A case of infective colitis due to Yersinia enterocolitica complicated by microliver abscesses mimicking multiple liver occult metastases: a case report

Background: We report an unusual case of infective colitis by Yersinia enterocolitica complicated by microliver abscesses mimicking multiple liver metastases in a 79 yr old female without any risk factors for bacteriaemia by this pathogen. Case presentation: The patient was admitted to the Internal Medicine with Stroke Care ward of University Policlinico “P. Giaccone” in Palermo because of the appearance of diarrhoea. After the antimicrobial treatment for infective colitis, the clinicians observed a persistently increased white blood cells (WBC) count and multiple hepatic lesions; after having excluded any neoplastic disease and inflammatory bowel disease (IBD), blood cultures positive for Y. enterocolitica allowed to establish the final diagnosis was infective micro liver abscesses consequent to infective colitis due to Y. enterocolitica, which were successfully treated with cefixime and doxycycline. Conclusions: This case report should make clinicians reflect on how complex the differential diagnosis between microliver abscesses and metastasis could be and the possibility of bacteriaemia by Y. enterocolitica even without iron overload conditions

A See-Saw S4S_4 model for fermion masses and mixings

We present a supersymmetric see-saw $S_4$ model giving rise to the most general neutrino mass matrix compatible with Tri-Bimaximal mixing. We adopt the $S_4\times Z_5$ flavour symmetry, broken by suitable vacuum expectation values of a small number of flavon fields. We show that the vacuum alignment is a natural solution of the most general superpotential allowed by the flavour symmetry, without introducing any soft breaking terms. In the charged lepton sector, mass hierarchies are controlled by the spontaneous breaking of the flavour symmetry caused by the vevs of one doublet and one triplet flavon fields instead of using the Froggatt-Nielsen U(1) mechanism. The next to leading order corrections to both charged lepton mass matrix and flavon vevs generate corrections to the mixing angles as large as ${\cal O}(\lambda_C^2)$. Applied to the quark sector, the symmetry group $S_4\times Z_5$ can give a leading order $V_{CKM}$ proportional to the identity as well as a matrix with ${\cal O}(1)$ coefficients in the Cabibbo $2\times 2$ submatrix. Higher order corrections produce non vanishing entries in the other $V_{CKM}$ entries which are generically of ${\cal O}(\lambda_C^2)$.Comment: 30 pages, 3 figures, minor changes to match the published versio

High sensitivity GEM experiment on double beta decay of 76-Ge

The GEM project is designed for the next generation 2 beta decay experiments with 76-Ge. One ton of ''naked'' HP Ge detectors (natural at the first GEM-I phase and enriched in 76-Ge to 86% at the second GEM-II stage) are operating in super-high purity liquid nitrogen contained in the Cu vacuum cryostat (sphere with diameter 5 m). The latest is placed in the water shield. Monte Carlo simulation evidently shows that sensitivity of the experiment (in terms of the T1/2 limit for neutrinoless 2 beta decay) is 10^27 yr with natural HP Ge crystals and 10^28 yr with enriched ones. These bounds corresponds to the restrictions on the neutrino mass less than 0.05 eV and 0.015 eV with natural and enriched detectors, respectively. Besides, the GEM-I set up could advance the current best limits on the existence of neutralinos - as dark matter candidates - by three order of magnitudes, and at the same time would be able to identify unambiguously the dark matter signal by detection of its seasonal modulation.Comment: LaTeX, 20 pages, 4 figure

S4 Flavor Symmetry and Fermion Masses: Towards a Grand Unified theory of Flavor

Pursuing a bottom-up approach to explore which flavor symmetry could serve as an explanation of the observed fermion masses and mixings, we discuss an extension of the standard model (SM) where the flavor structure for both quarks and leptons is determined by a spontaneously broken S4 and the requirement that its particle content is embeddable simultaneously into the conventional SO(10) grand unified theory (GUT) and a continuous flavor symmetry G_f like SO(3)_f or SU(3)_f. We explicitly provide the Yukawa and the Higgs sector of the model and show its viability in two numerical examples which arise as small deviations from rank one matrices. In the first case, the corresponding mass matrix is democratic and in the second one only its 2-3 block is non-vanishing. We demonstrate that the Higgs potential allows for the appropriate vacuum expectation value (VEV) configurations in both cases, if CP is conserved. For the first case, the chosen Yukawa couplings can be made natural by invoking an auxiliary Z2 symmetry. The numerical study we perform shows that the best-fit values for the lepton mixing angles theta_12 and theta_23 can be accommodated for normal neutrino mass hierarchy. The results for the quark mixing angles turn out to be too small. Furthermore the CP-violating phase delta can only be reproduced correctly in one of the examples. The small mixing angle values are likely to be brought into the experimentally allowed ranges by including radiative corrections. Interestingly, due to the S4 symmetry the mass matrix of the right-handed neutrinos is proportional to the unit matrix.Comment: 27 pages, published version with minor change

Analysis Techniques for the Evaluation of the Neutrinoless Double-Beta Decay Lifetime in 130^{130}Te with CUORE-0

We describe in detail the methods used to obtain the lower bound on the lifetime of neutrinoless double-beta ($0\nu\beta\beta$) decay in $^{130}$Te and the associated limit on the effective Majorana mass of the neutrino using the CUORE-0 detector. CUORE-0 is a bolometric detector array located at the Laboratori Nazionali del Gran Sasso that was designed to validate the background reduction techniques developed for CUORE, a next-generation experiment scheduled to come online in 2016. CUORE-0 is also a competitive $0\nu\beta\beta$ decay search in its own right and functions as a platform to further develop the analysis tools and procedures to be used in CUORE. These include data collection, event selection and processing, as well as an evaluation of signal efficiency. In particular, we describe the amplitude evaluation, thermal gain stabilization, energy calibration methods, and the analysis event selection used to create our final $0\nu\beta\beta$ decay search spectrum. We define our high level analysis procedures, with emphasis on the new insights gained and challenges encountered. We outline in detail our fitting methods near the hypothesized $0\nu\beta\beta$ decay peak and catalog the main sources of systematic uncertainty. Finally, we derive the $0\nu\beta\beta$ decay half-life limits previously reported for CUORE-0, $T^{0\nu}_{1/2}>2.7\times10^{24}$ yr, and in combination with the Cuoricino limit, $T^{0\nu}_{1/2}>4.0\times10^{24}$ yr.Comment: 18 pages, 18 figures. (Version 3 reflects only minor changes to the text. Few additional details, no major content changes.

CUORE-0 results and prospects for the CUORE experiment

With 741 kg of TeO2 crystals and an excellent energy resolution of 5 keV (0.2%) at the region of interest, the CUORE (Cryogenic Underground Observatory for Rare Events) experiment aims at searching for neutrinoless double beta decay of 130Te with unprecedented sensitivity. Expected to start data taking in 2015, CUORE is currently in an advanced construction phase at LNGS. CUORE projected neutrinoless double beta decay half-life sensitivity is 1.6E26 y at 1 sigma (9.5E25 y at the 90% confidence level), in five years of live time, corresponding to an upper limit on the effective Majorana mass in the range 40-100 meV (50-130 meV). Further background rejection with auxiliary bolometric detectors could improve CUORE sensitivity and competitiveness of bolometric detectors towards a full analysis of the inverted neutrino mass hierarchy. CUORE-0 was built to test and demonstrate the performance of the upcoming CUORE experiment. It consists of a single CUORE tower (52 TeO2 bolometers of 750 g each, arranged in a 13 floor structure) constructed strictly following CUORE recipes both for materials and assembly procedures. An experiment its own, CUORE-0 is expected to reach a sensitivity to the neutrinoless double beta decay half-life of 130Te around 3E24 y in one year of live time. We present an update of the data, corresponding to an exposure of 18.1 kg y. An analysis of the background indicates that the CUORE performance goal is satisfied while the sensitivity goal is within reach.Comment: 10 pages, 3 figures, to appear in the proceedings of NEUTRINO 2014, 26th International Conference on Neutrino Physics and Astrophysics, 2-7 June 2014, held at Boston, Massachusetts, US

Measurement of the Two-Neutrino Double Beta Decay Half-life of 130^{130}Te with the CUORE-0 Experiment

We report on the measurement of the two-neutrino double beta decay half-life of $^{130}$Te with the CUORE-0 detector. From an exposure of 33.4 kg$\cdot$y of TeO$_2$, the half-life is determined to be $T_{1/2}^{2\nu}$ = [8.2 $\pm$ 0.2 (stat.) $\pm$ 0.6 (syst.)] $\times$ 10$^{20}$y. This result is obtained after a detailed reconstruction of the sources responsible for the CUORE-0 counting rate, with a specific study of those contributing to the $^{130}$Te neutrinoless double beta decay region of interest.Comment: Corrected typo in section 9: 3.43E5 Bq/kg should have read 3.43E-5 Bq/k

Status of the CUORE and results from the CUORE-0 neutrinoless double beta decay experiments

CUORE is a 741 kg array of TeO2 bolometers for the search of neutrinoless double beta decay of 130Te. The detector is being constructed at the Laboratori Nazionali del Gran Sasso, Italy, where it will start taking data in 2015. If the target background of 0.01 counts/keV/kg/y will be reached, in five years of data taking CUORE will have a 1 sigma half life sensitivity of 10E26 y. CUORE-0 is a smaller experiment constructed to test and demonstrate the performances expected for CUORE. The detector is a single tower of 52 CUORE-like bolometers that started taking data in spring 2013. The status and perspectives of CUORE will be discussed, and the first CUORE-0 data will be presented.Comment: 7 pages, 4 figures, to be published in the proceedings of ICHEP 2014, 37th International Conference on High Energy Physics, Valencia (Spain) 2-9 July 201

Relic neutrino masses and the highest energy cosmic rays

We consider the possibility that a large fraction of the ultrahigh energy cosmic rays are decay products of Z bosons which were produced in the scattering of ultrahigh energy cosmic neutrinos on cosmological relic neutrinos. We compare the observed ultrahigh energy cosmic ray spectrum with the one predicted in the above Z-burst scenario and determine the required mass of the heaviest relic neutrino as well as the necessary ultrahigh energy cosmic neutrino flux via a maximum likelihood analysis. We show that the value of the neutrino mass obtained in this way is fairly robust against variations in presently unknown quantities, like the amount of neutrino clustering, the universal radio background, and the extragalactic magnetic field, within their anticipated uncertainties. Much stronger systematics arises from different possible assumptions about the diffuse background of ordinary cosmic rays from unresolved astrophysical sources. In the most plausible case that these ordinary cosmic rays are protons of extragalactic origin, one is lead to a required neutrino mass in the range 0.08 eV - 1.3 eV at the 68 % confidence level. This range narrows down considerably if a particular universal radio background is assumed, e.g. to 0.08 eV - 0.40 eV for a large one. The required flux of ultrahigh energy cosmic neutrinos near the resonant energy should be detected in the near future by AMANDA, RICE, and the Pierre Auger Observatory, otherwise the Z-burst scenario will be ruled out.Comment: 19 pages, 22 figures, REVTeX

The low radioactivity link of the CUORE experiment

CUORE will be an array of 988 TeO2 bolometers (5 × 5 × 5 cm3) held at about 10 mK. It will study the very rare double β decay process from 130Te. The electrical connections of the array to the room temperature electronics will consist in about 2000 wires. We will describe the design and characterization of the 3 interconnection sectors going from the detectors to the mixing chamber, the coldest stage at which the array is thermally and mechanically anchored, and from the mixing chamber to room temperature. The lower part consists of a set of 2.3 m long, 50 μm thick, Cu-insulator tapes having PEN (Polyethylene 2.6 Naphthalate) substrate, on which a pattern of copper tracks are etched. The differential layout pattern chosen allows obtaining a signal cross talk between adjacent channels of about 0.024%, together with a capacitance of about 26 pF/m and a resistance larger than 200 GΩ/m. On the top of the mixing chamber, Cu-Kapton boards are used to join the tapes to the second upward-going 2 m long links, implemented with twisted NbTi wires, interwoven in a NOMEX® texture. NbTi-NOMEX link features about 100 pF/m and negligible level of cross-talk. The radioactivity content of Cu-PEN tapes, Cu-Kapton boards, NbTi-NOMEX ribbons and connectors has been investigated and found to be compliant with the experimental requirements. A mechanical study has been done to quote the vibration transmission properties of the highly packaged tapes