Zeeman Slowers for Strontium based on Permanent Magnets

We present the design, construction, and characterisation of longitudinal- and transverse-field Zeeman slowers, based on arrays of permanent magnets, for slowing thermal beams of atomic Sr. The slowers are optimised for operation with deceleration related to the local laser intensity (by the parameter $\epsilon$), which uses more effectively the available laser power, in contrast to the usual constant deceleration mode. Slowing efficiencies of up to $\approx$ $18$ $$ are realised and compared to those predicted by modelling. We highlight the transverse-field slower, which is compact, highly tunable, light-weight, and requires no electrical power, as a simple solution to slowing Sr, well-suited to spaceborne application. For $^{88}$Sr we achieve a slow-atom flux of around $6\times 10^9$ atoms$\,$s$^{-1}$ at $30$ ms$^{-1}$, loading approximately $5\times 10^8$ atoms in to a magneto-optical-trap (MOT), and capture all isotopes in approximate relative natural abundances

Models of Planets and Brown Dwarfs in Mira Winds

We present numerical hydrodynamical models of the effects of planets or brown dwarfs orbiting within the extended atmosphere and wind formation zone of Mira variables. We find time-dependent wake dynamics and episodic accretion phenomena which may give rise to observable optical events and affect SiO maser emission.Comment: 4 pages, 3 figures, follow-up to JAAVSO pape

A Randomized Trial Evaluating a Parent Based Intervention to Reduce College Drinking

This study evaluated the effectiveness of a parent based intervention (PBI) in reducing drinking among first year college students (N = 443). Students were assigned to one of three conditions: PBI, PBI plus booster brochures (PBI-B), and an assessment only control group (CNT). At a 4-month post-intervention follow-up, results indicated students in the PBI-B group reported significantly less drinking to intoxication and peak drinking relative to the PBI group and CNT group. No significant differences were found between the PBI group and CNT group. Results provide further support for PBIs to reduce college student drinking and suggest that a booster brochure increases the effectiveness of PBIs

Solid-state characterization of novel active pharmaceutical ingredients: Cocrystal of a salbutamol hemiadipate salt with adipic acid (2:1:1) and salbutamol hemisuccinate salt.

The production of salt or cocrystalline forms is a common approach to alter the physicochemical properties of pharmaceutical compounds. The goal of this work was to evaluate the impact of anion choice (succinate, adipate, and sulfate) on the physicochemical characteristics of salbutamol forms. Novel crystals of salbutamol were produced by solvent evaporation: a cocrystal of salbutamol hemiadipate with adipic acid (salbutamol adipate, SA), salbutamol hemisuccinate tetramethanolate (SSU.MeOH), and its desolvated form (SSU). The crystalline materials obtained were characterized using thermal, X-ray, nuclear magnetic resonance, Fourier transform infrared spectroscopy, dynamic vapor sorption (DVS), and elemental analysis. The crystal forms of SA and SSU.MeOH were determined to be triclinic, (Pī), and monoclinic, (P21/n), respectively. DVS analysis confirmed that SSU and SA do not undergo hydration under increased relative humidity. Both thermal and elemental analyses confirmed the stoichiometry of the salt forms. The aqueous solubilities of SA and SSU were measured to be 82 ± 2 mg/mL (pH 4.5 ± 0.1) and 334 ± 13 mg/mL (pH 6.6 ± 0.1), respectively. Measured values corresponded well with the calculated pH solubility profiles. The intrinsic dissolution rate of cocrystallized SA was approximately four times lower than that of SSU, suggesting its use as an alternative to more rapidly dissolving salbutamol sulfate

Quenched narrow-line second- and third-stage laser cooling of 40Ca

We demonstrate three-dimensional (3-D) quenched narrow-line laser cooling and trapping of 40Ca. With 5 ms of cooling time we can transfer 28 % of the atoms from a magneto-optic trap based on the strong 423 nm cooling line to a trap based on the narrow 657 nm clock transition (that is quenched by an intercombination line at 552 nm), thereby reducing the atoms' temperature from 2 millikelvin to 10 microkelvin. This reduction in temperature should help reduce the overall systematic frequency uncertainty for our Ca optical frequency standard to < 1 Hz. Additional pulsed, quenched narrow-line third-stage cooling in 1-D yields sub-recoil temperatures as low as 300 nK, and makes possible the observation of high-contrast two-pulse Ramsey spectroscopic lineshapes.Comment: 21 Pages including figures. Submitted to JOSA

Motor vehicle accidents in patients with an implantable cardioverter-defibrillator

Objectives.This study was designed to examine driving safety in patients at risk for sudden death after implantation of a cardioverter-defibrillator.Background.Cardioverter-defibrillators are frequently implanted in patients at high risk for sudden death. Despite concern about the safety of driving in these patients, little is known about their actual motor vehicle accident rates.Methods.Surveys were sent to all 742 physicians in the United States involved in cardioverter-defibrillator implantation and follow-up. Physicians were questioned about numbers of patients followed up, numbers of fatal and nonfatal accidents, physician recommendations to patients about driving and knowledge of state driving laws.Results.Surveys were returned by 452 physicians (61%). A total of 30 motor vehicle accidents related to shocks from implantable defibrillators were reported by 25 physicians over a 12-year period from 1980 to 1992. Of these, nine were fatal accidents involving eight patients with a defibrillator and one passenger in a car driven by a patient. No bystanders were fatally injured. There were 21 nonfatal accidents involving 15 patients, 3 passengers and 3 bystanders. The estimated fatality rate for patients with a defibrillator, 7.5/100,000 patient-years, is significantly lower than that for the general population (18.4/100,000 patient-years, p < 0.05). The estimated injury rate, 17.6/100,000 patient-years, is also significantly lower than that for the general public (2,224/100,000 patient-years, p < 0.05). Only 10.5% (30 of 286) of all defibrillator discharges during driving resulted in accidents. Regarding physician recommendations, most physicians (58.1%) ask their patients to wait a mean (± SD) of 7.3 ± 3.4 months after implantation or a shock before driving again.Conclusions.The motor vehicle accident rate caused by discharge from an implantable cardioverter-defibrillator is low. Although restricting driving for a short period of time after implantation may be appropriate, excessive restrictions or a total ban on driving appears to be unwarranted

Continuous and Burst-like Accretion onto Substellar Companions in Mira Winds

We present numerical hydrodynamical modeling of the effects of a giant planet or brown dwarf companion orbiting within the extended atmosphere and wind formation zone of an approximately solar-mass Mira variable star. The large-scale, time-dependent accretion flows within the radially oscillating and outflowing circumstellar gas around Miras are related to Bondi-Hoyle-Lyttleton flows, but have not, to our knowledge, been previously modelled. The new models presented in this paper illustrate the changes in accretion and wake dynamics as the companion mass is varied over a range from 10 to 50 Jupiter masses ($M_J$). The character of the accretion onto the companion changes greatly as the companion mass is increased. At the lowest companion masses considered here, a low continuous rate of mass accretion is punctuated by large, nearly periodic bursts of accretion. When the companion mass is large, the mass accretion has both a continuous part, and a rapidly varying, nearly stochastic part. These trends can be understood as the result of the interplay between the shocks and radial oscillations in the circumstellar gas, and the wake flow behind the companion. Models with accretion bursts may produce observable optical brightenings, and may affect SiO maser emission. (Abridged)Comment: 16 pgs., 10 figures with low resolution versions of Figs. 1, 9. Accepted for publication in MNRA

The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into the evolution of a fish pathogen

Background Aeromonas salmonicida subsp. salmonicida is a Gram-negative bacterium that is the causative agent of furunculosis, a bacterial septicaemia of salmonid fish. While other species of Aeromonas are opportunistic pathogens or are found in commensal or symbiotic relationships with animal hosts, A. salmonicida subsp. salmonicida causes disease in healthy fish. The genome sequence of A. salmonicida was determined to provide a better understanding of the virulence factors used by this pathogen to infect fish. Results The nucleotide sequences of the A. salmonicida subsp. salmonicida A449 chromosome and two large plasmids are characterized. The chromosome is 4,702,402 bp and encodes 4388 genes, while the two large plasmids are 166,749 and 155,098 bp with 178 and 164 genes, respectively. Notable features are a large inversion in the chromosome and, in one of the large plasmids, the presence of a Tn21 composite transposon containing mercury resistance genes and an In2 integron encoding genes for resistance to streptomycin/spectinomycin, quaternary ammonia compounds, sulphonamides and chloramphenicol. A large number of genes encoding potential virulence factors were identified; however, many appear to be pseudogenes since they contain insertion sequences, frameshifts or in-frame stop codons. A total of 170 pseudogenes and 88 insertion sequences (of ten different types) are found in the A. salmonicida genome. Comparison with the A. hydrophila ATCC 7966T genome reveals multiple large inversions in the chromosome as well as an approximately 9% difference in gene content indicating instances of single gene or operon loss or gain. A limited number of the pseudogenes found in A. salmonicida A449 were investigated in other Aeromonas strains and species. While nearly all the pseudogenes tested are present in A. salmonicida subsp. salmonicida strains, only about 25% were found in other A. salmonicida subspecies and none were detected in other Aeromonas species. Conclusion Relative to the A. hydrophila ATCC 7966T genome, the A. salmonicida subsp. salmonicida genome has acquired multiple mobile genetic elements, undergone substantial rearrangement and developed a significant number of pseudogenes. These changes appear to be a consequence of adaptation to a specific host, salmonid fish, and provide insights into the mechanisms used by the bacterium for infection and avoidance of host defence systems.Peer reviewed: YesNRC publication: Ye