Visual complexity, player experience, performance and physical exertion in motion-based games for older adults

Motion-based video games can have a variety of benefits for the players and are increasingly applied in physical therapy, rehabilitation and prevention for older adults. However, little is known about how this audience experiences playing such games, how the player experience affects the way older adults interact with motion-based games, and how this can relate to therapy goals. In our work, we decompose the player experience of older adults engaging with motion-based games, focusing on the effects of manipulations of the game representation through the visual channel (visual complexity), since it is the primary interaction modality of most games and since vision impairments are common amongst older adults. We examine the effects of different levels of visual complexity on player experience, performance, and exertion in a study with fifteen participants. Our results show that visual complexity affects the way games are perceived in two ways: First, while older adults do have preferences in terms of visual complexity of video games, notable effects were only measurable following drastic variations. Second, perceived exertion shifts depending on the degree of visual complexity. These findings can help inform the design of motion-based games for therapy and rehabilitation for older adults

Autoimmune hepatitis in India: profile of an uncommon disease

BACKGROUND: Autoimmune hepatitis (AIH) has been reported to show considerable geographical variation in frequency and clinical manifestations. It is considered a rare cause of liver disease in India. The present study was undertaken to determine the incidence, clinical, biochemical and histological profile of AIH in this part of the world. METHODS: Patients presenting with acute or chronic liver disease between January 1999 and June 2002 were evaluated prospectively. AIH was diagnosed using the international autoimmune hepatitis group criteria. Workup included clinical, biochemical, USG, viral markers, UGI endoscopy, AI markers (ANA, SMA, Anti-LKM, AMA, RF, p-ANCA) using indirect immunofluorescence and liver biopsy if possible. RESULTS: Forty-one of 2401 (1.70%) patients were diagnosed to have autoimmune liver disease. Out of these, 38 had autoimmune hepatitis and the rest 3 had primary biliary cirrhosis. The mean age of the patients of autoimmune hepatitis was 36.2 (15.9) years, 34 (89.4%) were females, and the duration of symptoms was 20.3 (20.5) months. Nineteen (50%) of them presented with chronic hepatitis, 13 (34.2%) as cirrhosis, 5 (13.1%) with acute hepatitis and 1 (2.6%) with cholestatic hepatitis. The presentations were jaundice in 21 (55.2%), pedal edema and hepatomegaly in 17 (44.7%), splenomegaly in 13 (34.2%), encephalopathy, abdominal pain in 9 (23.6%) and fever in 8 (21%). Twelve had esophageal varices and 3 had bled. Biochemical parameters were ALT 187 (360) U/L, AST 157 (193) U/L, ALP 246 (254) U/L, globulin 4.1 (1.6) g/dL, albumin 2.8 (0.9) g/dL, bilirubin 5.2 (7.4) mg/dL, prothrombin time 17 (7) sec and ESR 47 (17) sec. The autoimmune markers were SMA (24), ANA (15), both SMA and ANA (4), AMA (1), rheumatoid factor (2), pANCA (1), and Anti-LKM in none. Thirty (79%) patients had definite AIH and eight (21%) had probable AI hepatitis. Associated autoimmune diseases was seen in 15/38 (39.4%), diabetes 4, hypothyroidism 3, vitiligo 2, thrombocytopenia 2, rheumatoid arthritis 2, Sjogren's syndrome 1 and autoimmune polyglandular syndrome III in 1. Viral markers were positive in two patients, one presenting as acute hepatitis and HEV-IgM positive and another anti-HCV positive. CONCLUSION: In India, autoimmune hepatitis is uncommon and usually presents with chronic hepatitis or cirrhosis, acute hepatitis being less common. Age at presentation was earlier but clinical parameters and associated autoimmune diseases were similar to that reported from the west. Primary biliary cirrhosis is rare. Type II AIH was not observed

Tip-surface forces, amplitude, and energy dissipation in amplitude-modulation (tapping mode) force microscopy

Amplitude-modulation (tapping mode) atomic force microscopy is a technique for high resolution imaging of a wide variety of surfaces in air and liquid environments. Here by using the virial theorem and energy conservation principles we have derived analytical relationships between the oscillation amplitude, phase shift, and average tip-surface forces. We find that the average value of the interaction force and oscillation and the average power dissipated by the tip-surface interaction are the quantities that control the amplitude reduction. The agreement obtained between analytical and numerical results supports the analytical method.This work has been supported by the Dirección General de Investigación Científica y Técnica (PB98-0471) and the European Union (BICEPS, BIO4-CT-2112). A. S. P. acknowledges financial support from the Comunidad Autónoma de Madrid.Peer reviewe

The Q_{1,2}-Q_7 interference contributions to b -> s gamma at O(alpha_s^2) for the physical value of m_c

The B -> X_s gamma branching ratio is currently measured with around 5% accuracy. Further improvement is expected from Belle II. To match such a precision on the theoretical side, evaluation of O(alpha_s^2) corrections to the partonic decay b -> X_s^part gamma are necessary, which includes the b -> s gamma, b -> s g gamma, b -> s g g gamma, b -> s qbar q gamma decay channels. Here, we evaluate the unrenormalized contribution to b -> s gamma that stems from the interference of the photonic dipole operator Q_7 and the current-current operators Q_1 and Q_2. Our results, obtained in the cut propagator approach at the 4-loop level, agree with those found in parallel by Fael et al. who have applied the amplitude approach at the 3-loop level. Partial results for the same quantities recently determined by Greub et al. agree with our findings, too.Comment: 9 pages, 1 figur

Recent Progress in Shearlet Theory: Systematic Construction of Shearlet Dilation Groups, Characterization of Wavefront Sets, and New Embeddings

The class of generalized shearlet dilation groups has recently been developed to allow the unified treatment of various shearlet groups and associated shearlet transforms that had previously been studied on a case-by-case basis. We consider several aspects of these groups: First, their systematic construction from associative algebras, secondly, their suitability for the characterization of wavefront sets, and finally, the question of constructing embeddings into the symplectic group in a way that intertwines the quasi-regular representation with the metaplectic one. For all questions, it is possible to treat the full class of generalized shearlet groups in a comprehensive and unified way, thus generalizing known results to an infinity of new cases. Our presentation emphasizes the interplay between the algebraic structure underlying the construction of the shearlet dilation groups, the geometric properties of the dual action, and the analytic properties of the associated shearlet transforms.Comment: 28 page

A ‘warm path’ for Gulf Stream–troposphere interactions

Warm advection by the Gulf Stream creates a characteristic ‘tongue’ of warm water leaving a strong imprint on the sea surface temperature (SST) distribution in the western North Atlantic. This study aims at quantifying the climatological impact of this feature on cyclones travelling across this region in winter using a combination of reanalysis data and numerical experiments. It is suggested that the Gulf Stream ‘warm tongue’ is conducive to enhanced upward motion in cyclones because (i) it helps maintain a high equivalent potential temperature of air parcels at low levels which favors deep ascent in the warm conveyor belt of cyclones and (ii) because the large SST gradients to the north of the warm tongue drive a thermally direct circulation reinforcing and, possibly, destabilizing, the transverse circulation embedded in cyclones. This hypothesis is confirmed by comparing simulations at 12 km resolution from the Met Office Unified Model forced with realistic SST distribution to simulations with an SST distribution from which the Gulf Stream warm tongue was artificially removed or made colder by . It is also supported by a dynamical diagnostic applied to the ERA interim data-set over the wintertime period (1979–2012). The mechanism of oceanic forcing highlighted in this study is associated with near thermal equilibration of low level air masses with SST in the warm sector of cyclones passing over the Gulf Stream warm tongue, which is in sharp contrast to what occurs in their cold sector. It is suggested that this ‘warm path’ for the climatic impact of the Gulf Stream on the North Atlantic storm-track is not currently represented in climate models because of their coarse horizontal resolution

Design of a robotic hand with a biologically-inspired parallel actuation system for prosthetic applications

Trabajo presentado al 34th Annual Mechanisms and Robotics Conference celebrado en Quebec del 15 al 18 de agosto de 2010.This paper presents the design of a robotic hand for prosthetic applications. The main characteristic of this robotic hand is its biologically-inspired parallel actuation system, which is based on the behavior/strength space of the Flexor Digitorum Profundus (FDP) and the Flexor Digitorum Superficialis (FDS) muscles. The design separates the strength space of the FDS and FDP muscles into a lighter strength region where finer manipulation and general approach tasks are executed, and a higher strength region where the more robust grasps are achieved. Two parallel actuator types and kinematic structures are designed to complement the requirements of both strength space regions.This research was performed under an award/contract from Telemedicine Advanced Technology Research Center (TATRC), of the U.S. Army Medical Research and Materiel Command (USAMRMC) of the U.S. Department of Defense.Peer Reviewe

Histological Remission during Corticosteroid Therapy of Overlapping Nonalcoholic Steatohepatitis and Autoimmune Hepatitis: Case Report and Literature Review

Concurrence of nonalcoholic steatohepatitis (NASH) with autoimmune hepatitis (AIH) is a rare condition that is challenging to diagnosis, due to the relatively high prevalence of autoantibodies in NASH. It is also difficult to determine the most effective treatment as corticosteroids are likely to worsen NASH despite being effective in the treatment of AIH. In this case report, we present a female diagnosed with NASH-AIH overlap with accompanying diabetes mellitus, who successfully achieved normalization of serum alanine aminotransferase levels following prednisolone therapy and weight loss. A follow-up liver biopsy performed 40 months after the initial diagnosis showed only minimal inflammatory infiltrates in the portal area without any NASH histology. Resolution of NASH, in conjunction with a reduction in hepatic fibrosis, might suggest that prednisolone itself does not aggravate steatohepatitis, but rather prevents disease progression. Appropriate immunosuppressive treatment may therefore be an important component of the optimum therapy for NASH-AIH overlap

The influence of annealings on structure and microhardness of Fe-Mo-V-Nb-C steel processed by high-pressure torsion

The influence of high-pressure torsion on microstructure, microhardness and thermal stability of lowcarbon steel Fe-0,1Mo-0,6Mn-0,8Cr-0,2Ni-0,3Si-0,2Cu-0,1V-0,06Nb-0,09C, (wt.%) was investigated. It was shown that ultrafine-grained structure formed by high-pressure torsion possesses a high microhardness (H[mu]=7,0 GPa) and high thermal stability up to the temperature of 400°С