Resistive damping implementation as a method to improve controllability in stiff ohmic RF-MEMS switches

This paper presents in detail the entire procedure of calculating the bias resistance of an ohmic RF-MEMS switch, controlled under resistive damping (charge drive technique). In case of a very stiff device, like the North Eastern University switch, the actuation control under resistive damping is the only way to achieve controllability. Due to the short switching time as well as the high actuation voltage, it is not practical to apply a tailored control pulse (voltage drive control technique). Implementing a bias resistor of 33 MΩ in series with the voltage source, the impact velocity of the cantilever has been reduced 80 % (13.2 from 65.9 cm/s), eliminating bouncing and high initial impact force during the pull-down phase. However, this results in an affordable cost of switching time increase from 2.38 to 4.34 μs. During the release phase the amplitude of bouncing has also been reduced 34 % (174 from 255 nm), providing significant improvement in both switching operation phases of the switch. © 2013 Springer-Verlag Berlin Heidelberg

RF-MEMS switch actuation pulse optimization using Taguchi's method

Copyright @ 2011 Springer-VerlagReliability and longevity comprise two of the most important concerns when designing micro-electro-mechanical-systems (MEMS) switches. Forcing the switch to perform close to its operating limits underlies a trade-off between response bandwidth and fatigue life due to the impact force of the cantilever touching its corresponding contact point. This paper presents for first time an actuation pulse optimization technique based on Taguchi’s optimization method to optimize the shape of the actuation pulse of an ohmic RF-MEMS switch in order to achieve better control and switching conditions. Simulation results show significant reduction in impact velocity (which results in less than 5 times impact force than nominal step pulse conditions) and settling time maintaining good switching speed for the pull down phase and almost elimination of the high bouncing phenomena during the release phase of the switch

Self-Sustained Micromechanical Oscillator with Linear Feedback

Autonomous oscillators, such as clocks and lasers, produce periodic signals without any external frequency reference. In order to sustain stable periodic motion, there needs to be an external energy supply as well as nonlinearity built into the oscillator to regulate the amplitude. Usually, nonlinearity is provided by the sustaining feedback mechanism, which also supplies energy, whereas the constituent resonator that determines the output frequency stays linear. Here, we propose a new self-sustaining scheme that relies on the nonlinearity originating from the resonator itself to limit the oscillation amplitude, while the feedback remains linear. We introduce a model for describing the working principle of the self-sustained oscillations and validate it with experiments performed on a nonlinear microelectromechanical oscillator.Fil: Chen, Changyao. Argonne National Laboratory; Estados UnidosFil: Zanette, Damian Horacio. Comisión Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones No Nucleares. Gerencia de Física (Centro Atómico Bariloche); Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Guest, Jeffrey R.. Argonne National Laboratory; Estados UnidosFil: Czaplewski, David A.. Argonne National Laboratory; Estados UnidosFil: López, Daniel. Argonne National Laboratory; Estados Unido

Nonlinearity-induced synchronization enhancement in micromechanical oscillators

An autonomous oscillator synchronizes to an external harmonic force only when the forcing frequency lies within a certain interval - known as the synchronization range - around the oscillator's natural frequency. Under ordinary conditions, the width of the synchronization range decreases when the oscillation amplitude grows, which constrains synchronized motion of micro- and nanomechanical resonators to narrow frequency and amplitude bounds. Here, we show that nonlinearity in the oscillator can be exploited to manifest a regime where the synchronization range increases with increasing oscillation amplitude. Experimental data are provided for self-sustained micromechanical oscillators operating in this regime, and analytical results show that nonlinearities are the key determinants of this effect. Our results provide a new strategy to enhance the synchronization of micromechanical oscillators by capitalizing on their intrinsic nonlinear dynamics.Fil: Antonio, Dario. Argonne National Laboratory; Estados UnidosFil: Czaplewski, David A.. Argonne National Laboratory; Estados UnidosFil: Guest, Jeffrey R.. Argonne National Laboratory; Estados UnidosFil: López, Daniel. Argonne National Laboratory; Estados UnidosFil: Arroyo, Sebastián Ismael. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; ArgentinaFil: Zanette, Damian Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentin

Evaluation of a library of FDA-approved drugs for their ability to potentiate antibiotics against multidrug resistant Gram-negative pathogens

The Prestwick library was screened for antibacterial activity or 'antibiotic-resistance breaking' (ARB) potential against four species of Gram-negative pathogens. Discounting known antibacterials, the screen identified very few ARB hits, which were strain/drug specific. These ARB hits included antimetabolites (zidovudine, floxuridine, didanosine, gemcitabine), anthracyclines (daunorubicin, mitoxantrone, epirubicin) and psychoactive drugs (gabapentin, fluspirilene, oxethazaine). This suggests that there are few approved drugs which could be directly repositioned as adjunct-antibacterials and these will need robust testing to validate efficacy. [Abstract copyright: © Crown copyright 2019.

New Early Eocene mammalian fauna from western Patagonia, Argentina

Two new fossil mammal localities from the Paleogene of central-western Patagonia are preliminarily described as the basis for a new possible biochronological unit for the early Eocene of Patagonia, correlated as being between two conventional SALMAs, the Riochican (older) and the Vacan subage of the Casamayoran SALMA. The mammal-bearing strata belong to the Middle Chubut River Volcanic-Pyroclastic Complex (northwestern Chubut Province, Argentina), of Paleocene-Eocene age. This complex includes a variety of volcaniclastic, intrusive, pyroclastic, and extrusive rocks deposited after the K-T boundary. Geochronological data taken from nearby volcanic deposits that underlie and overlie the mammal-bearing levels indicate that both faunas are of late early Eocene age (Ypresian-Lutetian boundary). In addition to more than 50 species of mammals, including marsupials, ungulates, and xenarthrans, two lower molars are the oldest evidence of bats in South America. Paleobotanical and palynological evidence from inferred contemporary localities nearby indicate subtropical environments characterized by warm and probably moderately humid climate. Remarkably, this new fauna is tentatively correlated with Eocene mammals from the La Meseta Formation in the Antarctic Peninsula. We conclude that the two localities mentioned above are part of a possible new biochronological unit, but the formal proposal of a new SALMA awaits completion of taxonomic analysis of the materials reported upon here. If the La Meseta fauna is correlated biochronologically to western Patagonia, this also suggests a continental extension of the biogeographic Weddelian Province as far north as central-western Patagonia

Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties

3-Methoxybenzamide (1) is a weak inhibitor of the essential bacterial cell division protein FtsZ. Alkyl derivatives of 1 are potent antistaphylococcal compounds with suboptimal drug-like properties. Exploration of the structure-activity relationships of analogues of these inhibitors led to the identification of potent antistaphylococcal compounds with improved pharmaceutical properties

Functional foldamers that target bacterial membranes: the effect of charge, amphiphilicity and conformation

By varying the molecular charge, shape and amphiphilicity of a series of conformationally distinct diarylureas it is possible to control the levels of phospholipid membrane lysis using membranes composed of bacterial lipid extracts. From the data obtained, it appears as though the lysis activity observed is not due to charge, conformation or amphiphilicity in isolation, but that surface aggregation, H-bonding and other factors may also play a part. The work provides evidence that this class of foldamer possesses potential for optimisation into new antibacterial agents

Knowledge-based energy functions for computational studies of proteins

This chapter discusses theoretical framework and methods for developing knowledge-based potential functions essential for protein structure prediction, protein-protein interaction, and protein sequence design. We discuss in some details about the Miyazawa-Jernigan contact statistical potential, distance-dependent statistical potentials, as well as geometric statistical potentials. We also describe a geometric model for developing both linear and non-linear potential functions by optimization. Applications of knowledge-based potential functions in protein-decoy discrimination, in protein-protein interactions, and in protein design are then described. Several issues of knowledge-based potential functions are finally discussed.Comment: 57 pages, 6 figures. To be published in a book by Springe