1,938 research outputs found
A closer look at interacting dark energy with statefinder hierarchy and growth rate of structure
We investigate the interacting dark energy models by using the diagnostics of
statefinder hierarchy and growth rate of structure. We wish to explore the
deviations from CDM and to differentiate possible degeneracies in the
interacting dark energy models with the geometrical and structure growth
diagnostics. We consider two interacting forms for the models, i.e., and , with being the dimensionless
coupling parameter. Our focus is the ICDM model that is a
one-parameter extension to CDM by considering a direct coupling
between the vacuum energy () and cold dark matter (CDM), with the only
additional parameter . But we begin with a more general case by
considering the ICDM model in which dark energy has a constant
(equation-of-state parameter). For calculating the growth rate of structure, we
employ the "parametrized post-Friedmann" theoretical framework for interacting
dark energy to numerically obtain the values for the models. We
show that in both geometrical and structural diagnostics the impact of is
much stronger than that of in the ICDM model. We thus wish to have a
closer look at the ICDM model by combining the geometrical and
structural diagnostics. We find that the evolutionary trajectories in the
-- plane exhibit distinctive features and the departures
from CDM could be well evaluated, theoretically, indicating that the
composite null diagnostic is a promising tool for
investigating the interacting dark energy models.Comment: 17 pages, 4 figures; accepted for publication in JCA
Risk for Gestational Diabetes Mellitus and Adverse Birth Outcomes in Chinese Women with Polycystic Ovary Syndrome
Objective. To examine the association of polycystic ovary syndrome (PCOS) in early pregnancy with gestational diabetes mellitus (GDM) and adverse birth outcomes. Methods. In this retrospective cohort study including 2389 pregnant women, the medical records of 352 women diagnosed with PCOS were evaluated. Outcomes included GDM, preterm birth, low birth weight, macrosomia, and being small and large for gestational age. Multivariable logistic regression models were used to examine the association of the risk for GDM and adverse birth outcomes with PCOS after adjusting for confounders. Results. Women previously diagnosed with PCOS had a higher risk of GDM (adjusted odds ratio [OR] 1.55, 95% confidence interval [CI]: 1.14–2.09). A strong association was seen between PCOS and preterm birth (adjusted OR 1.69, 95% CI: 1.08–2.67). On stratified analysis, the adjusted OR for GDM among women with PCOS undergoing assisted reproductive technology was 1.44 (95% CI: 1.03–1.92) and among women with PCOS who conceived spontaneously was 1.60 (1.18–2.15). No increased risk for other adverse birth outcomes was observed. Conclusions. Women with PCOS were more likely to experience GDM and preterm birth
Alteration of Intestinal Microbiota Composition in Oral Sensitized C3H/HeJ Mice Is Associated With Changes in Dendritic Cells and T Cells in Mesenteric Lymph Nodes
This research aimed to investigate the allergic reaction of C3H/HeJ mice after sensitization with ovalbumin (OVA) without any adjuvant and to analyze the association between intestinal microbiota and allergy-related immune cells in mesenteric lymph nodes (MLN). The allergic responses of C3H/HeJ mice orally sensitized with OVA were evaluated, and immune cell subsets in spleen and MLN and cytokines were also detected. The intestinal bacterial community structure was analyzed, followed by Spearman correlation analysis between changed gut microbiota species and allergic parameters. Sensitization induced a noticeable allergic response to the gavage of OVA without adjuvant. Increased levels of Th2, IL-4, CD103+CD86+ DC, and MHCII+CD86+ DC and decreased levels of Th1, Treg, IFN-γ, TGF-β1, and CD11C+CD103+ DC were observed in allergic mice. Furthermore, families of Lachnospiraceae, Clostridiaceae_1, Ruminococcaceae, and peprostreptococcaceae, all of which belonging to the order Clostridiales, were positively related to Treg and CD11C+CD103+ DC, while they were negatively related to an allergic reaction, levels of Th2, CD103+CD86+ DC, and MHCII+CD86+ DC in MLN. The family of norank_o_Mollicutes_RF39 belonging to the order Mollicutes_RF39 was similarly correlated with allergic reaction and immune cells in MLN of mice. To sum up, allergic reactions and intestinal flora disturbances could be induced by OVA oral administration alone. The orders of Clostridiales and Mollicutes_RF39 in intestinal flora are positively correlated with levels of Treg and CD11C+CD103+ DC in MLN of mice
Increased expression of heat shock protein 105 in rat uterus of early pregnancy and its significance in embryo implantation
<p>Abstract</p> <p>Background</p> <p>Heat shock proteins (Hsps) are a set of highly conserved proteins, Hsp105, has been suggested to play a role in reproduction.</p> <p>Methods</p> <p>Spatio-temporal expression of Hsp105 in rat uterus during peri-implantation period was examined by immunohistochemistry and Western blot, pseudopregnant uterus was used as control. Injection of antisense oligodeoxynucleotides to Hsp105 into pregnant rat uteri was carried out to look at effect of Hsp105 on embryo implantation.</p> <p>Results</p> <p>Expression of Hsp105 was mainly in the luminal epithelium on day 1 of pregnancy, and reached a peak level on day 5, whereas in stroma cells, adjacent to the implanting embryo, the strongest expression of Hsp105 was observed on day 6. The immunostaining profile in the uterus was consistent with that obtained by Western blot in the early pregnancy. In contrast, no obvious peak level of Hsp105 was observed in the uterus of pseudopregnant rat on day 5 or day 6. Furthermore, injection of antisense oligodeoxynucleotides to Hsp105 into the rat uterine horn on day 3 of pregnancy obviously suppressed the protein expression as expected and reduced number of the implanted embryos as compared with the control.</p> <p>Conclusion</p> <p>Temporal and spatial changes in Hsp105 expression in pregnant rat uterus may play a physiological role in regulating embryo implantation.</p
活性酸素の過剰生成とMAPKの活性化を介したバイカリンによる温熱誘発アポトーシスの増強
富山大学・富医薬博甲第311号・SHAHBAZ AHMAD ZAKKI・2019/09/27関連論文Zakki S, A, Cui Z, -G, Sun L, Feng Q, -W, Li M, -L, Inadera H: Baicalin Augments Hyperthermia-Induced Apoptosis in U937 Cells and Modulates the MAPK Pathway via ROS Generation. Cell Physiol Biochem 2018;45:2444-2460. doi: 10.1159/000488263The final, published version of this article is available at https://www.karger.com/?doi=10.1159/000488263富山大
SDSS J143030.22-001115.1: A misclassified narrow-line Seyfert 1 galaxy with flat X-ray spectrum
We used multi-component profiles to model H and [O III]4959,5007 lines for SDSS J143030.22-001115.1, a narrow-line Seyfert 1
galaxy (NLS1) in a sample of 150 NLS1s candidates selected from the Sloan
Digital Sky Survey (SDSS) Early Data Release (EDR). After subtracting the
H contribution from narrow line regions (NLRs), we found that its full
width half maximum (FWHM) of broad H line is nearly 2900 \kms,
significantly larger than the customarily adopted criterion of 2000 \kms. With
its weak Fe II multiples, we think that SDSS J143030.22-001115.1 can't be
classified as a genuine NLS1. When we calculate the virial black hole masses of
NLS1s, we should use the H linewidth after subtracting the H
contribution from NLRs.Comment: 7 pages, 1 table, accepted by ChJA
Glucocorticoid Receptor β Acts As a Co-activator of T-Cell Factor 4 and Enhances Glioma Cell Proliferation
We previously reported that glucocorticoid receptor β (GRβ) regulates injury-mediated astrocyte activation and contributes to glioma pathogenesis via modulation of β-catenin/T-cell factor/lymphoid enhancer factor (TCF/LEF) transcriptional activity. The aim of this study was to characterize the mechanism behind cross-talk between GRβ and β-catenin/TCF in the progression of glioma. Here, we reported that GRβ knockdown reduced U118 and Shg44 glioma cell proliferation in vitro and in vivo. Mechanistically, we found that GRβ knockdown decreased TCF/LEF transcriptional activity without affecting β-catenin/TCF complex. Both GRα and GRβ directly interact with TCF-4, while only GRβ is required for sustaining TCF/LEF activity under hormone-free condition. GRβ bound to the N-terminus domain of TCF-4 its influence on Wnt signaling required both ligand- and DNA-binding domains (LBD and DBD, respectively). GRβ and TCF-4 interaction is enough to maintain the TCF/LEF activity at a high level in the absence of β-catenin stabilization. Taken together, these results suggest a novel cross-talk between GRβ and TCF-4 which regulates Wnt signaling and the proliferation in gliomas
Paraconsistent Reasoning for OWL 2
A four-valued description logic has been proposed to reason with description logic based inconsistent knowledge bases. This approach has a distinct advantage that it can be implemented by invoking classical reasoners to keep the same complexity as under the classical semantics. However, this approach has so far only been studied for the basid description logic ALC. In this paper, we further study how to extend the four-valued semantics to the more expressive description logic SROIQ which underlies the forthcoming revision of the Web Ontology Language, OWL 2, and also investigate how it fares when adapated to tractable description logics including EL++, DL-Lite, and Horn-DLs. We define the four-valued semantics along the same lines as for ALC and show that we can retain most of the desired properties
An Updated Search of Steady TeV Ray Point Sources in Northern Hemisphere Using the Tibet Air Shower Array
Using the data taken from Tibet II High Density (HD) Array (1997
February-1999 September) and Tibet-III array (1999 November-2005 November), our
previous northern sky survey for TeV ray point sources has now been
updated by a factor of 2.8 improved statistics. From to
in declination (Dec) range, no new TeV ray point
sources with sufficiently high significance were identified while the
well-known Crab Nebula and Mrk421 remain to be the brightest TeV ray
sources within the field of view of the Tibet air shower array. Based on the
currently available data and at the 90% confidence level (C.L.), the flux upper
limits for different power law index assumption are re-derived, which are
approximately improved by 1.7 times as compared with our previous reported
limits.Comment: This paper has been accepted by hepn
- …