NUCLEIC-ACID BINDING-DRUGS .8. STRUCTURES OF 1-[2-(DIETHYLAMINO)ETHYLAMINO]ANTHRACENE-9,10-DIONE, C20H22N2O2 (I), AND 1,5-BIS[2-(DIETHYLAMINO)ETHYLAMINO]ANTHRACENE-9,10-DIONE, C26H36N4O2(II), MODELS FOR ANTI-TUMOR DRUGS

(I) M r = 322.41, P21/n, a = 7.118 (1), b = 26.873(2), c=8.886(1)A, fl=97.74(1)°, ~ V= 1684.3 (6) A 3, Z = 4, D m = 1.27, D x = 1.271 Mg m -3, 2 (Cu Ka) = 1.54178 A,/~ = 6.67 cm -1, F(000) = 688, T= 298 K, R w= 0.049 for 981 unique significant reflections. (II) Mr=436.61, P21/c, a= 15.360 (2), b = 5.245 (1), c= 15.483 (1)A, fl= 94.23 (1) °, V= 1244.0 (5)/~3, Z = 2, D m -- 1.17, D x = 1.165 Mg m -s, 2(Cu Kt~) = 1.54178/k, /t = 5.98 cm -1, F(000) = 472, T= 298 K, R w = 0.090 for 457 unique significant reflections. The chromophore is highly planar in both compounds

China’s Rule of Law is Australia’s Business

The purpose of this paper is to investigate the implications of China’s rule of law, in the context of commercial corruption, on the Australia-China business relationship. This paper involves the analysis of three separate case studies: the ‘Melamine milk case’, the ‘Stern Hu case’ and the ‘Matthew Ng case’. The research undertaken in this paper is divided into two main sections. The first section involves a content analysis of media frames in both the Chinese and Australian news coverage in three separate cases. The section undertakes a critical analysis of Australian media and political discourse concerning the three cases. This research demonstrates the different conceptions of the rule of law between China and Australia, and that essentially China’s practice of the rule of law impacts on Australia. This paper’s originality is in its refinement about understanding China’s rule of law and its place in broader debates concerning the Australian-China business relationship. Moreover, this dissertation takes a unique research angle in this field through the use of discourse analysis

China’s Rule of Law is Australia’s Business

The purpose of this paper is to investigate the implications of China’s rule of law, in the context of commercial corruption, on the Australia-China business relationship. This paper involves the analysis of three separate case studies: the ‘Melamine milk case’, the ‘Stern Hu case’ and the ‘Matthew Ng case’. The research undertaken in this paper is divided into two main sections. The first section involves a content analysis of media frames in both the Chinese and Australian news coverage in three separate cases. The section undertakes a critical analysis of Australian media and political discourse concerning the three cases. This research demonstrates the different conceptions of the rule of law between China and Australia, and that essentially China’s practice of the rule of law impacts on Australia. This paper’s originality is in its refinement about understanding China’s rule of law and its place in broader debates concerning the Australian-China business relationship. Moreover, this dissertation takes a unique research angle in this field through the use of discourse analysis

Idiopathic scoliosis and pineal lesions in Australian children

PURPOSE: To determine whether treatment of pineal lesions in children is associated with development of idiopathic scoliosis. METHODS: 38 boys and 10 girls with pineal lesions were identified. Their mean age at presentation was 10 years. The pineal pathology varied from cysts and epidermoid to teratoma, germinoma, pineocytoma, and glioblastoma. Treatment ranged from biopsy/extirpation to radiotherapy. RESULTS: 12 patients died. No scoliosis was found in any females or any of the deceased. Two boys had scoliosis: one had a 12-degree right upper thoracic curve with 32-degree kyphosis and the other had a 60-degree right thoracolumbar idiopathic curve, requiring a 2-stage arthrodesis. CONCLUSION: Pineal ablation is not related to the development of idiopathic scoliosis in humans

A Comparative Analysis of the Peptide Repertoires of HLA–DR Molecules Differentially Associated With Rheumatoid Arthritis

[Objective] To evaluate similarity of the peptide repertoires bound to HLA–DR molecules that are differentially associated with rheumatoid arthritis (RA), and to define structural features of the shared peptides. [Methods] Peptide pools bound to HLA–DRB1*01:01, HLA–DRB1*04:01, and HLA–DRB1*10:01 (RA associated) and those bound to HLA–DRB1*15:01 (non–RA–associated) were purified and analyzed by liquid chromatography (LC) matrix-assisted laser desorption ionization–time-of-flight mass spectrometry (MS) and LC–ion-trap MS. Peptide pools from each allotype were compared in terms of size, protein origin, composition, and affinity (both theoretical and experimental with some peptides). Finally, 1 peptide sequenced from DR1, DR4, and DR10, but not from DR15, was modeled in complex with all 4 HLA–DRB1 molecules and HLA–DRB5*01:01. [Results] A total of 6,309 masses and 962 unique peptide sequences were compared. DR10 shared 29 peptides with DR1, 9 with DR4, and 1 with DR15; DR1 shared 6 peptides with DR4 and 9 with DR15; and DR4 and DR15 shared 4 peptides. The direct identification of peptide ligands indicated that DR1 and DR10 were the most similar molecules regarding the peptides that they could share. The peptides common to these molecules contained a high proportion of Leu at P4 and basic residues at P8 binding core positions. [Conclusion] The degree of overlap between peptide repertoires associated with different HLA–DR molecules is low. The repertoires associated with DR1 and DR10 have the highest similarity among the molecules analyzed (∼10% overlap). Among the peptides shared between DR1 and DR10, a high proportion contained Leu4 and basic residues at the P8 position of the binding core.Supported by the Spanish Ministry of Economy and Competitiveness (project grant SAF2012-35344). The Spanish National Research Council/Universitat Autònoma de Barcelona (CSIC/UAB) Proteomics Laboratory and the Vall d'Hebron University Hospital Research Institute Proteomics Laboratory are members of ProteoRed-ISCIII, which is funded by Genoma Spain.Peer Reviewe

Women's Mourning in the Striparvan of the Mahabharata

The purpose of this thesis is to present various themes concerning women's mourning in the Striparvan of the Mahabharata. This paper is intended as a preliminary study upon which further work on death, grief and mourning in the Mahabharata may be built. Owing to this focus, it attempts to connect those themes found in the Sfripa1Van with similar themes found elsewhere in the Mahabharata. In this thesis, the mourning behaviour of the women is divided into three separate categories: the appearance of the women, the actions of the women, and the laments that the women utter. Each category is presented as it is found in the text, and analyzed accordingly. There is a strong emphasis on the symbolic and metaphorical connections between these women and other liminal beings, such as ascetics, menstruating women, gods, and animals. The meaning of these connections is subsequently explored. There are three significant findings within this thesis that stem from the analysis of the categories of mourning behaviour. Firstly, the symbolic and metaphorical links that mourning women have with the beings mentioned above lend the women an aura of power that is primarily used to hurt curses that destroy entire lineages. It is argued here that these curses are part of a background of women's curses that cause most of the suffering in the main plot of the Mahabharata. Mourning women also possess many erotic characteristics that are found both in their laments as well as through their metaphorical connections with other liminal beings. The main element of this eroticism is the expression of frustrated fertility. This frustrated fertility becomes destructive through symbolic connections with the doomsday mare. The longer the duration of the frustration, the more destructive the women become. Finally, the women's laments indicate that they firmly support the code of duty (ksatradharma) that warriors (ksatriyas) are supposed to adhere to. Just as the main villian Duryodhana does, the women place a priority on k~atradharma as a system of moral judgement. Owing to this priority, the women emphasize the responsibilty of humans for their own moral actions, which is directly opposed to the theological solution of Vaisniava bhakti (devotion) as it is presented in the text by the divine Krsna. The thesis concludes with some speculations as to the direction that further research on the same topic may take. An emphasis on men's grief and mourning is indicated.ThesisMaster of Arts (MA

Teen Dating Violence Perpetration among Middle School Youth: The Role of Bullying, Sexual Harassment, and Gender

Although teen dating violence (TDV) has been associated with bullying and sexual harassment, the developmental relationship among all three behaviors has rarely been examined, especially by gender. This dissertation used structural equation modeling to investigate the temporal sequence among perpetration of bullying, sexual harassment, and dating violence, and to determine if the sequence varies by gender. Study Aim 1first determined if the aggression measures were invariant for girls and boys. Study Aim 2a then tested whether sexual harassment perpetration mediates the relationship between bullying perpetration and TDV perpetration, while Study Aim 2b tested moderated mediation by assessing whether the developmental pathway varies by gender among middle school-aged youth. The data were collected from one cohort of 7th grade middle school students. Students were surveyed every 6 months during 7th and 8th grades for a total of four waves of data collection. Study Aim 1 was assessed using baseline (wave 1) data, whereas Study Aims 2a and 2b were assessed using data from waves 1 through 3. The first study examined measurement invariance by gender of all aggression measures: perpetration of bullying, sexual harassment, physical TDV, psychological TDV, and electronic TDV. Both the physical and psychological TDV perpetration measures and the sexual harassment measure achieved strict measurement invariance. Bullying perpetration demonstrated the next most stringent test of measurement invariance by gender, partial strict invariance. Electronic TDV achieved the next most stringent test of invariance by gender, metric/scalar invariance. The second study tested whether sexual harassment perpetration mediates the relationship between bullying perpetration and TDV perpetration (2a), and then tested moderated mediation by assessing whether the developmental pathway varies by gender (2b). Results indicate no evidence of mediation. However, in the overall model, bullying and sexual harassment both emerged as significant predictors of TDV at a later time point. Among girls, only bullying significantly predicted TDV at a later time point, and, among boys, only sexual harassment significantly predicted TDV at a later time point. Prevention programs that target bullying and sexual harassment perpetration may reduce later perpetration of TDV. Further research is needed to disentangle the temporal relationships between these aggressive behaviors among youth.Doctor of Philosoph

STRUCTURE OF 2,3-DIHYDRO-1H-IMIDAZO[1,2-B]PYRAZOLE (IMPY), AN INHIBITOR OF DNA-SYNTHESIS, C5H7N3

Mr= 109.13, orthorhombic, P212121, a= 7.098 (1), b=7.225 (1), c= 10.980 (3)A, V= 563.09A 3, Z-4, D m=1.29, D x=l.29Mgm -a, 2(CuKs)=l.54178A, p=0.70mm -~. Final R= 0.059 for 425 significant reflections measured at 298 K. The pyrazole portion is planar, while the dihydroimidazole group has a shallow half-chair conformation with C(4) deviating by 0.136 (4) A out of the plane of this ring

STRUCTURE OF 1-(PARA-METHOXYPHENYL)-TRANS-1,2-DIPHENYLBUT-1-ENE

C23H220 , triclinic, P1, a = 9.644 (3), b = 10.0001 (3), c = 10.4999 (3) A, c~ = 78.77 (3), fl = 67.53 (3), y= 74.91 (2) ° , V=898.3 A3, dc= 1.16 Mg m -3, Z = 2. There are two independent molecules in the asymmetric unit, which have very similar conformations. The structure was refined to a final R of 0.0586 for 2294 significant reflections

MOLECULAR-MODELLING AND BIOPHYSICAL STUDIES ON MODIFIED AND UNMODIFIED OLIGONUCLEOTIDES

Computer graphics modelling and energy calculations have been carried out on a series of modified and unmodified oligonucleotides to investigate the effects of base deletion, base substitution and base methylation, particularly 06-methylguanine and 5-methylcytosine, as well as the substitution of bases by analogues