan model pembelajaran deductive thinking dan model pembelajaran inductive thinking pada siswa kelas VII SMP Negeri 2 Kartasura tahun ajaran 2014/2015. 3) Untuk mengetahui perbedaan hasil belajar IPS materi pembelajaran kondisi geografis dan penduduk pada siswa perempuan yang disampaikan dengan model pembelajaran deductive thinking dan model pembelajaran inductive thinking pada siswa kelas VII SMP Negeri 2 Kartasura tahun ajaran 2014/2015. 4) Untuk mengetahui pengaruh interaksi antara model pembelajaran dan jenis kelamin terhadap hasil belajar IPS materi pembelajaran kondisi geografis dan penduduk pada siswa kelas VII SMP Negeri 2 Kartasura tahun ajaran 2014/2015. Jenis penelitian ini merupakan penelitian Quasi Eksperimental dengan rencana design grup factorial 2x2. Populasi penelitian adalah kelas VII SMP Negeri 2 Kartasura, Sukoharjo dan sampel penelitian adalah siswa kelas VIID dan VIIA Sampel tersebut diambil dengan menggunakan teknik simple random sampling. Teknik pengumpulan data menggunakan tes dalam bentuk tes obyektif pilihan ganda. Teknik analisis data yang digunakan dengan pengujian hipotesis analisis Anova Dua Arah (Two Way Anova) pada taraf signifikasi 5%
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