Congenital Junctional Ectopic Tachycardia: Presentation And Outcome

Junctional ectopic tachycardia (JET) is a rare type of supraventricular arrhythmia. Even if its management has improved in recent years, it remains a great challenge for the cardiologist. Two are the possible clinical presentations of this arrhythmia: as a primary idiopathic disorder during infancy, configuring the so called congenital JET, or more often as a transient phenomenon immediately after surgery for congenital heart disease, giving rise to the post-operative variety. The congenital form, firstly described as a distinct entity by Coumel et al. in 19761, usually occurs in the first six months of life presenting as a persistent sustained form, lasting up to 90% of the time. Its clinical presentation may be dramatic, being associated in up to 60% of cases with cardiomegaly and/or heart failure. Congenital JET is hampered by high mortality. Secondary dilated cardiomyopathy, ventricular fibrillation and sudden cardiac death have also been reported 2,3

1.6 Radiofrequency catheter ablation in paediatric age: For nodal re-entry tachycardia and atrio-ventricular re-entry tachycardia

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P2613Initial combination therapy with ambrisentan and tadalafil for pulmonary arterial hypertension: clinical effect and haemodynamic changes. A multicenter retrospective analysis

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Association Between Circulating CD4+ T Cell Methylation Signatures of Network-Oriented SOCS3 Gene and Hemodynamics in Patients Suffering Pulmonary Arterial Hypertension

Pathogenic DNA methylation changes may be involved in pulmonary arterial hypertension (PAH) onset and its progression, but there is no data on potential associations with patient-derived hemodynamic parameters. The reduced representation bisulfite sequencing (RRBS) platform identified N= 631 differentially methylated CpG sites which annotated to N= 408 genes (DMGs) in circulating CD4(+) T cells isolated from PAH patients vs. healthy controls (CTRLs). A promoter-restricted network analysis established the PAH subnetwork that included 5 hub DMGs (SOCS3, GNAS, ITGAL, NCOR2, NFIC) and 5 non-hub DMGs (NR4A2, GRM2, PGK1, STMN1, LIMS2). The functional analysis revealed that the SOCS3 gene was the most recurrent among the top ten significant pathways enriching the PAH subnetwork, including the growth hormone receptor and the interleukin-6 signaling. Correlation analysis showed that the promoter methylation levels of each network-oriented DMG were associated individually with hemodynamic parameters. In particular, SOCS3 hypomethylation was negatively associated with right atrial pressure (RAP) and positively associated with cardiac index (CI) (vertical bar r vertical bar >= 0.6). A significant upregulation of the SOCS3, ITGAL, NFIC, NCOR2, and PGK1 mRNA levels (qRT-PCR) in peripheral blood mononuclear cells from PAH patients vs. CTRLs was found (P <= 0.05). By immunoblotting, a significant upregulation of the SOCS3 protein was confirmed in PAH patients vs. CTRLs (P < 0.01). This is the first network-oriented study which integrates circulating CD4(+) T cell DNA methylation signatures, hemodynamic parameters, and validation experiments in PAH patients at first diagnosis or early follow-up. Our data suggests that SOCS3 gene might be involved in PAH pathogenesis and serve as potential prognostic biomarker

LAPORAN PRAKTIK KERJA LAPANGAN PADA PT INFRASTRUKTUR TELEKOMUNIKASI INDONESIA

RIBKA PA’KAMASE TARIALLO, Laporan Praktik Kerja Lapangan (PKL) pada PT Infrastruktur Telekomunikasi Indonesia. Program Studi S1 Manajemen, Fakultas Ekonomi, Universitas Negeri Jakarta, 2018. Pelaksanaan Praktik Kerja Lapangan (PKL) ini bertujuan untuk mendapatkan pengalaman yang berhubungan dengan studi Praktikan, guna memenuhi salah satu mata kuliah program S1 Manajemen Fakultas Ekonomi Universitas Negeri Jakarta dan memberikan praktikan pengalaman dan melatih diri untuk persiapan kerja di bidang Keuangan. Praktikan ditempatkan pada Unit Business and Performance. Tugas yang diberikan kepada praktikan antara lain: Menghitung perbandingan tiap bulan dan tiap tahun Comprehensive Income, Menyusun materi untuk laporan kinerja keuangan perusahaan, Merekapitulasi balance sheet dari tahun 2014 hingga 2017, Merekapitulasi rasio rasio keuangaan perusahaan dari tahun 2014 hingga 2017,dan Merekapitulasi perbandingan Comprehensive Income dari tahun 2014 hingga 2017. Kata Kunci: PKL, PT Infrastruktur Telekomunikasi Indonesia, Keuangan

Right ventricular-arterial uncoupling independently predicts survival in COVID-19 ARDS

Aim: To investigate the prevalence and prognostic impact of right heart failure and right ventricular-arterial uncoupling in Corona Virus Infectious Disease 2019 (COVID-19) complicated by an Acute Respiratory Distress Syndrome (ARDS). Methods: Ninety-four consecutive patients (mean age 64 years) admitted for acute respiratory failure on COVID-19 were enrolled. Coupling of right ventricular function to the pulmonary circulation was evaluated by a comprehensive trans-thoracic echocardiography with focus on the tricuspid annular plane systolic excursion (TAPSE) to systolic pulmonary artery pressure (PASP) ratio Results: The majority of patients needed ventilatory support, which was noninvasive in 22 and invasive in 37. There were 25 deaths, all in the invasively ventilated patients. Survivors were younger (62 ± 13 vs. 68 ± 12 years, p = 0.033), less often overweight or usual smokers, had lower NT-proBNP and interleukin-6, and higher arterial partial pressure of oxygen (PaO2)/fraction of inspired O2 (FIO2) ratio (270 ± 104 vs. 117 ± 57 mmHg, p < 0.001). In the non-survivors, PASP was increased (42 ± 12 vs. 30 ± 7 mmHg, p < 0.001), while TAPSE was decreased (19 ± 4 vs. 25 ± 4 mm, p < 0.001). Accordingly, the TAPSE/PASP ratio was lower than in the survivors (0.51 ± 0.22 vs. 0.89 ± 0.29 mm/mmHg, p < 0.001). At univariate/multivariable analysis, the TAPSE/PASP (HR: 0.026; 95%CI 0.01–0.579; p: 0.019) and PaO2/FIO2 (HR: 0.988; 95%CI 0.988–0.998; p: 0.018) ratios were the only independent predictors of mortality, with ROC-determined cutoff values of 159 mmHg and 0.635 mm/mmHg, respectively. Conclusions: COVID-19 ARDS is associated with clinically relevant uncoupling of right ventricular function from the pulmonary circulation; bedside echocardiography of TAPSE/PASP adds to the prognostic relevance of PaO2/FIO2 in ARDS on COVID-19

A Case Series of Blastic Plasmacytoid Dendritic Cell Neoplasia

Blastic plasmacytoid dendritic cell neoplasm (BPDCN), an extremely rare and aggressive tumor, derives from plasmacytoid dendritic cell precursors and is characterized by CD4 and CD56 positivity accompanied by the expression of isolated myeloid, B- or T-cell lineage markers. Despite the recent introduction of specific targeted therapies, prognosis is still poor with a median overall survival of one year, and allogeneic bone marrow transplantation remains the only curative treatment in eligible patients. In this series, we described two cases of adult BPDCN treated with high dose cytarabine and methotrexate and autologous hematopoietic stem cell transplantation, or fludarabine, cytarabine, and idarubicin achieving the first a complete lasting remission, while the second only a transient improvement in skin lesion

Personal Shopping Assistance and Navigator System for Visually Impaired People

International audienceIn this paper, a personal assistant and navigator system for visually impaired people will be described. The showcase presented in-tends to demonstrate how partially sighted people could be aided by the technology in performing an ordinary activity, like going to a mall and moving inside it to find a specific product. We propose an Android ap-plication that integrates Pedestrian Dead Reckoning and Computer Vi-sion algorithms, using an off-the-shelf Smartphone connected to a Smart-watch. The detection, recognition and pose estimation of specific objects or features in the scene derive an estimate of user location with sub-meter accuracy when combined with a hardware-sensor pedometer. The pro-posed prototype interfaces with a user by means of Augmented Reality, exploring a variety of sensorial modalities other than just visual overlay, namely audio and haptic modalities, to create a seamless immersive user experience. The interface and interaction of the preliminary platform have been studied through specific evaluation methods. The feedback gathered will be taken into consideration to further improve the pro-posed system