12 research outputs found

    Second-line treatment in advanced gastric cancer : Data from the Spanish AGAMENON registry

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    Second-line treatments boost overall survival in advanced gastric cancer (AGC). However, there is a paucity of information as to patterns of use and the results achieved in actual clinical practice. The study population comprised patients with AGC in the AGAMENON registry who had received second-line. The objective was to describe the pattern of second-line therapies administered, progression-free survival following second-line (PFS-2), and post-progression survival since first-line (PPS). 2311 cases with 2066 progression events since first-line (89.3%) were recorded; 245 (10.6%) patients died during first-line treatment and 1326/2066 (64.1%) received a second-line. Median PFS-2 and PPS were 3.1 (95% CI, 2.9-3.3) and 5.8 months (5.5-6.3), respectively. The most widely used strategies were monoCT (56.9%), polyCT (15.0%), ramucirumab+CT (12.6%), platinum-reintroduction (8.3%), trastuzumab+CT (6.1%), and ramucirumab (1.1%). PFS-2/PPS medians gradually increased in monoCT, 2.6/5.1 months; polyCT 3.4/6.3 months; ramucirumab+CT, 4.1/6.5 months; platinum-reintroduction, 4.2/6.7 months, and for the HER2+ subgroup in particular, trastuzumab+CT, 5.2/11.7 months. Correlation between PFS since first-line and OS was moderate in the series as a whole (Kendall's τ = 0.613), lower in those subjects who received second-line (Kendall's τ = 0.539), especially with ramucirumab+CT (Kendall's τ = 0.413). This analysis reveals the diversity in second-line treatment for AGC, highlighting the effectiveness of paclitaxel-ramucirumab and, for a selected subgroup of patients, platinum reintroduction; both strategies endorsed by recent clinical guidelines

    Search for excited quarks in the y+jet final state in proton-proton collisions at s=8 TeV

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    A search for excited quarks decaying into the γ+jet final state is presented. The analysis is based on data corresponding to an integrated luminosity of 19.7 fb −1 collected by the CMS experiment in proton–proton collisions at s=8 TeV at the LHC. Events with photons and jets with high transverse momenta are selected and the γ+jet invariant mass distribution is studied to search for a resonance peak. The 95% confidence level upper limits on the product of cross section and branching fraction are evaluated as a function of the excited quark mass. Limits on excited quarks are presented as a function of their mass and coupling strength; masses below 3.5 TeV are excluded at 95% confidence level for unit couplings to their standard model partners

    Proposal Of A Process Intensification And Green Technology On Ethyl Acetate Production

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    Although reactive distillation column is not a new concept, it has gained renewed interest in recent years as an effective way to pursue intensification of conventional chemical processes. Reactive distillation operations were first used by the chemical and petrochemical industry in esterification processes to separate reaction products from the reactants to increase product yields. Reactive distillation technology combines chemical synthesis steps with separations by distillation. This combination can lead to intensified, high-efficiency process systems with significant green engineering attributes. Among several approaches to process intensification are hybrid combinations of separation and reaction for chemical synthesis. These combinations offer new process alternatives that may have greatly improved efficiencies (e.g., in reduced energy requirements, lower solvent use, reduced equipment investment, and greater selectivity). Many of these potential advantages are intimately linked to the principles and challenges for green engineering. This work presents a study of establishment of a complete reactive distillation system for production of ethyl acetate via esterification of acetic acid with ethanol using ASPEN PLUS. Ethyl acetate is an important organic solvent widely used in the production of varnishes, ink, synthetic resins, and adhesive agents. Ethyl acetate is normally produced via reversible reaction of acetic acid with ethanol. There are only a few papers in the literature on the subject of the production of ethyl acetate via reactive distillation. A suitable NRTL (nonrandom two-liquid) model parameter set for calculating of liquid activity coefficients has been established with excellent prediction of the compositions and temperatures for the four azeotropes in the system. The predicted four azeotropes in this system include three homogeneous azeotropes of ethanol/ethyl acetate, ethanol/water and ethanol/ethyl acetate/water and also one heterogeneous azeotrope of ethyl acetate/water. A reactive distillation column with an overhead decanter can be designed to achieve over 93 wt% of ethyl acetate composition at organic phase top product stream while the bottom product stream is designed to be rich in acetic acid so that it can be recycled and mixed with fresh acid makeup stream to serve as acid feed to reactive distillation column. Since the purity of the optimum top organic product specification in industry, an additional column is designed to purify the ethyl acetate product of the reactive distillation column to over 99.5 wt%. The top draw of the second column will be recycled back to the decanter. Concluding, the process intensification of ethyl acetate production by reactive distillation was composed by two columns, including the reactive distillation column and the second column, one decanter, and two recycle streams. The optimum operating condition of the overall system will also be studied to minimize the total operating cost and the size of the plant wide of the overall system while meeting product specifications

    Erratum: Implementation Of Pseudopotential In The G3 Theory For Molecules Containing First-, Second-, And Non-transition Third-row Atoms (journal Of Chemical Physics (2011) 135 (034106))

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    [No abstract available]13521Pereira, D.H., Ramos, A.F., Morgon, N.H., Custodio, R., (2011) J. Chem. Phys., 135, p. 034106. , 10.1063/1.360924

    Design And Analysis Of A Classical Controller To The Residual Oil In A Small Scale Semibatch Extractor

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    The main effects of the variables concerned with the isothermal and isobaric supercritical extraction of grape oil are determined using a two levels factorial design. It is verified that the solvent velocity can be manipulated to control the residual oil content in the solids. Disturbances in the mean diameter of the particles can not be controlled during the extraction process. Parameter sensitivity supported the design and the performance investigation of the classical controller to the residual oil in the solid material. The proposed procedure was able to control the extraction process under individual and simultaneous step disturbances in the initial content of oil in the solids and in the solvent inlet concentration. © 2005 Elsevier B.V. All rights reserved.20C14411446Asteasuain, M., Brandolin, A., Sarmoria, C., Simultaneous Design and control of a Semibatch Styrene Polymerization Reactor (2004) Industrial & Engineering Chemistry Research, 43 (17), pp. 5233-5247Flores-Cerrillo, J., MacGregor, J.F., Control of Batch Product Quality by Trajectory Manipulation using Latent Variable Models (2004) Journal of Process Control, 14 (5), pp. 539-553Garcia-Munoz, S., Kourti, T., MacGregor, J.F., Model Predictive Monitoring for Batch Processes (2004) Industrial & Engineering Chemistry Research, 43 (18), pp. 5929-5941Grau, M.D., Puigjaner, L., Batch and Semibatch Reactors Modelling and Validation Based on Online pH Measurement (2000) Chemical Engineering Communications, 178, pp. 49-65Rezende, D.F., (1998) PhD Thesis (in portuguese), , 174p, LOPCA/FEQ/UNICAMP, S.P. BrasilSovová, H., Rate of Vegetable Oil Extraction with Supercritical CO2-I. Modelling of Extraction Curves (1994) Chemical Engineering Science, 49 (3), pp. 409-414Sovová, H., Kucera, J., Jez, J., Rate of Vegetable Oil Extraction with Superitical CO2-II. Extraction of Grape Oil (1994) Chemical Engineering Sciense, 49 (3), pp. 415-420Srinivasan, B., Bonvin, D., Visser, E., Dynamic Optimization of Batch Process-II. Role of Measurements in Handling Uncertainty (2003) Computers & Chemical Engineering, 27 (1), pp. 27-4

    Synthesis and studies of calcium channel blocking and antioxidant activities of novel 4-pyridinium and/or N-propargyl substituted 1,4-dihydropyridine derivatives

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    The novel 1,4-dihydropyridine derivatives containing the cationic pyridine moiety at the position 4, and the N-propargyl group as a substituent at position 1 of the 1,4-DHP cycle were designed, synthesised, and assessed in biological tests. Among all the novel compounds, the 4-(N-dodecyl) pyridinium group-containing compounds 11 (without the N-propargyl group) and 12 (with the N-propargyl group) demonstrated the highest calcium antagonistic properties against neuroblastoma SH-SY5Y (IC50 about 5–14 mM) and the vascular smooth muscle A7r5 cell (IC50 – 0.6–0.7 mM) lines, indicating that they predominantly target the L-type calcium channels. These compounds showed a slight total antioxidant activity. At concentrations close to those of L-type calcium channel blocking ones, compound 12 did not affect mitochondrial functioning; also, no toxicity was obtained in vivo. The N-propargyl group as a substituent at position 1 of the 1,4-DHP cycle did not essentially influence the compounds’ activity. The 4-(N-dodecyl) pyridinium moiety-containing compounds can be considered as prototype molecules for further chemical modifications and studies as cardioprotective/neuroprotective agents.This study was supported by ESF project No. 2009/ 0217/1DP/1.1.1.2.0/09/APIA/VIAA/031; the EuroNanoMed project ‘‘CheTherDel’’; Portuguese Research Council (FCT), Faculty of Medicine, Centre for Neuroscience and Cell Biology (CNC) and Marine and Environmental Research Centre (IMAR–CMA) of the University of Coimbra, Portugal

    Search for new physics in events with same-sign dileptons and jets in pp collisions at root s = 8 TeV (vol 01, pg 163, 2014)

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    Made available in DSpace on 2015-06-25T12:55:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2015Made available in DSpace on 2015-11-26T15:18:27Z (GMT). No. of bitstreams: 2 2-s2.0-84921407514.pdf: 236271 bytes, checksum: e9b67a8637560201105108af720ed1ff (MD5) 2-s2.0-84921407514.pdf.txt: 43801 bytes, checksum: a87aa49408e3fa7bb288c13764b65c79 (MD5) Previous issue date: 20152015111

    Search for the associated production of the Higgs boson with a top-quark pair

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    2014

    Differential cross section measurements for the production of a W boson in association with jets in proton-proton collisions at root s=7 TeV

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    Search For New Resonances Decaying Via Wz To Leptons In Proton-proton Collisions At √s=8tev

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