99 research outputs found
Anti‐dopamine D2 receptor antibodies in chronic tic disorders
AIM: To investigate the association between circulating anti-dopamine D2 receptor (D2R) autoantibodies and the exacerbation of tics in children with chronic tic disorders (CTDs). METHOD: One hundred and thirty-seven children with CTDs (108 males, 29 females; mean age [SD] 10y 0mo [2y 7mo], range 4-16y) were recruited over 18 months. Patients were assessed at baseline, at tic exacerbation, and at 2 months after exacerbation. Serum anti-D2R antibodies were evaluated using a cell-based assay and blinded immunofluorescence microscopy scoring was performed by two raters. The association between visit type and presence of anti-D2R antibodies was measured with McNemar's test and repeated-measure logistic regression models, adjusting for potential demographic and clinical confounders. RESULTS: At exacerbation, 11 (8%) participants became anti-D2R-positive ('early peri-exacerbation seroconverters'), and nine (6.6%) became anti-D2R-positive at post-exacerbation ('late peri-exacerbation seroconverters'). The anti-D2R antibodies were significantly associated with exacerbations when compared to baseline (McNemar's odds ratio=11, p=0.003) and conditional logistic regression confirmed this association (Z=3.49, p<0.001) after adjustment for demographic and clinical data and use of psychotropic drugs. INTERPRETATION: There is a potential association between immune mechanisms and the severity course of tics in adolescents with CTDs
SWIPE: a bolometric polarimeter for the Large-Scale Polarization Explorer
The balloon-borne LSPE mission is optimized to measure the linear
polarization of the Cosmic Microwave Background at large angular scales. The
Short Wavelength Instrument for the Polarization Explorer (SWIPE) is composed
of 3 arrays of multi-mode bolometers cooled at 0.3K, with optical components
and filters cryogenically cooled below 4K to reduce the background on the
detectors. Polarimetry is achieved by means of large rotating half-wave plates
and wire-grid polarizers in front of the arrays. The polarization modulator is
the first component of the optical chain, reducing significantly the effect of
instrumental polarization. In SWIPE we trade angular resolution for
sensitivity. The diameter of the entrance pupil of the refractive telescope is
45 cm, while the field optics is optimized to collect tens of modes for each
detector, thus boosting the absorbed power. This approach results in a FWHM
resolution of 1.8, 1.5, 1.2 degrees at 95, 145, 245 GHz respectively. The
expected performance of the three channels is limited by photon noise,
resulting in a final sensitivity around 0.1-0.2 uK per beam, for a 13 days
survey covering 25% of the sky.Comment: In press. Copyright 2012 Society of Photo-Optical Instrumentation
Engineers. One print or electronic copy may be made for personal use only.
Systematic reproduction and distribution, duplication of any material in this
paper for a fee or for commercial purposes, or modification of the content of
the paper are prohibite
The Large-Scale Polarization Explorer (LSPE)
The LSPE is a balloon-borne mission aimed at measuring the polarization of
the Cosmic Microwave Background (CMB) at large angular scales, and in
particular to constrain the curl component of CMB polarization (B-modes)
produced by tensor perturbations generated during cosmic inflation, in the very
early universe. Its primary target is to improve the limit on the ratio of
tensor to scalar perturbations amplitudes down to r = 0.03, at 99.7%
confidence. A second target is to produce wide maps of foreground polarization
generated in our Galaxy by synchrotron emission and interstellar dust emission.
These will be important to map Galactic magnetic fields and to study the
properties of ionized gas and of diffuse interstellar dust in our Galaxy. The
mission is optimized for large angular scales, with coarse angular resolution
(around 1.5 degrees FWHM), and wide sky coverage (25% of the sky). The payload
will fly in a circumpolar long duration balloon mission during the polar night.
Using the Earth as a giant solar shield, the instrument will spin in azimuth,
observing a large fraction of the northern sky. The payload will host two
instruments. An array of coherent polarimeters using cryogenic HEMT amplifiers
will survey the sky at 43 and 90 GHz. An array of bolometric polarimeters,
using large throughput multi-mode bolometers and rotating Half Wave Plates
(HWP), will survey the same sky region in three bands at 95, 145 and 245 GHz.
The wide frequency coverage will allow optimal control of the polarized
foregrounds, with comparable angular resolution at all frequencies.Comment: In press. Copyright 2012 Society of Photo-Optical Instrumentation
Engineers. One print or electronic copy may be made for personal use only.
Systematic reproduction and distribution, duplication of any material in this
paper for a fee or for commercial purposes, or modification of the content of
the paper are prohibite
Result on the Neutrinoless Double Beta Decay Search of Se-82 with the CUPID-0 Experiment
CUPID-0 is the first large array of scintillating Zn82Se cryogenic calorimeters (bolometers) implementing particle identification for the search of the neutrinoless double beta decay (0). The detector consists of 24 enriched Zn82Se bolometers for a total 82Se mass of 5.28 kg and it has been taking data in the underground LNGS (Italy) since March 2017. In this article we show how the dual read-out provides a powerful tool for the particles rejection. The simultaneous use of the heat and light information allows us to reduce the background down to (3.2-1.1+1.3)x10-3counts/(keV kg year), an unprecedented level for cryogenic calorimeters. In a total exposure of 5.46 kg year Zn82Se we set the most stringent limit on the 0 decay 82Se half-life T1/20>4.0x1024 year at 90% C.I
Lowering the CUORE energy threshold
The Cryogenic Underground Observatory for Rare Events (CUORE) is a ton-scale double beta decay experiment based on TeO2 cryogenic bolometers and is currently in the last construction stage at the Gran Sasso National Laboratory (LNGS). Its primary goal is to observe neutrino-less double beta decay of 130Te, however thanks to the ultra-low background and large projected exposure it could also be suitable for other rare event searches, as the detection of solar axions, neutrinos from type II supernovae or direct detection of dark matter. The sensitivity for these searches will depend on the performance achieved at the low energy threshold. For this reason a trigger algorithm based on continuous data filtering has been developed which will allow lowering the threshold down to the few keV region. The new trigger has been tested in CUORE-0, a single-tower CUORE prototype consisting of 52 TeO2 bolometers and recently concluded, and here we present the results in terms of trigger efficiency, data selection and low-energy calibration
Status and prospects for CUORE
CUORE is a cryogenic detector consisting of 988 TeO2 crystals, 750 g each, and will be operated at a temperature of ~10 mK, to search for neutrinoless double beta decay (0¿ßß) of 130Te. The detector, in the final stages of construction at the Laboratori Nazionali del Gran Sasso (Italy), will start its operations in 2016. CUORE-0, its pilot experiment, has proven the feasibility of CUORE, demonstrating that the target background of 0.01 counts/keV/kg/y and the energy resolution of 5 keV are within reach. CUORE-0 also made the most precise measurement of the 2¿ßß decay. The expected sensitivity of CUORE to the 0¿ßß 130Te half-life is 9 •1025y, for 5 years of data taking. Here, we report the most recent results of CUORE-0, their implications for CUORE, and the current status of the CUORE experiment
CUORE and CUORE-0 experiments
Neutrino oscillation experiments proved that neutrinos have mass and this enhanced the interest in neutrinoless double-beta decay (0vßß). The observation of this very rare hypothetical decay would prove the leptonic number violation and would give us indications about neutrinos mass hierarchy and absolute mass scale. CUORE (Cryogenic Underground Observatory for Rare Events) is an array of 988 crystals of TeO2, for a total sensitive mass of 741 kg. Its goal is the observation of 0vßß of 130Te. The crystals, placed into the a dilution cryostat, are operated as bolometers at a temperature close to 10 mK. CUORE commissioning phase has been concluded recently in Gran Sasso National Laboratory, Italy, and data taking is expected to start in spring 2017. If target background rate is reached (0.01counts/day/keV/kg), the sensibility of CUORE will be, in five years of data taking, T1/21026years (1? CL). In order to test the quality of materials and optimize the construction procedures, the collaboration realized CUORE-0, that took data from spring of 2013 to summer 2015. Here, after a brief description of CUORE, I report its commissioning status and CUORE-0 results
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