Caracterización litológica y mineralogica de los materiales permo-triásicos de Castellón utilizados como materia prima cerámica : la arcilla de Moró

Las lutitas de edad Pérmica que se utilizan como materia prima en la industria azulejera de Castellón se conocen en el sector cerámico como arcilla de Moró. En el presente trabajo se describen las características litológicas y composicionales de estas lutitas con el objetivo de establecer las variaciones en composición a lo largo de la serie estratigráfica tipo. Los resultados muestran una composición mineralógica de la roca total muy uniforme, formada esencialmente por cuarzo, filosilicatos y hematites. Ocasionalmente y en proporciones por debajo del 5% aparece también feldespato potásito, dolomita y calcita. La asociación de minerales de la arcilla está formada por illita ± caolinita ± clorita ± interestratificado illita-esmectita ± interestratificado clorita-esmectita y muestra un patrón de distribución sedimentario. Los resultados obtenidos ponen de manifiesto la importancia del análisis mineralógico en la caracterización de las materias primas y, por tanto, en el control de sus propiedades cerámicas y de los procesos productivos relacionados.The aim of this work is to establish the mineralogical (XRD) composition of the Permo-Triassic claystone known as Moró clay. Particular emphasis is placed on the compositional variations along the litostratigraphic section. Bulk rock XRD analysis shows a homogeneous composition dominated by quartz, phyllosilicates and hematite. Minor components (<5%) include potassium feldspar, dolomite and calcite. The clay minerals assemblage is formed by illite ± kaolin ± chlorite ± mixed-layer illite-smectite ± mixed-layer chlorite-smectite and reveals a sedimentary distribution pattern. The study of the lithological section allows the identification and valuation of changes in the mineralogical characteristics of the raw material. Results provide evidence for the importance of mineralogical analysis in the control of raw materials and hence their use in industrial processes

Altered sleep and neurovascular dysfunction in alpha-synucleinopathies: the perfect storm for glymphatic failure

Clinical and cognitive progression in alpha-synucleinopathies is highly heterogeneous. While some patients remain stable over long periods of time, other suffer early dementia or fast motor deterioration. Sleep disturbances and nocturnal blood pressure abnormalities have been identified as independent risk factors for clinical progression but a mechanistic explanation linking both aspects is lacking. We hypothesize that impaired glymphatic system might play a key role on clinical progression. Glymphatic system clears brain waste during specific sleep stages, being blood pressure the motive force that propels the interstitial fluid through brain tissue to remove protein waste. Thus, the combination of severe sleep alterations, such as REM sleep behavioral disorder, and lack of the physiological nocturnal decrease of blood pressure due to severe dysautonomia may constitute the perfect storm for glymphatic failure, causing increased abnormal protein aggregation and spreading. In Lewy body disorders (Parkinson’s disease and dementia with Lewy bodies) the increment of intraneuronal alpha-synuclein and extracellular amyloid-β would lead to cognitive deterioration, while in multisystemic atrophy, increased pathology in oligodendroglia would relate to the faster and malignant motor progression. We present a research model that may help in developing studies aiming to elucidate the role of glymphatic function and associated factors mainly in alpha-synucleinopathies, but that could be relevant also for other protein accumulation-related neurodegenerative diseases. If the model is proven to be useful could open new lines for treatments targeting glymphatic function (for example through control of nocturnal blood pressure) with the objective to ameliorate cognitive and motor progression in alpha-synucleinopathies

Resistencia mecánica y porosidad de soportes para pavimentos y revestimientos cerámicos obtenidos con arcillas de Castellón

We have tried to establish a relationship between the raw material and the mechanical properties of ceramic pieces subjected to different firing processes, so under the determinant of the thermal process we have done a follow up on the petrogenetic process that the manufacture of ceramics represents. This is evaluated in terms of the mechanical behaviour of the ceramic tile bodies, which have been normalised and submitted to tests for flexion. The principal objective is to be able to indicate what the optimum firing temperature for each sample is, and to determine what it is in the ceramic body which offers the greatest resistance when a specific force is applied. The study of the texture of the ceramic body will be considered mainly in relation to the existent porosity, as well as its distribution, which conditions its characteristics and specifications. The relation between porosity and the parameters that describe the porous texture of the ceramic tile pieces studied is complicated because of the fact that these have many pores with a complex and irregular spatial disposition, with a broad distribution of forms and sizes, and as such they do not fit into established empirical equations.Se ha tratado de establecer la relación entre materia prima y propiedades mecánicas de piezas cerámicas sometidas a procesos de cocción diversos. Bajo el condicionante del proceso térmico se realiza un seguimiento del proceso petrogenético que representa la fabricación cerámica y se evalúa a través del comportamiento mecánico de probetas cerámicas normalizadas y sometidas a ensayos de flexión. El objetivo principal es poder indicar cuál es la temperatura óptima de cocción para cada muestra y determinar cuál es aquélla en que la probeta cerámica ofrece una mayor resistencia al aplicarle una determinada carga. El estudio de la textura de la matriz cerámica es de gran interés en relación con la porosidad, asi como su distribución, que condiciona sus características y aplicaciones. La relación existente entre la porosidad y los parámetros relacionados con la textura porosa es muy compleja debido a la distribución irregular de formas y tamaños de poro, que no se ajusta a ninguna ecuación empírica establecida, pero aun así hay aproximaciones teóricas que pueden permitir prevenir la relación entre la porosidad y las propiedades mecánicas

Reducing health effects on deceit in heterosexual sexual-affective relationships: the impact of the preventive socialization program (PSP)

Background: Health research has provided robust evidence of the negative effects caused by facing deceit in sexual-affective relationships. In this regard, several analyses have been conducted addressing psychological, family therapies, and educational interventions to improve marital problems. On the other hand, many investigations have addressed how the preventive socialization program (PSP), framed on the analysis of a dominant coercive discourse that is connected with the promotion of specific traditional masculine models, impacts on young people's relationships free of violence. However, the link between deceit, health, and the PSP has not yet been analyzed. To cover this gap, a qualitative study has been performed with a methodology framed on the communicative approach. We enrolled heterosexual women and men aged 25 to 42 years old who have been in contact with the PSP and have experienced or know of any cases of deceit. Two different analytical categories emerged from the analysis, which distinguishes between exclusionary and transformative dimensions. Findings show that the majority of people involved in PSP were able to understand the reasons for deceit as well as to take decisions in their further sexual-affective relationships. Therefore, this study corroborates that access to scientific evidence in the framework of PSP is positively impacting interviewees' health status (...

Efficacy and safety of lurbinectedin and doxorubicin in relapsed small cell lung cancer. Results from an expansion cohort of a phase I study

Background A phase I study found remarkable activity and manageable toxicity for doxorubicin (bolus) plus lurbinectedin (1-h intravenous [i.v.] infusion) on Day 1 every three weeks (q3wk) as second-line therapy in relapsed small cell lung cancer (SCLC). An expansion cohort further evaluated this combination. Patients and methods Twenty-eight patients with relapsed SCLC after no more than one line of cytotoxic-containing chemotherapy were treated: 18 (64%) with sensitive disease (chemotherapy-free interval [CTFI] ≥90 days) and ten (36%) with resistant disease (CTFI <90 days; including six with refractory disease [CTFI ≤30 days]). Results Ten patients showed confirmed response (overall response rate [ORR] = 36%); median progression-free survival (PFS) = 3.3 months; median overall survival (OS) = 7.9 months. ORR was 50% in sensitive disease (median PFS = 5.7 months; median OS = 11.5 months) and 10% in resistant disease (median PFS = 1.3 months; median OS = 4.6 months). The main toxicity was transient and reversible myelosuppression. Treatment-related non-hematological events (fatigue, nausea, decreased appetite, vomiting, alopecia) were mostly mild or moderate. Conclusion Doxorubicin 40 mg/m(2) and lurbinectedin 2.0 mg/m(2) on Day 1 q3wk has shown noteworthy activity in relapsed SCLC and a manageable safety profile. The combination is being evaluated as second-line therapy for SCLC in an ongoing, randomized phase III trial. Clinical trial registration www.ClinicalTrials.gov code: NCT01970540. Date of registration: 22 October, 2013

An Introduction to the Study of Gastrotricha, with a Taxonomic Key to Families and Genera of the Group

Gastrotricha is a group of meiofaunal-sized, free-living invertebrates present in all aquatic ecosystems. The phylum includes over 860 species globally, of which 505 nominal species have been recorded in marine sandy sediments; another 355 taxa inhabit the freshwater environments, where they are recurrent members of the periphyton and epibenthos, and, to a lesser degree, of the plankton and interstitial fauna. Gastrotrichs are part of the permanent meiofauna and, in general, they rank among the top five groups for abundance within meiobenthic assemblages. The diversity, abundance, and ubiquity of Gastrotricha allow us to suppose an important role for these animals in aquatic ecosystems; however, ecological studies to prove this idea have been comparatively very few. This is mainly because the small size and transparency of their bodies make gastrotrichs dicult to discover in benthic samples; moreover, their contractility and fragility make their handling and morphological survey of the specimens rather dicult. Here we oer an overview, describe the basic techniques used to study these animals, and provide a key to known genera in an attempt to promote easy identification and to increase the number of researchers who may be interested in conducting studies on this understudied ecological group of microscopic organisms

Las comunidades terapéuticas como tratamiento para las drogodependencias: una revisión sistemática del seguimiento a corto plazo

Objetivo. Las comunidades terapéuticas (CT) constituyen uno de los tratamientos más extensos para las drogodependencias; sin embargo, su investigación es escasa. El objetivo fue realizar una revisión sistemática para conocer los elementos metodológicos de los estudios de seguimiento a corto plazo y, a su vez, describir las consecuencias de las CT. Material y método. Se aplicó el "Preferred Reporting Items for Systematic reviews and meta- Analyses" (PRISMA) para la búsqueda en Medline, PsycINFO, PsycARTICLES y PsycCRITIQUES de estudios de seguimiento a corto plazo de CT entre 1980 y 2010. Resultados. El seguimiento consiste en un registro inicial y, al menos, otro al medio año de tratamiento; la muestra mínima contiene 60 usuarios con una mayor prevalencia de hombres solteros;el 50% continúa en seguimiento y/o alcanza la abstinencia. Conclusión. Las CT parecen ser beneficiosas para el ajuste del consumo y otros aspectos psicosociales, aunque la falta de información dificulta garantizar la comparación de estos hallazgos. © 2013 Elsevier España, S.L. y SET. Todos los derechos reservados

ENVEJECIMIENTO Y SOLEDAD

Objective: The aim of this study is to analyze whether elderly people in a state of fragility, visited by the Emergency Domiciliary Care service, have received a follow-up program by the nursing staff and whether they were labeled as “Elderly people in state of fragility.” Material and method: A two-phase observational study. Firstly, in phase I, a population comprising people older than 64 and visited by the emergency domiciliary service from the Raval Nord Primary Care Centre was selected. Whether they had received nursing follow-up and whether they had been diagnosed as elderly people in a frail state was analyzed. In phase II, a simple random sample from this population was chosen. Here, it was analyzed whether there had been changes in the nursing diagnosis and follow-up. Results: Of a total was seen that of 776 medical emergency domiciliary visits, 568 (73.19%) were people belonging to the over 64 group. Out of the total, 57 cases (10%) belonged to the age group between 75 and 85 years old (80%). Out of this group, 77.26% were women; 94% were diagnosed with a chronic condition (diabetes, hypertension, chronic obstructive pulmonary disease, etc); and 77.2% were polymedicated. In addition, 66.7% were not included in the Domiciliary Care Program and were not diagnosed as frail elderly people. In phase II, an increase in nursing care, as well as in the “frail elderly people” diagnosis were found. Conclusions: The use of nursing diagnosis for elderly people in a frail state is an indispensable tool for the monitoring and follow-up of that population.Objetivo: Analizar si en las personas mayores en situación de fragilidad que han sido atendidas por el servicio de urgencias domiciliarias, constaba el seguimiento por el personal de enfermería del centro y  si constaba  el diagnóstico de “Personas mayores en situación de fragilidad”. Material y método: Se realizó un estudio observacional en dos fases: 1ª se analizaron todas las personas mayores de 64 años que fueron atendidas en el servicio de urgencias domiciliarias del centro de Atención Primaría de Raval Nord, se analizó si en dicha población constaba el seguimiento de enfermería y el diagnóstico de personas mayores en situación de fragilidad ; 2ª fase, se realizó un muestreo simple  de la población analizada y se evaluó si se produjeron cambios en  los diagnósticos de enfermería y seguimiento de dicha población. Resultados: De un total de 776 visitas domiciliarias de urgencias médicas, se observó que 568 (73,19%) eran mayores de 64 años. Del total, se estudiaron 57 (10%) casos y se observó que el 80% pertenecían al grupo de edad comprendido entre 75 y 85 años; el 77,26% eran mujeres; el 94% con diagnóstico crónico (Diabetes, Hipertensión Epoc...); el 77,2% eran personas polimedicadas y el 66,7% del total no estaban incluidas en el programa de Atención Domiciliaria y no constaba ningún diagnóstico de “personas mayores frágiles”. En la segunda fase se observa un incremento  en la atención por parte de los profesionales de enfermería y un aumento en el diagnóstico de “Personas mayores frágiles”. Conclusiones: La utilización del diagnóstico de enfermería en las personas en situación de fragilidad es una herramienta imprescindible para el seguimiento y control de dicha población.