Elderly with Autism: Executive Functions and Memory

Cognitive autism research is mainly focusing on children and young adults even though we know that autism is a life-long disorder and that healthy aging already has a strong impact on cognitive functioning. We compared the neuropsychological profile of 23 individuals with autism and 23 healthy controls (age range 51–83 years). Deficits were observed in attention, working memory, and fluency. Aging had a smaller impact on fluency in the high functioning autism (HFA) group than in the control group, while aging had a more profound effect on visual memory performance in the HFA group. Hence, we provide novel evidence that elderly with HFA have subtle neuropsychological deficits and that the developmental trajectories differ between elderly with and without HFA in particular cognitive domains

Rejection sensitivity as a vulnerability marker for depressive symptom deterioration in men

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Design considerations for haptic-enabled virtual reality simulation for interactive learning of nanoscale science in schools

This paper reports on a study which investigated whether the addition of haptics (virtual touch) to a 3D virtual reality (VR) simulation promotes understanding of key nanoscale concepts in membrane systems for students aged 12 to 13. We developed a virtual model of a section of the cell membrane and a haptic enabled interface that enables students to interact with the model and to manipulate objects in the model. Students, in two schools in England, worked collaboratively in pairs on activities designed to develop their understanding of key concepts of cell membrane function. Results of pre-and post-tests of conceptual knowledge and understanding showed significant knowledge gains but there were no significant differences between the haptic and non-haptic condition. However, findings from observation of the activities and student interviews revealed that students were very positive about using the system and believed that being able to feel structures and manipulate objects within the model assisted their learning. We examine some of the design challenges and issues affecting the perception of haptic feedback

Does Older Age Confer an Increased Risk of Incident Neurocognitive Disorders Among Persons Living with HIV Disease?

OBJECTIVE: This study aimed to determine the combined effects of age and HIV infection on the risk of incident neurocognitive disorders. METHOD: A total of 146 neurocognitively normal participants were enrolled at baseline into one of four groups based on age (≤ 40 years and ≥ 50 years) and HIV serostatus resulting in 24 younger HIV−, 27 younger HIV+, 39 older HIV−, and 56 older HIV+ individuals. All participants were administered a standardized clinical neuropsychological battery at baseline and 14.3 ±0.2 months later. RESULTS: A logistic regression predicting incident neurocognitive disorders from HIV, age group, and their interaction was significant (χ(2)[4] = 13.56, p = .009), with a significant main effect of HIV serostatus (χ(2)[1] = 5.01, p = .025), but no main effect of age or age by HIV interaction (ps > .10). Specifically, 15.7 percent of the HIV+ individuals had an incident neurocognitive disorder as compared to 3.2 percent of the HIV− group (odds ratio = 4.8 [1.2, 32.6]). Among older HIV+ adults, lower baseline cognitive reserve, prospective memory, and verbal fluency each predicted incident neurocognitive disorders at follow-up. CONCLUSIONS: Independent of age, HIV infection confers a nearly 5-fold risk for developing a neurocognitive disorder over approximately one year. Individuals with lower cognitive reserve and mild weaknesses in higher-order neurocognitive functions may be targeted for closer clinical monitoring and preventative measures